Department of Genetics

2013

Depleting gene activities in early drosophila embryos with the "maternal-Gal4-shRNA" system

Staller, M. V., Yan, D., Randklev, S., Bragdon, M. D., Wunderlich, Z. B., Tao, R., Perkins, L. A., De Pace, A. H. & Perrimon, N., Jan 2013, In: Genetics. 193, 1, p. 51-61 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

71 Scopus citations

Developmental arrest of Drosophila survival motor neuron (Smn) mutants accounts for differences in expression of minor intron-containing genes

Garcia, E. L., Lu, Z., Meers, M. P., Praveen, K. & Matera, A. G., Nov 2013, In: RNA. 19, 11, p. 1510-1516 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Development of translating ribosome affinity purification for zebrafish

Tryon, R. C., Pisat, N., Johnson, S. L. & Dougherty, J. D., Mar 2013, In: Genesis. 51, 3, p. 187-192 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Discovery of Anthelmintic Drug Targets and Drugs Using Chokepoints in Nematode Metabolic Pathways

Taylor, C. M., Wang, Q., Rosa, B. A., Huang, S. C. C., Powell, K., Schedl, T., Pearce, E. J., Abubucker, S. & Mitreva, M., Aug 2013, In: PLoS pathogens. 9, 8, e1003505.

Research output: Contribution to journal › Article › peer-review

Open Access

74 Scopus citations

Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking

Stephens, S. H., Hartz, S. M., Hoft, N. R., Saccone, N. L., Corley, R. C., Hewitt, J. K., Hopfer, C. J., Breslau, N., Coon, H., Chen, X., Ducci, F., Dueker, N., Franceschini, N., Frank, J., Han, Y., Hansel, N. N., Jiang, C., Korhonen, T., Lind, P. A. & Liu, J. & 106 others, Lyytikäinen, L. P., Michel, M., Shaffer, J. R., Short, S. E., Sun, J., Teumer, A., Thompson, J. R., Vogelzangs, N., Vink, J. M., Wenzlaff, A., Wheeler, W., Yang, B. Z., Aggen, S. H., Balmforth, A. J., Baumeister, S. E., Beaty, T. H., Benjamin, D. J., Bergen, A. W., Broms, U., Cesarini, D., Chatterjee, N., Chen, J., Cheng, Y. C., Cichon, S., Couper, D., Cucca, F., Dick, D., Foroud, T., Furberg, H., Giegling, I., Gillespie, N. A., Gu, F., Hall, A. S., Hällfors, J., Han, S., Hartmann, A. M., Heikkilä, K., Hickie, I. B., Hottenga, J. J., Jousilahti, P., Kaakinen, M., Kähönen, M., Koellinger, P. D., Kittner, S., Konte, B., Landi, M. T., Laatikainen, T., Leppert, M., Levy, S. M., Mathias, R. A., Mcneil, D. W., Medland, S. E., Montgomery, G. W., Murray, T., Nauck, M., North, K. E., Paré, P. D., Pergadia, M., Ruczinski, I., Salomaa, V., Viikari, J., Willemsen, G., Barnes, K. C., Boerwinkle, E., Boomsma, D. I., Caporaso, N., Edenberg, H. J., Francks, C., Gelernter, J., Grabe, H. J., Hops, H., Jarvelin, M. R., Johannesson, M., Kendler, K. S., Lehtimäki, T., Magnusson, P. K. E., Marazita, M. L., Marchini, J., Mitchell, B. D., Nöthen, M. M., Penninx, B. W., Raitakari, O., Rietschel, M., Rujescu, D., Samani, N. J., Schwartz, A. G., Shete, S., Spitz, M., Swan, G. E., Völzke, H., Veijola, J., Wei, Q., Amos, C., Cannon, D. S., Grucza, R., Hatsukami, D., Heath, A., Johnson, E. O., Kaprio, J., Madden, P., Martin, N. G., Stevens, V. L., Weiss, R. B., Kraft, P., Bierut, L. J. & Ehringer, M. A., Dec 2013, In: Genetic Epidemiology. 37, 8, p. 846-859 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape

Xie, M., Hong, C., Zhang, B., Lowdon, R. F., Xing, X., Li, D., Zhou, X., Lee, H. J., Maire, C. L., Ligon, K. L., Gascard, P., Sigaroudinia, M., Tlsty, T. D., Kadlecek, T., Weiss, A., O'Geen, H., Farnham, P. J., Madden, P. A. F., Mungall, A. J. & Tam, A. & 7 others, Kamoh, B., Cho, S., Moore, R., Hirst, M., Marra, M. A., Costello, J. F. & Wang, T., Jul 2013, In: Nature Genetics. 45, 7, p. 836-841 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

176 Scopus citations

DNA unmethylome profiling by covalent capture of CpG sites

Kriukiene, E., Labrie, V., Khare, T., Urbanavičiute, G., Lapinaite, A., Koncevičius, K., Li, D., Wang, T., Pai, S., Ptak, C., Gordevičius, J., Wang, S. C., Petronis, A. & Klimašauskas, S., 2013, In: Nature communications. 4, 2190.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption

