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  • 2010

    Hundreds of variants clustered in genomic loci and biological pathways affect human height

    Allen, H. L., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., Rivadeneira, F., Willer, C. J., Jackson, A. U., Vedantam, S., Raychaudhuri, S., Ferreira, T., Wood, A. R., Weyant, R. J., Segrè, A. V., Speliotes, E. K., Wheeler, E., Soranzo, N., Park, J. H., Yang, J. & Gudbjartsson, D. & 273 others, Heard-Costa, N. L., Randall, J. C., Qi, L., Smith, A. V., Mägi, R., Pastinen, T., Liang, L., Heid, I. M., Luan, J., Thorleifsson, G., Winkler, T. W., Goddard, M. E., Lo, K. S., Palmer, C., Workalemahu, T., Aulchenko, Y. S., Johansson, Å., Zillikens, M. C., Feitosa, M. F., Esko, T., Johnson, T., Ketkar, S., Kraft, P., Mangino, M., Prokopenko, I., Absher, D., Albrecht, E., Ernst, F., Glazer, N. L., Hayward, C., Hottenga, J. J., Jacobs, K. B., Knowles, J. W., Kutalik, Z., Monda, K. L., Polasek, O., Preuss, M., Rayner, N. W., Robertson, N. R., Steinthorsdottir, V., Tyrer, J. P., Voight, B. F., Wiklund, F., Xu, J., Zhao, J. H., Nyholt, D. R., Pellikka, N., Perola, M., Perry, J. B., Surakka, I., Tammesoo, M. L., Altmaier, E. L., Amin, N., Aspelund, T., Bhangale, T., Boucher, G., Chasman, D. I., Chen, C., Coin, L., Cooper, M. N., Dixon, A. L., Gibson, Q., Grundberg, E., Hao, K., Junttila, M. J., Kaplan, L. M., Kettunen, J., König, I. R., Kwan, T., Lawrence, R. W., Levinson, D. F., Lorentzon, M., McKnight, B., Morris, A. P., Müller, M., Ngwa, J. S., Purcell, S., Rafelt, S., Salem, R. M., Salvi, E., Sanna, S., Shi, J., Sovio, U., Thompson, J. R., Turchin, M. C., Vandenput, L., Verlaan, D. J., Vitart, V., White, C. C., Ziegler, A., Almgren, P., Balmforth, A. J., Campbell, H., Citterio, L., De Grandi, A., Dominiczak, A., Duan, J., Elliott, P., Elosua, R., Eriksson, J. G., Freimer, N. B., Geus, E. J. C., Glorioso, N., Haiqing, S., Hartikainen, A. L., Havulinna, A. S., Hicks, A. A., Hui, J., Igl, W., Illig, T., Jula, A., Kajantie, E., Kilpeläinen, T. O., Koiranen, M., Kolcic, I., Koskinen, S., Kovacs, P., Laitinen, J., Liu, J., Lokki, M. L., Marusic, A., Maschio, A., Meitinger, T., Mulas, A., Paré, G., Parker, A. N., Peden, J. F., Petersmann, A., Pichler, I., Pietiläinen, K. H., Pouta, A., Ridderstråle, M., Rotter, J. I., Sambrook, J. G., Sanders, A. R., Schmidt, C. O., Sinisalo, J., Smit, J. H., Stringham, H. M., Walters, G. B., Widen, E., Wild, S. H., Willemsen, G., Zagato, L., Zgaga, L., Zitting, P., Alavere, H., Farrall, M., McArdle, W. L., Nelis, M., Peters, M. J., Ripatti, S., Van Meurs, J. B. J., Aben, K. K., Ardlie, K. G., Beckmann, J. S., Beilby, J. P., Bergman, R. N., Bergmann, S., Collins, F. S., Cusi, D., Den Heijer, M., Eiriksdottir, G., Gejman, P. V., Hall, A. S., Hamsten, A., Huikuri, H. V., Iribarren, C., Kähönen, M., Kaprio, J., Kathiresan, S., Kiemeney, L., Kocher, T., Launer, L. J., Lehtimäki, T., Melander, O., Mosley, T. H., Musk, A. W., Nieminen, M. S., O'Donnell, C. J., Ohlsson, C., Oostra, B., Palmer, L. J., Raitakari, O., Ridker, P. M., Rioux, J. D., Rissanen, A., Rivolta, C., Schunkert, H., Shuldiner, A. R., Siscovick, D. S., Stumvoll, M., Tönjes, A., Tuomilehto, J., Van Ommen, G. J., Viikari, J., Heath, A. C., Martin, N. G., Montgomery, G. W., Province, M. A., Kayser, M., Arnold, A. M., D.Atwood, L., Boerwinkle, E., Chanock, S. J., Deloukas, P., Gieger, C., Grönberg, H., Hall, P., Hattersley, A. T., Hengstenberg, C., Hoffman, W., Lathrop, G. M., Salomaa, V., Schreiber, S., Uda, M., Waterworth, D., Wright, A. F., Assimes, T. L., Barroso, I., Hofman, A., Mohlke, K. L., Boomsma, D. I., Caulfield, M. J., Cupples, L. A., Erdmann, J., Fox, C. S., Gudnason, V., Gyllensten, U., Harris, T. B., Hayes, R. B., Jarvelin, M. R., Mooser, V., Munroe, P. B., Ouwehand, W. H., Penninx, B. W., Pramstaller, P. P., Quertermous, T., Rudan, I., Samani, N. J., Spector, T. D., Völzke, H., Watkins, H., Wilson, J. F., Groop, L. C., Haritunians, T., Hu, F. B., Kaplan, R. C., Metspalu, A., North, K. E., Schlessinger, D., Wareham, N. J., Hunter, D. J., O'Connell, J. R., Strachan, D. P., Wichmann, H. E., Borecki, I. B., Van Duijn, C. M., Schadt, E. E., Thorsteinsdottir, U., Peltonen, L., Uitterlinden, A. G., Visscher, P. M., Chatterjee, N., Loos, R. J. F., Boehnke, M., McCarthy, M. I., Ingelsson, E., Lindgren, C. M., Abecasis, G. R., Stefansson, K., Frayling, T. M. & Hirschhorn, J. N., Oct 14 2010, In: Nature. 467, 7317, p. 832-838 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1575 Scopus citations

