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  • 2012

    Interplay of genetic risk factors (CHRNA 5-CHRNA 3-CHRNB4) and cessation treatments in smoking cessation success

    Chen, L. S., Baker, T. B., Piper, M. E., Breslau, N., Cannon, D. S., Doheny, K. F., Gogarten, S. M., Johnson, E. O., Saccone, N. L., Wang, J. C., Weiss, R. B., Goate, A. M. & Bierut, L. J., Jul 1 2012, In: American Journal of Psychiatry. 169, 7, p. 735-742 8 p.

    Research output: Contribution to journalArticlepeer-review

    107 Scopus citations
  • IS-seq: a novel high throughput survey of in vivo IS6110 transposition in multiple Mycobacterium tuberculosis genomes

    Reyes, A., Sandoval, A., Cubillos-Ruiz, A., Varley, K. E., Hernández-Neuta, I., Samper, S., Martín, C., García, M. J., Ritacco, V., López, L., Robledo, J., Zambrano, M. M., Mitra, R. D. & Del Portillo, P., Jun 15 2012, In: BMC genomics. 13, 1, 249.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    22 Scopus citations
  • JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production

    Labranche, T. P., Jesson, M. I., Radi, Z. A., Storer, C. E., Guzova, J. A., Bonar, S. L., Thompson, J. M., Happa, F. A., Stewart, Z. S., Zhan, Y., Bollinger, C. S., Bansal, P. N., Wellen, J. W., Wilkie, D. P., Bailey, S. A., Symanowicz, P. T., Hegen, M., Head, R. D., Kishore, N., Mbalaviele, G., & 1 othersMeyer, D. M., Nov 2012, In: Arthritis and rheumatism. 64, 11, p. 3531-3542 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    101 Scopus citations
  • Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

    Scott, R. A., Lagou, V., Welch, R. P., Wheeler, E., Montasser, M. E., Luan, JA., MäGi, R., Strawbridge, R. J., Rehnberg, E., Gustafsson, S., Kanoni, S., Rasmussen-Torvik, L. J., Yengo, L., Lecoeur, C., Shungin, D., Sanna, S., Sidore, C., Johnson, P. C. D., Jukema, J. W., Johnson, T., & 194 othersMahajan, A., Verweij, N., Thorleifsson, G., Hottenga, J. J., Shah, S., Smith, A. V., Sennblad, B., Gieger, C., Salo, P., Perola, M., Timpson, N. J., Evans, D. M., Pourcain, B. S., Wu, Y., Andrews, J. S., Hui, J., Bielak, L. F., Zhao, W., Horikoshi, M., Navarro, P., Isaacs, A., O'Connell, J. R., Stirrups, K., Vitart, V., Hayward, C., Esko, T., Mihailov, E., Fraser, R. M., Fall, T., Voight, B. F., Raychaudhuri, S., Chen, H., Lindgren, C. M., Morris, A. P., Rayner, N. W., Robertson, N., Rybin, D., Liu, C. T., Beckmann, J. S., Willems, S. M., Chines, P. S., Jackson, A. U., Kang, H. M., Stringham, H. M., Song, K., Tanaka, T., Peden, J. F., Goel, A., Hicks, A. A., An, P., MüLler-Nurasyid, M., Franco-Cereceda, A., Folkersen, L., Marullo, L., Jansen, H., Oldehinkel, A. J., Bruinenberg, M., Pankow, J. S., North, K. E., Forouhi, N. G., Loos, R. J. F., Edkins, S., Varga, T. V., Hallmans, G., Oksa, H., Antonella, M., Nagaraja, R., Trompet, S., Ford, I., Bakker, S. J. L., Kong, A., Kumari, M., Gigante, B., Herder, C., Munroe, P. B., Caulfield, M., Antti, J., Mangino, M., Small, K., Miljkovic, I., Liu, Y., Atalay, M., Kiess, W., James, A. L., Rivadeneira, F., Uitterlinden, A. G., Palmer, C. N. A., Doney, A. S. F., Willemsen, G., Smit, J. H., Campbell, S., Polasek, O., Bonnycastle, L. L., Hercberg, S., Dimitriou, M., Bolton, J. L., Fowkes, G. R., Kovacs, P., LindströM, J., Zemunik, T., Bandinelli, S., Wild, S. H., Basart, H. V., Rathmann, W., Grallert, H., Maerz, W., Kleber, M. E., Boehm, B. O., Peters, A., Pramstaller, P. P., Province, M. A., Borecki, I. B., Hastie, N. D., Rudan, I., Campbell, H., Watkins, H., Farrall, M., Stumvoll, M., Ferrucci, L., Waterworth, D. M., Bergman, R. N., Collins, F. S., Tuomilehto, J., Watanabe, R. M., De Geus, E. J. C., Penninx, B. W., Hofman, A., Oostra, B. A., Psaty, B. M., Vollenweider, P., Wilson, J. F., Wright, A. F., Hovingh, G. K., Metspalu, A., Uusitupa, M., Magnusson, P. K. E., Kyvik, K. O., Kaprio, J., Price, J. F., Dedoussis, G. V., Deloukas, P., Meneton, P., Lind, L., Boehnke, M., Shuldiner, A. R., Van Duijn, C. M., Morris, A. D., Toenjes, A., Peyser, P. A., Beilby, J. P., KöRner, A., Kuusisto, J., Laakso, M., Bornstein, S. R., Schwarz, P. E. H., Lakka, T. A., Rauramaa, R., Adair, L. S., Smith, G. D., Spector, T. D., Illig, T., Faire, U. D., Hamsten, A., Gudnason, V., Kivimaki, M., Hingorani, A., Keinanen-Kiukaanniemi, S. M., Saaristo, T. E., Boomsma, D. I., Stefansson, K., Van Der Harst, P., Dupuis, J., Pedersen, N. L., Sattar, N., Harris, T. B., Cucca, F., Ripatti, S., Salomaa, V., Mohlke, K. L., Balkau, B., Froguel, P., Pouta, A., Jarvelin, M. R., Wareham, N. J., Bouatia-Naji, N., McCarthy, M. I., Franks, P. W., Meigs, J. B., Teslovich, T. M., Florez, J. C., Langenberg, C., Ingelsson, E., Prokopenko, I. & Barroso, I., Sep 2012, In: Nature Genetics. 44, 9, p. 991-1005 15 p.