Bloom, A. J., Murphy, S. E., Martinez, M., Von Weymarn, L. B., Bierut, L. J. & Goate, A., Feb 2013, In: Pharmacogenetics and Genomics. 23, 2, p. 62-68 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Estimating absolute methylation levels at single-CpG resolution from methylation enrichment and restriction enzyme sequencing methods

Stevens, M., Cheng, J. B., Li, D., Xie, M., Hong, C., Maire, C. L., Ligon, K. L., Hirst, M., Marra, M. A., Costello, J. F. & Wang, T., Sep 2013, In: Genome research. 23, 9, p. 1541-1553 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

129 Scopus citations

Exceptional memory performance in the Long Life Family Study

Barral, S., Cosentino, S., Costa, R., Andersen, S. L., Christensen, K., Eckfeldt, J. H., Newman, A. B., Perls, T. T., Province, M. A., Hadley, E. C., Rossi, W. K. & Mayeux, R., Nov 2013, In: Neurobiology of Aging. 34, 11, p. 2445-2448 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Expression and function of scalloped during Drosophila development

Guss, K. A., Benson, M., Gubitosi, N., Brondell, K., Broadie, K. & Skeath, J. B., Jul 2013, In: Developmental Dynamics. 242, 7, p. 874-885 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Families enriched for exceptional longevity also have increased health-span: Findings from the long life family study

Sebastiani, P., Sun, F. X., Andersen, S. L., Lee, J. H., Wojczynski, M. K., Sanders, J. L., Yashin, A., Newman, A. B. & Perls, T. T., Sep 30 2013, In: Frontiers in Public Health. 1, SEP, p. 38 1 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

Flow cytometry-based enrichment for cell shape mutants identifies multiple genes that influence Helicobacter pylori morphology

Sycuro, L. K., Rule, C. S., Petersen, T. W., Wyckoff, T. J., Sessler, T., Nagarkar, D. B., Khalid, F., Pincus, Z., Biboy, J., Vollmer, W. & Salama, N. R., Nov 2013, In: Molecular Microbiology. 90, 4, p. 869-883 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

69 Scopus citations

Functional characterization of piggyBat from the bat Myotis lucifugus unveils an active mammalian DNA transposon

Mitra, R., Li, X., Kapusta, A., Mayhew, D., Mitra, R. D., Feschotte, C. & Craig, N. L., Jan 2 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 234-239 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

64 Scopus citations

Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm

Zhang, B., Zhou, Y., Lin, N., Lowdon, R. F., Hong, C., Nagarajan, R. P., Cheng, J. B., Li, D., Stevens, M., Lee, H. J., Xing, X., Zhou, J., Sundaram, V., Elliott, G., Gu, J., Shi, T., Gascard, P., Sigaroudinia, M., Tlsty, T. D. & Kadlecek, T. & 13 others, Weiss, A., O'Geen, H., Farnham, P. J., Maire, C. L., Ligon, K. L., Madden, P. A. F., Tam, A., Moore, R., Hirst, M., Marra, M. A., Zhang, B., Costello, J. F. & Wang, T., Sep 2013, In: Genome research. 23, 9, p. 1522-1540 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

152 Scopus citations

Gene Expression Analysis of Zebrafish Melanocytes, Iridophores, and Retinal Pigmented Epithelium Reveals Indicators of Biological Function and Developmental Origin

Higdon, C. W., Mitra, R. D. & Johnson, S. L., Jul 9 2013, In: PloS one. 8, 7, e67801.

Research output: Contribution to journal › Article › peer-review

Open Access

85 Scopus citations

Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study

Kraja, A. T., Borecki, I. B., Tsai, M. Y., Ordovas, J. M., Hopkins, P. N., Lai, C. Q., Frazier-Wood, A. C., Straka, R. J., Hixson, J. E., Province, M. A. & Arnett, D. K., Feb 2013, In: Lipids. 48, 2, p. 155-165 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Genetics of coronary artery calcification among African Americans, a meta-analysis

Wojczynski, M. K., Li, M., Bielak, L. F., Kerr, K. F., Reiner, A. P., Wong, N. D., Yanek, L. R., Qu, L., White, C. C., Lange, L. A., Ferguson, J. F., He, J., Young, T., Mosley, T. H., Smith, J. A., Kral, B. G., Guo, X., Wong, Q., Ganesh, S. K. & Heckbert, S. R. & 25 others, Griswold, M. E., O'Leary, D. H., Budoff, M., Carr, J. J., Taylor, H. A., Bluemke, D. A., Demissie, S., Hwang, S. J., Paltoo, D. N., Polak, J. F., Psaty, B. M., Becker, D. M., Province, M. A., Post, W. S., O'Donnell, C. J., Wilson, J. G., Harris, T. B., Kavousi, M., Cupples, L. A., Rotter, J. I., Fornage, M., Becker, L. C., Peyser, P. A., Borecki, I. B. & Reilly, M. P., Jul 19 2013, In: BMC Medical Genetics. 14, 1, 75.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: The long life family study

Lee, J. H., Cheng, R., Honig, L. S., Feitosa, M., Kammerer, C. M., Kang, M. S., Schupf, N., Lin, S. J., Sanders, J. L., Bae, H., Druley, T., Perls, T., Christensen, K., Province, M. & Mayeux, R., 2013, In: Frontiers in Genetics. 4, JAN, Article 310.

