Department of Genetics

Search results

  • 2010

    Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications

    Harris, R. A., Wang, T., Coarfa, C., Nagarajan, R. P., Hong, C., Downey, S. L., Johnson, B. E., Fouse, S. D., Delaney, A., Zhao, Y., Olshen, A., Ballinger, T., Zhou, X., Forsberg, K. J., Gu, J., Echipare, L., O'Geen, H., Lister, R., Pelizzola, M. & Xi, Y. & 19 others, Epstein, C. B., Bernstein, B. E., Hawkins, R. D., Ren, B., Chung, W. Y., Gu, H., Bock, C., Gnirke, A., Zhang, M. Q., Haussler, D., Ecker, J. R., Li, W., Farnham, P. J., Waterland, R. A., Meissner, A., Marra, M. A., Hirst, M., Milosavljevic, A. & Costello, J. F., Oct 2010, In: Nature Biotechnology. 28, 10, p. 1097-1105 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    587 Scopus citations

  • Conserved role of intragenic DNA methylation in regulating alternative promoters

    Maunakea, A. K., Nagarajan, R. P., Bilenky, M., Ballinger, T. J., Dsouza, C., Fouse, S. D., Johnson, B. E., Hong, C., Nielsen, C., Zhao, Y., Turecki, G., Delaney, A., Varhol, R., Thiessen, N., Shchors, K., Heine, V. M., Rowitch, D. H., Xing, X., Fiore, C. & Schillebeeckx, M. & 6 others, Jones, S. J. M., Haussler, D., Marra, M. A., Hirst, M., Wang, T. & Costello, J. F., Jul 8 2010, In: Nature. 466, 7303, p. 253-257 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1392 Scopus citations

  • Current Protocols in Bioinformatics: Preface

    Baxevanis, A. D., Davison, D. B., Page, R. D. M., Petsko, G. A., Stein, L. D., Stormo, G. D. & Yates, J., 2010, In: Current Protocols in Bioinformatics. SUPPL. 29, p. iii-vi

    Research output: Contribution to journal › Editorial

    2 Scopus citations

  • Detecting coevolution of functionally related proteins for automated protein annotation

    Kwan, A. L., Dutcher, S. K. & Stormo, G. D., 2010, 10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010. p. 99-105 7 p. 5521705. (10th IEEE International Conference on Bioinformatics and Bioengineering 2010, BIBE 2010).

    Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

    Open Access
    3 Scopus citations

  • Determining the specificity of protein-DNA interactions

    Stormo, G. D. & Zhao, Y., Nov 1 2010, In: Nature Reviews Genetics. 11, 11, p. 751-760 10 p.

    Research output: Contribution to journal › Review article › peer-review

    258 Scopus citations

  • Developmental biomarkers of aging in Caenorhabditis elegans

    Pincus, Z. & Slack, F. J., May 2010, In: Developmental Dynamics. 239, 5, p. 1306-1314 9 p.

    Research output: Contribution to journal › Review article › peer-review

    48 Scopus citations

  • Diverse voltage-sensitive dyes modulate GABAA receptor function

    Mennerick, S., Chisari, M., Shu, H. J., Taylor, A., Vasek, M., Eisenman, L. N. & Zorumski, C. F., Feb 24 2010, In: Journal of Neuroscience. 30, 8, p. 2871-2879 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    70 Scopus citations

  • Efficient spatiotemporal analysis of the flagellar waveform of Chlamydomonas reinhardtii

    Bayly, P. V., Lewis, B. L., Kemp, P. S., Pless, R. B. & Dutcher, S. K., 2010, In: Cytoskeleton. 67, 1, p. 56-69 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    52 Scopus citations

  • EOR-2 is an obligate binding partner of the BTB-zinc finger protein EOR-1 in Caenorhabditis elegans

    Howell, K., Arur, S., Schedl, T. & Sundaram, M. V., Apr 2010, In: Genetics. 184, 4, p. 899-913 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    12 Scopus citations

  • Epistasis in a quantitative trait captured by a molecular model of transcription factor interactions

    Gertz, J., Gerke, J. P. & Cohen, B. A., Feb 2010, In: Theoretical Population Biology. 77, 1, p. 1-5 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    25 Scopus citations

  • Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116))

    Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Mägi, R., Morris, A. P., Randall, J., Johnson, T., Elliott, P., Rybin, D., Thorleifsson, G., Steinthorsdottir, V. & Henneman, P. & 287 others, Grallert, H., Dehghan, A., Hottenga, J. J., Franklin, C. S., Navarro, P., Song, K., Goel, A., Perry, J. R. B., Egan, J. M., Lajunen, T., Grarup, N., Sparsø, T., Doney, A., Voight, B. F., Stringham, H. M., Li, M., Kanoni, S., Shrader, P., Cavalcanti-Proença, C., Kumari, M., Qi, L., Timpson, N. J., Gieger, C., Zabena, C., Rocheleau, G., Ingelsson, E., An, P., O'Connell, J., Luan, J., Elliott, A., McCarroll, S. A., Payne, F., Roccasecca, R. M., Pattou, F., Sethupathy, P., Ardlie, K., Ariyurek, Y., Balkau, B., Barter, P., Beilby, J. P., Ben-Shlomo, Y., Benediktsson, R., Bennett, A. J., Bergmann, S., Bochud, M., Boerwinkle, E., Bonnefond, A., Bonnycastle, L. L., Borch-Johnsen, K., Böttcher, Y., Brunner, E., Bumpstead, S. J., Charpentier, G., Chen, Y. D. I., Chines, P., Clarke, R., Coin, L. J. M., Cooper, M. N., Cornelis, M., Crawford, G., Crisponi, L., Day, I. N. M., De Geus, E. J. C., Delplanque, J., Dina, C., Erdos, M. R., Fedson, A. C., Fischer-Rosinsky, A., Forouhi, N. G., Fox, C. S., Frants, R., Franzosi, M. G., Galan, P., Goodarzi, M. O., Graessler, J., Groves, C. J., Grundy, S., Gwilliam, R., Gyllensten, U., Hadjadj, S., Hallmans, G., Hammond, N., Han, X., Hartikainen, A. L., Hassanali, N., Hayward, C., Heath, S. C., Hercberg, S., Herder, C., Hicks, A. A., Hillman, D. R., Hingorani, A. D., Hofman, A., Hui, J., Hung, J., Isomaa, B., Johnson, P. R. V., Jørgensen, T., Jula, A., Kaakinen, M., Kaprio, J., Kesaniemi, Y. A., Kivimaki, M., Knight, B., Koskinen, S., Kovacs, P., Kyvik, K. O., Lathrop, G. M., Lawlor, D. A., Le Bacquer, O., Lecoeur, C., Li, Y., Lyssenko, V., Mahley, R., Mangino, M., Manning, A. K., Martínez-Larrad, M. T., McAteer, J. B., McCulloch, L. J., McPherson, R., Meisinger, C., Melzer, D., Meyre, D., Mitchell, B. D., Morken, M. A., Mukherjee, S., Naitza, S., Narisu, N., Neville, M. J., Oostra, B. A., Orr, M., Pakyz, R., Palmer, C. N. A., Paolisso, G., Pattaro, C., Pearson, D., Peden, J. F., Pedersen, N. L., Perola, M., Pfeiffer, A. F. H., Pichler, I., Polasek, O., Posthuma, D., Potter, S. C., Pouta, A., Province, M. A., Psaty, B. M., Rathmann, W., Rayner, N. W., Rice, K., Ripatti, S., Rivadeneira, F., Roden, M., Rolandsson, O., Sandbaek, A., Sandhu, M., Sanna, S., Sayer, A. A., Scheet, P., Scott, L. J., Seedorf, U., Sharp, S. J., Shields, B., Sigursson, G., Sijbrands, E. J. G., Silveira, A., Simpson, L., Singleton, A., Smith, N. L., Sovio, U., Swift, A., Syddall, H., Syvänen, A. C., Tanaka, T., Thorand, B., Tichet, J., Tönjes, A., Tuomi, T., Uitterlinden, A. G., Van Dijk, K. W., Van Hoek, M., Varma, D., Visvikis-Siest, S., Vitart, V., Vogelzangs, N., Waeber, G., Wagner, P. J., Walley, A., Walters, G. B., Ward, K. L., Watkins, H., Weedon, M. N., Wild, S. H., Willemsen, G., Witteman, J. C. M., Yarnell, J. W. G., Zeggini, E., Zelenika, D., Zethelius, B., Zhai, G., Zhao, J. H., Zillikens, M. C., Consortium, D., Consortium, G., Consortium, G. B., Borecki, I. B., Loos, R. J. F., Meneton, P., Magnusson, P. K. E., Nathan, D. M., Williams, G. H., Hattersley, A. T., Silander, K., Salomaa, V., Smith, G. D., Bornstein, S. R., Schwarz, P., Spranger, J., Karpe, F., Shuldiner, A. R., Cooper, C., Dedoussis, G. V., Serrano-Ríos, M., Morris, A. D., Lind, L., Palmer, L. J., Hu, F. B., Franks, P. W., Ebrahim, S., Marmot, M., Kao, W. H. L., Pankow, J. S., Sampson, M. J., Kuusisto, J., Laakso, M., Hansen, T., Pedersen, O., Pramstaller, P. P., Wichmann, H. E., Illig, T., Rudan, I., Wright, A. F., Stumvoll, M., Campbell, H., Wilson, J. F., Hamsten, A., Bergman, R. N., Buchanan, T. A., Collins, F. S., Mohlke, K. L., Tuomilehto, J., Valle, T. T., Altshuler, D., Rotter, J. I., Siscovick, D. S., Penninx, B. W. J. H., Boomsma, D. I., Deloukas, P., Spector, T. D., Frayling, T. M., Ferrucci, L., Kong, A., Thorsteinsdottir, U., Stefansson, K., Van Duijn, C. M., Aulchenko, Y. S., Cao, A., Scuteri, A., Schlessinger, D., Uda, M., Ruokonen, A., Jarvelin, M. R., Waterworth, D. M., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G. R., Wareham, N. J., Sladek, R., Froguel, P., Watanabe, R. M., Meigs, J. B., Groop, L., Boehnke, M., McCarthy, M. I., Florez, J. C. & Barroso, I., May 2010, In: Nature Genetics. 42, 5, p. 464 1 p.