    Research output: Contribution to journalArticlepeer-review

    592 Scopus citations
  • Medicago truncatula transporter database: A comprehensive database resource for M. truncatula transporters

    Miao, Z., Li, D., Zhang, Z., Dong, J., Su, Z. & Wang, T., Feb 6 2012, In: BMC genomics. 13, 1, 60.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    9 Scopus citations
  • Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

    Okada, Y., Sim, X., Go, M. J., Wu, J. Y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S. C., Wong, T. Y., Liu, J., Young, T. L., Aung, T., Seielstad, M., Teo, Y. Y., Kim, Y. J., Lee, J. Y., Han, B. G., & 469 othersKang, D., Chen, C. H., Tsai, F. J., Chang, L. C., Fann, S. J., Mei, H., Rao, D. C., Hixson, J. E., Chen, S., Katsuya, T., Isono, M., Ogihara, T., Chambers, J. C., Zhang, W., Kooner, J. S., Albrecht, E., Yamamoto, K., Kubo, M., Nakamura, Y., Kamatani, N., Kato, N., He, J., Chen, Y. T., Cho, Y. S., Tai, E. S., Tanaka, T., Chambers, J. C., Zhang, W., Lord, G. M., van der Harst, P., Lawlor, D. A., Sehmi, J. S., Gale, D. P., Wass, M. N., Ahmadi, K. R., Bakker, S. J., Beckmann, J., Bilo, H. J., Bochud, M., Brown, M. J., Caulfield, M. J., Connell, J. M., Cook, H. T., Cotlarciuc, I., Smith, G. D., de Silva, R., Deng, G., Devuyst, O., Dikkeschei, L. D., Dimkovic, N., Dockrell, M., Dominiczak, A., Ebrahim, S., Eggermann, T., Farrall, M., Ferrucci, L., Floege, J., Forouhi, N. G., Gansevoort, R. T., Han, X., Hedblad, B., van der Heide, J. J., Hepkema, B. G., Hernandez-Fuentes, M., Hypponen, E., Johnson, T., de Jong, P. E., Kleefstra, N., Lagou, V., Lapsley, M., Li, Y., Loos, R. J., Luan, J., Luttropp, K., Maréchal, C., Melander, O., Munroe, P. B., Nordfors, L., Parsa, A., Peltonen, L., Penninx, B. W., Perucha, E., Pouta, A., Prokopenko, I., Roderick, P. J., Ruokonen, A., Samani, N. J., Sanna, S., Schalling, M., Schlessinger, D., Schlieper, G., Seelen, M. A., Shuldiner, A. R., Sjögren, M., Smit, J. H., Snieder, H., Soranzo, N., Spector, T. D., Stenvinkel, P., Sternberg, M. J., Swaminathan, R., Tanaka, T., Ubink-Veltmaat, L. J., Uda, M., Vollenweider, P., Wallace, C., Waterworth, D., Zerres, K., Waeber, G., Wareham, N. J., Maxwell, P. H., McCarthy, M. I., Jarvelin, M. R., Mooser, V., Abecasis, G. R., Lightstone, L., Scott, J., Navis, G., Elliott, P., Kooner, J. S., Köttgen, A., Pattaro, C., Böger, C. A., Fuchsberger, C., Olden, M., Glazer, N. L., Parsa, A., Gao, X., Yang, Q., Smith, A. V., O'connell, J. R., Li, M., Schmidt, H., Tanaka, T., Isaacs, A., Ketkar, S., Hwang, S. J., Johnson, A. D., Dehghan, A., Teumer, A., Paré, G., Atkinson, E. J., Zeller, T., Lohman, K., Cornelis, M. C., Probst-Hensch, N. M., Kronenberg, F., Tönjes, A., Hayward, C., Aspelund, T., Eiriksdottir, G., Launer, L. J., Harris, T. B., Rampersaud, E., Mitchell, B. D., Arking, D. E., Boerwinkle, E., Struchalin, M., Cavalieri, M., Singleton, A., Giallauria, F., Metter, J., de Boer, I. H., Haritunians, T., Lumley, T., Siscovick, D., Psaty, B. M., Zillikens, M. C., Oostra, B. A., Feitosa, M., Province, M., de Andrade, M., Turner, S. T., Schillert, A., Ziegler, A., Wild, P. S., Schnabel, R. B., Wilde, S., Munzel, T. F., Leak, T. S., Illig, T., Klopp, N., Meisinger, C., Wichmann, H. E., Koenig, W., Zgaga, L., Zemunik, T., Kolcic, I., Minelli, C., Hu, F. B., Johansson, Igl, W., Zaboli, G., Wild, S. H., Wright, A. F., Campbell, H., Ellinghaus, D., Schreiber, S., Aulchenko, Y. S., Felix, J. F., Rivadeneira, F., Uitterlinden, A. G., Hofman, A., Imboden, M., Nitsch, D., Brandstätter, A., Kollerits, B., Kedenko, L., Mägi, R., Stumvoll, M., Kovacs, P., Boban, M., Campbell, S., Endlich, K., Völzke, H., Kroemer, H. K., Nauck, M., Völker, U., Polasek, O., Vitart, V., Badola, S., Parker, A. N., Ridker, P. M., Kardia, S. L., Blankenberg, S., Liu, Y., Curhan, G. C., Franke, A., Rochat, T., Paulweber, B., Prokopenko, I., Wang, W., Gudnason, V., Shuldiner, A. R., Coresh, J., Schmidt, R., Shlipak, M. G., van