Department of Genetics

Search results

  • 2012

    Formation of distinct cell types in the mouse blastocyst

    Morris, S. A. & Zernicka-Goetz, M., 2012, Mouse Development: From Oocyte to Stem Cells. Springer Verlag, p. 203-217 15 p. (Results and Problems in Cell Differentiation; vol. 55).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

    16 Scopus citations

  • FTO genotype is associated with phenotypic variability of body mass index

    Yang, J., Loos, R. J. F., Powell, J. E., Medland, S. E., Speliotes, E. K., Chasman, D. I., Rose, L. M., Thorleifsson, G., Steinthorsdottir, V., Mägi, R., Waite, L., Vernon Smith, A., Yerges-Armstrong, L. M., Monda, K. L., Hadley, D., Mahajan, A., Li, G., Kapur, K., Vitart, V. & Huffman, J. E. & 152 others, Wang, S. R., Palmer, C., Esko, T., Fischer, K., Hua Zhao, J., Demirkan, A., Isaacs, A., Feitosa, M. F., Luan, J., Heard-Costa, N. L., White, C., Jackson, A. U., Preuss, M., Ziegler, A., Eriksson, J., Kutalik, Z., Frau, F., Nolte, I. M., Van Vliet-Ostaptchouk, J. V., Hottenga, J. J., Jacobs, K. B., Verweij, N., Goel, A., Medina-Gomez, C., Estrada, K., Bragg-Gresham, J. L., Sanna, S., Sidore, C., Tyrer, J., Teumer, A., Prokopenko, I., Mangino, M., Lindgren, C. M., Assimes, T. L., Shuldiner, A. R., Hui, J., Beilby, J. P., McArdle, W. L., Hall, P., Haritunians, T., Zgaga, L., Kolcic, I., Polasek, O., Zemunik, T., Oostra, B. A., Juhani Junttila, M., Grönberg, H., Schreiber, S., Peters, A., Hicks, A. A., Stephens, J., Foad, N. S., Laitinen, J., Pouta, A., Kaakinen, M., Willemsen, G., Vink, J. M., Wild, S. H., Navis, G., Asselbergs, F. W., Homuth, G., John, U., Iribarren, C., Harris, T., Launer, L., Gudnason, V., O'Connell, J. R., Boerwinkle, E., Cadby, G., Palmer, L. J., James, A. L., Musk, A. W., Ingelsson, E., Psaty, B. M., Beckmann, J. S., Waeber, G., Vollenweider, P., Hayward, C., Wright, A. F., Rudan, I., Groop, L. C., Metspalu, A., Tee Khaw, K., Van Duijn, C. M., Borecki, I. B., Province, M. A., Wareham, N. J., Tardif, J. C., Huikuri, H. V., Adrienne Cupples, L., Atwood, L. D., Fox, C. S., Boehnke, M., Collins, F. S., Mohlke, K. L., Erdmann, J., Schunkert, H., Hengstenberg, C., Stark, K., Lorentzon, M., Ohlsson, C., Cusi, D., Staessen, J. A., Van Der Klauw, M. M., Pramstaller, P. P., Kathiresan, S., Jolley, J. D., Ripatti, S., Jarvelin, M. R., De Geus, E. J. C., Boomsma, D. I., Penninx, B., Wilson, J. F., Campbell, H., Chanock, S. J., Van Der Harst, P., Hamsten, A., Watkins, H., Hofman, A., Witteman, J. C., Carola Zillikens, M., Uitterlinden, A. G., Rivadeneira, F., Carola Zillikens, M., Kiemeney, L. A., Vermeulen, S. H., Abecasis, G. R., Schlessinger, D., Schipf, S., Stumvoll, M., Tönjes, A., Spector, T. D., North, K. E., Lettre, G., McCarthy, M. I., Berndt, S. I., Heath, A. C., Madden, P. A. F., Nyholt, D. R., Montgomery, G. W., Martin, N. G., McKnight, B., Strachan, D. P., Hill, W. G., Snieder, H., Ridker, P. M., Thorsteinsdottir, U., Stefansson, K., Frayling, T. M., Hirschhorn, J. N., Goddard, M. E. & Visscher, P. M., Oct 11 2012, In: Nature. 490, 7419, p. 267-273 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    338 Scopus citations

  • Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations

    Elbers, C. C., Guo, Y., Tragante, V., van Iperen, E. P. A., Lanktree, M. B., Castillo, B. A., Chen, F., Yanek, L. R., Wojczynski, M. K., Li, Y. R., Ferwerda, B., Ballantyne, C. M., Buxbaum, S. G., Chen, Y. D. I., Chen, W. M., Cupples, L. A., Cushman, M., Duan, Y., Duggan, D. & Evans, M. K. & 50 others, Fernandes, J. K., Fornage, M., Garcia, M., Garvey, W. T., Glazer, N., Gomez, F., Harris, T. B., Halder, I., Howard, V. J., Keller, M. F., Kamboh, M. I., Kooperberg, C., Kritchevsky, S. B., LaCroix, A., Liu, K., Liu, Y., Musunuru, K., Newman, A. B., Onland-Moret, N. C., Ordovas, J., Peter, I., Post, W., Redline, S., Reis, S. E., Saxena, R., Schreiner, P. J., Volcik, K. A., Wang, X., Yusuf, S., Zonderland, A. B., Anand, S. S., Becker, D. M., Psaty, B., Rader, D. J., Reiner, A. P., Rich, S. S., Rotter, J. I., Sale, M. M., Tsai, M. Y., Borecki, I. B., Hegele, R. A., Kathiresan, S., Nalls, M. A., Taylor, H. A., Hakonarson, H., Sivapalaratnam, S., Asselbergs, F. W., Drenos, F., Wilson, J. G. & Keating, B. J., Dec 7 2012, In: PloS one. 7, 12, e50198.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    38 Scopus citations

