Search results

  • 2015

    Are genetic variants for tobacco smoking associated with cannabis involvement?

    Agrawal, A., Lynskey, M. T., Kapoor, M., Bucholz, K. K., Edenberg, H. J., Schuckit, M., Brooks, A., Hesselbrock, V., Kramer, J., Saccone, N., Tischfield, J. & Bierut, L. J., May 1 2015, In: Drug and Alcohol Dependence. 150, p. 183-187 5 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    11 Scopus citations
  • Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis

    Diaz, M. F., Li, N., Lee, H. J., Adamo, L., Evans, S. M., Willey, H. E., Arora, N., Torisawa, Y. S., Vickers, D. A., Morris, S. A., Naveiras, O., Murthy, S. K., Ingber, D. E., Daley, G. Q., García-Cardeña, G. & Wenzel, P. L., May 4 2015, In: Journal of Experimental Medicine. 212, 5, p. 665-680 16 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    65 Scopus citations
  • Caenorhabditis elegans glp-4 encodes a valyl aminoacyl tRNA synthetase

    Rastogi, S., Borgo, B., Pazdernik, N., Fox, P., Mardis, E. R., Kohara, Y., Havranek, J. & Schedl, T., 2015, In: G3: Genes, Genomes, Genetics. 5, 12, p. 2719-2728 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    25 Scopus citations
  • Can psychometric measurement models inform behavior genetic models? A bayesian model comparison approach

    Wang, T., Wood, P. K. & Heath, A. C., 2015, Dependent Data in Social Sciences Research: Forms, Issues, and Methods of Analysis. Wiedermann, W., von Eye, A. & Stemmler, M. (eds.). Springer New York LLC, p. 231-259 29 p. (Springer Proceedings in Mathematics and Statistics; vol. 145).

    Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

    4 Scopus citations
  • Cell-to-Cell Variability in the Propensity to Transcribe Explains Correlated Fluctuations in Gene Expression

    Sherman, M. S., Lorenz, K., Lanier, M. H. & Cohen, B. A., Nov 1 2015, In: Cell Systems. 1, 5, p. 315-325 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    54 Scopus citations
  • Characterization of Leber congenital amaurosis-associated NMNAT1 mutants

    Sasaki, Y., Margolin, Z., Borgo, B., Havranek, J. J. & Milbrandt, J., Jul 10 2015, In: Journal of Biological Chemistry. 290, 28, p. 17228-17238 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    31 Scopus citations
  • CHRNA5 Risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis-a meta-analysis

    Chen, L. S., Hung, R. J., Baker, T., Horton, A., Culverhouse, R., Saccone, N., Cheng, I., Deng, B., Han, Y., Hansen, H. M., Horsman, J., Kim, C., Lutz, S., Rosenberger, A., Aben, K. K., Andrew, A. S., Breslau, N., Chang, S. C., Dieffenbach, A. K., Dienemann, H., & 36 othersFrederiksen, B., Han, J., Hatsukami, D. K., Johnson, E. O., Pande, M., Wrensch, M. R., McLaughlin, J., Skaug, V., Van Der Heijden, H. F., Wampfler, J., Wenzlaff, A., Woll, P., Zienolddiny, S., Bickeböller, H., Brenner, H., Duell, E. J., Haugen, A., Heinrich, J., Hokanson, J. E., Hunter, D. J., Kiemeney, L. A., Lazarus, P., Le Marchand, L., Liu, G., Mayordomo, J., Risch, A., Schwartz, A. G., Teare, D., Wu, X., Wiencke, J. K., Yang, P., Zhang, Z. F., Spitz, M. R., Kraft, P., Amos, C. I. & Bierut, L. J., May 1 2015, In: Journal of the National Cancer Institute. 107, 5

    Research output: Contribution to journalReview articlepeer-review

    Open Access
    64 Scopus citations
  • Cis-expression quantitative trait loci mapping reveals replicable associations with heroin addiction in OPRM1

    Hancock, D. B., Levy, J. L., Gaddis, N. C., Glasheen, C., Saccone, N. L., Page, G. P., Hulse, G. K., Wildenauer, D., Kelty, E. A., Schwab, S. G., Degenhardt, L., Martin, N. G., Montgomery, G. W., Attia, J., Holliday, E. G., McEvoy, M., Scott, R. J., Bierut, L. J., Nelson, E. C., Kral, A. H., & 1 othersJohnson, E. O., Oct 1 2015, In: Biological Psychiatry. 78, 7, p. 474-484 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    52 Scopus citations
  • Combining MeDIP-seq and MRE-seq to investigate genome-wide CpG methylation

    Li, D., Zhang, B., Xing, X. & Wang, T., 2015, In: Methods. 72, C, p. 29-40 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    84 Scopus citations
  • Construction and evaluation of novel rhesus monkey adenovirus vaccine vectors

    Abbink, P., Maxfield, L. F., Ng'ang'a, D., Borducchi, E. N., Iampietro, M. J., Bricault, C. A., Teigler, J. E., Blackmore, S., Parenteau, L., Wagh, K., Handley, S. A., Zhao, G., Virgin, H. W., Korber, B. & Barouch, D. H., 2015, In: Journal of virology. 89, 3, p. 1512-1522 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    42 Scopus citations
  • Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: A meta-analysis of 50,345 Caucasians