Duijn, C. M., Borecki, I., Krämer, B. K., Rudan, I., Gyllensten, U., Wilson, J. F., Witteman, J. C., Pramstaller, P. P., Rettig, R., Hastie, N., Chasman, D. I., Kao, W. H., Heid, I. M., Fox, C. S., Köttgen, A., Albrecht, E., Teumer, A., Vitart, V., Krumsiek, J., Hundertmark, C., Pistis, G., Ruggiero, D., O'seaghdha, M., Haller, T., Yang, Q., Tanaka, T., Johnson, A. D., Kutalik, Z., Smith, A. V., Shi, J., Struchalin, M., Middelberg, P. S., Brown, M. J., Gaffo, A. L., Pirastu, N., Li, G., Hayward, C., Zemunik, T., Huffman, J., Yengo, L., Zhao, J. H., Demirkan, A., Feitosa, M. F., Liu, X., Malerba, G., Lopez, L. M., Li, X., Kleber, M. E., Hicks, A. A., Nolte, I. M., Johansson, A., Murgia, F., Wild, S. H., Bakker, S. J., Peden, J. F., Dehghan, A., Steri, M., Tenesa, A., Lagou, V., Salo, P., Mangino, M., Rose, L. M., Lehtimäki, T., Woodward, O. M., Tin, A., Müller, C., Oldmeadow, C., Putku, M., Czamara, D., Kraft, P., Frogheri, L., Thun, G. A., Grotevendt, A., Gislason, G. K., Harris, T. B., Launer, L. J., McArdle, P., Shuldiner, A. R., Boerwinkle, E., Schmidt, H., Schallert, M., Martin, N. G., Montgomery, G. W., Kubo, M., Nakamura, Y., Tanaka, T., Jacobs, D. R., Liu, K., D'adamo, P., Ulivi, S., Rotter, J. I., Psaty, B. M., Vollenweider, P., Waeber, G., Campbell, S., Devuyst, O., Navaro, P., Kolcic, I., Hastie, N., Balkau, B., Froguel, P., Esko, T., Salumets, A., Khaw, K. T., Langenberg, C., Isaacs, A., Kraja, A., Zhang, Q., Wild, P. S., Scott, R. J., Holliday, E. G., Org, E., Viigimaa, M., Bandinelli, S., Metter, J. E., Lupo, A., Trabetti, E., Sorice, R., Döring, A., Lattka, E., Strauch, K., Theis, F., Waldenberger, M., Wichmann, H. E., Davies, G., Gow, A. J., Bruinenberg, M., Stolk, R. P., Kooner, J. S., Zhang, W., Winkelmann, B. R., Boehm, B. O., Lucae, S., Penninx, B. W., Smit, J. H., Curhan, G., Mudgal, P., Plenge, R. M., Portas, L., Persico, I., Kirin, M., Wilson, J. F., Mateo Leach, I., van Gilst, W. H., Goel, A., Ongen, H., Hofman, A., Rivadeneira, F., Uitterlinden, A. G., Imboden, M., von Eckardstein, A., Cucca, F., Nagaraja, R., Piras, M. G., Nauck, M., Schurmann, C., Budde, K., Ernst, F., Farrington, S. M., Theodoratou, E., Prokopenko, I., Stumvoll, M., Jula, A., Perola, M., Salomaa, V., Shin, S. Y., Spector, T. D., Sala, C., Ridker, P. M., Kähönen, M., Viikari, J., Hengstenberg, C., Nelson, C. P., Meschia, J. F., Nalls, M. A., Sharma, P., Singleton, A. B., Kamatani, N., Zeller, T., Burnier, M., Attia, J., Laan, M., Klopp, N., Hillege, H. L., Kloiber, S., Choi, H., Pirastu, M., Tore, S., Probst-Hensch, N. M., Völzke, H., Gudnason, V., Parsa, A., Schmidt, R., Whitfield, J. B., Fornage, M., Gasparini, P., Siscovick, D. S., Polasek, O., Campbell, H., Rudan, I., Bouatia-Naji, N., Metspalu, A., Loos, R. J., van Duijn, C. M., Borecki, I. B., Gambaro, G., Deary, I. J., Wolffenbuttel, B. H., Chambers, J. C., März, W., Pramstaller, P. P., Snieder, H., Gyllensten, U., Wright, A. F., Navis, G., Watkins, H., Witteman, J. C., Sanna, S., Schipf, S., Dunlop, M. G., Tönjes, A., Ripatti, S., Soranzo, N., Toniolo, D., Chasman, D. I., Raitakari, O., Kao, W. H., Ciullo, M., Fox, C. S., Caulfield, M., Bochud, M. & Gieger, C., Aug 1 2012, In: Nature Genetics. 44, 8, p. 904-909 6 p.

