Department of Genetics

Research output

Research output per year 1978 2001 2005 2007 2009 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023

• 2070 Article
• 120 Review article
• 76 Comment/debate
• 35 Chapter
• 69 More
  • 19 Letter
  • 17 Conference contribution
  • 17 Editorial
  • 11 Short survey
  • 2 Foreword/postscript
  • 2 Conference article
  • 1 Book

Research output per year

Research output per year

Search results

• 2010

  Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans

  Saccone, N. L., Schwantes-An, T. H., Wang, J. C., Grucza, R. A., Breslau, N., Hatsukami, D., Johnson, E. O., Rice, J. P., Goate, A. M. & Bierut, L. J., Oct 2010, In: Genes, Brain and Behavior. 9, 7, p. 741-750 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Tobacco Use Disorder 100%
  • Cholinergic Receptors 90%
  • Nicotinic Receptors 90%
  • African Americans 76%
  • Genes 32%
  79 Scopus citations

• Multiple independent loci at chromosome 15q25.1 affect smoking quantity: A meta-analysis and comparison with lung cancer and COPD

  Saccone, N. L., Culverhouse, R. C., Schwantes-An, T. H., Cannon, D. S., Chen, X., Cichon, S., Giegling, I., Han, S., Han, Y., Keskitalo-Vuokko, K., Kong, X., Landi, M. T., Ma, J. Z., Short, S. E., Stephens, S. H., Stevens, V. L., Sun, L., Wang, Y., Wenzlaff, A. S., Aggen, S. H., & 43 othersBreslau, N., Broderick, P., Chatterjee, N., Chen, J., Heath, A. C., Heliövaara, M., Hoft, N. R., Hunter, D. J., Jensen, M. K., Martin, N. G., Montgomery, G. W., Niu, T., Payne, T. J., Peltonen, L., Pergadia, M. L., Rice, J. P., Sherva, R., Spitz, M. R., Sun, J., Wang, J. C., Weiss, R. B., Wheeler, W., Witt, S. H., Yang, B. Z., Caporaso, N. E., Ehringer, M. A., Eisen, T., Gapstur, S. M., Gelernter, J., Houlston, R., Kaprio, J., Kendler, K. S., Kraft, P., Leppert, M. F., Li, M. D., Madden, P. A. F., Nöthen, M. M., Pillai, S., Rietschel, M., Rujescu, D., Schwartz, A., Amos, C. I. & Bierut, L. J., Aug 2010, In: PLoS genetics. 6, 8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • chronic obstructive pulmonary disease 100%
  • lung neoplasms 90%
  • meta-analysis 78%
  • smoking 76%
  • respiratory tract diseases 74%
  300 Scopus citations