  • Incorporating age at onset of smoking into genetic models for nicotine dependence: Evidence for interaction with multiple genes

    Grucza, R. A., Johnson, E. O., Krueger, R. F., Breslau, N., Saccone, N. L., Chen, L. S., Derringer, J., Agrawal, A., Lynskey, M. & Bierut, L. J., Jul 2010, In: Addiction Biology. 15, 3, p. 346-357 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    32 Scopus citations

  • Interaction between the UCP2 -866 G>A polymorphism, diabetes, and β-blocker use among patients with acute coronary syndromes

    Beitelshees, A. L., Finck, B. N., Leone, T. C., Cresci, S., Wu, J., Province, M. A., Fabbrini, E., Kirk, E., Zineh, I., Klein, S., Spertus, J. A. & Kelly, D. R., Apr 2010, In: Pharmacogenetics and Genomics. 20, 4, p. 231-238 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    14 Scopus citations

  • Mechanisms of nucleotide trafficking during siRNA delivery to endothelial cells using perfluorocarbon nanoemulsions

    Kaneda, M. M., Sasaki, Y., Lanza, G. M., Milbrandt, J. & Wickline, S. A., Apr 2010, In: Biomaterials. 31, 11, p. 3079-3086 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    55 Scopus citations

  • MicroRNAs both promote and antagonize longevity in C. elegans

    De Lencastre, A., Pincus, Z., Zhou, K., Kato, M., Lee, S. S. & Slack, F. J., Dec 21 2010, In: Current Biology. 20, 24, p. 2159-2168 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    253 Scopus citations

  • Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice

    Wang, Q., Frolova, A. I., Purcell, S., Adastra, K., Schoeller, E., Chi, M. M., Schedl, T. & Moley, K. H., 2010, In: PloS one. 5, 12, e15901.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    101 Scopus citations

  • Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex

    Misko, A., Jiang, S., Wegorzewska, I., Milbrandt, J. & Baloh, R. H., Mar 24 2010, In: Journal of Neuroscience. 30, 12, p. 4232-4240 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    519 Scopus citations

  • Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder

    McEachin, R. C., Saccone, N. L., Saccone, S. F., Kleyman-Smith, Y. D., Kar, T., Kare, R. K., Ade, A. S., Sartor, M. A., Cavalcoli, J. D. & McInnis, M. G., Jan 26 2010, In: BMC Medical Genetics. 11, 1, 14.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    27 Scopus citations

  • Motif discovery using expectation maximization and gibbs’ sampling

    Stormo, G. D., 2010, In: Methods in Molecular Biology. 674, p. 85-95 11 p.

    Research output: Contribution to journal › Article › peer-review

    9 Scopus citations

  • Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans

    Saccone, N. L., Schwantes-An, T. H., Wang, J. C., Grucza, R. A., Breslau, N., Hatsukami, D., Johnson, E. O., Rice, J. P., Goate, A. M. & Bierut, L. J., Oct 2010, In: Genes, Brain and Behavior. 9, 7, p. 741-750 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    84 Scopus citations

  • Multiple independent loci at chromosome 15q25.1 affect smoking quantity: A meta-analysis and comparison with lung cancer and COPD

    Saccone, N. L., Culverhouse, R. C., Schwantes-An, T. H., Cannon, D. S., Chen, X., Cichon, S., Giegling, I., Han, S., Han, Y., Keskitalo-Vuokko, K., Kong, X., Landi, M. T., Ma, J. Z., Short, S. E., Stephens, S. H., Stevens, V. L., Sun, L., Wang, Y., Wenzlaff, A. S. & Aggen, S. H. & 43 others, Breslau, N., Broderick, P., Chatterjee, N., Chen, J., Heath, A. C., Heliövaara, M., Hoft, N. R., Hunter, D. J., Jensen, M. K., Martin, N. G., Montgomery, G. W., Niu, T., Payne, T. J., Peltonen, L., Pergadia, M. L., Rice, J. P., Sherva, R., Spitz, M. R., Sun, J., Wang, J. C., Weiss, R. B., Wheeler, W., Witt, S. H., Yang, B. Z., Caporaso, N. E., Ehringer, M. A., Eisen, T., Gapstur, S. M., Gelernter, J., Houlston, R., Kaprio, J., Kendler, K. S., Kraft, P., Leppert, M. F., Li, M. D., Madden, P. A. F., Nöthen, M. M., Pillai, S., Rietschel, M., Rujescu, D., Schwartz, A., Amos, C. I. & Bierut, L. J., Aug 2010, In: PLoS genetics. 6, 8