    Research output: Contribution to journal › Comment/debate

    Open Access
    16 Scopus citations

  • Erratum: A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4 (Nat. Genet. (2010) 42 (525-529))

    Beaty, T. H., Murray, J. C., Marazita, M. L., Munger, R. G., Hetmanski, I. R. J. B., Liang, K. Y., Wu, T., Murray, T., Fallin, M. D., Redett, R. A., Raymond, G., Schwender, H., Jin, S. C., Cooper, M. E., Dunnwald, M., Mansilla, M. A., Leslie, E., Bullard, S., Lidral, A. C. & Moreno, L. M. & 32 others, Menezes, R., Vieira, A. R., Petrin, A., Wilcox, A. J., Lie, R. T., Jabs, E. W., Wu-Chou, Y. H., Chen, P. K., Wang, H., Ye, X., Huang, S., Yeow, V., Chong, S. S., Jee, S. H., Shi, B., Christensen, K., Melbye, M., Doheny, K. F., Pugh, E. W., Ling, H., Castilla, E. E., Czeizel, A. E., Ma, L., Field, L. L., Brody, L., Pangilinan, F., Mills, J. L., Molloy, A. M., Kirke, P. N., Scott, J. M., Arcos-Burgos, M. & Scott, A. F., Aug 2010, In: Nature Genetics. 42, 8, p. 727 1 p.

    Research output: Contribution to journal › Comment/debate

    Open Access
    3 Scopus citations

  • Fenofibrate and metabolic syndrome

    Kraja, A. T., Province, M. A., Straka, R. J., Ordovas, J. M., Borecki, I. B. & Arnett, D. K., 2010, In: Endocrine, Metabolic and Immune Disorders - Drug Targets. 10, 2, p. 138-148 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    37 Scopus citations

  • Gene-environment interactions at nucleotide resolution

    Gerke, J., Lorenz, K., Ramnarine, S. & Cohen, B., Sep 2010, In: PLoS genetics. 6, 9, e1001144.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    43 Scopus citations

  • Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model

    Lawson, H. A., Zelle, K. M., Fawcett, G. L., Wang, B., Pletscher, L. S., Maxwell, T. J., Ehrich, T. H., Kenney-Hunt, J. P., Wolf, J. B., Semenkovich, C. F. & Cheverud, J. M., Oct 2010, In: Journal of lipid research. 51, 10, p. 2976-2984 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    25 Scopus citations

  • Genetic Mapping of Complex Traits

    Saccone, N. L., Nov 22 2010, Genomics: Essential Methods. John Wiley and Sons, p. 67-90 24 p.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

    1 Scopus citations

  • Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology

    Levy, D., Neuhausen, S. L., Hunt, S. C., Kimura, M., Hwang, S. J., Chen, W., Bis, J. C., Fitzpatrick, A. L., Smith, E., Johnson, A. D., Gardner, J. P., Srinivasan, S. R., Schork, N., Rotter, J. I., Herbig, U., Psaty, B. M., Sastrasinh, M., Murray, S. S., Vasan, R. S. & Province, M. A. & 9 others, Glazer, N. L., Lu, X., Cao, X., Kronmal, R., Mangino, M., Soranzo, N., Spector, T. D., Berenson, G. S. & Aviv, A., May 18 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 20, p. 9293-9298 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    231 Scopus citations

  • Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists

    Johnson, A. D., Yanek, L. R., Chen, M. H., Faraday, N., Larson, M. G., Tofler, G., Lin, S. J., Kraja, A. T., Province, M. A., Yang, Q., Becker, D. M., O'Donnell, C. J. & Becker, L. C., Jul 2010, In: Nature Genetics. 42, 7, p. 608-613 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    232 Scopus citations

  • High-throughput discovery of rare insertions and deletions in large cohorts

    Vallania, F. L. M., Druley, T. E., Ramos, E., Wang, J., Borecki, I., Province, M. & Mitra, R. D., Dec 2010, In: Genome research. 20, 12, p. 1711-1718 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    45 Scopus citations

  • Hundreds of variants clustered in genomic loci and biological pathways affect human height