  • Genome-wide association and functional follow-up reveals new loci for kidney function

    Pattaro, C., Köttgen, A., Teumer, A., Garnaas, M., Böger, C. A., Fuchsberger, C., Olden, M., Chen, M. H., Tin, A., Taliun, D., Li, M., Gao, X., Gorski, M., Yang, Q., Hundertmark, C., Foster, M. C., O'Seaghdha, C. M., Glazer, N., Isaacs, A. & Liu, C. T. & 146 others, Smith, A. V., O'Connell, J. R., Struchalin, M., Tanaka, T., Li, G., Johnson, A. D., Gierman, H. J., Feitosa, M., Hwang, S. J., Atkinson, E. J., Lohman, K., Cornelis, M. C., Johansson, Å., Tönjes, A., Dehghan, A., Chouraki, V., Holliday, E. G., Sorice, R., Kutalik, Z., Lehtimäki, T., Esko, T., Deshmukh, H., Ulivi, S., Chu, A. Y., Murgia, F., Trompet, S., Imboden, M., Kollerits, B., Pistis, G., Harris, T. B., Launer, L. J., Aspelund, T., Eiriksdottir, G., Mitchell, B. D., Boerwinkle, E., Schmidt, H., Cavalieri, M., Rao, M., Hu, F. B., Demirkan, A., Oostra, B. A., de Andrade, M., Turner, S. T., Ding, J., Andrews, J. S., Freedman, B. I., Koenig, W., Illig, T., Döring, A., Wichmann, H. E., Kolcic, I., Zemunik, T., Boban, M., Minelli, C., Wheeler, H. E., Igl, W., Zaboli, G., Wild, S. H., Wright, A. F., Campbell, H., Ellinghaus, D., Nöthlings, U., Jacobs, G., Biffar, R., Endlich, K., Ernst, F., Homuth, G., Kroemer, H. K., Nauck, M., Stracke, S., Völker, U., Völzke, H., Kovacs, P., Stumvoll, M., Mägi, R., Hofman, A., Uitterlinden, A. G., Rivadeneira, F., Aulchenko, Y. S., Polasek, O., Hastie, N., Vitart, V., Helmer, C., Wang, J. J., Ruggiero, D., Bergmann, S., Kähönen, M., Viikari, J., Nikopensius, T., Province, M., Ketkar, S., Colhoun, H., Doney, A., Robino, A., Giulianini, F., Krämer, B. K., Portas, L., Ford, I., Buckley, B. M., Adam, M., Thun, G. A., Paulweber, B., Haun, M., Sala, C., Metzger, M., Mitchell, P., Ciullo, M., Kim, S. K., Vollenweider, P., Raitakari, O., Metspalu, A., Palmer, C., Gasparini, P., Pirastu, M., Jukema, J. W., Probst-Hensch, N. M., Kronenberg, F., Toniolo, D., Gudnason, V., Shuldiner, A. R., Coresh, J., Schmidt, R., Ferrucci, L., Siscovick, D. S., van Duijn, C. M., Borecki, I., Kardia, S. L. R., Liu, Y., Curhan, G. C., Rudan, I., Gyllensten, U., Wilson, J. F., Franke, A., Pramstaller, P. P., Rettig, R., Prokopenko, I., Witteman, J. C. M., Hayward, C., Ridker, P., Parsa, A., Bochud, M., Heid, I. M., Goessling, W., Chasman, D. I., Kao, W. H. L. & Fox, C. S., Mar 2012, In: PLoS genetics. 8, 3, e1002584.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    165 Scopus citations

  • Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction

    Wilk, J. B., Shrine, N. R. G., Loehr, L. R., Zhao, J. H., Manichaikul, A., Lopez, L. M., Smith, A. V., Heckbert, S. R., Smolonska, J., Tang, W., Loth, D. W., Curjuric, I., Hui, J., Cho, M. H., Latourelle, J. C., Henry, A. P., Aldrich, M., Bakke, P., Beaty, T. H. & Bentley, A. R. & 59 others, Borecki, I. B., Brusselle, G. G., Burkart, K. M., Chen, T. H., Couper, D., Crapo, J. D., Davies, G., Dupuis, J., Franceschini, N., Gulsvik, A., Hancock, D. B., Harris, T. B., Hofman, A., Imboden, M., James, A. L., Khaw, K. T., Lahousse, L., Launer, L. J., Litonjua, A., Liu, Y., Lohman, K. K., Lomas, D. A., Lumley, T., Marciante, K. D., McArdle, W. L., Meibohm, B., Morrison, A. C., Musk, A. W., Myers, R. H., North, K. E., Postma, D. S., Psaty, B. M., Rich, S. S., Rivadeneira, F., Rochat, T., Rotter, J. I., Soler Artigas, M., Starr, J. M., Uitterlinden, A. G., Wareham, N. J., Wijmenga, C., Zanen, P., Province, M. A., Silverman, E. K., Deary, I. J., Palmer, L. J., Cassano, P. A., Gudnason, V., Barr, R. G., Loos, R. J. F., Strachan, D. P., London, S. J., Boezen, H. M., Probst-Hensch, N., Gharib, S. A., Hall, I. P., O'Connor, G. T., Tobin, M. D. & Stricker, B. H., Oct 1 2012, In: American journal of respiratory and critical care medicine. 186, 7, p. 622-632 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    156 Scopus citations

  • Genome-wide association study to identify common variants associated with brachial circumference: A meta-analysis of 14 cohorts