    Research output: Contribution to journalArticlepeer-review

    202 Scopus citations
  • Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration

    Misko, A. L., Sasaki, Y., Tuck, E., Milbrandt, J. & Baloh, R. H., Mar 21 2012, In: Journal of Neuroscience. 32, 12, p. 4145-4155 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    133 Scopus citations
  • Mouse transgenesis in a single locus with independent regulation for multiple fluorophores

    Dougherty, J. D., Zhang, J., Feng, H., Gong, S. & Heintz, N., Jul 12 2012, In: PloS one. 7, 7, e40511.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    8 Scopus citations
  • Multiple peptidoglycan modification networks modulate helicobacter pylori's cell shape, motility, and colonization potential

    Sycuro, L. K., Wyckoff, T. J., Biboy, J., Born, P., Pincus, Z., Vollmer, W. & Salama, N. R., Mar 2012, In: PLoS pathogens. 8, 3, e1002603.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    101 Scopus citations
  • Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

    Yadav, M., Louvet, C., Davini, D., Gardner, J. M., Martinez-Llordella, M., Bailey-Bucktrout, S., Anthony, B. A., Sverdrup, F. M., Head, R., Kuster, D. J., Ruminski, P., Weiss, D., Von Schack, D. & Bluestone, J. A., Sep 2012, In: Journal of Experimental Medicine. 209, 10, p. 1713-1722 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    487 Scopus citations
  • Next generation analytic tools for large scale genetic epidemiology studies of complex diseases

    Mechanic, L. E., Chen, H. S., Amos, C. I., Chatterjee, N., Cox, N. J., Divi, R. L., Fan, R., Harris, E. L., Jacobs, K., Kraft, P., Leal, S. M., McAllister, K., Moore, J. H., Paltoo, D. N., Province, M. A., Ramos, E. M., Ritchie, M. D., Roeder, K., Schaid, D. J., Stephens, M., & 7 othersThomas, D. C., Weinberg, C. R., Witte, J. S., Zhang, S., Zöllner, S., Feuer, E. J. & Gillanders, E. M., Jan 2012, In: Genetic Epidemiology. 36, 1, p. 22-35 14 p.

    Research output: Contribution to journalArticlepeer-review

    49 Scopus citations
  • Nicotine dependence and comorbid psychiatric disorders: Examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes

    Chen, L. S., Xian, H., Grucza, R. A., Saccone, N. L., Wang, J. C., Johnson, E. O., Breslau, N., Hatsukami, D. & Bierut, L. J., Jun 2012, In: Drug and Alcohol Dependence. 123, SUPPL.1, p. S42-S51

    Research output: Contribution to journalArticlepeer-review

    11 Scopus citations
  • Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: A multi-ethnic meta-analysis of 45,891 individuals