    Research output: Contribution to journal › Article › peer-review

    Open Access
    312 Scopus citations

  • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

    Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Mägi, R., Morris, A. P., Randall, J., Johnson, T., Elliott, P., Rybin, D., Thorleifsson, G., Steinthorsdottir, V. & Henneman, P. & 283 others, Grallert, H., Dehghan, A., JanHottenga, J., Franklin, C. S., Navarro, P., Song, K., Goel, A., Perry, J. R. B., Egan, J. M., Lajunen, T., Grarup, N., Sparsø, T., Doney, A., Voight, B. F., Stringham, H. M., Li, M., Kanoni, S., Shrader, P., Cavalcanti-Proença, C., Kumari, M., Qi, L., Timpson, N. J., Gieger, C., Zabena, C., Rocheleau, G., Ingelsson, E., An, P., O'Connell, J., Luan, J., Elliott, A., McCarroll, S. A., Payne, F., Roccasecca, R. M., Pattou, F., Sethupathy, P., Ardlie, K., Ariyurek, Y., Balkau, B., Barter, P., Beilby, J. P., Ben-Shlomo, Y., Benediktsson, R., Bennett, A. J., Bergmann, S., Bochud, M., Boerwinkle, E., Bonnefond, A., Bonnycastle, L. L., Borch-Johnsen, K., Böttcher, Y., Brunner, E., Bumpstead, S. J., Charpentier, G., Der IdaChen, Y., Chines, P., Clarke, R., McOin, L. J., Cooper, M. N., Cornelis, M., Crawford, G., Crisponi, L., Day, I. N. M., De Geus, E. J. C., Delplanque, J., Dina, C., Erdos, M. R., Fedson, A. C., Fischer-Rosinsky, A., Forouhi, N. G., Fox, C. S., Frants, R., GraziaFranzosi, M., Galan, P., Goodarzi, M. O., Graessler, J., Groves, C. J., Grundy, S., Gwilliam, R., Gyllensten, U., Hadjadj, S., Hallmans, G., Hammond, N., Han, X., -LiisaHartikainen, A., Hassanali, N., Hayward, C., Heath, S. C., Hercberg, S., Herder, C., Hicks, A. A., Hillman, D. R., Hingorani, A. D., Hofman, A., Hui, J., Hung, J., Isomaa, B., Johnson, P. R. V., Jørgensen, T., Jula, A., Kaakinen, M., Kaprio, J., AnteroKesaniemi, Y., Kivimaki, M., Knight, B., Koskinen, S., Kovacs, P., Kyvik, K. O., Lathrop, G. M., Lawlor, D. A., Bacquer, O. L., Lecoeur, C., Li, Y., Lyssenko, V., Mahley, R., Mangino, M., Manning, A. K., TeresaMartínez-Larrad, M., McAteer, J. B., McCulloch, L. J., McPherson, R., Meisinger, C., Melzer, D., Meyre, D., Mitchell, B. D., Morken, M. A., Mukherjee, S., Naitza, S., Narisu, N., Neville, M. J., Oostra, B. A., Orrù, M., Pakyz, R., APalmer, C. N., Paolisso, G., Pattaro, C., Pearson, D., Peden, J. F., Pedersen, N. L., Perola, M., Pfeiffer, A. F. H., Pichler, I., Polasek, O., Posthuma, D., Potter, S. C., Pouta, A., Province, M. A., Psaty, B. M., Rathmann, W., Rayner, N. W., Rice, K., Ripatti, S., Rivadeneira, F., Roden, M., Rolandsson, O., Sandbaek, A., Sandhu, M., Sanna, S., Sayer, A. A., Scheet, P., Scott, L. J., Seedorf, U., Sharp, S. J., Shields, B., Sigursson, G., Sijbrands, E. J. G., Silveira, A., Simpson, L., Singleton, A., Smith, N. L., Sovio, U., Swift, A., Syddall, H., -ChristineSyvänen, A., Tanaka, T., Thorand, B., Tichet, J., Tönjes, A., Tuomi, T., Uitterlinden, A. G., Van Dijk, K. W., Hoek, M. V., Varma, D., Visvikis-Siest, S., Vitart, V., Vogelzangs, N., Waeber, G., Wagner, P. J., Walley, A., BragiWalters, G., Ward, K. L., Watkins, H., Weedon, M. N., Wild, S. H., Willemsen, G., MWitteman, J. C., GYarnell, J. W., Zeggini, E., Zelenika, D., Zethelius, B., Zhai, G., Zhao, J. H., Zillikens, M. C., Borecki, I. B., Loos, R. J. F., Meneton, P., Magnusson, P. K. E., Nathan, D. M., Williams, G. H., Hattersley, A. T., Silander, K., Salomaa, V., Smith, G. D., Bornstein, S. R., Schwarz, P., Spranger, J., Karpe, F., Shuldiner, A. R., Cooper, C., Dedoussis, G. V., Serrano-Ríos, M., Morris, A. D., Lind, L., Palmer, L. J., Hu, F. B., Franks, P. W., Ebrahim, S., Marmot, M., Linda Kao, W. H., Pankow, J. S., Sampson, M. J., Kuusisto, J., Laakso, M., Hansen, T., Pedersen, O., Pramstaller, P. P., Wichmann, H. E., Illig, T., Rudan, I., Wright, A. F., Stumvoll, M., Campbell, H., Wilson, J. F., Bergman, R. N., Buchanan, T. A., Collins, F. S., Mohlke, K. L., Tuomilehto, J., Valle, T. T., Altshuler, D., Rotter, J. I., Siscovick, D. S., Penninx, B. W. J. H., Boomsma, D. I., Deloukas, P., Spector, T. D., Frayling, T. M., Ferrucci, L., Kong, A., Thorsteinsdottir, U., Stefansson, K., Van Duijn, C. M., Aulchenko, Y. S., Cao, A., Scuteri, A., Schlessinger, D., Uda, M., Ruokonen, A., -RiittaJarvelin, M., Waterworth, D. M., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G. R., Wareham, N. J., Sladek, R., Froguel, P., Watanabe, R. M., Meigs, J. B., Groop, L., Boehnke, M., McCarthy, M. I., Florez, J. C. & Barroso, I., Feb 2010, In: Nature Genetics. 42, 2, p. 105-116 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1822 Scopus citations