Research output: Contribution to journal › Article › peer-review

Open Access

60 Scopus citations

Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci

Liu, C. T., Monda, K. L., Taylor, K. C., Lange, L., Demerath, E. W., Palmas, W., Wojczynski, M. K., Ellis, J. C., Vitolins, M. Z., Liu, S., Papanicolaou, G. J., Irvin, M. R., Xue, L., Griffin, P. J., Nalls, M. A., Adeyemo, A., Liu, J., Li, G., Ruiz-Narvaez, E. A. & Chen, W. M. & 73 others, Chen, F., Henderson, B. E., Millikan, R. C., Ambrosone, C. B., Strom, S. S., Guo, X., Andrews, J. S., Sun, Y. V., Mosley, T. H., Yanek, L. R., Shriner, D., Haritunians, T., Rotter, J. I., Speliotes, E. K., Smith, M., Rosenberg, L., Mychaleckyj, J., Nayak, U., Spruill, I., Garvey, W. T., Pettaway, C., Nyante, S., Bandera, E. V., Britton, A. F., Zonderman, A. B., Rasmussen-Torvik, L. J., Chen, Y. D. I., Ding, J., Lohman, K., Kritchevsky, S. B., Zhao, W., Peyser, P. A., Kardia, S. L. R., Kabagambe, E., Broeckel, U., Chen, G., Zhou, J., Wassertheil-Smoller, S., Neuhouser, M. L., Rampersaud, E., Psaty, B., Kooperberg, C., Manson, J. A. E., Kuller, L. H., Ochs-Balcom, H. M., Johnson, K. C., Sucheston, L., Ordovas, J. M., Palmer, J. R., Haiman, C. A., McKnight, B., Howard, B. V., Becker, D. M., Bielak, L. F., Liu, Y., Allison, M. A., Grant, S. F. A., Burke, G. L., Patel, S. R., Schreiner, P. J., Borecki, I. B., Evans, M. K., Taylor, H., Sale, M. M., Howard, V., Carlson, C. S., Rotimi, C. N., Cushman, M., Harris, T. B., Reiner, A. P., Cupples, L. A., North, K. E. & Fox, C. S., Aug 2013, In: PLoS genetics. 9, 8, e1003681.

Research output: Contribution to journal › Article › peer-review

Open Access

107 Scopus citations

Genome-wide characterization of endogenous retroviruses in the bat Myotis lucifugus reveals recent and diverse infections