    Dastani, Z., Hivert, M. F., Timpson, N., Perry, J. R. B., Yuan, X., Scott, R. A., Henneman, P., Heid, I. M., Kizer, J. R., Lyytikäinen, L. P., Fuchsberger, C., Tanaka, T., Morris, A. P., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., Kanoni, S., & 528 othersPankow, J. S., Uh, H. W., Wu, Y., Bidulescu, A., Rasmussen-Torvik, L. J., Greenwood, C. M. T., Ladouceur, M., Grimsby, J., Manning, A. K., Liu, C. T., Kooner, J., Mooser, V. E., Vollenweider, P., Kapur, K. A., Chambers, J., Wareham, N. J., Langenberg, C., Frants, R., Willems-VanDijk, K., Oostra, B. A., Willems, S. M., Lamina, C., Winkler, T. W., Psaty, B. M., Tracy, R. P., Brody, J., Chen, I., Viikari, J., Kähönen, M., Pramstaller, P. P., Evans, D. M., St. Pourcain, B., Sattar, N., Wood, A. R., Bandinelli, S., Carlson, O. D., Egan, J. M., Böhringer, S., van Heemst, D., Kedenko, L., Kristiansson, K., Nuotio, M. L., Loo, B. M., Harris, T., Garcia, M., Kanaya, A., Haun, M., Klopp, N., Wichmann, H. E., Deloukas, P., Katsareli, E., Couper, D. J., Duncan, B. B., Kloppenburg, M., Adair, L. S., Borja, J. B., Florez, J. C., MAGIC Consortium, C., GLGC Investigators, I., MuTHER Consortium, C., Wilson, J. G., Musani, S., Guo, X., Johnson, T., Semple, R., Teslovich, T. M., Redline, S., Buxbaum, S. G., Mohlke, K. L., Meulenbelt, I., Ballantyne, C. M., Dedoussis, G. V., Hu, F. B., Liu, Y., Paulweber, B., Spector, T. D., Slagboom, P. E., Ferrucci, L., Jula, A., Perola, M., Raitakari, O., Salomaa, V., Eriksson, J. G., Frayling, T. M., Hicks, A. A., Lehtimäki, T., Smith, G. D., Siscovick, D. S., Kronenberg, F., van Duijn, C., Loos, R. J. F., Waterworth, D. M., Meigs, J. B., Meigs, J. B., Richards, J. B., Voight, B. F., Scott, L. J., Steinthorsdottir, V., Dina, C., Welch, R. P., Zeggini, E., Huth, C., Aulchenko, Y. S., Thorleifsson, G., McCulloch, L. J., Ferreira, T., Grallert, H., Amin, N., Wu, G., Willer, C. J., Raychaudhuri, S., McCarroll, S. A., Hofmann, O. M., Segrè, A. V., van Hoek, M., Navarro, P., Ardlie, K., Balkau, B., Benediktsson, R., Bennett, A. J., Blagieva, R., Boerwinkle, E., Bonnycastle, L. L., Boström, K. B., Bravenboer, B., Bumpstead, S., Burtt, N. P., Charpentier, G., Chines, P. S., Cornelis, M., Crawford, G., Doney, A. S. F., Elliott, K. S., Elliott, A. L., Erdos, M. R., Fox, C. S., Franklin, C. S., Ganser, M., Gieger, C., Grarup, N., Green, T., Griffin, S., Groves, C. J., Guiducci, C., Hadjadj, S., Hassanali, N., Herder, C., Isomaa, B., Jackson, A. U., Johnson, P. R. V., Jørgensen, T., Kao, W. H. L., Kong, A., Kraft, P., Kuusisto, J., Lauritzen, T., Li, M., Lieverse, A., Lindgren, C. M., Lyssenko, V., Marre, M., Meitinger, T., Midthjell, K., Morken, M. A., Narisu, N., Nilsson, P., Owen, K. R., Payne, F., Petersen, A. K., Platou, C., Proenca, C., Prokopenko, I., Rathmann, W., Rayner, N. W., Robertson, N. R., Rocheleau, G., Roden, M., Sampson, M. J., Saxena, R., Shields, B. M., Shrader, P., Sigurdsson, G., Sparsø, T., Strassburger, K., Stringham, H. M., Sun, Q., Swift, A. J., Thorand, B., Tichet, J., Tuomi, T., van Dam, R. M., van Haeften, T. W., van Herpt, T., van Vliet-Ostaptchouk, J. V., Walters, G. B., Weedon, M. N., Wijmenga, C., Witteman, J., Bergman, R. N., Cauchi, S., Gloyn, A. L., Gyllensten, U., Hansen, T., Hide, W. A., Hitman, G. A., Hofman, A., Hunter, D. J., Hveem, K., Laakso, M., Morris, A. D., Palmer, C. N. A., Rudan, I., Sijbrands, E., Stein, L. D., Tuomilehto, J., Uitterlinden, A., Walker, M., Watanabe, R. M., Abecasis, G. R., Boehm, B. O., Campbell, H., Daly, M. J., Hattersley, A. T., Pedersen, O., Barroso, I., Groop, L., Sladek, R., Thorsteinsdottir, U., Wilson, J. F., Illig, T., Froguel, P., van Duijn, C. M., Stefansson, K., Altshuler, D., Boehnke, M., McCarthy, M. I., David, T., Soranzo, N., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Mägi, R., Randall, J., Elliott, P., Rybin, D., Dehghan, A., Hottenga, J. 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A., Kastelein, J. J. P., Schadt, E. E., Strachan, D. P., Reilly, M. P., Samani, N. J., Schunkert, H., Cupples, L. A., Sandhu, M. S., Ridker, P. M. & Munroe, P. B., Mar 29 2012, In: PLoS genetics. 8, 3, e1002607.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    327 Scopus citations
  • Novel Modeling of Combinatorial miRNA Targeting Identifies SNP with Potential Role in Bone Density

    Coronnello, C., Hartmaier, R., Arora, A., Huleihel, L., Pandit, K. V., Bais, A. S., Butterworth, M., Kaminski, N., Stormo, G. D., Oesterreich, S. & Benos, P. V., Dec 2012, In: PLoS computational biology. 8, 12, e1002830.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    33 Scopus citations
  • Obesity-insulin targeted genes in the 3p26-25 region in human studies and LG/J and SM/J mice

    Kraja, A. T., Lawson, H. A., Arnett, D. K., Borecki, I. B., Broeckel, U., De Las Fuentes, L., Hunt, S. C., Province, M. A., Cheverud, J. & Rao, D. C., Aug 2012, In: Metabolism: clinical and experimental. 61, 8, p. 1129-1141 13 p.