• New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

  Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Mägi, R., Morris, A. P., Randall, J., Johnson, T., Elliott, P., Rybin, D., Thorleifsson, G., Steinthorsdottir, V., Henneman, P., & 283 othersGrallert, H., Dehghan, A., JanHottenga, J., Franklin, C. S., Navarro, P., Song, K., Goel, A., Perry, J. R. B., Egan, J. M., Lajunen, T., Grarup, N., Sparsø, T., Doney, A., Voight, B. F., Stringham, H. M., Li, M., Kanoni, S., Shrader, P., Cavalcanti-Proença, C., Kumari, M., Qi, L., Timpson, N. J., Gieger, C., Zabena, C., Rocheleau, G., Ingelsson, E., An, P., O'Connell, J., Luan, JA., Elliott, A., McCarroll, S. A., Payne, F., Roccasecca, R. M., Pattou, F., Sethupathy, P., Ardlie, K., Ariyurek, Y., Balkau, B., Barter, P., Beilby, J. P., Ben-Shlomo, Y., Benediktsson, R., Bennett, A. J., Bergmann, S., Bochud, M., Boerwinkle, E., Bonnefond, A., Bonnycastle, L. L., Borch-Johnsen, K., Böttcher, Y., Brunner, E., Bumpstead, S. J., Charpentier, G., Der IdaChen, Y., Chines, P., Clarke, R., McOin, L. J., Cooper, M. N., Cornelis, M., Crawford, G., Crisponi, L., Day, I. N. M., De Geus, E. J. C., Delplanque, J., Dina, C., Erdos, M. R., Fedson, A. C., Fischer-Rosinsky, A., Forouhi, N. G., Fox, C. S., Frants, R., GraziaFranzosi, M., Galan, P., Goodarzi, M. O., Graessler, J., Groves, C. J., Grundy, S., Gwilliam, R., Gyllensten, U., Hadjadj, S., Hallmans, G., Hammond, N., Han, X., -LiisaHartikainen, A., Hassanali, N., Hayward, C., Heath, S. C., Hercberg, S., Herder, C., Hicks, A. A., Hillman, D. R., Hingorani, A. D., Hofman, A., Hui, J., Hung, J., Isomaa, B., Johnson, P. R. V., Jørgensen, T., Jula, A., Kaakinen, M., Kaprio, J., AnteroKesaniemi, Y., Kivimaki, M., Knight, B., Koskinen, S., Kovacs, P., Kyvik, K. O., Lathrop, G. M., Lawlor, D. A., Bacquer, O. L., Lecoeur, C., Li, Y., Lyssenko, V., Mahley, R., Mangino, M., Manning, A. K., TeresaMartínez-Larrad, M., McAteer, J. B., McCulloch, L. J., McPherson, R., Meisinger, C., Melzer, D., Meyre, D., Mitchell, B. D., Morken, M. A., Mukherjee, S., Naitza, S., Narisu, N., Neville, M. J., Oostra, B. A., Orrù, M., Pakyz, R., APalmer, C. N., Paolisso, G., Pattaro, C., Pearson, D., Peden, J. F., Pedersen, N. L., Perola, M., Pfeiffer, A. F. H., Pichler, I., Polasek, O., Posthuma, D., Potter, S. C., Pouta, A., Province, M. A., Psaty, B. M., Rathmann, W., Rayner, N. W., Rice, K., Ripatti, S., Rivadeneira, F., Roden, M., Rolandsson, O., Sandbaek, A., Sandhu, M., Sanna, S., Sayer, A. A., Scheet, P., Scott, L. J., Seedorf, U., Sharp, S. J., Shields, B., Sigursson, G., Sijbrands, E. J. G., Silveira, A., Simpson, L., Singleton, A., Smith, N. L., Sovio, U., Swift, A., Syddall, H., -ChristineSyvänen, A., Tanaka, T., Thorand, B., Tichet, J., Tönjes, A., Tuomi, T., Uitterlinden, A. G., Van Dijk, K. W., Hoek, M. V., Varma, D., Visvikis-Siest, S., Vitart, V., Vogelzangs, N., Waeber, G., Wagner, P. J., Walley, A., BragiWalters, G., Ward, K. L., Watkins, H., Weedon, M. N., Wild, S. H., Willemsen, G., MWitteman, J. C., GYarnell, J. W., Zeggini, E., Zelenika, D., Zethelius, B., Zhai, G., Zhao, J. H., Zillikens, M. C., Borecki, I. B., Loos, R. J. F., Meneton, P., Magnusson, P. K. E., Nathan, D. M., Williams, G. H., Hattersley, A. T., Silander, K., Salomaa, V., Smith, G. D., Bornstein, S. R., Schwarz, P., Spranger, J., Karpe, F., Shuldiner, A. R., Cooper, C., Dedoussis, G. V., Serrano-Ríos, M., Morris, A. D., Lind, L., Palmer, L. J., Hu, F. B., Franks, P. W., Ebrahim, S., Marmot, M., Linda Kao, W. H., Pankow, J. S., Sampson, M. J., Kuusisto, J., Laakso, M., Hansen, T., Pedersen, O., Pramstaller, P. P., Wichmann, H. E., Illig, T., Rudan, I., Wright, A. F., Stumvoll, M., Campbell, H., Wilson, J. F., Bergman, R. N., Buchanan, T. A., Collins, F. S., Mohlke, K. L., Tuomilehto, J., Valle, T. T., Altshuler, D., Rotter, J. I., Siscovick, D. S., Penninx, B. W. J. H., Boomsma, D. I., Deloukas, P., Spector, T. D., Frayling, T. M., Ferrucci, L., Kong, A., Thorsteinsdottir, U., Stefansson, K., Van Duijn, C. M., Aulchenko, Y. S., Cao, A., Scuteri, A., Schlessinger, D., Uda, M., Ruokonen, A., -RiittaJarvelin, M., Waterworth, D. M., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G. R., Wareham, N. J., Sladek, R., Froguel, P., Watanabe, R. M., Meigs, J. B., Groop, L., Boehnke, M., McCarthy, M. I., Florez, J. C. & Barroso, I., Feb 2010, In: Nature Genetics. 42, 2, p. 105-116 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Genetic Loci 100%
  • B-insulin 68%
  • Fasting 65%
  • Type 2 Diabetes Mellitus 61%
  • Homeostasis 60%
  1279 Scopus citations

• New loci associated with kidney function and chronic kidney disease

  Köttgen, A., Pattaro, C., Böger, C. A., Fuchsberger, C., Olden, M., Glazer, N. L., Parsa, A., Gao, X., Yang, Q., Smith, A. V., O'Connel, J. R., Li, M., Schmidt, H., Tanaka, T., Isaacs, A., Ketkar, S., Hwang, S. J., Johnson, A. D., Dehghan, A., Teumer, A., & 112 othersParé, G., Atkinson, E. J., Zeller, T., Lohman, K., Cornelis, M. C., Probst-Hensch, N. M., Kronenberg, F., Tönjes, A., Hayward, C., Aspelund, T., Eiriksdottir, G., Launer, L. J., Harris, T. B., Rampersaud, E., Mitchel, B. D., Arking, D. E., Boerwinkle, E., Struchalin, M., Cavalieri, M., Singleton, A., Giallauria, F., Metter, J., De Boer, I. H., Haritunians, T., Lumley, T., Siscovick, D., Psaty, B. M., CarolaZillikens, M., Oostra, B. A., Feitosa, M., Province, M., Andrade, M. D., Turner, S. T., Schillert, A., Ziegler, A., Wild, P. S., Schnabel, R. B., Wilde, S., Munzel, T. F., Leak, T. S., Illig, T., Klopp, N., Meisinger, C., Wichmann, H. E., Koenig, W., Zgaga, L., Zemunik, T., Kolcic, I., Minelli, C., Hu, F. B., Johansson, Å., Igl, W., Zaboli, G., Wild, S. H., Wright, A. F., Campbell, H., Ellinghaus, D., Schreiber, S., Aulchenko, Y. S., Felix, J. F., Rivadeneira, F., Uitterlinden, A. G., Hofman, A., Imboden, M., Nitsch, D., Brandstätter, A., Kollerits, B., Kedenko, L., Mägi, R., Stumvoll, M., Kovacs, P., Boban, M., Campbell, S., Endlich, K., Völzke, H., Kroemer, H. K., Nauck, M., Völker, U., Polasek, O., Vitart, V., Badola, S., Parker, A. N., Ridker, P. M., Kardia, S. L. R., Blankenberg, S., Liu, Y., Curhan, G. C., Franke, A., Rochat, T., Paulweber, B., Prokopenko, I., Wang, W., Gudnason, V., Shuldine, A. R., Coresh, J., Schmidt, R., Ferrucci, L., Shlipak, M. G., Van Duijn, C. M., Borecki, I., Krämer, B. K., Rudan, I., Gyllensten, U., Wilson, J. F., Witteman, J. C., Pramstaller, P. P., Rettig, R., Hastie, N., Chasman, D. I., Kao, W. H., Heid, I. M. & Fox, C. S., May 2010, In: Nature Genetics. 42, 5, p. 376-384 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Chronic Renal Insufficiency 100%
  • Kidney 58%
  • Creatinine 34%
  • Cystatins 32%
  • Genome 29%
  412 Scopus citations

• Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus

  Chang, J., Zhang, B., Heath, H., Galjart, N., Wang, X. & Milbrandt, J., Dec 14 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21836-21841 6 p.

  Research output: Contribution to journal › Article › peer-review

  • CCCTC-Binding Factor 100%
  • cohesins 89%
  • Brain-Derived Neurotrophic Factor 65%
  • NAD 64%
  • DNA Methylation 61%
  46 Scopus citations

• Novel sequence-based method for identifying transcription factor binding sites in prokaryotic genomes

  Sahota, G. & Stormo, G. D., Nov 2010, In: Bioinformatics. 26, 21, p. 2672-2677 6 p., btq501.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transcription Factor 100%
  • Transcription factors 91%
  • Binding sites 88%
  • Specificity 76%
  • Genome 70%
  18 Scopus citations

• Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice

  Jain, S., Knoten, A., Hoshi, M., Wang, H., Vohra, B., Heuckeroth, R. O. & Milbrandt, J., Mar 1 2010, In: Journal of Clinical Investigation. 120, 3, p. 778-790 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Urogenital System 100%
  • Enteric Nervous System 96%
  • Hirschsprung Disease 93%
  • Mutation 81%
  • Autonomic Nervous System 79%
  46 Scopus citations

• Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo

  Morris, S. A., Teo, R. T. Y., Li, H., Robson, P., Glover, D. M. & Zernicka-Goetz, M., Apr 6 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 6364-6369 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Embryonic Structures 100%
  • Endoderm 38%
  • Germ Layers 29%
  • Blastocyst 8%
  • Cell Division 7%
  232 Scopus citations

• Peer smoking and the nicotinic receptor genes: An examination of genetic and environmental risks for nicotine dependence

  Johnson, E. O., Chen, L. S., Breslau, N., Hatsukami, D., Robbins, T., Saccone, N. L., Grucza, R. A. & Bierut, L. J., Nov 2010, In: Addiction. 105, 11, p. 2014-2022 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Tobacco Use Disorder 100%
  • Nicotinic Receptors 90%
  • Smoking 59%
  • Genes 32%
  • Genotype 32%
  49 Scopus citations

• Peptidoglycan crosslinking relaxation promotes helicobacter pylori's helical shape and stomach colonization

  Sycuro, L. K., Pincus, Z., Gutierrez, K. D., Biboy, J., Stern, C. A., Vollmer, W. & Salama, N. R., May 2010, In: Cell. 141, 5, p. 822-833 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Peptidoglycan 100%
  • Helicobacter pylori 75%
  • Crosslinking 65%
  • Stomach 56%
  • Shape 50%
  189 Scopus citations

• Persephin signaling through GFRα1: The potential for the treatment of Parkinson's disease

  Sidorova, Y. A., Mätlik, K., Paveliev, M., Lindahl, M., Piranen, E., Milbrandt, J., Arumäe, U., Saarma, M. & Bespalov, M. M., Jul 2010, In: Molecular and Cellular Neuroscience. 44, 3, p. 223-232 10 p.

  Research output: Contribution to journal › Article › peer-review

  • persephin 100%
  • Glial Cell Line-Derived Neurotrophic Factor 46%
  • Parkinson Disease 43%
  • Ligands 24%
  • Nerve Growth Factor Receptors 23%
  28 Scopus citations

• Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery

  Mao, X. R. & Crowder, C. M., Nov 2010, In: Molecular and cellular biology. 30, 21, p. 5033-5042 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Unfolded Protein Response 100%
  • Hypoxia 31%
  • Proteins 29%
  • X-Box Binding Protein 1 20%
  • Aminoacylation 19%
  46 Scopus citations

• PRP-17 and the pre-mRNA splicing pathway are preferentially required for the proliferation versus meiotic development decision and germline sex determination in Caenorhabditis elegans

  Kerins, J. A., Hanazawa, M., Dorsett, M. & Schedl, T., May 2010, In: Developmental Dynamics. 239, 5, p. 1555-1572 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Splicing Factors 100%
  • RNA Precursors 85%
  • Caenorhabditis elegans 82%
  • Glucagon-Like Peptide 1 58%
  • Yeasts 40%
  55 Scopus citations

• RET signaling is required for survival and normal function of nonpeptidergic nociceptors

  Golden, J. P., Hoshi, M., Nassar, M. A., Enomoto, H., Wood, J. N., Milbrandt, J., Gereau IV, R. W., Johnson, E. M. & Jain, S., Mar 17 2010, In: Journal of Neuroscience. 30, 11, p. 3983-3994 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nociceptors 100%
  • Glial Cell Line-Derived Neurotrophic Factors 42%
  • Knockout Mice 27%
  • prostatic acid phosphatase 21%
  • Nerve Growth Factor 15%
  63 Scopus citations

• Synthesizing and salvaging NAD⁺: Lessons learned from Chlamydomonas reinhardtii