Zhuo, X., Rho, M. & Feschotte, C., 2013, In: Journal of virology. 87, 15, p. 8493-8501 9 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Berndt, S. I., Gustafsson, S., Mägi, R., Ganna, A., Wheeler, E., Feitosa, M. F., Justice, A. E., Monda, K. L., Croteau-Chonka, D. C., Day, F. R., Esko, T., Fall, T., Ferreira, T., Gentilini, D., Jackson, A. U., Luan, J., Randall, J. C., Vedantam, S., Willer, C. J. & Winkler, T. W. & 302 others, Wood, A. R., Workalemahu, T., Hu, Y. J., Lee, S. H., Liang, L., Lin, D. Y., Min, J. L., Neale, B. M., Thorleifsson, G., Yang, J., Albrecht, E., Amin, N., Bragg-Gresham, J. L., Cadby, G., Heijer, M. D., Eklund, N., Fischer, K., Goel, A., Hottenga, J. J., Huffman, J. E., Jarick, I., Johansson, Å., Johnson, T., Kanoni, S., Kleber, M. E., König, I. R., Kristiansson, K., Kutalik, Z., Lamina, C., Lecoeur, C., Li, G., Mangino, M., McArdle, W. L., Medina-Gomez, C., Müller-Nurasyid, M., Ngwa, J. S., Nolte, I. M., Paternoster, L., Pechlivanis, S., Perola, M., Peters, M. J., Preuss, M., Rose, L. M., Shi, J., Shungin, D., Smith, A. V., Strawbridge, R. J., Surakka, I., Teumer, A., Trip, M. D., Tyrer, J., Van Vliet-Ostaptchouk, J. V., Vandenput, L., Waite, L. L., Zhao, J. H., Absher, D., Asselbergs, F. W., Atalay, M., Attwood, A. P., Balmforth, A. J., Basart, H., Beilby, J., Bonnycastle, L. L., Brambilla, P., Bruinenberg, M., Campbell, H., Chasman, D. I., Chines, P. S., Collins, F. S., Connell, J. M., O Cookson, W., De Faire, U., De Vegt, F., Dei, M., Dimitriou, M., Edkins, S., Estrada, K., Evans, D. M., Farrall, M., Ferrario, M. M., Ferrières, J., Franke, L., Frau, F., Gejman, P. V., Grallert, H., Grönberg, H., Gudnason, V., Hall, A. S., Hall, P., Hartikainen, A. L., Hayward, C., Heard-Costa, N. L., Heath, A. C., Hebebrand, J., Homuth, G., Hu, F. B., Hunt, S. E., Hyppönen, E., Iribarren, C., Jacobs, K. B., Jansson, J. O., Jula, A., Kähönen, M., Kathiresan, S., Kee, F., Khaw, K. T., Kivimäki, M., Koenig, W., Kraja, A. T., Kumari, M., Kuulasmaa, K., Kuusisto, J., Laitinen, J. H., Lakka, T. A., Langenberg, C., Launer, L. J., Lind, L., Lindström, J., Liu, J., Liuzzi, A., Lokki, M. L., Lorentzon, M., Madden, P. A., Magnusson, P. K., Manunta, P., Marek, D., März, W., Leach, I. M., McKnight, B., Medland, S. E., Mihailov, E., Milani, L., Montgomery, G. W., Mooser, V., Mühleisen, T. W., Munroe, P. B., Musk, A. W., Narisu, N., Navis, G., Nicholson, G., Nohr, E. A., Ong, K. K., Oostra, B. A., Palmer, C. N., Palotie, A., Peden, J. F., Pedersen, N., Peters, A., Polasek, O., Pouta, A., Pramstaller, P. P., Prokopenko, I., Pütter, C., Radhakrishnan, A., Raitakari, O., Rendon, A., Rivadeneira, F., Rudan, I., Saaristo, T. E., Sambrook, J. G., Sanders, A. R., Sanna, S., Saramies, J., Schipf, S., Schreiber, S., Schunkert, H., Shin, S. Y., Signorini, S., Sinisalo, J., Skrobek, B., Soranzo, N., Stancáková, A., Stark, K., Stephens, J. C., Stirrups, K., Stolk, R. P., Stumvoll, M., Swift, A. J., Theodoraki, E. V., Thorand, B., Tregouet, D. A., Tremoli, E., Van Der Klauw, M. M., Van Meurs, J. B., Vermeulen, S. H., Viikari, J., Virtamo, J., Vitart, V., Waeber, G., Wang, Z., Widén, E., Wild, S. H., Willemsen, G., Winkelmann, B. R., Witteman, J. C., Wolffenbuttel, B. H., Wong, A., Wright, A. F., Zillikens, M. C., Amouyel, P., Boehm, B. O., Boerwinkle, E., Boomsma, D. I., Caulfield, M. J., Chanock, S. J., Cupples, L. A., Cusi, D., Dedoussis, G. V., Erdmann, J., Eriksson, J. G., Franks, P. W., Froguel, P., Gieger, C., Gyllensten, U., Hamsten, A., Harris, T. B., Hengstenberg, C., Hicks, A. A., Hingorani, A., Hinney, A., Hofman, A., Hovingh, K. G., Hveem, K., Illig, T., Jarvelin, M. R., Jöckel, K. H., Keinanen-Kiukaanniemi, S. M., Kiemeney, L. A., Kuh, D., Laakso, M., Lehtimäki, T., Levinson, D. F., Martin, N. G., Metspalu, A., Morris, A. D., Nieminen, M. S., Njølstad, I., Ohlsson, C., Oldehinkel, A. J., Ouwehand, W. H., Palmer, L. J., Penninx, B., Power, C., Province, M. A., Psaty, B. M., Qi, L., Rauramaa, R., Ridker, P. M., Ripatti, S., Salomaa, V., Samani, N. J., Snieder, H., Sørensen, T. I., Spector, T. D., Stefansson, K., Tönjes, A., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., Van Der Harst, P., Vollenweider, P., Wallaschofski, H., Wareham, N. J., Watkins, H., Wichmann, H. E., Wilson, J. F., Abecasis, G. R., Assimes, T. L., Barroso, I., Boehnke, M., Borecki, I. B., Deloukas, P., Fox, C. S., Frayling, T., Groop, L. C., Haritunian, T., Heid, I. M., Hunter, D., Kaplan, R. C., Karpe, F., Moffatt, M. F., Mohlke, K. L., O'Connell, J. R., Pawitan, Y., Schadt, E. E., Schlessinger, D., Steinthorsdottir, V., Strachan, D. P., Thorsteinsdottir, U., Van Duijn, C. M., Visscher, P. M., Di Blasio, A. M., Hirschhorn, J. N., Lindgren, C. M., Morris, A. P., Meyre, D., Scherag, A., McCarthy, M. I., Speliotes, E. K., North, K. E., Loos, R. J. & Ingelsson, E., May 2013, In: Nature Genetics. 45, 5, p. 501-512 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

498 Scopus citations

Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake

Tanaka, T., Ngwa, J. S., Van Rooij, F. J. A., Zillikens, M. C., Wojczynski, M. K., Frazier-Wood, A. C., Houston, D. K., Kanoni, S., Lemaitre, R. N., Luan, J. N. A., Mikkilä, V., Renstrom, F., Sonestedt, E., Zhao, J. H., Chu, A. Y., Qi, L., Chasman, D. I., De Oliveira Otto, M. C., Dhurandhar, E. J. & Feitosa, M. F. & 46 others, Johansson, I., Khaw, K. T., Lohman, K. K., Manichaikul, A., McKeown, N. M., Mozaffarian, D., Singleton, A., Stirrups, K., Viikari, J., Ye, Z., Bandinelli, S., Barroso, I., Deloukas, P., Forouhi, N. G., Hofman, A., Liu, Y., Lyytikäinen, L. P., North, K. E., Dimitriou, M., Hallmans, G., Kähönen, M., Langenberg, C., Ordovas, J. M., Uitterlinden, A. G., Hu, F. B., Kalafati, I. P., Raitakari, O., Franco, O. H., Johnson, A., Emilsson, V., Schrack, J. A., Semba, R. D., Siscovick, D. S., Arnett, D. K., Borecki, I. B., Franks, P. W., Kritchevsky, S. B., Loos, T. L. R. J. F., Orho-Melander, M., Rotter, J. I., Wareham, N. J., Witteman, J. C. M., Ferrucci, L., Dedoussis, G., Cupples, L. A. & Nettleton, J. A., Jun 1 2013, In: American Journal of Clinical Nutrition. 97, 6, p. 1395-1402 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