    Research output: Contribution to journalArticlepeer-review

    8 Scopus citations
  • Ontology-based federated data access to human studies information.

    Sim, I., Carini, S., Tu, S. W., Detwiler, L. T., Brinkley, J., Mollah, S. A., Burke, K., Lehmann, H. P., Chakraborty, S., Wittkowski, K. M., Pollock, B. H., Johnson, T. M., Huser, V. & Human Studies Database Project, S. D. P., 2012, In: Unknown Journal. 2012, p. 856-865 10 p.

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations
  • Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort

    Jin, S. C., Pastor, P., Cooper, B., Cervantes, S., Benitez, B. A., Razquin, C., Goate, A. & Cruchaga, C., 2012, In: Alzheimer's Research and Therapy. 4, 4, 34.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    80 Scopus citations
  • Population-based rare variant detection via pooled exome or custom hybridization capture with or without individual indexing

    Ramos, E., Levinson, B. T., Chasnoff, S., Hughes, A., Young, A. L., Thornton, K., Li, A., Vallania, F. L. M., Province, M. & Druley, T. E., Dec 6 2012, In: BMC genomics. 13, 1, 683.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    18 Scopus citations
  • Rapid and efficient human mutation detection using a bench-top next-generation DNA sequencer

    Jiang, Q., Turner, T., Sosa, M. X., Rakha, A., Arnold, S. & Chakravarti, A., Jan 2012, In: Human mutation. 33, 1, p. 281-289 9 p.

    Research output: Contribution to journalArticlepeer-review

    36 Scopus citations
  • Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence

    Haller, G., Druley, T., Vallania, F. L., Mitra, R. D., Li, P., Akk, G., Steinbach, J. H., Breslau, N., Johnson, E., Hatsukami, D., Stitzel, J., Bierut, L. J. & Goate, A. M., Feb 2012, In: Human molecular genetics. 21, 3, p. 647-655 9 p., ddr498.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    47 Scopus citations
  • Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families

    Cruchaga, C., Chakraverty, S., Mayo, K., Vallania, F. L. M., Mitra, R. D., Faber, K., Williamson, J., Bird, T., Diaz-Arrastia, R., Foroud, T. M., Boeve, B. F., Graff-Radford, N. R., St. Jean, P., Lawson, M., Ehm, M. G., Mayeux, R., Goate, A. M. & for the NIA-LOAD - NCRAD Family Study Consortium, T. NIA-LOAD. . NCRAD. F. S. C., Feb 1 2012, In: PloS one. 7, 2, e31039.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    214 Scopus citations
  • Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases

    Gao, W., Zhu, J., Westfield, L. A., Tuley, E. A., Anderson, P. J. & Sadler, J. E., Aug 3 2012, In: Journal of Biological Chemistry. 287, 32, p. 26944-26952 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    21 Scopus citations
  • Recognition models to predict DNA-binding specificities of homeodomain proteins

    Christensen, R. G., Enuameh, M. S., Noyes, M. B., Brodsky, M. H., Wolfe, S. A. & Stormo, G. D., Jun 2012, In: Bioinformatics. 28, 12, p. i84-i89 bts202.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    28 Scopus citations
  • Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord

    Tien, A. C., Tsai, H. H., Molofsky, A. V., McMahon, M., Foo, L. C., Kaul, A., Dougherty, J. D., Heintz, N., Gutmann, D. H., Barres, B. A. & Rowitch, D. H., Jul 2012, In: Development (Cambridge). 139, 14, p. 2477-2487 11 p.

    Research output: Contribution to journalArticlepeer-review

    80 Scopus citations
  • Retrotransposon profiling of RNA polymerase III initiation sites

    Qi, X., Daily, K., Nguyen, K., Wang, H., Mayhew, D., Rigor, P., Forouzan, S., Johnston, M., Mitra, R. D., Baldi, P. & Sandmeyer, S., Apr 2012, In: Genome research. 22, 4, p. 681-692 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    27 Scopus citations
  • ScerTF: A comprehensive database of benchmarked position weight matrices for Saccharomyces species

    Spivak, A. T. & Stormo, G. D., Jan 2012, In: Nucleic acids research. 40, D1, p. D162-D168

    Research output: Contribution to journalArticlepeer-review

    Open Access
    51 Scopus citations
  • SCG10 is a JNK target in the axonal degeneration pathway

    Shin, J. E., Miller, B. R., Babetto, E., Cho, Y., Sasaki, Y., Qayum, S., Russler, E. V., Cavalli, V., Milbrandt, J. & DiAntonio, A., Dec 26 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 52, p. E3696-E3705

    Research output: Contribution to journalArticlepeer-review

    Open Access
    113 Scopus citations
  • Sex and race differences in the prevalence of fatty liver disease as measured by computed tomography liver attenuation in European American and African American participants of the NHLBI family heart study

    North, K. E., Graff, M., Franceschini, N., Reiner, A. P., Feitosa, M. F., Carr, J. J., Gordon-Larsen, P., Wojczynski, M. K. & Borecki, I. B., Jan 2012, In: European Journal of Gastroenterology and Hepatology. 24, 1, p. 9-16 8 p.