  Lin, H., Kwan, A. L. & Dutcher, S. K., Sep 2010, In: PLoS genetics. 6, 9, e1001105.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • salvaging 100%
  • Chlamydomonas reinhardtii 94%
  • nicotinamide 67%
  • NAD (coenzyme) 65%
  • mutant 64%
  37 Scopus citations

• TATA is a modular component of synthetic promoters

  Mogno, I., Vallania, F., Mitra, R. D. & Cohen, B. A., Oct 2010, In: Genome research. 20, 10, p. 1391-1397 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • TATA Box 100%
  • DNA-Directed RNA Polymerases 43%
  • Transcription Factors 38%
  • Thermodynamics 31%
  • Gene Expression 31%
  71 Scopus citations

• The effect of a novel intergenic polymorphism (rs11774572) on HDL-cholesterol concentrations depends on TaqIB polymorphism in the cholesterol ester transfer protein gene

  Junyent, M., Lee, Y. C., Smith, C. E., Arnett, D. K., Tsai, M. Y., Kabagambe, E. K., Straka, R. J., Province, M., An, P., Lai, C. Q., Parnell, L. D., Shen, J., Borecki, I. & Ordovas, J. M., Jan 2010, In: Nutrition, Metabolism and Cardiovascular Diseases. 20, 1, p. 34-40 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Cholesterol Ester Transfer Proteins 100%
  • HDL Cholesterol 63%
  • Single Nucleotide Polymorphism 59%
  • oxidized low density lipoprotein 47%
  • Metabolic Syndrome 32%
  8 Scopus citations

• The genetics of obesity and the metabolic syndrome

  Monda, K. L., North, K. E., Hunt, S. C., Rao, D. C., Province, M. A. & Kraja, A. T., 2010, In: Endocrine, Metabolic and Immune Disorders - Drug Targets. 10, 2, p. 86-108 23 p.

  Research output: Contribution to journal › Article › peer-review

  • Metabolic Syndrome 100%
  • Obesity 75%
  • Genome-Wide Association Study 68%
  • Gene Regulatory Networks 47%
  • H-cadherin 36%
  57 Scopus citations
• 2011

  A bivariate genome-wide approach to metabolic syndrome: STAMPEED Consortium

  Kraja, A. T., Vaidya, D., Pankow, J. S., Goodarzi, M. O., Assimes, T. L., Kullo, I. J., Sovio, U., Mathias, R. A., Sun, Y. V., Franceschini, N., Absher, D., Li, G., Zhang, Q., Feitosa, M. F., Glazer, N. L., Haritunians, T., Hartikainen, A. L., Knowles, J. W., North, K. E., Iribarren, C., & 19 othersKral, B., Yanek, L., O'Reilly, P. F., McCarthy, M. I., Jaquish, C., Couper, D. J., Chakravarti, A., Psaty, B. M., Becker, L. C., Province, M. A., Boerwinkle, E., Quertermous, T., Palotie, L., Jarvelin, M. R., Becker, D. M., Kardia, S. L. R., Rotter, J. I., Chen, Y. D. I. & Borecki, I. B., Apr 2011, In: Diabetes. 60, 4, p. 1329-1339 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Metabolic Syndrome 100%
  • Genome 73%
  • Single Nucleotide Polymorphism 54%
  • Lipid Metabolism Disorders 32%
  • Cholesterol 32%
  195 Scopus citations

• A data-driven method for identifying rare variants with heterogeneous trait effects

  Zhang, Q., Irvin, M. R., Arnett, D. K., Province, M. A. & Borecki, I., Nov 2011, In: Genetic Epidemiology. 35, 7, p. 679-685 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Fenofibrate 100%
  • PPAR alpha 93%
  • Triglycerides 59%
  • Direction compound 53%
  • Body Mass Index 52%
  12 Scopus citations

• A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue

  Green, R. A., Kao, H. L., Audhya, A., Arur, S., Mayers, J. R., Fridolfsson, H. N., Schulman, M., Schloissnig, S., Niessen, S., Laband, K., Wang, S., Starr, D. A., Hyman, A. A., Schedl, T., Desai, A., Piano, F., Gunsalus, K. C. & Oegema, K., Apr 29 2011, In: Cell. 145, 3, p. 470-482 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Essential Genes 100%
  • Gene Regulatory Networks 95%
  • Reaction Yield 35%
  • Genes 35%
  • Macromolecular Substances 24%
  148 Scopus citations

• A modified bacterial one-hybrid system yields improved quantitative models of transcription factor specificity

  Christensen, R. G., Gupta, A., Zuo, Z., Schriefer, L. A., Wolfe, S. A. & Stormo, G. D., Jul 2011, In: Nucleic acids research. 39, 12, p. e83

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transcription Factors 100%
  • Libraries 33%
  • CYS2-HIS2 Zinc Fingers 30%
  • Isopropyl Thiogalactoside 25%
  • Benchmarking 20%
  22 Scopus citations

• An axonemal PP2A B-subunit is required for PP2A localization and flagellar motility

  Elam, C. A., Wirschell, M., Yamamoto, R., Fox, L. A., York, K., Kamiya, R., Dutcher, S. K. & Sale, W. S., Jul 2011, In: Cytoskeleton. 68, 7, p. 363-372 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Axoneme 100%
  • Chlamydomonas 41%
  • Axonemal Dyneins 24%
  • Dyneins 17%
  • Phosphoprotein Phosphatases 15%
  18 Scopus citations

• An introduction to recognizing functional domains

  Stormo, G. D., Jun 2011, In: Current Protocols in Bioinformatics. SUPPL. 34, p. 1-6 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Nucleotide Sequence 100%
  • Sequence Alignment 98%
  • Consensus Sequence 92%
  • DNA Sequence 83%
  • Protein 66%
  3 Scopus citations