  • New loci associated with kidney function and chronic kidney disease

    Köttgen, A., Pattaro, C., Böger, C. A., Fuchsberger, C., Olden, M., Glazer, N. L., Parsa, A., Gao, X., Yang, Q., Smith, A. V., O'Connel, J. R., Li, M., Schmidt, H., Tanaka, T., Isaacs, A., Ketkar, S., Hwang, S. J., Johnson, A. D., Dehghan, A. & Teumer, A. & 112 others, Paré, G., Atkinson, E. J., Zeller, T., Lohman, K., Cornelis, M. C., Probst-Hensch, N. M., Kronenberg, F., Tönjes, A., Hayward, C., Aspelund, T., Eiriksdottir, G., Launer, L. J., Harris, T. B., Rampersaud, E., Mitchel, B. D., Arking, D. E., Boerwinkle, E., Struchalin, M., Cavalieri, M., Singleton, A., Giallauria, F., Metter, J., De Boer, I. H., Haritunians, T., Lumley, T., Siscovick, D., Psaty, B. M., CarolaZillikens, M., Oostra, B. A., Feitosa, M., Province, M., Andrade, M. D., Turner, S. T., Schillert, A., Ziegler, A., Wild, P. S., Schnabel, R. B., Wilde, S., Munzel, T. F., Leak, T. S., Illig, T., Klopp, N., Meisinger, C., Wichmann, H. E., Koenig, W., Zgaga, L., Zemunik, T., Kolcic, I., Minelli, C., Hu, F. B., Johansson, Å., Igl, W., Zaboli, G., Wild, S. H., Wright, A. F., Campbell, H., Ellinghaus, D., Schreiber, S., Aulchenko, Y. S., Felix, J. F., Rivadeneira, F., Uitterlinden, A. G., Hofman, A., Imboden, M., Nitsch, D., Brandstätter, A., Kollerits, B., Kedenko, L., Mägi, R., Stumvoll, M., Kovacs, P., Boban, M., Campbell, S., Endlich, K., Völzke, H., Kroemer, H. K., Nauck, M., Völker, U., Polasek, O., Vitart, V., Badola, S., Parker, A. N., Ridker, P. M., Kardia, S. L. R., Blankenberg, S., Liu, Y., Curhan, G. C., Franke, A., Rochat, T., Paulweber, B., Prokopenko, I., Wang, W., Gudnason, V., Shuldine, A. R., Coresh, J., Schmidt, R., Ferrucci, L., Shlipak, M. G., Van Duijn, C. M., Borecki, I., Krämer, B. K., Rudan, I., Gyllensten, U., Wilson, J. F., Witteman, J. C., Pramstaller, P. P., Rettig, R., Hastie, N., Chasman, D. I., Kao, W. H., Heid, I. M. & Fox, C. S., May 2010, In: Nature Genetics. 42, 5, p. 376-384 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    708 Scopus citations

  • Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus

    Chang, J., Zhang, B., Heath, H., Galjart, N., Wang, X. & Milbrandt, J., Dec 14 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21836-21841 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    50 Scopus citations

  • Novel sequence-based method for identifying transcription factor binding sites in prokaryotic genomes

    Sahota, G. & Stormo, G. D., Nov 2010, In: Bioinformatics. 26, 21, p. 2672-2677 6 p., btq501.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    20 Scopus citations

  • Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice

    Jain, S., Knoten, A., Hoshi, M., Wang, H., Vohra, B., Heuckeroth, R. O. & Milbrandt, J., Mar 1 2010, In: Journal of Clinical Investigation. 120, 3, p. 778-790 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    49 Scopus citations

  • Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo

    Morris, S. A., Teo, R. T. Y., Li, H., Robson, P., Glover, D. M. & Zernicka-Goetz, M., Apr 6 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 6364-6369 6 p.