    Research output: Contribution to journalArticlepeer-review

    20 Scopus citations
  • Single ABCA3 mutations increase risk for neonatal respiratory distress syndrome

    Wambach, J. A., Wegner, D. J., DePass, K., Heins, H., Druley, T. E., Mitra, R. D., An, P., Zhang, Q., Nogee, L. M., Cole, F. S. & Hamvas, A., Dec 2012, In: Pediatrics. 130, 6, p. e1575-e1582

    Research output: Contribution to journalArticlepeer-review

    72 Scopus citations
  • Small- and large-effect quantitative trait locus interactions underlie variation in yeast sporulation efficiency

    Lorenz, K. & Cohen, B. A., Nov 1 2012, In: Genetics. 192, 3, p. 1123-1132 10 p.

    Research output: Contribution to journalArticlepeer-review

    33 Scopus citations
  • Smoking and genetic risk variation across populations of European, Asian, and African American ancestry-a meta-analysis of chromosome 15q25

    Chen, L. S., Saccone, N. L., Culverhouse, R. C., Bracci, P. M., Chen, C. H., Dueker, N., Han, Y., Huang, H., Jin, G., Kohno, T., Ma, J. Z., Przybeck, T. R., Sanders, A. R., Smith, J. A., Sung, Y. J., Wenzlaff, A. S., Wu, C., Yoon, D., Chen, Y. T., Cheng, Y. C., & 42 othersCho, Y. S., David, S. P., Duan, J., Eaton, C. B., Furberg, H., Goate, A. M., Gu, D., Hansen, H. M., Hartz, S., Hu, Z., Kim, Y. J., Kittner, S. J., Levinson, D. F., Mosley, T. H., Payne, T. J., Rao, D. C., Rice, J. P., Rice, T. K., Schwantes-An, T. H., Shete, S. S., Shi, J., Spitz, M. R., Sun, Y. V., Tsai, F. J., Wang, J. C., Wrensch, M. R., Xian, H., Gejman, P. V., He, J., Hunt, S. C., Kardia, S. L., Li, M. D., Lin, D., Mitchell, B. D., Park, T., Schwartz, A. G., Shen, H., Wiencke, J. K., Wu, J. Y., Yokota, J., Amos, C. I. & Bierut, L. J., May 2012, In: Genetic Epidemiology. 36, 4, p. 340-351 12 p.

    Research output: Contribution to journalArticlepeer-review

    64 Scopus citations
  • Spark: A navigational paradigm for genomic data exploration

    Nielsen, C. B., Younesy, H., O'Geen, H., Xu, X., Jackson, A. R., Milosavljevic, A., Wang, T., Costello, J. F., Hirst, M., Farnham, P. J. & Jones, S. J. M., Nov 2012, In: Genome research. 22, 11, p. 2262-2269 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    27 Scopus citations
  • TEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factor

    Wang, C., Wilson-Berry, L., Schedl, T. & Hansen, D., Mar 2012, In: Developmental Dynamics. 241, 3, p. 505-521 17 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    17 Scopus citations
  • The AMPK ß2 Subunit Is Required for Energy Homeostasis during Metabolic Stress

    Dasgupta, B., Ju, J. S., Sasaki, Y., Liu, X., Jung, S. R., Higashida, K., Lindquist, D. & Milbrandt, J., Jul 2012, In: Molecular and cellular biology. 32, 14, p. 2837-2848 12 p.

    Research output: Contribution to journalArticlepeer-review

    48 Scopus citations
  • Thermodynamic state ensemble models of cis-regulation

    Sherman, M. S. & Cohen, B. A., Mar 2012, In: PLoS computational biology. 8, 3, e1002407.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    48 Scopus citations
  • Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET-signaling complex in a cohort of living US patients with urinary tract malformations

    Chatterjee, R., Ramos, E., Hoffman, M., Vanwinkle, J., Martin, D. R., Davis, T. K., Hoshi, M., Hmiel, S. P., Beck, A., Hruska, K., Coplen, D., Liapis, H., Mitra, R., Druley, T., Austin, P. & Jain, S., Nov 2012, In: Human genetics. 131, 11, p. 1725-1738 14 p.

    Research output: Contribution to journalArticlepeer-review

    71 Scopus citations
  • Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6

    Bloom, A. J., Harari, O., Martinez, M., Madden, P. A. F., Martin, N. G., Montgomery, G. W., Rice, J. P., Murphy, S. E., Bierut, L. J. & Goate, A., Jul 2012, In: Human molecular genetics. 21, 13, p. 3050-3062 13 p., dds114.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    30 Scopus citations
  • Using the wash U Epigenome browser to examine genome-wide sequencing data

    Zhou, X. & Wang, T., 2012, In: Current Protocols in Bioinformatics. SUPPL.40, 10.10.