    Allen, H. L., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., Rivadeneira, F., Willer, C. J., Jackson, A. U., Vedantam, S., Raychaudhuri, S., Ferreira, T., Wood, A. R., Weyant, R. J., Segrè, A. V., Speliotes, E. K., Wheeler, E., Soranzo, N., Park, J. H., Yang, J. & Gudbjartsson, D. & 273 others, Heard-Costa, N. L., Randall, J. C., Qi, L., Smith, A. V., Mägi, R., Pastinen, T., Liang, L., Heid, I. M., Luan, J., Thorleifsson, G., Winkler, T. W., Goddard, M. E., Lo, K. S., Palmer, C., Workalemahu, T., Aulchenko, Y. S., Johansson, Å., Zillikens, M. C., Feitosa, M. F., Esko, T., Johnson, T., Ketkar, S., Kraft, P., Mangino, M., Prokopenko, I., Absher, D., Albrecht, E., Ernst, F., Glazer, N. L., Hayward, C., Hottenga, J. J., Jacobs, K. B., Knowles, J. W., Kutalik, Z., Monda, K. L., Polasek, O., Preuss, M., Rayner, N. W., Robertson, N. R., Steinthorsdottir, V., Tyrer, J. P., Voight, B. F., Wiklund, F., Xu, J., Zhao, J. H., Nyholt, D. R., Pellikka, N., Perola, M., Perry, J. B., Surakka, I., Tammesoo, M. L., Altmaier, E. L., Amin, N., Aspelund, T., Bhangale, T., Boucher, G., Chasman, D. I., Chen, C., Coin, L., Cooper, M. N., Dixon, A. L., Gibson, Q., Grundberg, E., Hao, K., Junttila, M. J., Kaplan, L. M., Kettunen, J., König, I. R., Kwan, T., Lawrence, R. W., Levinson, D. F., Lorentzon, M., McKnight, B., Morris, A. P., Müller, M., Ngwa, J. S., Purcell, S., Rafelt, S., Salem, R. M., Salvi, E., Sanna, S., Shi, J., Sovio, U., Thompson, J. R., Turchin, M. C., Vandenput, L., Verlaan, D. J., Vitart, V., White, C. C., Ziegler, A., Almgren, P., Balmforth, A. J., Campbell, H., Citterio, L., De Grandi, A., Dominiczak, A., Duan, J., Elliott, P., Elosua, R., Eriksson, J. G., Freimer, N. B., Geus, E. J. C., Glorioso, N., Haiqing, S., Hartikainen, A. L., Havulinna, A. S., Hicks, A. A., Hui, J., Igl, W., Illig, T., Jula, A., Kajantie, E., Kilpeläinen, T. O., Koiranen, M., Kolcic, I., Koskinen, S., Kovacs, P., Laitinen, J., Liu, J., Lokki, M. L., Marusic, A., Maschio, A., Meitinger, T., Mulas, A., Paré, G., Parker, A. N., Peden, J. F., Petersmann, A., Pichler, I., Pietiläinen, K. H., Pouta, A., Ridderstråle, M., Rotter, J. I., Sambrook, J. G., Sanders, A. R., Schmidt, C. O., Sinisalo, J., Smit, J. H., Stringham, H. M., Walters, G. B., Widen, E., Wild, S. H., Willemsen, G., Zagato, L., Zgaga, L., Zitting, P., Alavere, H., Farrall, M., McArdle, W. L., Nelis, M., Peters, M. J., Ripatti, S., Van Meurs, J. B. J., Aben, K. K., Ardlie, K. G., Beckmann, J. S., Beilby, J. P., Bergman, R. N., Bergmann, S., Collins, F. S., Cusi, D., Den Heijer, M., Eiriksdottir, G., Gejman, P. V., Hall, A. S., Hamsten, A., Huikuri, H. V., Iribarren, C., Kähönen, M., Kaprio, J., Kathiresan, S., Kiemeney, L., Kocher, T., Launer, L. J., Lehtimäki, T., Melander, O., Mosley, T. H., Musk, A. W., Nieminen, M. S., O'Donnell, C. J., Ohlsson, C., Oostra, B., Palmer, L. J., Raitakari, O., Ridker, P. M., Rioux, J. D., Rissanen, A., Rivolta, C., Schunkert, H., Shuldiner, A. R., Siscovick, D. S., Stumvoll, M., Tönjes, A., Tuomilehto, J., Van Ommen, G. J., Viikari, J., Heath, A. C., Martin, N. G., Montgomery, G. W., Province, M. A., Kayser, M., Arnold, A. M., D.Atwood, L., Boerwinkle, E., Chanock, S. J., Deloukas, P., Gieger, C., Grönberg, H., Hall, P., Hattersley, A. T., Hengstenberg, C., Hoffman, W., Lathrop, G. M., Salomaa, V., Schreiber, S., Uda, M., Waterworth, D., Wright, A. F., Assimes, T. L., Barroso, I., Hofman, A., Mohlke, K. L., Boomsma, D. I., Caulfield, M. J., Cupples, L. A., Erdmann, J., Fox, C. S., Gudnason, V., Gyllensten, U., Harris, T. B., Hayes, R. B., Jarvelin, M. R., Mooser, V., Munroe, P. B., Ouwehand, W. H., Penninx, B. W., Pramstaller, P. P., Quertermous, T., Rudan, I., Samani, N. J., Spector, T. D., Völzke, H., Watkins, H., Wilson, J. F., Groop, L. C., Haritunians, T., Hu, F. B., Kaplan, R. C., Metspalu, A., North, K. E., Schlessinger, D., Wareham, N. J., Hunter, D. J., O'Connell, J. R., Strachan, D. P., Wichmann, H. E., Borecki, I. B., Van Duijn, C. M., Schadt, E. E., Thorsteinsdottir, U., Peltonen, L., Uitterlinden, A. G., Visscher, P. M., Chatterjee, N., Loos, R. J. F., Boehnke, M., McCarthy, M. I., Ingelsson, E., Lindgren, C. M., Abecasis, G. R., Stefansson, K., Frayling, T. M. & Hirschhorn, J. N., Oct 14 2010, In: Nature. 467, 7317, p. 832-838 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1574 Scopus citations

  • Incorporating age at onset of smoking into genetic models for nicotine dependence: Evidence for interaction with multiple genes