    Research output: Contribution to journal › Article › peer-review

    256 Scopus citations

  • Peer smoking and the nicotinic receptor genes: An examination of genetic and environmental risks for nicotine dependence

    Johnson, E. O., Chen, L. S., Breslau, N., Hatsukami, D., Robbins, T., Saccone, N. L., Grucza, R. A. & Bierut, L. J., Nov 2010, In: Addiction. 105, 11, p. 2014-2022 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    50 Scopus citations

  • Peptidoglycan crosslinking relaxation promotes helicobacter pylori's helical shape and stomach colonization

    Sycuro, L. K., Pincus, Z., Gutierrez, K. D., Biboy, J., Stern, C. A., Vollmer, W. & Salama, N. R., May 2010, In: Cell. 141, 5, p. 822-833 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    208 Scopus citations

  • Persephin signaling through GFRα1: The potential for the treatment of Parkinson's disease

    Sidorova, Y. A., Mätlik, K., Paveliev, M., Lindahl, M., Piranen, E., Milbrandt, J., Arumäe, U., Saarma, M. & Bespalov, M. M., Jul 2010, In: Molecular and Cellular Neuroscience. 44, 3, p. 223-232 10 p.

    Research output: Contribution to journal › Article › peer-review

    28 Scopus citations

  • Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery

    Mao, X. R. & Crowder, C. M., Nov 2010, In: Molecular and cellular biology. 30, 21, p. 5033-5042 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    51 Scopus citations

  • PRP-17 and the pre-mRNA splicing pathway are preferentially required for the proliferation versus meiotic development decision and germline sex determination in Caenorhabditis elegans

    Kerins, J. A., Hanazawa, M., Dorsett, M. & Schedl, T., May 2010, In: Developmental Dynamics. 239, 5, p. 1555-1572 18 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    58 Scopus citations

  • RET signaling is required for survival and normal function of nonpeptidergic nociceptors

    Golden, J. P., Hoshi, M., Nassar, M. A., Enomoto, H., Wood, J. N., Milbrandt, J., Gereau IV, R. W., Johnson, E. M. & Jain, S., Mar 17 2010, In: Journal of Neuroscience. 30, 11, p. 3983-3994 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    68 Scopus citations

  • Synthesizing and salvaging NAD+: Lessons learned from Chlamydomonas reinhardtii

    Lin, H., Kwan, A. L. & Dutcher, S. K., Sep 2010, In: PLoS genetics. 6, 9, e1001105.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    43 Scopus citations

  • TATA is a modular component of synthetic promoters

    Mogno, I., Vallania, F., Mitra, R. D. & Cohen, B. A., Oct 2010, In: Genome research. 20, 10, p. 1391-1397 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    83 Scopus citations

  • The effect of a novel intergenic polymorphism (rs11774572) on HDL-cholesterol concentrations depends on TaqIB polymorphism in the cholesterol ester transfer protein gene

    Junyent, M., Lee, Y. C., Smith, C. E., Arnett, D. K., Tsai, M. Y., Kabagambe, E. K., Straka, R. J., Province, M., An, P., Lai, C. Q., Parnell, L. D., Shen, J., Borecki, I. & Ordovas, J. M., Jan 2010, In: Nutrition, Metabolism and Cardiovascular Diseases. 20, 1, p. 34-40 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    9 Scopus citations

  • The genetics of obesity and the metabolic syndrome

    Monda, K. L., North, K. E., Hunt, S. C., Rao, D. C., Province, M. A. & Kraja, A. T., 2010, In: Endocrine, Metabolic and Immune Disorders - Drug Targets. 10, 2, p. 86-108 23 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    61 Scopus citations
  • 2011

    A bivariate genome-wide approach to metabolic syndrome: STAMPEED Consortium

    Kraja, A. T., Vaidya, D., Pankow, J. S., Goodarzi, M. O., Assimes, T. L., Kullo, I. J., Sovio, U., Mathias, R. A., Sun, Y. V., Franceschini, N., Absher, D., Li, G., Zhang, Q., Feitosa, M. F., Glazer, N. L., Haritunians, T., Hartikainen, A. L., Knowles, J. W., North, K. E. & Iribarren, C. & 19 others, Kral, B., Yanek, L., O'Reilly, P. F., McCarthy, M. I., Jaquish, C., Couper, D. J., Chakravarti, A., Psaty, B. M., Becker, L. C., Province, M. A., Boerwinkle, E., Quertermous, T., Palotie, L., Jarvelin, M. R., Becker, D. M., Kardia, S. L. R., Rotter, J. I., Chen, Y. D. I. & Borecki, I. B., Apr 2011, In: Diabetes. 60, 4, p. 1329-1339 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    219 Scopus citations