    Research output: Contribution to journalArticlepeer-review

    45 Scopus citations
  • Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia

    Horani, A., Druley, T. E., Zariwala, M. A., Patel, A. C., Levinson, B. T., Van Arendonk, L. G., Thornton, K. C., Giacalone, J. C., Albee, A. J., Wilson, K. S., Turner, E. H., Nickerson, D. A., Shendure, J., Bayly, P. V., Leigh, M. W., Knowles, M. R., Brody, S. L., Dutcher, S. K. & Ferkol, T. W., Oct 5 2012, In: American journal of human genetics. 91, 4, p. 685-693 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    123 Scopus citations
  • Whole-genome sequencing to identify mutants and polymorphisms in chlamydomonas reinhardtii

    Dutcher, S. K., Li, L., Lin, H., Meyer, L., Giddings, T. H., Kwan, A. L. & Lewis, B. L., Jan 2012, In: G3: Genes, Genomes, Genetics. 2, 1, p. 15-22 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    36 Scopus citations
  • Zcchc11 Uridylates Mature miRNAs to Enhance Neonatal IGF-1 Expression, Growth, and Survival

    Jones, M. R., Blahna, M. T., Kozlowski, E., Matsuura, K. Y., Ferrari, J. D., Morris, S. A., Powers, J. T., Daley, G. Q., Quinton, L. J. & Mizgerd, J. P., Nov 2012, In: PLoS genetics. 8, 11, e1003105.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    44 Scopus citations
  • Zinc-finger nuclease mediated disruption of Rag1 in the LEW/Ztm rat

    Zschemisch, N. H., Glage, S., Wedekind, D., Weinstein, E. J., Cui, X., Dorsch, M. & Hedrich, H. J., Nov 8 2012, In: BMC Immunology. 13, 60.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    24 Scopus citations
  • 2011

    A bivariate genome-wide approach to metabolic syndrome: STAMPEED Consortium

    Kraja, A. T., Vaidya, D., Pankow, J. S., Goodarzi, M. O., Assimes, T. L., Kullo, I. J., Sovio, U., Mathias, R. A., Sun, Y. V., Franceschini, N., Absher, D., Li, G., Zhang, Q., Feitosa, M. F., Glazer, N. L., Haritunians, T., Hartikainen, A. L., Knowles, J. W., North, K. E., Iribarren, C., & 19 othersKral, B., Yanek, L., O'Reilly, P. F., McCarthy, M. I., Jaquish, C., Couper, D. J., Chakravarti, A., Psaty, B. M., Becker, L. C., Province, M. A., Boerwinkle, E., Quertermous, T., Palotie, L., Jarvelin, M. R., Becker, D. M., Kardia, S. L. R., Rotter, J. I., Chen, Y. D. I. & Borecki, I. B., Apr 2011, In: Diabetes. 60, 4, p. 1329-1339 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    192 Scopus citations
  • A data-driven method for identifying rare variants with heterogeneous trait effects

    Zhang, Q., Irvin, M. R., Arnett, D. K., Province, M. A. & Borecki, I., Nov 2011, In: Genetic Epidemiology. 35, 7, p. 679-685 7 p.

    Research output: Contribution to journalArticlepeer-review

    12 Scopus citations
  • A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue

    Green, R. A., Kao, H. L., Audhya, A., Arur, S., Mayers, J. R., Fridolfsson, H. N., Schulman, M., Schloissnig, S., Niessen, S., Laband, K., Wang, S., Starr, D. A., Hyman, A. A., Schedl, T., Desai, A., Piano, F., Gunsalus, K. C. & Oegema, K., Apr 29 2011, In: Cell. 145, 3, p. 470-482 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    147 Scopus citations
  • A modified bacterial one-hybrid system yields improved quantitative models of transcription factor specificity

    Christensen, R. G., Gupta, A., Zuo, Z., Schriefer, L. A., Wolfe, S. A. & Stormo, G. D., Jul 2011, In: Nucleic acids research. 39, 12, p. e83

    Research output: Contribution to journalArticlepeer-review

    Open Access
    20 Scopus citations
  • An axonemal PP2A B-subunit is required for PP2A localization and flagellar motility

    Elam, C. A., Wirschell, M., Yamamoto, R., Fox, L. A., York, K., Kamiya, R., Dutcher, S. K. & Sale, W. S., Jul 2011, In: Cytoskeleton. 68, 7, p. 363-372 10 p.

    Research output: Contribution to journalArticlepeer-review

    18 Scopus citations
  • An introduction to recognizing functional domains

    Stormo, G. D., Jun 2011, In: Current Protocols in Bioinformatics. SUPPL. 34, p. 1-6 6 p.

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations
  • A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression

    Grimm, A. A., Brace, C. S., Wang, T., Stormo, G. D. & Imai, S. I., Apr 2011, In: Aging Cell. 10, 2, p. 305-317 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    18 Scopus citations
  • Application of Bayesian network structure learning to identify causal variant SNPs from resequencing data

    Schlosberg, C. E., Schwantes-An, T. H., Duan, W. & Saccone, N. L., 2011, In: BMC Proceedings. 5, SUPPL. 9, S109.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    10 Scopus citations