    Boraska, V., Day-Williams, A., Franklin, C. S., Elliott, K. S., Panoutsopoulou, K., Tachmazidou, I., Albrecht, E., Bandinelli, S., Beilin, L. J., Bochud, M., Cadby, G., Ernst, F., Evans, D. M., Hayward, C., Hicks, A. A., Huffman, J., Huth, C., James, A. L., Klopp, N. & Kolcic, I. & 46 others, Kutalik, Z., Lawlor, D. A., Musk, A. W., Pehlic, M., Pennell, C. E., Perry, J. R. B., Peters, A., Polasek, O., Pourcain, B. S., Ring, S. M., Salvi, E., Schipf, S., Staessen, J. A., Teumer, A., Timpson, N., Vitart, V., Warrington, N. M., Yaghootkar, H., Zemunik, T., Zgaga, L., An, P., Anttila, V., Borecki, I. B., Holmen, J., Ntalla, I., Palotie, A., Pietiläinen, K. H., Wedenoja, J., Winsvold, B. S., Dedoussis, G. V., Kaprio, J., Province, M. A., Zwart, J. A., Burnier, M., Campbell, H., Cusi, D., Davey Smith, G., Frayling, T. M., Gieger, C., Palmer, L. J., Pramstaller, P. P., Rudan, I., Völzke, H., Wichmann, H. E., Wright, A. F. & Zeggini, E., Mar 29 2012, In: PloS one. 7, 3, e31369.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    2 Scopus citations

  • Genome-wide meta-analysis points to CTC1 and ZNf676 as genes regulating telomere homeostasis in humans

    Mangino, M., Hwang, S. J., Spector, T. D., Hunt, S. C., Kimura, M., Fitzpatrick, A. L., Christiansen, L., Petersen, I., Elbers, C. C., Harris, T., Chen, W., Srinivasan, S. R., Kark, J. D., Benetos, A., El shamieh, S., Visvikis-Siest, S., Christensen, K., Berenson, G. S., Valdes, A. M. & Vinuela, A. & 19 others, Garcia, M., Arnett, D. K., Broeckel, U., Province, M. A., Pankow, J. S., Kammerer, C., Liu, Y., Nalls, M., Tishkoff, S., Thomas, F., Ziv, E., Psaty, B. M., Bis, J. C., Rotter, J. I., Taylor, K. D., Smith, E., Schork, N. J., Levy, D. & Aviv, A., Dec 2012, In: Human molecular genetics. 21, 24, p. 5385-5394 10 p., dds382.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    194 Scopus citations

  • Global gene deletion analysis exploring yeast filamentous growth

    Ryan, O., Shapiro, R. S., Kurat, C. F., Mayhew, D., Baryshnikova, A., Chin, B., Lin, Z. Y., Cox, M. J., Vizeacoumar, F., Cheung, D., Bahr, S., Tsui, K., Tebbji, F., Sellam, A., Istel, F., Schwarzmüller, T., Reynolds, T. B., Kuchler, K., Gifford, D. K. & Whiteway, M. & 9 others, Giaever, G., Nislow, C., Costanzo, M., Gingras, A. C., Mitra, R. D., Andrews, B., Fink, G. R., Cowen, L. E. & Boone, C., Sep 14 2012, In: Science. 337, 6100, p. 1352-1356 5 p.

    Research output: Contribution to journal › Article › peer-review

    170 Scopus citations

  • Healing quantitative trait loci in a combined cross analysis using related mouse strain crosses

    Cheverud, J. M., Lawson, H. A., Funk, R., Zhou, J., Blankenhorn, E. P. & Heber-Katz, E., Apr 2012, In: Heredity. 108, 4, p. 441-446 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    17 Scopus citations

  • High Fat Diet Induced Developmental Defects in the Mouse: Oocyte Meiotic Aneuploidy and Fetal Growth Retardation/Brain Defects

    Luzzo, K. M., Wang, Q., Purcell, S. H., Chi, M., Jimenez, P. T., Grindler, N., Schedl, T. & Moley, K. H., Nov 12 2012, In: PloS one. 7, 11, e49217.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    290 Scopus citations

  • Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature

    Rinkevich, Y., Mori, T., Sahoo, D., Xu, P. X., Bermingham, J. R. & Weissman, I. L., Dec 2012, In: Nature Cell Biology. 14, 12, p. 1251-1260 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    146 Scopus citations

  • Identification of MW polyomavirus, a novel polyomavirus in human stool

    Siebrasse, E. A., Reyes, A., Lim, E. S., Zhao, G., Mkakosya, R. S., Manary, M. J., Gordon, J. I. & Wang, D., Oct 2012, In: Journal of virology. 86, 19, p. 10321-10326 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    165 Scopus citations

  • Impact of common variation in bone-related genes on type 2 diabetes and related traits

    Billings, L. K., Hsu, Y. H., Ackerman, R. J., Dupuis, J., Voight, B. F., Rasmussen-Torvik, L. J., Hercberg, S., Lathrop, M., Barnes, D., Langenberg, C., Hui, J., Fu, M., Bouatia-Naji, N., Lecoeur, C., An, P., Magnusson, P. K., Surakka, I., Ripatti, S., Christiansen, L. & Dalgård, C. & 20 others, Folkersen, L., Grundberg, E., Eriksson, P., Kaprio, J., Kyvik, K. O., Pedersen, N. L., Borecki, I. B., Province, M. A., Balkau, B., Froguel, P., Shuldiner, A. R., Palmer, L. J., Wareham, N., Meneton, P., Johnson, T., Pankow, J. S., Karasik, D., Meigs, J. B., Kiel, D. P. & Florez, J. C., Aug 2012, In: Diabetes. 61, 8, p. 2176-2186 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    29 Scopus citations

  • Improved models for transcription factor binding site identification using nonindependent interactions

    Zhao, Y., Ruan, S., Pandey, M. & Stormo, G. D., Jul 1 2012, In: Genetics. 191, 3, p. 781-790 10 p.