  • A data-driven method for identifying rare variants with heterogeneous trait effects

    Zhang, Q., Irvin, M. R., Arnett, D. K., Province, M. A. & Borecki, I., Nov 2011, In: Genetic Epidemiology. 35, 7, p. 679-685 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    13 Scopus citations

  • A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue

    Green, R. A., Kao, H. L., Audhya, A., Arur, S., Mayers, J. R., Fridolfsson, H. N., Schulman, M., Schloissnig, S., Niessen, S., Laband, K., Wang, S., Starr, D. A., Hyman, A. A., Schedl, T., Desai, A., Piano, F., Gunsalus, K. C. & Oegema, K., Apr 29 2011, In: Cell. 145, 3, p. 470-482 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    169 Scopus citations

  • A modified bacterial one-hybrid system yields improved quantitative models of transcription factor specificity

    Christensen, R. G., Gupta, A., Zuo, Z., Schriefer, L. A., Wolfe, S. A. & Stormo, G. D., Jul 2011, In: Nucleic acids research. 39, 12, p. e83

    Research output: Contribution to journal › Article › peer-review

    Open Access
    25 Scopus citations

  • An axonemal PP2A B-subunit is required for PP2A localization and flagellar motility

    Elam, C. A., Wirschell, M., Yamamoto, R., Fox, L. A., York, K., Kamiya, R., Dutcher, S. K. & Sale, W. S., Jul 2011, In: Cytoskeleton. 68, 7, p. 363-372 10 p.

    Research output: Contribution to journal › Article › peer-review

    21 Scopus citations

  • An introduction to recognizing functional domains

    Stormo, G. D., Jun 2011, In: Current Protocols in Bioinformatics. SUPPL. 34, p. 1-6 6 p.

    Research output: Contribution to journal › Article › peer-review

    3 Scopus citations

  • A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression

    Grimm, A. A., Brace, C. S., Wang, T., Stormo, G. D. & Imai, S. I., Apr 2011, In: Aging Cell. 10, 2, p. 305-317 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    19 Scopus citations

  • Application of Bayesian network structure learning to identify causal variant SNPs from resequencing data

    Schlosberg, C. E., Schwantes-An, T. H., Duan, W. & Saccone, N. L., 2011, In: BMC Proceedings. 5, SUPPL. 9, S109.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    10 Scopus citations

  • Assessing the effects of symmetry on motif discovery and modeling

    Motlhabi, L. M. & Stormo, G. D., Sep 20 2011, In: PloS one. 6, 9, e24908.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    3 Scopus citations

  • Ataxin-1 occupies the promoter region of E-cadherin in vivo and activates CtBP2-repressed promoter

    Lee, S., Hong, S., Kim, S. & Kang, S., May 2011, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 5, p. 713-722 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    25 Scopus citations

  • A unified taxonomy for ciliary dyneins

    Hom, E. F. Y., Witman, G. B., Harris, E. H., Dutcher, S. K., Kamiya, R., Mitchell, D. R., Pazour, G. J., Porter, M. E., Sale, W. S., Wirschell, M., Yagi, T. & King, S. M., Oct 2011, In: Cytoskeleton. 68, 10, p. 555-565 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    72 Scopus citations

  • A user's guide to the Encyclopedia of DNA elements (ENCODE)