191 Scopus citations

Global analysis of Drosophila Cys₂-His₂ zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants

Enuameh, M. S., Asriyan, Y., Richards, A., Christensen, R. G., Hall, V. L., Kazemian, M., Zhu, C., Pham, H., Cheng, Q., Blatti, C., Brasefield, J. A., Basciotta, M. D., Ou, J., McNulty, J. C., Zhu, L. J., Celniker, S. E., Sinha, S., Stormo, G. D., Brodsky, M. H. & Wolfe, S. A., Jun 2013, In: Genome research. 23, 6, p. 928-940 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

GWAS of cerebrospinal fluid tau levels identifies risk variants for alzheimer's disease

Cruchaga, C., Kauwe, J. S. K., Harari, O., Jin, S. C., Cai, Y., Karch, C. M., Benitez, B. A., Jeng, A. T., Skorupa, T., Carrell, D., Bertelsen, S., Bailey, M., McKean, D., Shulman, J. M., De Jager, P. L., Chibnik, L., Bennett, D. A., Arnold, S. E., Harold, D. & Sims, R. & 17 others, Gerrish, A., Williams, J., Van Deerlin, V. M., Lee, V. M. Y., Shaw, L. M., Trojanowski, J. Q., Haines, J. L., Mayeux, R., Pericak-Vance, M. A., Farrer, L. A., Schellenberg, G. D., Peskind, E. R., Galasko, D., Fagan, A. M., Holtzman, D. M., Morris, J. C. & Goate, A. M., Apr 24 2013, In: Neuron. 78, 2, p. 256-268 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

308 Scopus citations

Higher magnesium intake is associated with lower fasting glucose and insulin, with no evidence of interaction with select genetic loci, in a meta-analysis of 15 CHARGE consortium studies^1-4

Hruby, A., Ngwa, J. S., Renström, F., Mary, M. K., Ganna, A., Hallmans, G., Houston, D. K., Jacques, P. F., Kanoni, S., Lehtimäki, T., Lemaitre, R. N., Manichaikul, A., North, K. E., Ntalla, I., Sonestedt, E., Tanaka, T., van Rooij, F. J. A., Bandinelli, S., Djoussé, L. & Grigoriou, E. & 39 others, Johansson, I., Lohman, K. K., Pankow, J. S., Raitakari, O. T., Riserus, U., Yannakoulia, M., Zillikens, M. C., Hassanali, N., Liu, Y., Mozaffarian, D., Papoutsakis, C., Syvänen, A. C., Uitterlinden, A. G., Viikari, J., Groves, C. J., Lind, A. H., Lind, L., McCarthy, M. I., Mikkilä̈, V., Mukamal, K., Franco, O. H., Borecki, I. B., Cupples, L. A., Dedoussis, G. V., Ferrucci, L., Hu, F. B., Ingelsson, E., Kähönen, M., Kao, W. H. L., Kritchevsky, S. B., Orho-Melander, M., Prokopenko, I., Rotter, J. I., Siscovick, D. S., Witteman, J. C. M., Franks, P. W., Meigs, J. B., McKeown, N. M. & Nettleton, J. A., Mar 2013, In: Journal of Nutrition. 143, 3, p. 345-353 9 p.

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51 Scopus citations

Identification of a novel strain of human papillomavirus from children with diarrhea in China

Yu, J. M., Ao, Y. Y., Zhao, G., Li, L. L., Wang, D. & Duan, Z. J., 2013, In: Genome Announcements. 1, 5, e00761-13.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Identification of cilia genes that affect cell-cycle progression using whole-genome transcriptome analysis in chlamydomonas reinhardtti

Albee, A. J., Kwan, A. L., Lin, H., Granas, D., Stormo, G. D. & Dutcher, S. K., Jun 2013, In: G3: Genes, Genomes, Genetics. 3, 6, p. 979-991 13 p.

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Open Access

54 Scopus citations

Identification of Novel Viruses Using VirusHunter -- an Automated Data Analysis Pipeline

Zhao, G., Krishnamurthy, S., Cai, Z., Popov, V. L., Travassos da Rosa, A. P., Guzman, H., Cao, S., Virgin, H. W., Tesh, R. B. & Wang, D., Oct 22 2013, In: PloS one. 8, 10, e78470.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

Imputation across genotyping arrays for genome-wide association studies: Assessment of bias and a correction strategy

Johnson, E. O., Hancock, D. B., Levy, J. L., Gaddis, N. C., Saccone, N. L., Bierut, L. J. & Page, G. P., May 2013, In: Human genetics. 132, 5, p. 509-522 14 p.