• A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression

  Grimm, A. A., Brace, C. S., Wang, T., Stormo, G. D. & Imai, S. I., Apr 2011, In: Aging Cell. 10, 2, p. 305-317 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sirtuin 1 100%
  • C-Reactive Protein 66%
  • Nutrients 64%
  • Hepatocytes 14%
  • Mason-Type Diabetes 12%
  19 Scopus citations

• Application of Bayesian network structure learning to identify causal variant SNPs from resequencing data

  Schlosberg, C. E., Schwantes-An, T. H., Duan, W. & Saccone, N. L., 2011, In: BMC Proceedings. 5, SUPPL. 9, S109.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Single Nucleotide Polymorphism 100%
  • Learning 87%
  • Simulation 74%
  • Application 37%
  • Education 13%
  10 Scopus citations

• Assessing the effects of symmetry on motif discovery and modeling

  Motlhabi, L. M. & Stormo, G. D., Sep 20 2011, In: PloS one. 6, 9, e24908.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Binding Sites 100%
  • Binding Site 91%
  • binding sites 46%
  • Transcription Factors 39%
  • Error 38%
  3 Scopus citations

• Ataxin-1 occupies the promoter region of E-cadherin in vivo and activates CtBP2-repressed promoter

  Lee, S., Hong, S., Kim, S. & Kang, S., May 2011, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 5, p. 713-722 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ataxin-1 100%
  • Cadherins 57%
  • Genetic Promoter Regions 55%
  • Luciferases 8%
  • Proteins 7%
  11 Scopus citations

• A unified taxonomy for ciliary dyneins

  Hom, E. F. Y., Witman, G. B., Harris, E. H., Dutcher, S. K., Kamiya, R., Mitchell, D. R., Pazour, G. J., Porter, M. E., Sale, W. S., Wirschell, M., Yagi, T. & King, S. M., Oct 2011, In: Cytoskeleton. 68, 10, p. 555-565 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Dyneins 100%
  • Chlamydomonas 46%
  • Flagella 37%
  • Terminology 30%
  • Chlamydomonas reinhardtii 23%
  56 Scopus citations

• A user's guide to the Encyclopedia of DNA elements (ENCODE)

  Myers, R. M., Stamatoyannopoulos, J., Snyder, M., Dunham, I., Hardison, R. C., Bernstein, B. E., Gingeras, T. R., Kent, W. J., Birney, E., Wold, B., Crawford, G. E., Epstein, C. B., Shoresh, N., Ernst, J., Mikkelsen, T. S., Kheradpour, P., Zhang, X., Wang, L., Issner, R., Coyne, M. J., & 295 othersDurham, T., Ku, M., Truong, T., Ward, L. D., Altshuler, R. C., Lin, M. F., Kellis, M., Davis, C. A., Kapranov, P., Dobin, A., Zaleski, C., Schlesinger, F., Batut, P., Chakrabortty, S., Jha, S., Lin, W., Drenkow, J., Wang, H., Bell, K., Bell, I., Gao, H., Dumais, E., Dumais, J., Antonarakis, S. E., Ucla, C., Borel, C., Guigo, R., Djebali, S., Lagarde, J., Kingswood, C., Ribeca, P., Sammeth, M., Alioto, T., Merkel, A., Tilgner, H., Carninci, P., Hayashizaki, Y., Lassmann, T., Takahashi, H., Abdelhamid, R. F., Hannon, G., Fejes, K. T., Preall, J., Gordon, A., Sotirova, V., Reymond, A., Howald, C., Graison, E. A. Y., Chrast, J., Ruan, Y., Ruan, X., Shahab, A., Poh, W. T., Wei, C. L., Furey, T. S., Boyle, A. P., Sheffield, N. C., Song, L., Shibata, Y., Vales, T., Winter, D., Zhang, Z., London, D., Wang, T., Keefe, D., Iyer, V. R., Lee, B. K., McDaniell, R. M., Liu, Z., Battenhouse, A., Bhinge, A. A., Lieb, J. D., Grasfeder, L. L., Showers, K. A., Giresi, P. G., Kim, S. K. C., Shestak, C., Pauli, F., Reddy, T. E., Gertz, J., Partridge, E. C., Jain, P., Sprouse, R. O., Bansal, A., Pusey, B., Muratet, M. A., Varley, K. E., Bowling, K. M., Newberry, K. M., Nesmith, A. S., Dilocker, J. A., Parker, S. L., Waite, L. L., Thibeault, K., Roberts, K., Absher, D. M., Mortazavi, A., Williams, B., Marinov, G., Trout, D., King, B., McCue, K., Kirilusha, A., DeSalvo, G., Fisher, K. A., Amrhein, H., Pepke, S., Vielmetter, J., Sherlock, G., Sidow, A., Batzoglou, S., Rauch, R., Kundaje, A., Libbrecht, M., Margulies, E. H., Parker, S. C. J., Elnitski, L., Green, E. D., Hubbard, T., Harrow, J., Searle, S., Kokocinski, F., Aken, B., Frankish, A., Hunt, T., Despacio-Reyes, G., Kay, M., Mukherjee, G., Bignell, A., Saunders, G., Boychenko, V., Brent, M., van Baren, M. J., Brown, R. H., Gerstein, M., Khurana, E., Balasubramanian, S., Lam, H., Cayting, P., Robilotto, R., Lu, Z., Derrien, T., Tanzer, A., Knowles, D. G., Mariotti, M., Haussler, D., Harte, R., Diekhans, M., Lin, M., Valencia, A., Tress, M., Landt, S. G., Raha, D., Shi, M., Euskirchen, G., Grubert, F., Kasowski, M., Lian, J., Lacroute, P., Xu, Y., Monahan, H., Patacsil, D., Slifer, T., Yang, X., Charos, A., Reed, B., Wu, L., Auerbach, R. K., Habegger, L., Hariharan, M., Rozowsky, J., Abyzov, A., Weissman, S. M., Struhl, K., Lamarre-Vincent, N., Lindahl-Allen, M., Miotto, B., Moqtaderi, Z., Fleming, J. D., Newburger, P., Farnham, P. J., Frietze, S., O'Geen, H., Xu, X., Blahnik, K. R., Cao, A. R., Iyengar, S., Kaul, R., Thurman, R. E., Wang, H., Navas, P. A., Sandstrom, R., Sabo, P. J., Weaver, M., Canfield, T., Lee, K., Neph, S., Roach, V., Reynolds, A., Johnson, A., Rynes, E., Giste, E., Vong, S., Neri, J., Frum, T., Nguyen, E. D., Ebersol, A. K., Sanchez, M. E., Sheffer, H. H., Lotakis, D., Haugen, E., Humbert, R., Kutyavin, T., Shafer, T., Noble, W. S., Dekker, J., Lajoie, B. R., Sanyal, A., Rosenbloom, K. R., Dreszer, T. R., Raney, B. J., Barber, G. P., Meyer, L. R., Sloan, C. A., Malladi, V. S., Cline, M. S., Learned, K., Swing, V. K., Zweig, A. S., Rhead, B., Fujita, P. A., Roskin, K., Karolchik, D., Kuhn, R. M., Wilder, S. P., Sobral, D., Herrero, J., Beal, K., Lukk, M., Brazma, A., Vaquerizas, J. M., Luscombe, N. M., Bickel, P. J., Boley, N., Brown, J. B., Li, Q., Huang, H., Sboner, A., Yip, K. Y., Cheng, C., Yan, K. K., Bhardwaj, N., Wang, J., Lochovsky, L., Jee, J., Gibson, T., Leng, J., Du, J., Harris, R. S., Song, G., Miller, W., Suh, B., Paten, B., Hoffman, M. M., Buske, O. J., Weng, Z., Dong, X., Wang, J., Xi, H., Tenenbaum, S. A., Doyle, F., Chittur, S., Penalva, L. O., Tullius, T. D., White, K. P., Karmakar, S., Victorsen, A., Jameel, N., Bild, N., Grossman, R. L., Collins, P. J., Trinklein, N. D., Giddings, M. C., Khatun, J., Maier, C., Wang, T., Whitfield, T. W., Chen, X., Yu, Y., Gunawardena, H., Feingold, E. A., Lowdon, R. F., Dillon, L. A. L., Good, P. J. & Risk, B., Apr 1 2011, In: PLoS biology. 9, 4, e1001046.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Encyclopedias 100%
  • Human Genome 81%
  • DNA 43%
  • genome 32%
  • Nucleic Acid Regulatory Sequences 29%
  1125 Scopus citations