    Grucza, R. A., Johnson, E. O., Krueger, R. F., Breslau, N., Saccone, N. L., Chen, L. S., Derringer, J., Agrawal, A., Lynskey, M. & Bierut, L. J., Jul 2010, In: Addiction Biology. 15, 3, p. 346-357 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    32 Scopus citations

  • Interaction between the UCP2 -866 G>A polymorphism, diabetes, and β-blocker use among patients with acute coronary syndromes

    Beitelshees, A. L., Finck, B. N., Leone, T. C., Cresci, S., Wu, J., Province, M. A., Fabbrini, E., Kirk, E., Zineh, I., Klein, S., Spertus, J. A. & Kelly, D. R., Apr 2010, In: Pharmacogenetics and Genomics. 20, 4, p. 231-238 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    14 Scopus citations

  • Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: A meta-analysis of 14 cohort studies

    Nettleton, J. A., McKeown, N. M., Kanoni, S., Lemaitre, R. N., Hivert, M. F., Ngwa, J., Van Rooij, F. J. A., Sonestedt, E., Wojczynski, M. K., Ye, Z., Tanaka, T., Garcia, M., Anderson, J. S., Follis, J. L., Djousse, L., Mukamal, K., Papoutsakis, C., Mozaffarian, D., Zillikens, M. C. & Bandinelli, S. & 44 others, Bennett, A. J., Borecki, I. B., Feitosa, M. F., Ferrucci, L., Forouhi, N. G., Groves, C. J., Hallmans, G., Harris, T., Hofman, A., Houston, D. K., Hu, F. B., Johansson, I., Kritchevsky, S. B., Langenberg, C., Launer, L., Liu, Y., Loos, R. J., Nalls, M., Orho-Melander, M., Renstrom, F., Rice, K., Riserus, U., Rolandsson, O., Rotter, J. I., Saylor, G., Sijbrands, E. J. G., Sjogren, P., Smith, A., Steingrímsdóttir, L., Uitterlinden, A. G., Wareham, N. J., Prokopenko, I., Pankow, J. S., Van Duijn, C. M., Florez, J. C., Witteman, J. C. M., Dupuis, J., Dedoussis, G. V., Ordovas, J. M., Ingelsson, E., Cupples, L. A., Siscovick, D. S., Franks, P. W. & Meigs, J. B., Dec 2010, In: Diabetes care. 33, 12, p. 2684-2691 8 p.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    126 Scopus citations

  • Mechanisms of nucleotide trafficking during siRNA delivery to endothelial cells using perfluorocarbon nanoemulsions

    Kaneda, M. M., Sasaki, Y., Lanza, G. M., Milbrandt, J. & Wickline, S. A., Apr 2010, In: Biomaterials. 31, 11, p. 3079-3086 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    55 Scopus citations

  • Metabolic syndrome components in murine models

    Lawson, H. A. & Cheverud, J. M., Mar 2010, In: Endocrine, Metabolic and Immune Disorders - Drug Targets. 10, 1, p. 25-40 16 p.

    Research output: Contribution to journal › Review article › peer-review

    Open Access
    18 Scopus citations

  • MicroRNAs both promote and antagonize longevity in C. elegans

    De Lencastre, A., Pincus, Z., Zhou, K., Kato, M., Lee, S. S. & Slack, F. J., Dec 21 2010, In: Current Biology. 20, 24, p. 2159-2168 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    250 Scopus citations

  • Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice

    Wang, Q., Frolova, A. I., Purcell, S., Adastra, K., Schoeller, E., Chi, M. M., Schedl, T. & Moley, K. H., 2010, In: PloS one. 5, 12, e15901.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    100 Scopus citations

  • Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex

    Misko, A., Jiang, S., Wegorzewska, I., Milbrandt, J. & Baloh, R. H., Mar 24 2010, In: Journal of Neuroscience. 30, 12, p. 4232-4240 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    519 Scopus citations

  • Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder

    McEachin, R. C., Saccone, N. L., Saccone, S. F., Kleyman-Smith, Y. D., Kar, T., Kare, R. K., Ade, A. S., Sartor, M. A., Cavalcoli, J. D. & McInnis, M. G., Jan 26 2010, In: BMC Medical Genetics. 11, 1, 14.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    27 Scopus citations

  • Motif discovery using expectation maximization and gibbs’ sampling

    Stormo, G. D., 2010, In: Methods in Molecular Biology. 674, p. 85-95 11 p.

    Research output: Contribution to journal › Article › peer-review

    9 Scopus citations

  • Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans

    Saccone, N. L., Schwantes-An, T. H., Wang, J. C., Grucza, R. A., Breslau, N., Hatsukami, D., Johnson, E. O., Rice, J. P., Goate, A. M. & Bierut, L. J., Oct 2010, In: Genes, Brain and Behavior. 9, 7, p. 741-750 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    84 Scopus citations

  • Multiple independent loci at chromosome 15q25.1 affect smoking quantity: A meta-analysis and comparison with lung cancer and COPD