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Open Access

37 Scopus citations

Interpreting joint SNP analysis results: When are two distinct signals really two distinct signals?

Schwantes-An, T. H., Culverhouse, R., Duan, W., Ramnarine, S., Rice, J. P. & Saccone, N. L., Apr 2013, In: Genetic Epidemiology. 37, 3, p. 301-309 9 p.

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Open Access

2 Scopus citations

Katanin Localization Requires Triplet Microtubules in Chlamydomonas reinhardtii

Esparza, J. M., O'Toole, E., Li, L., Giddings, T. H., Kozak, B., Albee, A. J. & Dutcher, S. K., Jan 8 2013, In: PloS one. 8, 1, e53940.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Laser capture microdissection-reduced representation bisulfite sequencing (LCM-RRBS) maps changes in DNA methylation associated with gonadectomy-induced adrenocortical neoplasia in the mouse

Schillebeeckx, M., Schrade, A., Löbs, A. K., Pihlajoki, M., Wilson, D. B. & Mitra, R. D., Jun 2013, In: Nucleic acids research. 41, 11, p. e116

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Lipoprotein receptor-related protein 1 variants and dietary fatty acids: Meta-analysis of European origin and African American studies

Smith, C. E., Ngwa, J., Tanaka, T., Qi, Q., Wojczynski, M. K., Lemaitre, R. N., Anderson, J. S., Manichaikul, A., Mikkilä, V., Van Rooij, F. J. A., Ye, Z., Bandinelli, S., Frazier-Wood, A. C., Houston, D. K., Hu, F., Langenberg, C., McKeown, N. M., Mozaffarian, D., North, K. E. & Viikari, J. & 28 others, Zillikens, M. C., Djoussé, L., Hofman, A., Kähönen, M., Kabagambe, E. K., Loos, R. J. F., Saylor, G. B., Forouhi, N. G., Liu, Y., Mukamal, K. J., Chen, Y. D., Tsai, M. Y., Uitterlinden, A. G., Raitakari, O., Van Duijn, C. M., Arnett, D. K., Borecki, I. B., Cupples, L. A., Ferrucci, L., Kritchevsky, S. B., Lehtimäki, T., Qi, L., Rotter, J. I., Siscovick, D. S., Wareham, N. J., Witteman, J. C. M., Ordovás, J. M. & Nettleton, J. A., Sep 2013, In: International Journal of Obesity. 37, 9, p. 1211-1220 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Loss of the spectraplakin short stop activates the DLK injury response pathway in drosophila

Valakh, V., Walker, L. J., Skeath, J. B. & DiAntonio, A., 2013, In: Journal of Neuroscience. 33, 45, p. 17863-17873 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

LRRC6 Mutation Causes Primary Ciliary Dyskinesia with Dynein Arm Defects

Horani, A., Ferkol, T. W., Shoseyov, D., Wasserman, M. G., Oren, Y. S., Kerem, B., Amirav, I., Cohen-Cymberknoh, M., Dutcher, S. K., Brody, S. L., Elpeleg, O. & Kerem, E., Mar 19 2013, In: PloS one. 8, 3, e59436.

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Open Access

80 Scopus citations

Massively parallel in vivo enhancer assay reveals that highly local features determine the cis-regulatory function of ChIP-seq peaks

White, M. A., Myers, C. A., Corbo, J. C. & Cohen, B. A., Jul 16 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 29, p. 11952-11957 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

154 Scopus citations

Massively parallel synthetic promoter assays reveal the in vivo effects of binding site variants

Mogno, I., Kwasnieski, J. C. & Cohen, B. A., Nov 2013, In: Genome research. 23, 11, p. 1908-1915 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

76 Scopus citations

Meta-analysis investigating associations between healthy diet and fasting glucose and insulin levels and modification by loci associated with glucose homeostasis in data from 15 cohorts

Nettleton, J. A., Hivert, M. F., Lemaitre, R. N., McKeown, N. M., Mozaffarian, D., Tanaka, T., Wojczynski, M. K., Hruby, A., Djoussé, L., Ngwa, J. S., Follis, J. L., Dimitriou, M., Ganna, A., Houston, D. K., Kanoni, S., Mikkilä, V., Manichaikul, A., Ntalla, I., Renström, F. & Sonestedt, E. & 45 others, Van Rooij, F. J. A., Bandinelli, S., De Koning, L., Ericson, U., Hassanali, N., Kiefte-De Jong, J. C., Lohman, K. K., Raitakari, O., Papoutsakis, C., Sjogren, P., Stirrups, K., Ax, E., Deloukas, P., Groves, C. J., Jacques, P. F., Johansson, I., Liu, Y., McCarthy, M. I., North, K., Viikari, J., Zillikens, M. C., Dupuis, J., Hofman, A., Kolovou, G., Mukamal, K., Prokopenko, I., Rolandsson, O., Seppälä, I., Cupples, L. A., Hu, F. B., Kähönen, M., Uitterlinden, A. G., Borecki, I. B., Ferrucci, L., Jacobs, D. R., Kritchevsky, S. B., Orho-Melander, M., Pankow, J. S., Lehtimäki, T., Witteman, J. C. M., Ingelsson, E., Siscovick, D. S., Dedoussis, G., Meigs, J. B. & Franks, P. W., Jan 2013, In: American journal of epidemiology. 177, 2, p. 103-115 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