    Myers, R. M., Stamatoyannopoulos, J., Snyder, M., Dunham, I., Hardison, R. C., Bernstein, B. E., Gingeras, T. R., Kent, W. J., Birney, E., Wold, B., Crawford, G. E., Epstein, C. B., Shoresh, N., Ernst, J., Mikkelsen, T. S., Kheradpour, P., Zhang, X., Wang, L., Issner, R. & Coyne, M. J. & 295 others, Durham, T., Ku, M., Truong, T., Ward, L. D., Altshuler, R. C., Lin, M. F., Kellis, M., Davis, C. A., Kapranov, P., Dobin, A., Zaleski, C., Schlesinger, F., Batut, P., Chakrabortty, S., Jha, S., Lin, W., Drenkow, J., Wang, H., Bell, K., Bell, I., Gao, H., Dumais, E., Dumais, J., Antonarakis, S. E., Ucla, C., Borel, C., Guigo, R., Djebali, S., Lagarde, J., Kingswood, C., Ribeca, P., Sammeth, M., Alioto, T., Merkel, A., Tilgner, H., Carninci, P., Hayashizaki, Y., Lassmann, T., Takahashi, H., Abdelhamid, R. F., Hannon, G., Fejes, K. T., Preall, J., Gordon, A., Sotirova, V., Reymond, A., Howald, C., Graison, E. A. Y., Chrast, J., Ruan, Y., Ruan, X., Shahab, A., Poh, W. T., Wei, C. L., Furey, T. S., Boyle, A. P., Sheffield, N. C., Song, L., Shibata, Y., Vales, T., Winter, D., Zhang, Z., London, D., Wang, T., Keefe, D., Iyer, V. R., Lee, B. K., McDaniell, R. M., Liu, Z., Battenhouse, A., Bhinge, A. A., Lieb, J. D., Grasfeder, L. L., Showers, K. A., Giresi, P. G., Kim, S. K. C., Shestak, C., Pauli, F., Reddy, T. E., Gertz, J., Partridge, E. C., Jain, P., Sprouse, R. O., Bansal, A., Pusey, B., Muratet, M. A., Varley, K. E., Bowling, K. M., Newberry, K. M., Nesmith, A. S., Dilocker, J. A., Parker, S. L., Waite, L. L., Thibeault, K., Roberts, K., Absher, D. M., Mortazavi, A., Williams, B., Marinov, G., Trout, D., King, B., McCue, K., Kirilusha, A., DeSalvo, G., Fisher, K. A., Amrhein, H., Pepke, S., Vielmetter, J., Sherlock, G., Sidow, A., Batzoglou, S., Rauch, R., Kundaje, A., Libbrecht, M., Margulies, E. H., Parker, S. C. J., Elnitski, L., Green, E. D., Hubbard, T., Harrow, J., Searle, S., Kokocinski, F., Aken, B., Frankish, A., Hunt, T., Despacio-Reyes, G., Kay, M., Mukherjee, G., Bignell, A., Saunders, G., Boychenko, V., Brent, M., van Baren, M. J., Brown, R. H., Gerstein, M., Khurana, E., Balasubramanian, S., Lam, H., Cayting, P., Robilotto, R., Lu, Z., Derrien, T., Tanzer, A., Knowles, D. G., Mariotti, M., Haussler, D., Harte, R., Diekhans, M., Lin, M., Valencia, A., Tress, M., Landt, S. G., Raha, D., Shi, M., Euskirchen, G., Grubert, F., Kasowski, M., Lian, J., Lacroute, P., Xu, Y., Monahan, H., Patacsil, D., Slifer, T., Yang, X., Charos, A., Reed, B., Wu, L., Auerbach, R. K., Habegger, L., Hariharan, M., Rozowsky, J., Abyzov, A., Weissman, S. M., Struhl, K., Lamarre-Vincent, N., Lindahl-Allen, M., Miotto, B., Moqtaderi, Z., Fleming, J. D., Newburger, P., Farnham, P. J., Frietze, S., O'Geen, H., Xu, X., Blahnik, K. R., Cao, A. R., Iyengar, S., Kaul, R., Thurman, R. E., Wang, H., Navas, P. A., Sandstrom, R., Sabo, P. J., Weaver, M., Canfield, T., Lee, K., Neph, S., Roach, V., Reynolds, A., Johnson, A., Rynes, E., Giste, E., Vong, S., Neri, J., Frum, T., Nguyen, E. D., Ebersol, A. K., Sanchez, M. E., Sheffer, H. H., Lotakis, D., Haugen, E., Humbert, R., Kutyavin, T., Shafer, T., Noble, W. S., Dekker, J., Lajoie, B. R., Sanyal, A., Rosenbloom, K. R., Dreszer, T. R., Raney, B. J., Barber, G. P., Meyer, L. R., Sloan, C. A., Malladi, V. S., Cline, M. S., Learned, K., Swing, V. K., Zweig, A. S., Rhead, B., Fujita, P. A., Roskin, K., Karolchik, D., Kuhn, R. M., Wilder, S. P., Sobral, D., Herrero, J., Beal, K., Lukk, M., Brazma, A., Vaquerizas, J. M., Luscombe, N. M., Bickel, P. J., Boley, N., Brown, J. B., Li, Q., Huang, H., Sboner, A., Yip, K. Y., Cheng, C., Yan, K. K., Bhardwaj, N., Wang, J., Lochovsky, L., Jee, J., Gibson, T., Leng, J., Du, J., Harris, R. S., Song, G., Miller, W., Suh, B., Paten, B., Hoffman, M. M., Buske, O. J., Weng, Z., Dong, X., Wang, J., Xi, H., Tenenbaum, S. A., Doyle, F., Chittur, S., Penalva, L. O., Tullius, T. D., White, K. P., Karmakar, S., Victorsen, A., Jameel, N., Bild, N., Grossman, R. L., Collins, P. J., Trinklein, N. D., Giddings, M. C., Khatun, J., Maier, C., Wang, T., Whitfield, T. W., Chen, X., Yu, Y., Gunawardena, H., Feingold, E. A., Lowdon, R. F., Dillon, L. A. L., Good, P. J. & Risk, B., Apr 1 2011, In: PLoS biology. 9, 4, e1001046.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1204 Scopus citations

  • bop5 mutations reveal new roles for the IC138 phosphoprotein in the regulation of flagellar motility and asymmetric waveforms

    VanderWaal, K. E., Yamamoto, R., Wakabayashi, K. I., Fox, L., Kamiya, R., Dutcher, S. K., Bayly, P. V., Sale, W. S. & Porter, M. E., Aug 15 2011, In: Molecular biology of the cell. 22, 16, p. 2862-2874 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    36 Scopus citations

  • Calling Cards enable multiplexed identification of the genomic targets of DNA-binding proteins

    Wang, H., Mayhew, D., Chen, X., Johnston, M. & Mitra, R. D., May 2011, In: Genome research. 21, 5, p. 748-755 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    37 Scopus citations