    Research output: Contribution to journal › Article › peer-review

    101 Scopus citations

  • Imputation of single-nucleotide polymorphisms in inbred mice using local phylogeny

    Wang, J. R., de Villena, F. P. M., Lawson, H. A., Cheverud, J. M., Churchill, G. A. & McMillan, L., Feb 2012, In: Genetics. 190, 2, p. 449-458 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    40 Scopus citations

  • Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers

    Hartz, S. M., Short, S. E., Saccone, N. L., Culverhouse, R., Chen, L. S., Schwantes-An, T. H., Coon, H., Han, Y., Stephens, S. H., Sun, J., Chen, X., Ducci, F., Dueker, N., Franceschini, N., Frank, J., Geller, F., Guobjartsson, D., Hansel, N. N., Jiang, C. & Keskitalo-Vuokko, K. & 132 others, Liu, Z., Lyytikäinen, L. P., Michel, M., Rawal, R., Rosenberger, A., Scheet, P., Shaffer, J. R., Teumer, A., Thompson, J. R., Vink, J. M., Vogelzangs, N., Wenzlaff, A. S., Wheeler, W., Xiao, X., Yang, B. Z., Aggen, S. H., Balmforth, A. J., Baumeister, S. E., Beaty, T., Bennett, S., Bergen, A. W., Boyd, H. A., Broms, U., Campbell, H., Chatterjee, N., Chen, J., Cheng, Y. C., Cichon, S., Couper, D., Cucca, F., Dick, D. M., Foroud, T., Furberg, H., Giegling, I., Gu, F., Hall, A. S., Hällfors, J., Han, S., Hartmann, A. M., Hayward, C., Heikkilä, K., Hewitt, J. K., Hottenga, J. J., Jensen, M. K., Jousilahti, P., Kaakinen, M., Kittner, S. J., Konte, B., Korhonen, T., Landi, M. T., Laatikainen, T., Leppert, M., Levy, S. M., Mathias, R. A., McNeil, D. W., Medland, S. E., Montgomery, G. W., Muley, T., Murray, T., Nauck, M., North, K., Pergadia, M., Polasek, O., Ramos, E. M., Ripatti, S., Risch, A., Ruczinski, I., Rudan, I., Salomaa, V., Schlessinger, D., Styrkársdóttir, U., Terracciano, A., Uda, M., Willemsen, G., Wu, X., Abecasis, G., Barnes, K., Bickeböller, H., Boerwinkle, E., Boomsma, D. I., Caporaso, N., Duan, J., Edenberg, H. J., Francks, C., Gejman, P. V., Gelernter, J., Grabe, H. J., Hops, H., Jarvelin, M. R., Viikari, J., Kähönen, M., Kendler, K. S., Lehtimäki, T., Levinson, D. F., Marazita, M. L., Marchini, J., Melbye, M., Mitchell, B. D., Murray, J. C., Nöthen, M. M., Penninx, B. W., Raitakari, O., Rietschel, M., Rujescu, D., Samani, N. J., Sanders, A. R., Schwartz, A. G., Shete, S., Shi, J., Spitz, M., Stefansson, K., Swan, G. E., Thorgeirsson, T., Völzke, H., Wei, Q., Wichmann, H. E., Amos, C. I., Breslau, N., Cannon, D. S., Ehringer, M., Grucza, R., Hatsukami, D., Heath, A., Johnson, E. O., Kaprio, J., Madden, P., Martin, N. G., Stevens, V. L., Stitzel, J. A., Weiss, R. B., Kraft, P. & Bierut, L. J., Aug 2012, In: Archives of General Psychiatry. 69, 8, p. 854-861 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    64 Scopus citations

  • Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

    Chasman, D. I., Fuchsberger, C., Pattaro, C., Teumer, A., Böger, C. A., Endlich, K., Olden, M., Chen, M. H., Tin, A., Taliun, D., Li, M., Gao, X., Gorski, M., Yang, Q., Hundertmark, C., Foster, M. C., O'Seaghdha, C. M., Glazer, N., Isaacs, A. & Liu, C. T. & 144 others, Smith, A. V., O'Connell, J. R., Struchalin, M., Tanaka, T., Li, G., Johnson, A. D., Gierman, H. J., Feitosa, M. F., Hwang, S. J., Atkinson, E. J., Lohman, K., Cornelis, M. C., Johansson, Å., Tönjes, A., Dehghan, A., Lambert, J. C., Holliday, E. G., Sorice, R., Kutalik, Z., Lehtimäki, T., Esko, T., Deshmukh, H., Ulivi, S., Chu, A. Y., Murgia, F., Trompet, S., Imboden, M., Coassin, S., Pistis, G., Harris, T. B., Launer, L. J., Aspelund, T., Eiriksdottir, G., Mitchell, B. D., Boerwinkle, E., Schmidt, H., Cavalieri, M., Rao, M., Hu, F., Demirkan, A., Oostra, B. A., de Andrade, M., Turner, S. T., Ding, J., Andrews, J. S., Freedman, B. I., Giulianini, F., Koenig, W., Illig, T., Meisinger, C., Gieger, C., Zgaga, L., Zemunik, T., Boban, M., Minelli, C., Wheeler, H. E., Igl, W., Zaboli, G., Wild, S. H., Wright, A. F., Campbell, H., Ellinghaus, D., Nöthlings, U., Jacobs, G., Biffar, R., Ernst, F., Homuth, G., Kroemer, H. K., Nauck, M., Stracke, S., Völker, U., Völzke, H., Kovacs, P., Stumvoll, M., Mägi, R., Hofman, A., Uitterlinden, A. G., Rivadeneira, F., Aulchenko, Y. S., Polasek, O., Hastie, N., Vitart, V., Helmer, C., Wang, J. J., Stengel, B., Ruggiero, D., Bergmann, S., Kähönen, M., Viikari, J., Nikopensius, T., Province, M., Ketkar, S., Colhoun, H., Doney, A., Robino, A., Krämer, B. K., Portas, L., Ford, I., Buckley, B. M., Adam, M., Thun, G. A., Paulweber, B., Haun, M., Sala, C., Mitchell, P., Ciullo, M., Kim, S. K., Vollenweider, P., Raitakari, O., Metspalu, A., Palmer, C., Gasparini, P., Pirastu, M., Jukema, J. W., Probst-Hensch, N. M., Kronenberg, F., Toniolo, D., Gudnason, V., Shuldiner, A. R., Coresh, J., Schmidt, R., Ferrucci, L., Siscovick, D. S., van Duijn, C. M., Borecki, I. B., Kardia, S. L. R., Liu, Y., Curhan, G. C., Rudan, I., Gyllensten, U., Wilson, J. F., Franke, A., Pramstaller, P. P., Rettig, R., Prokopenko, I., Witteman, J., Hayward, C., Ridker, P. M., Parsa, A., Bochud, M., Heid, I. M., Kao, W. H. L., Fox, C. S. & Köttgen, A., Dec 2012, In: Human molecular genetics. 21, 24, p. 5329-5343 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    59 Scopus citations