• bop5 mutations reveal new roles for the IC138 phosphoprotein in the regulation of flagellar motility and asymmetric waveforms

  VanderWaal, K. E., Yamamoto, R., Wakabayashi, K. I., Fox, L., Kamiya, R., Dutcher, S. K., Bayly, P. V., Sale, W. S. & Porter, M. E., Aug 15 2011, In: Molecular biology of the cell. 22, 16, p. 2862-2874 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dyneins 100%
  • Phosphoproteins 89%
  • Phototaxis 51%
  • Mutation 42%
  • Axoneme 22%
  25 Scopus citations

• Calling Cards enable multiplexed identification of the genomic targets of DNA-binding proteins

  Wang, H., Mayhew, D., Chen, X., Johnston, M. & Mitra, R. D., May 2011, In: Genome research. 21, 5, p. 748-755 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • DNA-Binding Proteins 100%
  • Transcription Factors 67%
  • Genome 30%
  • DNA Transposable Elements 28%
  • Chromosome Mapping 27%
  33 Scopus citations

• Characterization of autosomal copy-number variation in African Americans: The HyperGEN Study

  Wineinger, N. E., Pajewski, N. M., Kennedy, R. E., Wojczynski, M. K., Vaughan, L. K., Hunt, S. C., Gu, C. C., Rao, D. C., Lorier, R., Broeckel, U., Arnett, D. K. & Tiwari, H. K., Dec 2011, In: European Journal of Human Genetics. 19, 12, p. 1271-1275 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Molecular Epidemiology 100%
  • African Americans 80%
  • Hypertension 55%
  • Population Genetics 20%
  • Quality Control 16%
  5 Scopus citations

• Chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease

  Gong, Y., Beitelshees, A. L., Cooper-DeHoff, R. M., Lobmeyer, M. T., Langaee, T. Y., Wu, J., Cresci, S., Province, M. A., Spertus, J. A., Pepine, C. J. & Johnson, J. A., Apr 2011, In: Circulation: Cardiovascular Genetics. 4, 2, p. 169-178 10 p.

  Research output: Contribution to journal › Article › peer-review

  • African Continental Ancestry Group 100%
  • Haplotypes 95%
  • Single Nucleotide Polymorphism 85%
  • Coronary Artery Disease 84%
  • Chromosomes 80%
  26 Scopus citations

• Cilia and models for studying structure and function

  Ostrowski, L. E., Dutcher, S. K. & Lo, C. W., Sep 15 2011, In: Proceedings of the American Thoracic Society. 8, 5, p. 423-429 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Cilia 100%
  • Chlamydomonas 65%
  • Ciliopathies 63%
  • Axoneme 63%
  • Mucociliary Clearance 28%
  21 Scopus citations

• Common polymorphisms in FMO1 are associated with nicotine dependence

  Hinrichs, A. L., Murphy, S. E., Wang, J. C., Saccone, S., Saccone, N., Steinbach, J. H., Goate, A., Stevens, V. L. & Bierut, L. J., Jul 2011, In: Pharmacogenetics and Genomics. 21, 7, p. 397-402 6 p.