  • Characterization of autosomal copy-number variation in African Americans: The HyperGEN Study

    Wineinger, N. E., Pajewski, N. M., Kennedy, R. E., Wojczynski, M. K., Vaughan, L. K., Hunt, S. C., Gu, C. C., Rao, D. C., Lorier, R., Broeckel, U., Arnett, D. K. & Tiwari, H. K., Dec 2011, In: European Journal of Human Genetics. 19, 12, p. 1271-1275 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    6 Scopus citations

  • Chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease

    Gong, Y., Beitelshees, A. L., Cooper-DeHoff, R. M., Lobmeyer, M. T., Langaee, T. Y., Wu, J., Cresci, S., Province, M. A., Spertus, J. A., Pepine, C. J. & Johnson, J. A., Apr 2011, In: Circulation: Cardiovascular Genetics. 4, 2, p. 169-178 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    26 Scopus citations

  • Cilia and models for studying structure and function

    Ostrowski, L. E., Dutcher, S. K. & Lo, C. W., Sep 15 2011, In: Proceedings of the American Thoracic Society. 8, 5, p. 423-429 7 p.

    Research output: Contribution to journal › Article › peer-review

    36 Scopus citations

  • Common polymorphisms in FMO1 are associated with nicotine dependence

    Hinrichs, A. L., Murphy, S. E., Wang, J. C., Saccone, S., Saccone, N., Steinbach, J. H., Goate, A., Stevens, V. L. & Bierut, L. J., Jul 2011, In: Pharmacogenetics and Genomics. 21, 7, p. 397-402 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    20 Scopus citations

  • Comparative and demographic analysis of orang-utan genomes

    Locke, D. P., Hillier, L. W., Warren, W. C., Worley, K. C., Nazareth, L. V., Muzny, D. M., Yang, S. P., Wang, Z., Chinwalla, A. T., Minx, P., Mitreva, M., Cook, L., Delehaunty, K. D., Fronick, C., Schmidt, H., Fulton, L. A., Fulton, R. S., Nelson, J. O., Magrini, V. & Pohl, C. & 81 others, Graves, T. A., Markovic, C., Cree, A., Dinh, H. H., Hume, J., Kovar, C. L., Fowler, G. R., Lunter, G., Meader, S., Heger, A., Ponting, C. P., Marques-Bonet, T., Alkan, C., Chen, L., Cheng, Z., Kidd, J. M., Eichler, E. E., White, S., Searle, S., Vilella, A. J., Chen, Y., Flicek, P., Ma, J., Raney, B., Suh, B., Burhans, R., Herrero, J., Haussler, D., Faria, R., Fernando, O., Darré, F., Farré, D., Gazave, E., Oliva, M., Navarro, A., Roberto, R., Capozzi, O., Archidiacono, N., Valle, G. D., Purgato, S., Rocchi, M., Konkel, M. K., Walker, J. A., Ullmer, B., Batzer, M. A., Smit, A. F. A., Hubley, R., Casola, C., Schrider, D. R., Hahn, M. W., Quesada, V., Puente, X. S., Ordõez, G. R., Ĺpez-Otín, C., Vinar, T., Brejova, B., Ratan, A., Harris, R. S., Miller, W., Kosiol, C., Lawson, H. A., Taliwal, V., Martins, A. L., Siepel, A., Roychoudhury, A., Ma, X., Degenhardt, J., Bustamante, C. D., Gutenkunst, R. N., Mailund, T., Dutheil, J. Y., Hobolth, A., Schierup, M. H., Ryder, O. A., Yoshinaga, Y., De Jong, P. J., Weinstock, G. M., Rogers, J., Mardis, E. R., Gibbs, R. A. & Wilson, R. K., Jan 27 2011, In: Nature. 469, 7331, p. 529-533 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    416 Scopus citations

  • Cyclin e and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline

    Fox, P. M., Vought, V. E., Hanazawa, M., Lee, M. H., Maine, E. M. & Sched, T., Jun 1 2011, In: Development. 138, 11, p. 2223-2234 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    119 Scopus citations

  • Diet-dependent genetic and genomic imprinting effects on obesity in mice

    Cheverud, J. M., Lawson, H. A., Fawcett, G. L., Wang, B., Pletscher, L. S., R. Fox, A., Maxwell, T. J., Ehrich, T. H., Kenney-Hunt, J. P., Wolf, J. B. & Semenkovich, C. F., Jan 2011, In: Obesity. 19, 1, p. 160-170 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    41 Scopus citations

  • Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction

    Viader, A., Wright-Jin, E. C., Vohra, B. P. S., Heuckeroth, R. O. & Milbrandt, J., Nov 16 2011, In: PloS one. 6, 11, e27727.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    28 Scopus citations

  • Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficits

    Kulminski, A. M., Arbeev, K. G., Christensen, K., Mayeux, R., Newman, A. B., Province, M. A., Hadley, E. C., Rossi, W., Perls, T. T., Elo, I. T. & Yashin, A. I., Apr 2011, In: Mechanisms of Ageing and Development. 132, 4, p. 195-201 7 p.

    Research output: Contribution to journal › Article › peer-review

    19 Scopus citations