    Saccone, N. L., Culverhouse, R. C., Schwantes-An, T. H., Cannon, D. S., Chen, X., Cichon, S., Giegling, I., Han, S., Han, Y., Keskitalo-Vuokko, K., Kong, X., Landi, M. T., Ma, J. Z., Short, S. E., Stephens, S. H., Stevens, V. L., Sun, L., Wang, Y., Wenzlaff, A. S. & Aggen, S. H. & 43 others, Breslau, N., Broderick, P., Chatterjee, N., Chen, J., Heath, A. C., Heliövaara, M., Hoft, N. R., Hunter, D. J., Jensen, M. K., Martin, N. G., Montgomery, G. W., Niu, T., Payne, T. J., Peltonen, L., Pergadia, M. L., Rice, J. P., Sherva, R., Spitz, M. R., Sun, J., Wang, J. C., Weiss, R. B., Wheeler, W., Witt, S. H., Yang, B. Z., Caporaso, N. E., Ehringer, M. A., Eisen, T., Gapstur, S. M., Gelernter, J., Houlston, R., Kaprio, J., Kendler, K. S., Kraft, P., Leppert, M. F., Li, M. D., Madden, P. A. F., Nöthen, M. M., Pillai, S., Rietschel, M., Rujescu, D., Schwartz, A., Amos, C. I. & Bierut, L. J., Aug 2010, In: PLoS genetics. 6, 8

    Research output: Contribution to journal › Article › peer-review

    Open Access
    312 Scopus citations

  • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

    Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A. U., Wheeler, E., Glazer, N. L., Bouatia-Naji, N., Gloyn, A. L., Lindgren, C. M., Mägi, R., Morris, A. P., Randall, J., Johnson, T., Elliott, P., Rybin, D., Thorleifsson, G., Steinthorsdottir, V. & Henneman, P. & 283 others, Grallert, H., Dehghan, A., JanHottenga, J., Franklin, C. S., Navarro, P., Song, K., Goel, A., Perry, J. R. B., Egan, J. M., Lajunen, T., Grarup, N., Sparsø, T., Doney, A., Voight, B. F., Stringham, H. M., Li, M., Kanoni, S., Shrader, P., Cavalcanti-Proença, C., Kumari, M., Qi, L., Timpson, N. J., Gieger, C., Zabena, C., Rocheleau, G., Ingelsson, E., An, P., O'Connell, J., Luan, J., Elliott, A., McCarroll, S. A., Payne, F., Roccasecca, R. M., Pattou, F., Sethupathy, P., Ardlie, K., Ariyurek, Y., Balkau, B., Barter, P., Beilby, J. P., Ben-Shlomo, Y., Benediktsson, R., Bennett, A. J., Bergmann, S., Bochud, M., Boerwinkle, E., Bonnefond, A., Bonnycastle, L. L., Borch-Johnsen, K., Böttcher, Y., Brunner, E., Bumpstead, S. J., Charpentier, G., Der IdaChen, Y., Chines, P., Clarke, R., McOin, L. J., Cooper, M. N., Cornelis, M., Crawford, G., Crisponi, L., Day, I. N. M., De Geus, E. J. C., Delplanque, J., Dina, C., Erdos, M. R., Fedson, A. C., Fischer-Rosinsky, A., Forouhi, N. G., Fox, C. S., Frants, R., GraziaFranzosi, M., Galan, P., Goodarzi, M. O., Graessler, J., Groves, C. J., Grundy, S., Gwilliam, R., Gyllensten, U., Hadjadj, S., Hallmans, G., Hammond, N., Han, X., -LiisaHartikainen, A., Hassanali, N., Hayward, C., Heath, S. C., Hercberg, S., Herder, C., Hicks, A. A., Hillman, D. R., Hingorani, A. D., Hofman, A., Hui, J., Hung, J., Isomaa, B., Johnson, P. R. V., Jørgensen, T., Jula, A., Kaakinen, M., Kaprio, J., AnteroKesaniemi, Y., Kivimaki, M., Knight, B., Koskinen, S., Kovacs, P., Kyvik, K. O., Lathrop, G. M., Lawlor, D. A., Bacquer, O. L., Lecoeur, C., Li, Y., Lyssenko, V., Mahley, R., Mangino, M., Manning, A. K., TeresaMartínez-Larrad, M., McAteer, J. B., McCulloch, L. J., McPherson, R., Meisinger, C., Melzer, D., Meyre, D., Mitchell, B. D., Morken, M. A., Mukherjee, S., Naitza, S., Narisu, N., Neville, M. J., Oostra, B. A., Orrù, M., Pakyz, R., APalmer, C. N., Paolisso, G., Pattaro, C., Pearson, D., Peden, J. F., Pedersen, N. L., Perola, M., Pfeiffer, A. F. H., Pichler, I., Polasek, O., Posthuma, D., Potter, S. C., Pouta, A., Province, M. A., Psaty, B. M., Rathmann, W., Rayner, N. W., Rice, K., Ripatti, S., Rivadeneira, F., Roden, M., Rolandsson, O., Sandbaek, A., Sandhu, M., Sanna, S., Sayer, A. A., Scheet, P., Scott, L. J., Seedorf, U., Sharp, S. J., Shields, B., Sigursson, G., Sijbrands, E. J. G., Silveira, A., Simpson, L., Singleton, A., Smith, N. L., Sovio, U., Swift, A., Syddall, H., -ChristineSyvänen, A., Tanaka, T., Thorand, B., Tichet, J., Tönjes, A., Tuomi, T., Uitterlinden, A. G., Van Dijk, K. W., Hoek, M. V., Varma, D., Visvikis-Siest, S., Vitart, V., Vogelzangs, N., Waeber, G., Wagner, P. J., Walley, A., BragiWalters, G., Ward, K. L., Watkins, H., Weedon, M. N., Wild, S. H., Willemsen, G., MWitteman, J. C., GYarnell, J. W., Zeggini, E., Zelenika, D., Zethelius, B., Zhai, G., Zhao, J. H., Zillikens, M. C., Borecki, I. B., Loos, R. J. F., Meneton, P., Magnusson, P. K. E., Nathan, D. M., Williams, G. H., Hattersley, A. T., Silander, K., Salomaa, V., Smith, G. D., Bornstein, S. R., Schwarz, P., Spranger, J., Karpe, F., Shuldiner, A. R., Cooper, C., Dedoussis, G. V., Serrano-Ríos, M., Morris, A. D., Lind, L., Palmer, L. J., Hu, F. B., Franks, P. W., Ebrahim, S., Marmot, M., Linda Kao, W. H., Pankow, J. S., Sampson, M. J., Kuusisto, J., Laakso, M., Hansen, T., Pedersen, O., Pramstaller, P. P., Wichmann, H. E., Illig, T., Rudan, I., Wright, A. F., Stumvoll, M., Campbell, H., Wilson, J. F., Bergman, R. N., Buchanan, T. A., Collins, F. S., Mohlke, K. L., Tuomilehto, J., Valle, T. T., Altshuler, D., Rotter, J. I., Siscovick, D. S., Penninx, B. W. J. H., Boomsma, D. I., Deloukas, P., Spector, T. D., Frayling, T. M., Ferrucci, L., Kong, A., Thorsteinsdottir, U., Stefansson, K., Van Duijn, C. M., Aulchenko, Y. S., Cao, A., Scuteri, A., Schlessinger, D., Uda, M., Ruokonen, A., -RiittaJarvelin, M., Waterworth, D. M., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G. R., Wareham, N. J., Sladek, R., Froguel, P., Watanabe, R. M., Meigs, J. B., Groop, L., Boehnke, M., McCarthy, M. I., Florez, J. C. & Barroso, I., Feb 2010, In: Nature Genetics. 42, 2, p. 105-116 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    1818 Scopus citations