  • Interplay of genetic risk factors (CHRNA 5-CHRNA 3-CHRNB4) and cessation treatments in smoking cessation success

    Chen, L. S., Baker, T. B., Piper, M. E., Breslau, N., Cannon, D. S., Doheny, K. F., Gogarten, S. M., Johnson, E. O., Saccone, N. L., Wang, J. C., Weiss, R. B., Goate, A. M. & Bierut, L. J., Jul 1 2012, In: American Journal of Psychiatry. 169, 7, p. 735-742 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    121 Scopus citations

  • IS-seq: a novel high throughput survey of in vivo IS6110 transposition in multiple Mycobacterium tuberculosis genomes

    Reyes, A., Sandoval, A., Cubillos-Ruiz, A., Varley, K. E., Hernández-Neuta, I., Samper, S., Martín, C., García, M. J., Ritacco, V., López, L., Robledo, J., Zambrano, M. M., Mitra, R. D. & Del Portillo, P., Jun 15 2012, In: BMC genomics. 13, 1, 249.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    29 Scopus citations

  • Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

    Scott, R. A., Lagou, V., Welch, R. P., Wheeler, E., Montasser, M. E., Luan, J., MäGi, R., Strawbridge, R. J., Rehnberg, E., Gustafsson, S., Kanoni, S., Rasmussen-Torvik, L. J., Yengo, L., Lecoeur, C., Shungin, D., Sanna, S., Sidore, C., Johnson, P. C. D., Jukema, J. W. & Johnson, T. & 194 others, Mahajan, A., Verweij, N., Thorleifsson, G., Hottenga, J. J., Shah, S., Smith, A. V., Sennblad, B., Gieger, C., Salo, P., Perola, M., Timpson, N. J., Evans, D. M., Pourcain, B. S., Wu, Y., Andrews, J. S., Hui, J., Bielak, L. F., Zhao, W., Horikoshi, M., Navarro, P., Isaacs, A., O'Connell, J. R., Stirrups, K., Vitart, V., Hayward, C., Esko, T., Mihailov, E., Fraser, R. M., Fall, T., Voight, B. F., Raychaudhuri, S., Chen, H., Lindgren, C. M., Morris, A. P., Rayner, N. W., Robertson, N., Rybin, D., Liu, C. T., Beckmann, J. S., Willems, S. M., Chines, P. S., Jackson, A. U., Kang, H. M., Stringham, H. M., Song, K., Tanaka, T., Peden, J. F., Goel, A., Hicks, A. A., An, P., MüLler-Nurasyid, M., Franco-Cereceda, A., Folkersen, L., Marullo, L., Jansen, H., Oldehinkel, A. J., Bruinenberg, M., Pankow, J. S., North, K. E., Forouhi, N. G., Loos, R. J. F., Edkins, S., Varga, T. V., Hallmans, G., Oksa, H., Antonella, M., Nagaraja, R., Trompet, S., Ford, I., Bakker, S. J. L., Kong, A., Kumari, M., Gigante, B., Herder, C., Munroe, P. B., Caulfield, M., Antti, J., Mangino, M., Small, K., Miljkovic, I., Liu, Y., Atalay, M., Kiess, W., James, A. L., Rivadeneira, F., Uitterlinden, A. G., Palmer, C. N. A., Doney, A. S. F., Willemsen, G., Smit, J. H., Campbell, S., Polasek, O., Bonnycastle, L. L., Hercberg, S., Dimitriou, M., Bolton, J. L., Fowkes, G. R., Kovacs, P., LindströM, J., Zemunik, T., Bandinelli, S., Wild, S. H., Basart, H. V., Rathmann, W., Grallert, H., Maerz, W., Kleber, M. E., Boehm, B. O., Peters, A., Pramstaller, P. P., Province, M. A., Borecki, I. B., Hastie, N. D., Rudan, I., Campbell, H., Watkins, H., Farrall, M., Stumvoll, M., Ferrucci, L., Waterworth, D. M., Bergman, R. N., Collins, F. S., Tuomilehto, J., Watanabe, R. M., De Geus, E. J. C., Penninx, B. W., Hofman, A., Oostra, B. A., Psaty, B. M., Vollenweider, P., Wilson, J. F., Wright, A. F., Hovingh, G. K., Metspalu, A., Uusitupa, M., Magnusson, P. K. E., Kyvik, K. O., Kaprio, J., Price, J. F., Dedoussis, G. V., Deloukas, P., Meneton, P., Lind, L., Boehnke, M., Shuldiner, A. R., Van Duijn, C. M., Morris, A. D., Toenjes, A., Peyser, P. A., Beilby, J. P., KöRner, A., Kuusisto, J., Laakso, M., Bornstein, S. R., Schwarz, P. E. H., Lakka, T. A., Rauramaa, R., Adair, L. S., Smith, G. D., Spector, T. D., Illig, T., Faire, U. D., Hamsten, A., Gudnason, V., Kivimaki, M., Hingorani, A., Keinanen-Kiukaanniemi, S. M., Saaristo, T. E., Boomsma, D. I., Stefansson, K., Van Der Harst, P., Dupuis, J., Pedersen, N. L., Sattar, N., Harris, T. B., Cucca, F., Ripatti, S., Salomaa, V., Mohlke, K. L., Balkau, B., Froguel, P., Pouta, A., Jarvelin, M. R., Wareham, N. J., Bouatia-Naji, N., McCarthy, M. I., Franks, P. W., Meigs, J. B., Teslovich, T. M., Florez, J. C., Langenberg, C., Ingelsson, E., Prokopenko, I. & Barroso, I., Sep 2012, In: Nature Genetics. 44, 9, p. 991-1005 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    687 Scopus citations