  Research output: Contribution to journal › Article › peer-review

  • dimethylaniline monooxygenase (N-oxide forming) 100%
  • Tobacco Use Disorder 77%
  • Nicotine 52%
  • Cytochrome P-450 Enzyme System 20%
  • 4,6-dinitro-o-cresol 15%
  16 Scopus citations

• Comparative and demographic analysis of orang-utan genomes

  Locke, D. P., Hillier, L. W., Warren, W. C., Worley, K. C., Nazareth, L. V., Muzny, D. M., Yang, S. P., Wang, Z., Chinwalla, A. T., Minx, P., Mitreva, M., Cook, L., Delehaunty, K. D., Fronick, C., Schmidt, H., Fulton, L. A., Fulton, R. S., Nelson, J. O., Magrini, V., Pohl, C., & 81 othersGraves, T. A., Markovic, C., Cree, A., Dinh, H. H., Hume, J., Kovar, C. L., Fowler, G. R., Lunter, G., Meader, S., Heger, A., Ponting, C. P., Marques-Bonet, T., Alkan, C., Chen, L., Cheng, Z., Kidd, J. M., Eichler, E. E., White, S., Searle, S., Vilella, A. J., Chen, Y., Flicek, P., Ma, J., Raney, B., Suh, B., Burhans, R., Herrero, J., Haussler, D., Faria, R., Fernando, O., Darré, F., Farré, D., Gazave, E., Oliva, M., Navarro, A., Roberto, R., Capozzi, O., Archidiacono, N., Valle, G. D., Purgato, S., Rocchi, M., Konkel, M. K., Walker, J. A., Ullmer, B., Batzer, M. A., Smit, A. F. A., Hubley, R., Casola, C., Schrider, D. R., Hahn, M. W., Quesada, V., Puente, X. S., Ordõez, G. R., Ĺpez-Otín, C., Vinar, T., Brejova, B., Ratan, A., Harris, R. S., Miller, W., Kosiol, C., Lawson, H. A., Taliwal, V., Martins, A. L., Siepel, A., Roychoudhury, A., Ma, X., Degenhardt, J., Bustamante, C. D., Gutenkunst, R. N., Mailund, T., Dutheil, J. Y., Hobolth, A., Schierup, M. H., Ryder, O. A., Yoshinaga, Y., De Jong, P. J., Weinstock, G. M., Rogers, J., Mardis, E. R., Gibbs, R. A. & Wilson, R. K., Jan 27 2011, In: Nature. 469, 7331, p. 529-533 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hominidae 100%
  • Genome 60%
  • Demography 57%
  • Primates 47%
  • Pongo 39%
  378 Scopus citations

• Cyclin e and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline

  Fox, P. M., Vought, V. E., Hanazawa, M., Lee, M. H., Maine, E. M. & Sched, T., Jun 1 2011, In: Development. 138, 11, p. 2223-2234 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Cyclins 100%
  • Cell Cycle 65%
  • Glucagon-Like Peptide 1 48%
  • Prophase 18%
  • Cyclin E 17%
  59 Scopus citations

• Diet-dependent genetic and genomic imprinting effects on obesity in mice

  Cheverud, J. M., Lawson, H. A., Fawcett, G. L., Wang, B., Pletscher, L. S., R. Fox, A., Maxwell, T. J., Ehrich, T. H., Kenney-Hunt, J. P., Wolf, J. B. & Semenkovich, C. F., Jan 2011, In: Obesity. 19, 1, p. 160-170 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Genomic Imprinting 100%
  • Obesity 50%
  • Diet 49%
  • Quantitative Trait Loci 38%
  • Fats 23%
  18 Scopus citations

• Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction

  Viader, A., Wright-Jin, E. C., Vohra, B. P. S., Heuckeroth, R. O. & Milbrandt, J., Nov 16 2011, In: PloS one. 6, 11, e27727.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Enteric Coating 100%
  • Enteric Nervous System 97%
  • nervous system 64%
  • neurons 61%
  • Neurons 45%
  24 Scopus citations

• Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficits

  Kulminski, A. M., Arbeev, K. G., Christensen, K., Mayeux, R., Newman, A. B., Province, M. A., Hadley, E. C., Rossi, W., Perls, T. T., Elo, I. T. & Yashin, A. I., Apr 2011, In: Mechanisms of Ageing and Development. 132, 4, p. 195-201 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Morbidity 100%
  • Health 82%
  • Aged, 80 and over 29%
  • Physical Functional Performance 26%
  • Denmark 25%
  18 Scopus citations

• Evidence for gene-environment interaction in a genome wide study of nonsyndromic cleft palate

  Beaty, T. H., Ruczinski, I., Murray, J. C., Marazita, M. L., Munger, R. G., Hetmanski, J. B., Murray, T., Redett, R. J., Fallin, M. D., Liang, K. Y., Wu, T., Patel, P. J., Jin, S. C., Zhang, T. X., Schwender, H., Wu-Chou, Y. H., Chen, P. K., Chong, S. S., Cheah, F., Yeow, V., & 13 othersYe, X., Wang, H., Huang, S., Jabs, E. W., Shi, B., Wilcox, A. J., Lie, R. T., Jee, S. H., Christensen, K., Doheny, K. F., Pugh, E. W., Ling, H. & Scott, A. F., Sep 2011, In: Genetic Epidemiology. 35, 6, p. 469-478 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene-Environment Interaction 100%
  • Cleft Palate 88%
  • Single Nucleotide Polymorphism 67%
  • Genome 54%
  • Mothers 30%
  126 Scopus citations