  • New loci associated with kidney function and chronic kidney disease

    Köttgen, A., Pattaro, C., Böger, C. A., Fuchsberger, C., Olden, M., Glazer, N. L., Parsa, A., Gao, X., Yang, Q., Smith, A. V., O'Connel, J. R., Li, M., Schmidt, H., Tanaka, T., Isaacs, A., Ketkar, S., Hwang, S. J., Johnson, A. D., Dehghan, A. & Teumer, A. & 112 others, Paré, G., Atkinson, E. J., Zeller, T., Lohman, K., Cornelis, M. C., Probst-Hensch, N. M., Kronenberg, F., Tönjes, A., Hayward, C., Aspelund, T., Eiriksdottir, G., Launer, L. J., Harris, T. B., Rampersaud, E., Mitchel, B. D., Arking, D. E., Boerwinkle, E., Struchalin, M., Cavalieri, M., Singleton, A., Giallauria, F., Metter, J., De Boer, I. H., Haritunians, T., Lumley, T., Siscovick, D., Psaty, B. M., CarolaZillikens, M., Oostra, B. A., Feitosa, M., Province, M., Andrade, M. D., Turner, S. T., Schillert, A., Ziegler, A., Wild, P. S., Schnabel, R. B., Wilde, S., Munzel, T. F., Leak, T. S., Illig, T., Klopp, N., Meisinger, C., Wichmann, H. E., Koenig, W., Zgaga, L., Zemunik, T., Kolcic, I., Minelli, C., Hu, F. B., Johansson, Å., Igl, W., Zaboli, G., Wild, S. H., Wright, A. F., Campbell, H., Ellinghaus, D., Schreiber, S., Aulchenko, Y. S., Felix, J. F., Rivadeneira, F., Uitterlinden, A. G., Hofman, A., Imboden, M., Nitsch, D., Brandstätter, A., Kollerits, B., Kedenko, L., Mägi, R., Stumvoll, M., Kovacs, P., Boban, M., Campbell, S., Endlich, K., Völzke, H., Kroemer, H. K., Nauck, M., Völker, U., Polasek, O., Vitart, V., Badola, S., Parker, A. N., Ridker, P. M., Kardia, S. L. R., Blankenberg, S., Liu, Y., Curhan, G. C., Franke, A., Rochat, T., Paulweber, B., Prokopenko, I., Wang, W., Gudnason, V., Shuldine, A. R., Coresh, J., Schmidt, R., Ferrucci, L., Shlipak, M. G., Van Duijn, C. M., Borecki, I., Krämer, B. K., Rudan, I., Gyllensten, U., Wilson, J. F., Witteman, J. C., Pramstaller, P. P., Rettig, R., Hastie, N., Chasman, D. I., Kao, W. H., Heid, I. M. & Fox, C. S., May 2010, In: Nature Genetics. 42, 5, p. 376-384 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    705 Scopus citations

  • Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus

    Chang, J., Zhang, B., Heath, H., Galjart, N., Wang, X. & Milbrandt, J., Dec 14 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 50, p. 21836-21841 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    50 Scopus citations

  • Novel sequence-based method for identifying transcription factor binding sites in prokaryotic genomes

    Sahota, G. & Stormo, G. D., Nov 2010, In: Bioinformatics. 26, 21, p. 2672-2677 6 p., btq501.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    20 Scopus citations

  • Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice

    Jain, S., Knoten, A., Hoshi, M., Wang, H., Vohra, B., Heuckeroth, R. O. & Milbrandt, J., Mar 1 2010, In: Journal of Clinical Investigation. 120, 3, p. 778-790 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    49 Scopus citations

  • Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo

    Morris, S. A., Teo, R. T. Y., Li, H., Robson, P., Glover, D. M. & Zernicka-Goetz, M., Apr 6 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 6364-6369 6 p.

    Research output: Contribution to journal › Article › peer-review

    256 Scopus citations

  • Peer smoking and the nicotinic receptor genes: An examination of genetic and environmental risks for nicotine dependence

    Johnson, E. O., Chen, L. S., Breslau, N., Hatsukami, D., Robbins, T., Saccone, N. L., Grucza, R. A. & Bierut, L. J., Nov 2010, In: Addiction. 105, 11, p. 2014-2022 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    50 Scopus citations

  • Peptidoglycan crosslinking relaxation promotes helicobacter pylori's helical shape and stomach colonization

    Sycuro, L. K., Pincus, Z., Gutierrez, K. D., Biboy, J., Stern, C. A., Vollmer, W. & Salama, N. R., May 2010, In: Cell. 141, 5, p. 822-833 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    207 Scopus citations

  • Persephin signaling through GFRα1: The potential for the treatment of Parkinson's disease

    Sidorova, Y. A., Mätlik, K., Paveliev, M., Lindahl, M., Piranen, E., Milbrandt, J., Arumäe, U., Saarma, M. & Bespalov, M. M., Jul 2010, In: Molecular and Cellular Neuroscience. 44, 3, p. 223-232 10 p.

    Research output: Contribution to journal › Article › peer-review

    28 Scopus citations

  • Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery

    Mao, X. R. & Crowder, C. M., Nov 2010, In: Molecular and cellular biology. 30, 21, p. 5033-5042 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    51 Scopus citations

  • PRP-17 and the pre-mRNA splicing pathway are preferentially required for the proliferation versus meiotic development decision and germline sex determination in Caenorhabditis elegans

    Kerins, J. A., Hanazawa, M., Dorsett, M. & Schedl, T., May 2010, In: Developmental Dynamics. 239, 5, p. 1555-1572 18 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    58 Scopus citations

  • Response to "dizziness genes"

    Ehringer, M. A., McQueen, M. B., Hoft, N. R., Saccone, N. L., Stitzel, J. A., Wang, J. C. & Bierut, L. J., Sep 2010, In: American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 153, 6, p. 1248-1249 2 p.

    Research output: Contribution to journal › Letter › peer-review

  • RET signaling is required for survival and normal function of nonpeptidergic nociceptors

    Golden, J. P., Hoshi, M., Nassar, M. A., Enomoto, H., Wood, J. N., Milbrandt, J., Gereau IV, R. W., Johnson, E. M. & Jain, S., Mar 17 2010, In: Journal of Neuroscience. 30, 11, p. 3983-3994 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    68 Scopus citations

  • Synthesizing and salvaging NAD+: Lessons learned from Chlamydomonas reinhardtii

    Lin, H., Kwan, A. L. & Dutcher, S. K., Sep 2010, In: PLoS genetics. 6, 9, e1001105.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    43 Scopus citations

  • TATA is a modular component of synthetic promoters

    Mogno, I., Vallania, F., Mitra, R. D. & Cohen, B. A., Oct 2010, In: Genome research. 20, 10, p. 1391-1397 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    83 Scopus citations

  • The effect of a novel intergenic polymorphism (rs11774572) on HDL-cholesterol concentrations depends on TaqIB polymorphism in the cholesterol ester transfer protein gene

    Junyent, M., Lee, Y. C., Smith, C. E., Arnett, D. K., Tsai, M. Y., Kabagambe, E. K., Straka, R. J., Province, M., An, P., Lai, C. Q., Parnell, L. D., Shen, J., Borecki, I. & Ordovas, J. M., Jan 2010, In: Nutrition, Metabolism and Cardiovascular Diseases. 20, 1, p. 34-40 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    9 Scopus citations

  • The genetics of obesity and the metabolic syndrome

    Monda, K. L., North, K. E., Hunt, S. C., Rao, D. C., Province, M. A. & Kraja, A. T., 2010, In: Endocrine, Metabolic and Immune Disorders - Drug Targets. 10, 2, p. 86-108 23 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    61 Scopus citations

  • The Harvey Lectures: Delivered Under the Auspices of The Harvey Society of New York, 2006-2007

    Anderson, K. V., Dutcher, S. K., Greenberg, M. E., Karin, M., Rapoport, T. A., Verdine, G. L. & Zon, L. I., Sep 29 2010, wiley. 189 p.

    Research output: Book/Report › Book › peer-review