  • Medicago truncatula transporter database: A comprehensive database resource for M. truncatula transporters

    Miao, Z., Li, D., Zhang, Z., Dong, J., Su, Z. & Wang, T., Feb 6 2012, In: BMC genomics. 13, 1, 60.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    11 Scopus citations

  • Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

    Okada, Y., Sim, X., Go, M. J., Wu, J. Y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S. C., Wong, T. Y., Liu, J., Young, T. L., Aung, T., Seielstad, M., Teo, Y. Y., Kim, Y. J., Lee, J. Y. & Han, B. G. & 469 others, Kang, D., Chen, C. H., Tsai, F. J., Chang, L. C., Fann, S. J., Mei, H., Rao, D. C., Hixson, J. E., Chen, S., Katsuya, T., Isono, M., Ogihara, T., Chambers, J. C., Zhang, W., Kooner, J. S., Albrecht, E., Yamamoto, K., Kubo, M., Nakamura, Y., Kamatani, N., Kato, N., He, J., Chen, Y. T., Cho, Y. S., Tai, E. S., Tanaka, T., Chambers, J. C., Zhang, W., Lord, G. M., van der Harst, P., Lawlor, D. A., Sehmi, J. S., Gale, D. P., Wass, M. N., Ahmadi, K. R., Bakker, S. J., Beckmann, J., Bilo, H. J., Bochud, M., Brown, M. J., Caulfield, M. J., Connell, J. M., Cook, H. T., Cotlarciuc, I., Smith, G. D., de Silva, R., Deng, G., Devuyst, O., Dikkeschei, L. D., Dimkovic, N., Dockrell, M., Dominiczak, A., Ebrahim, S., Eggermann, T., Farrall, M., Ferrucci, L., Floege, J., Forouhi, N. G., Gansevoort, R. T., Han, X., Hedblad, B., van der Heide, J. J., Hepkema, B. G., Hernandez-Fuentes, M., Hypponen, E., Johnson, T., de Jong, P. E., Kleefstra, N., Lagou, V., Lapsley, M., Li, Y., Loos, R. J., Luan, J., Luttropp, K., Maréchal, C., Melander, O., Munroe, P. B., Nordfors, L., Parsa, A., Peltonen, L., Penninx, B. W., Perucha, E., Pouta, A., Prokopenko, I., Roderick, P. J., Ruokonen, A., Samani, N. J., Sanna, S., Schalling, M., Schlessinger, D., Schlieper, G., Seelen, M. A., Shuldiner, A. R., Sjögren, M., Smit, J. H., Snieder, H., Soranzo, N., Spector, T. D., Stenvinkel, P., Sternberg, M. J., Swaminathan, R., Tanaka, T., Ubink-Veltmaat, L. J., Uda, M., Vollenweider, P., Wallace, C., Waterworth, D., Zerres, K., Waeber, G., Wareham, N. J., Maxwell, P. H., McCarthy, M. I., Jarvelin, M. R., Mooser, V., Abecasis, G. 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    Research output: Contribution to journal › Article › peer-review

    Open Access
    247 Scopus citations

  • Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration

    Misko, A. L., Sasaki, Y., Tuck, E., Milbrandt, J. & Baloh, R. H., Mar 21 2012, In: Journal of Neuroscience. 32, 12, p. 4145-4155 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    162 Scopus citations

  • Mouse transgenesis in a single locus with independent regulation for multiple fluorophores

    Dougherty, J. D., Zhang, J., Feng, H., Gong, S. & Heintz, N., Jul 12 2012, In: PloS one. 7, 7, e40511.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    9 Scopus citations

  • Multiple peptidoglycan modification networks modulate helicobacter pylori's cell shape, motility, and colonization potential

    Sycuro, L. K., Wyckoff, T. J., Biboy, J., Born, P., Pincus, Z., Vollmer, W. & Salama, N. R., Mar 2012, In: PLoS pathogens. 8, 3, e1002603.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    122 Scopus citations

  • Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

    Yadav, M., Louvet, C., Davini, D., Gardner, J. M., Martinez-Llordella, M., Bailey-Bucktrout, S., Anthony, B. A., Sverdrup, F. M., Head, R., Kuster, D. J., Ruminski, P., Weiss, D., Von Schack, D. & Bluestone, J. A., Sep 2012, In: Journal of Experimental Medicine. 209, 10, p. 1713-1722 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    548 Scopus citations

  • Next generation analytic tools for large scale genetic epidemiology studies of complex diseases

    Mechanic, L. E., Chen, H. S., Amos, C. I., Chatterjee, N., Cox, N. J., Divi, R. L., Fan, R., Harris, E. L., Jacobs, K., Kraft, P., Leal, S. M., McAllister, K., Moore, J. H., Paltoo, D. N., Province, M. A., Ramos, E. M., Ritchie, M. D., Roeder, K., Schaid, D. J. & Stephens, M. & 7 others, Thomas, D. C., Weinberg, C. R., Witte, J. S., Zhang, S., Zöllner, S., Feuer, E. J. & Gillanders, E. M., Jan 2012, In: Genetic Epidemiology. 36, 1, p. 22-35 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    52 Scopus citations

  • NF-κB in neurons-mechanisms and myths

    Barger, S. W. & Mao, X. R., 2012, Transcription Factors CREB and NF-kB: Involvement in Synaptic Plasticity and Memory Formation. Bentham Science Publishers Ltd., p. 113-129 17 p.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

    2 Scopus citations

  • Nicotine dependence and comorbid psychiatric disorders: Examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes

    Chen, L. S., Xian, H., Grucza, R. A., Saccone, N. L., Wang, J. C., Johnson, E. O., Breslau, N., Hatsukami, D. & Bierut, L. J., Jun 2012, In: Drug and Alcohol Dependence. 123, SUPPL.1, p. S42-S51

    Research output: Contribution to journal › Article › peer-review

    Open Access
    13 Scopus citations

  • Novel Modeling of Combinatorial miRNA Targeting Identifies SNP with Potential Role in Bone Density

    Coronnello, C., Hartmaier, R., Arora, A., Huleihel, L., Pandit, K. V., Bais, A. S., Butterworth, M., Kaminski, N., Stormo, G. D., Oesterreich, S. & Benos, P. V., Dec 2012, In: PLoS computational biology. 8, 12, e1002830.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    35 Scopus citations

  • Obesity-insulin targeted genes in the 3p26-25 region in human studies and LG/J and SM/J mice

    Kraja, A. T., Lawson, H. A., Arnett, D. K., Borecki, I. B., Broeckel, U., De Las Fuentes, L., Hunt, S. C., Province, M. A., Cheverud, J. & Rao, D. C., Aug 2012, In: Metabolism: clinical and experimental. 61, 8, p. 1129-1141 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    11 Scopus citations

  • Ontology-based federated data access to human studies information.

    Sim, I., Carini, S., Tu, S. W., Detwiler, L. T., Brinkley, J., Mollah, S. A., Burke, K., Lehmann, H. P., Chakraborty, S., Wittkowski, K. M., Pollock, B. H., Johnson, T. M., Huser, V. & Human Studies Database Project, S. D. P., 2012, In: Unknown Journal. 2012, p. 856-865 10 p.

    Research output: Contribution to journal › Article › peer-review

    5 Scopus citations

  • Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome

    Handley, S. A., Thackray, L. B., Zhao, G., Presti, R., Miller, A. D., Droit, L., Abbink, P., Maxfield, L. F., Kambal, A., Duan, E., Stanley, K., Kramer, J., MacRi, S. C., Permar, S. R., Schmitz, J. E., Mansfield, K., Brenchley, J. M., Veazey, R. S., Stappenbeck, T. S. & Wang, D. & 2 others, Barouch, D. H. & Virgin, H. W., Oct 12 2012, In: Cell. 151, 2, p. 253-266 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    242 Scopus citations

  • Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort

    Jin, S. C., Pastor, P., Cooper, B., Cervantes, S., Benitez, B. A., Razquin, C., Goate, A. & Cruchaga, C., 2012, In: Alzheimer's Research and Therapy. 4, 4, 34.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    91 Scopus citations

  • Population-based rare variant detection via pooled exome or custom hybridization capture with or without individual indexing

    Ramos, E., Levinson, B. T., Chasnoff, S., Hughes, A., Young, A. L., Thornton, K., Li, A., Vallania, F. L. M., Province, M. & Druley, T. E., Dec 6 2012, In: BMC genomics. 13, 1, 683.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    20 Scopus citations

  • Rapid and efficient human mutation detection using a bench-top next-generation DNA sequencer

    Jiang, Q., Turner, T., Sosa, M. X., Rakha, A., Arnold, S. & Chakravarti, A., Jan 2012, In: Human mutation. 33, 1, p. 281-289 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    37 Scopus citations

  • Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence

    Haller, G., Druley, T., Vallania, F. L., Mitra, R. D., Li, P., Akk, G., Steinbach, J. H., Breslau, N., Johnson, E., Hatsukami, D., Stitzel, J., Bierut, L. J. & Goate, A. M., Feb 2012, In: Human molecular genetics. 21, 3, p. 647-655 9 p., ddr498.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    47 Scopus citations

  • Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families

    Cruchaga, C., Chakraverty, S., Mayo, K., Vallania, F. L. M., Mitra, R. D., Faber, K., Williamson, J., Bird, T., Diaz-Arrastia, R., Foroud, T. M., Boeve, B. F., Graff-Radford, N. R., St. Jean, P., Lawson, M., Ehm, M. G., Mayeux, R., Goate, A. M. & for the NIA-LOAD - NCRAD Family Study Consortium, T.N.-L. N. F. S. C., Feb 1 2012, In: PloS one. 7, 2, e31039.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    262 Scopus citations

  • Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases

    Gao, W., Zhu, J., Westfield, L. A., Tuley, E. A., Anderson, P. J. & Sadler, J. E., Aug 3 2012, In: Journal of Biological Chemistry. 287, 32, p. 26944-26952 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    28 Scopus citations

  • Recognition models to predict DNA-binding specificities of homeodomain proteins

    Christensen, R. G., Enuameh, M. S., Noyes, M. B., Brodsky, M. H., Wolfe, S. A. & Stormo, G. D., Jun 2012, In: Bioinformatics. 28, 12, p. i84-i89 bts202.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    34 Scopus citations

  • Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord

    Tien, A. C., Tsai, H. H., Molofsky, A. V., McMahon, M., Foo, L. C., Kaul, A., Dougherty, J. D., Heintz, N., Gutmann, D. H., Barres, B. A. & Rowitch, D. H., Jul 2012, In: Development (Cambridge). 139, 14, p. 2477-2487 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    107 Scopus citations

  • Retrotransposon profiling of RNA polymerase III initiation sites

    Qi, X., Daily, K., Nguyen, K., Wang, H., Mayhew, D., Rigor, P., Forouzan, S., Johnston, M., Mitra, R. D., Baldi, P. & Sandmeyer, S., Apr 2012, In: Genome research. 22, 4, p. 681-692 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    29 Scopus citations

  • ScerTF: A comprehensive database of benchmarked position weight matrices for Saccharomyces species

    Spivak, A. T. & Stormo, G. D., Jan 2012, In: Nucleic acids research. 40, D1, p. D162-D168

    Research output: Contribution to journal › Article › peer-review

    Open Access
    61 Scopus citations

  • SCG10 is a JNK target in the axonal degeneration pathway

    Shin, J. E., Miller, B. R., Babetto, E., Cho, Y., Sasaki, Y., Qayum, S., Russler, E. V., Cavalli, V., Milbrandt, J. & DiAntonio, A., Dec 26 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 52, p. E3696-E3705

    Research output: Contribution to journal › Article › peer-review

    Open Access
    139 Scopus citations

  • Sex and race differences in the prevalence of fatty liver disease as measured by computed tomography liver attenuation in European American and African American participants of the NHLBI family heart study

    North, K. E., Graff, M., Franceschini, N., Reiner, A. P., Feitosa, M. F., Carr, J. J., Gordon-Larsen, P., Wojczynski, M. K. & Borecki, I. B., Jan 2012, In: European Journal of Gastroenterology and Hepatology. 24, 1, p. 9-16 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    21 Scopus citations

  • Single ABCA3 mutations increase risk for neonatal respiratory distress syndrome

    Wambach, J. A., Wegner, D. J., DePass, K., Heins, H., Druley, T. E., Mitra, R. D., An, P., Zhang, Q., Nogee, L. M., Cole, F. S. & Hamvas, A., Dec 2012, In: Pediatrics. 130, 6, p. e1575-e1582

    Research output: Contribution to journal › Article › peer-review

    Open Access
    89 Scopus citations

  • Small- and large-effect quantitative trait locus interactions underlie variation in yeast sporulation efficiency

    Lorenz, K. & Cohen, B. A., Nov 1 2012, In: Genetics. 192, 3, p. 1123-1132 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    36 Scopus citations

  • Smoking and genetic risk variation across populations of European, Asian, and African American ancestry-a meta-analysis of chromosome 15q25

    Chen, L. S., Saccone, N. L., Culverhouse, R. C., Bracci, P. M., Chen, C. H., Dueker, N., Han, Y., Huang, H., Jin, G., Kohno, T., Ma, J. Z., Przybeck, T. R., Sanders, A. R., Smith, J. A., Sung, Y. J., Wenzlaff, A. S., Wu, C., Yoon, D., Chen, Y. T. & Cheng, Y. C. & 42 others, Cho, Y. S., David, S. P., Duan, J., Eaton, C. B., Furberg, H., Goate, A. M., Gu, D., Hansen, H. M., Hartz, S., Hu, Z., Kim, Y. J., Kittner, S. J., Levinson, D. F., Mosley, T. H., Payne, T. J., Rao, D. C., Rice, J. P., Rice, T. K., Schwantes-An, T. H., Shete, S. S., Shi, J., Spitz, M. R., Sun, Y. V., Tsai, F. J., Wang, J. C., Wrensch, M. R., Xian, H., Gejman, P. V., He, J., Hunt, S. C., Kardia, S. L., Li, M. D., Lin, D., Mitchell, B. D., Park, T., Schwartz, A. G., Shen, H., Wiencke, J. K., Wu, J. Y., Yokota, J., Amos, C. I. & Bierut, L. J., May 2012, In: Genetic Epidemiology. 36, 4, p. 340-351 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    67 Scopus citations

  • Spark: A navigational paradigm for genomic data exploration

    Nielsen, C. B., Younesy, H., O'Geen, H., Xu, X., Jackson, A. R., Milosavljevic, A., Wang, T., Costello, J. F., Hirst, M., Farnham, P. J. & Jones, S. J. M., Nov 2012, In: Genome research. 22, 11, p. 2262-2269 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    28 Scopus citations

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    Loh, J., Popkin, D. L., Droit, L., Braaten, D. C., Zhao, G., Zhang, X., Vachharajani, P., Myers, N., Hansen, T. H. & Virgin, H. W., Mar 2012, In: Journal of virology. 86, 5, p. 2887-2893 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    5 Scopus citations