71 Scopus citations

Meta-analysis of gene-level associations for rare variants based on single-variant statistics

Hu, Y. J., Berndt, S. I., Gustafsson, S., Ganna, A., Ingelsson, E., Hirschhorn, J., North, K. E., Lin, D. Y., Berndt, S. I., Gustafsson, S., Mägi, R., Ganna, A., Wheeler, E., Feitosa, M. F., Justice, A. E., Monda, K. L., Croteau-Chonka, D. C., Day, F. R., Esko, T. & Fall, T. & 307 others, Ferreira, T., Gentilini, D., Jackson, A. U., Luan, J., Randall, J. C., Vedantam, S., Willer, C. J., Winkler, T. W., Wood, A. R., Workalemahu, T., Hu, Y. J., Lee, S. H., Liang, L., Lin, D. Y., Min, J. L., Neale, B. M., Thorleifsson, G., Yang, J., Albrecht, E., Amin, N., Bragg-Gresham, J. L., Cadby, G., Heijer, M. D., Eklund, N., Fischer, K., Goel, A., Hottenga, J. J., Huffman, J. E., Jarick, I., Johansson, A., Johnson, T., Kanoni, S., Kleber, M. E., König, I. R., Kristiansson, K., Kutalik, Z., Lamina, C., Lecoeur, C., Li, G., Mangino, M., McArdle, W. L., Medina-Gomez, C., Müller-Nurasyid, M., Ngwa, J. S., Nolte, I. M., Paternoster, L., Pechlivanis, S., Perola, M., Peters, M. J., Preuss, M., Rose, L. M., Shi, J., Shungin, D., Smith, A. V., Strawbridge, R. J., Surakka, I., Teumer, A., Trip, M. D., Tyrer, J., Vliet-Ostaptchouk, J. V. V., Vandenput, L., Waite, L. L., Zhao, J. H., Absher, D., Asselbergs, F. W., Atalay, M., Attwood, A. P., Balmforth, A. J., Basart, H., Beilby, J., Bonnycastle, L. L., Brambilla, P., Bruinenberg, M., Campbell, H., Chasman, D. I., Chines, P. S., Connell, J. M., Cookson, W., Faire, U. D., Vegt, F. D., Dei, M., Dimitriou, M., Edkins, S., Estrada, K., Evans, D. M., Farrall, M., Ferrario, M. M., Ferrières, J., Franke, L., Frau, F., Gejman, P. V., Grallert, H., Grönberg, H., Gudnason, V., Hall, A. S., Hall, P., Hartikainen, A. L., Hayward, C., Heard-Costa, N. L., Heath, A. C., Hebebrand, J., Homuth, G., Hu, F. B., Hunt, S. E., Hyppönen, E., Iribarren, C., Jacobs, K. B., Jansson, J. O., Jula, A., Kähönen, M., Kathiresan, S., Kee, F., Khaw, K. T., Kivimaki, M., Koenig, W., Kraja, A. T., Kumari, M., Kuulasmaa, K., Kuusisto, J., Laitinen, J. H., Lakka, T. A., Langenberg, C., Launer, L. J., Lind, L., Lindström, J., Liu, J., Liuzzi, A., Lokki, M. L., Lorentzon, M., Magnusson, P. A. M., Magnusson, P. A. M., Manunta, P., Marek, D., März, W., Leach, I. M., McKnight, B., Medland, S. E., Mihailov, E., Milani, L., Montgomery, G. W., Mooser, V., Mühleisen, T. W., Munroe, P. B., Musk, A. W., Narisu, N., Navis, G., Nicholson, G., Nohr, E. A., Ong, K. K., Oostra, B. A., Palmer, C. N. A., Palotie, A., Peden, J. F., Pedersen, N., Peters, A., Polasek, O., Pouta, A., Pramstaller, P. P., Prokopenko, I., Pütter, C., Radhakrishnan, A., Raitakari, O., Rendon, A., Rivadeneira, F., Rudan, I., Saaristo, T. E., Sambrook, J. G., Sanders, A. R., Sanna, S., Saramies, J., Schipf, S., Schreiber, S., Schunkert, H., Shin, S. Y., Signorini, S., Sinisalo, J., Skrobek, B., Soranzo, N., Stancáková, A., Stark, K., Stephens, J. C., Stirrups, K., Stolk, R. P., Stumvoll, M., Swift, A. J., Theodoraki, E. V., Thorand, B., Tregouet, D. A., Tremoli, E., Klauw, M. M. V. D., Meurs, J. B. J. V., Vermeulen, S. H., Viikari, J., Virtamo, J., Vitart, V., Waeber, G., Wang, Z., Widén, E., Wild, S. H., Willemsen, G., Winkelmann, B. R., Witteman, J. C. M., Wolffenbuttel, B. H. R., Wong, A., Wright, A. F., Zillikens, M. C., Amouyel, P., Boehm, B. O., Boerwinkle, E., Boomsma, D. I., Caulfield, M. J., Chanock, S. J., Cupples, L. A., Cusi, D., Dedoussis, G. V., Erdmann, J., Eriksson, J. G., Franks, P. W., Froguel, P., Gieger, C., Gyllensten, U., Hamsten, A., Harris, T. B., Hengstenberg, C., Hicks, A. A., Hingorani, A., Hinney, A., Hofman, A., Hovingh, K. G., Hveem, K., Illig, T., Jarvelin, M. R., Jöckel, K. H., Keinanen-Kiukaanniemi, S. M., Kiemeney, L. A., Kuh, D., Laakso, M., Lehtimäki, T., Levinson, D. F., Martin, N. G., Metspalu, A., Morris, A. D., Nieminen, M. S., Njølstad, I., Ohlsson, C., Oldehinkel, A. J., Ouwehand, W. H., Palmer, L. J., Penninx, B., Power, C., Province, M. A., Psaty, B. M., Qi, L., Rauramaa, R., Ridker, P. M., Ripatti, S., Salomaa, V., Samani, N. J., Snieder, H., Sørensen, T. I. A., Spector, T. D., Stefansson, K., Tönjes, A., Tuomilehto, J., Uitterlinden, A. G., Uusitupa, M., Harst, P. V. D., Vollenweider, P., Wallaschofski, H., Wareham, N. J., Watkins, H., Wichmann, H. E., Wilson, J. F., Abecasis, G. R., Assimes, T. L., Barroso, I., Boehnke, M., Borecki, I. B., Deloukas, P., Fox, C. S., Frayling, T., Groop, L. C., Haritunian, T., Heid, I. M., Hunter, D., Kaplan, R. C., Karpe,MiriamMoffatt, F., Mohlke, K. L., O’Connell, J. R., Pawitan, Y., Schadt, E. E., Schlessinger, D., Steinthorsdottir, V., Strachan, D. P., Thorsteinsdottir, U., Duijn, C. M. V., Visscher, P. M., Blasio, A. M. D., Hirschhorn, J. N., Lindgren, C. M., Morris, A. P., Meyre, D., Scherag, A., McCarthy, M. I., Speliotes, E. K., North, K. E. & Loos, R. J. F., Aug 8 2013, In: American journal of human genetics. 93, 2, p. 236-248 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