• Five blood pressure loci identified by an updated genome-wide linkage scan: Meta-analysis of the family blood pressure program

  Simino, J., Shi, G., Kume, R., Schwander, K., Province, M. A., Gu, C. C., Kardia, S., Chakravarti, A., Ehret, G., Olshen, R. A., Turner, S. T., Ho, L. T., Zhu, X., Jaquish, C., Paltoo, D., Cooper, R. S., Weder, A., Curb, J. D., Boerwinkle, E., Hunt, S. C., & 1 othersRao, D. C., Mar 2011, In: American Journal of Hypertension. 24, 3, p. 347-354 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Meta-Analysis 100%
  • Genome 90%
  • Blood Pressure 85%
  • Quantitative Trait Loci 63%
  • Mexican Americans 43%
  10 Scopus citations

• Genetic and environmental determinants of plasma total homocysteine levels: Impact of population-wide folate fortification

  Nagele, P., Meissner, K., Francis, A., Födinger, M. & Saccone, N. L., Jul 2011, In: Pharmacogenetics and Genomics. 21, 7, p. 426-431 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Homocysteine 100%
  • Folic Acid 91%
  • Population 36%
  • Linear Models 13%
  • Smoking 12%
  27 Scopus citations

• Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations

  Lawson, H. A., Cady, J. E., Partridge, C., Wolf, J. B., Semenkovich, C. F. & Cheverud, J. M., Sep 2011, In: PLoS genetics. 7, 9, e1002256.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • genetic effect 100%
  • genetic variation 83%
  • Genetic Variation 67%
  • diet 60%
  • metabolic syndrome 56%
  21 Scopus citations

• Genetic factors and diet affect long-bone length in the F34 LG,SM advanced intercross

  Norgard, E. A., Lawson, H. A., Pletscher, L. S., Wang, B., Brooks, V. R., Wolf, J. B. & Cheverud, J. M., Apr 2011, In: Mammalian Genome. 22, 3-4, p. 178-196 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Quantitative Trait Loci 100%
  • Diet 54%
  • Bone and Bones 47%
  • Fat-Restricted Diet 14%
  • Ulna 14%
  12 Scopus citations

• Genetics of hypertension and cardiovascular disease and their interconnected pathways: Lessons from large studies

  Kraja, A. T., Hunt, S. C., Rao, D. C., Dávila-Román, V. G., Arnett, D. K. & Province, M. A., Feb 2011, In: Current Hypertension Reports. 13, 1, p. 46-54 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Inborn Genetic Diseases 100%
  • Cardiovascular Diseases 78%
  • Hypertension 70%
  • Blood Pressure 68%
  • Overlapping Genes 31%
  28 Scopus citations

• Genomewide analysis of inherited variation associated with phosphorylation of PI3K/AKT/mTOR signaling proteins

  Hutz, J. E., Manning, W. A., Province, M. A. & McLeod, H. L., Sep 19 2011, In: PloS one. 6, 9, e24873.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • TOR Serine-Threonine Kinases 100%
  • 70-kDa Ribosomal Protein S6 Kinases 95%
  • Phosphatidylinositol 3-Kinases 88%
  • Phosphorylation 61%
  • Proteins 32%
  8 Scopus citations

• Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

  GIANT Consortium, Global BPgen Consortium, NASH CRN, GIANT Consortium, MAGIC Investigators, GOLD Consortium, MAGIC, on behalf of Procardis Consortium & DIAGRAM Consortium, Mar 1 2011, In: PLoS genetics. 7, 3, e1001324.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • fatty liver 100%
  • genome-wide association study 93%
  • Non-alcoholic Fatty Liver Disease 86%
  • Genome-Wide Association Study 84%
  • genome 75%
  693 Scopus citations

• Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction

  Odonnell, C. J., Kavousi, M., Smith, A. V., Kardia, S. L. R., Feitosa, M. F., Hwang, S. J., Sun, Y. V., Province, M. A., Aspelund, T., Dehghan, A., Hoffmann, U., Bielak, L. F., Zhang, Q., Eiriksdottir, G., Van Duijn, C. M., Fox, C. S., De Andrade, M., Kraja, A. T., Sigurdsson, S., Elias-Smale, S. E., & 47 othersMurabito, J. M., Launer, L. J., Van Der Lugt, A., Kathiresan, S., Krestin, G. P., Herrington, D. M., Howard, T. D., Liu, Y., Post, W., Mitchell, B. D., Oconnell, J. R., Shen, H., Shuldiner, A. R., Altshuler, D., Elosua, R., Salomaa, V., Schwartz, S. M., Siscovick, D. S., Voight, B. F., Bis, J. C., Glazer, N. L., Psaty, B. M., Boerwinkle, E., Heiss, G., Blankenberg, S., Zeller, T., Wild, P. S., Schnabel, R. B., Schillert, A., Ziegler, A., Münzel, T. F., White, C. C., Rotter, J. I., Nalls, M., Oudkerk, M., Johnson, A. D., Newman, A. B., Uitterlinden, A. G., Massaro, J. M., Cunningham, J., Harris, T. B., Hofman, A., Peyser, P. A., Borecki, I. B., Cupples, L. A., Gudnason, V. & Witteman, J. C. M., Dec 20 2011, In: Circulation. 124, 25, p. 2855-2864 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genome-Wide Association Study 100%
  • Coronary Vessels 78%
  • Myocardial Infarction 69%
  • Single Nucleotide Polymorphism 56%
  • Genes 19%
  230 Scopus citations