N-cadherin relocalizes from the periphery to the center of the synapse after transient synaptic stimulation in hippocampal neurons

Yam, P. T., Pincus, Z., Gupta, G. D., Bashkurov, M., Charron, F., Pelletier, L. & Colman, D. R., Nov 2013, In: PloS one. 8, 11, e79679.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

New mutations in flagellar motors identified by whole genome sequencing in Chlamydomonas

Lin, H., Nauman, N. P., Albee, A. J., Hsu, S. & Dutcher, S. K., Oct 30 2013, In: Cilia. 2, 1, 14.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Plot protein: Visualization of mutations

Turner, T., Jul 22 2013, In: Journal of Clinical Bioinformatics. 3, 1, 14.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

PNPLA3 gene-by-visceral adipose tissue volume interaction and the pathogenesis of fatty liver disease: The NHLBI Family Heart Study

Graff, M., North, K. E., Franceschini, N., Reiner, A. P., Feitosa, M., Carr, J. J., Gordon-Larsen, P., Wojczynski, M. K. & Borecki, I. B., Mar 2013, In: International Journal of Obesity. 37, 3, p. 432-438 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1

Zhu, Y., Zhang, L., Sasaki, Y., Milbrandt, J. & Gidday, J. M., Jan 2013, In: Investigative Ophthalmology and Visual Science. 54, 1, p. 25-36 12 p.

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression

Culverhouse, R. C., Bowes, L., Breslau, N., Nurnberger, J. I., Burmeister, M., Fergusson, D. M., Munafò, M., Saccone, N. L. & Bierut, L. J., Nov 12 2013, In: BMC Psychiatry. 13, 304.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Radiosynthesis and biological evaluation of alpha-[F-18]fluoromethyl phenylalanine for brain tumor imaging

Huang, C., Yuan, L., Rich, K. M. & McConathy, J., May 2013, In: Nuclear Medicine and Biology. 40, 4, p. 498-506 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Reexposure to nicotine during withdrawal increases the pacemaking activity of cholinergic habenular neurons

Görlich, A., Antolin-Fontes, B., Ables, J. L., Frahm, S., Ślimak, M. A., Dougherty, J. D. & Ibañez-Tallon, I., Oct 15 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 42, p. 17077-17082 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

86 Scopus citations

Role of oxygen consumption in hypoxia protection by translation factor depletion

Scott, B., Sun, C. L., Mao, X., Yu, C., Vohra, B. P. S., Milbrandt, J. & Crowder, C. M., Jun 2013, In: Journal of Experimental Biology. 216, 12, p. 2283-2292 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Sarm1-mediated axon degeneration requires both SAM and TIR interactions

Gerdts, J., Summers, D. W., Sasaki, Y., DiAntonio, A. & Milbrandt, J., 2013, In: Journal of Neuroscience. 33, 33, p. 13569-13580 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

275 Scopus citations

Department of Genetics

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