    Fretts, A. M., Follis, J. L., Nettleton, J. A., Lemaitre, R. N., Ngwa, J. S., Wojczynski, M. K., Kalafati, I. P., Varga, T. V., Frazier-Wood, A. C., Houston, D. K., Lahti, J., Ericson, U., Van Den Hooven, E. H., Mikkilä, V., Kiefte-De Jong, J. C., Mozaffarian, D., Rice, K., Renström, F., North, K. E., McKeown, N. M., & 42 othersFeitosa, M. F., Kanoni, S., Smith, C. E., Garcia, M. E., Tiainen, A. M., Sonestedt, E., Manichaikul, A., Van Rooij, F. J. A., Dimitriou, M., Raitakari, O., Pankow, J. S., Djoussé, L., Province, M. A., Hu, F. B., Lai, C. Q., Keller, M. F., Perälä, M. M., Rotter, J. I., Hofman, A., Graff, M., Kähönen, M., Mukamal, K., Johansson, I., Ordovas, J. M., Liu, Y., Männistö, S., Uitterlinden, A. G., Deloukas, P., Seppälä, I., Psaty, B. M., Cupples, L. A., Borecki, I. B., Franks, P. W., Arnett, D. K., Nalls, M. A., Eriksson, J. G., Orho-Melander, M., Franco, O. H., Lehtimäki, T., Dedoussis, G. V., Meigs, J. B. & Siscovick, D. S., Nov 1 2015, In: American Journal of Clinical Nutrition. 102, 5, p. 1266-1278 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    65 Scopus citations
  • Cross-Species Transmission and Differential Fate of an Endogenous Retrovirus in Three Mammal Lineages

    Zhuo, X. & Feschotte, C., Nov 1 2015, In: PLoS pathogens. 11, 11, e1005279.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    37 Scopus citations
  • De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies

    Homsy, J., Zaidi, S., Shen, Y., Ware, J. S., Samocha, K. E., Karczewski, K. J., DePalma, S. R., McKean, D., Wakimoto, H., Gorham, J., Jin, S. C., Deanfield, J., Giardini, A., Porter, G. A., Kim, R., Bilguvar, K., López-Giráldez, F., Tikhonova, I., Mane, S., Romano-Adesman, A., & 21 othersQi, H., Vardarajan, B., Ma, L., Daly, M., Roberts, A. E., Russell, M. W., Mital, S., Newburger, J. W., Gaynor, J. W., Breitbart, R. E., Iossifov, I., Ronemus, M., Sanders, S. J., Kaltman, J. R., Seidman, J. G., Brueckner, M., Gelb, B. D., Goldmuntz, E., Lifton, R. P., Seidman, C. E. & Chung, W. K., Dec 4 2015, In: Science. 350, 6265, p. 1262-1266 5 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    551 Scopus citations
  • De novo transcriptome analysis of Medicago falcata reveals novel insights about the mechanisms underlying abiotic stress-responsive pathway

    Miao, Z., Xu, W., Li, D., Hu, X., Liu, J., Zhang, R., Tong, Z., Dong, J., Su, Z., Zhang, L., Sun, M., Li, W., Du, Z., Hu, S. & Wang, T., Oct 19 2015, In: BMC genomics. 16, 1, p. 1-18 18 p., 818.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    45 Scopus citations
  • Determination of specificity influencing residues for key transcription factor families

    Patel, R. Y., Garde, C. & Stormo, G. D., Sep 1 2015, In: Quantitative Biology. 3, 3, p. 115-123 9 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    2 Scopus citations
  • Developmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos

    Lee, H. J., Lowdon, R. F., Maricque, B., Zhang, B., Stevens, M., Li, D., Johnson, S. L. & Wang, T., Feb 20 2015, In: Nature communications. 6, 6315.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    67 Scopus citations
  • Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation

    Hou, X., Zhang, L., Han, L., Ge, J., Ma, R., Zhang, X., Moley, K., Schedl, T. & Wang, Q., 2015, In: Journal of cell science. 128, 13, p. 2319-2329 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    33 Scopus citations
  • Disease-specific alterations in the enteric virome in inflammatory bowel disease

    Norman, J. M., Handley, S. A., Baldridge, M. T., Droit, L., Liu, C. Y., Keller, B. C., Kambal, A., Monaco, C. L., Zhao, G., Fleshner, P., Stappenbeck, T., McGovern, D. P. B., Keshavarzian, A., Mutlu, E. A., Sauk, J., Gevers, D., Xavier, R. J., Wang, D., Parkes, M. & Virgin, S., Jan 29 2015, In: Cell. 160, 3, p. 447-460 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    873 Scopus citations
  • DNA Motif Databases and Their Uses

    Stormo, G. D., Sep 1 2015, In: Current Protocols in Bioinformatics. 51, 1, p. 2.15.1-2.15.6

    Research output: Contribution to journalArticlepeer-review

    15 Scopus citations
  • Dynein-deficient flagella respond to increased viscosity with contrasting changes in power and recovery strokes

    Wilson, K. S., Gonzalez, O., Dutcher, S. K. & Bayly, P. V., Sep 1 2015, In: Cytoskeleton. 72, 9, p. 477-490 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    13 Scopus citations
  • Early life dynamics of the human gut virome and bacterial microbiome in infants

    Lim, E. S., Zhou, Y., Zhao, G., Bauer, I. K., Droit, L., Ndao, I. M., Warner, B. B., Tarr, P. I., Wang, D. & Holtz, L. R., Oct 1 2015, In: Nature medicine. 21, 10, p. 1228-1234 7 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    447 Scopus citations
  • Epigenetic and transcriptional determinants of the human breast

    Gascard, P., Bilenky, M., Sigaroudinia, M., Zhao, J., Li, L., Carles, A., Delaney, A., Tam, A., Kamoh, B., Cho, S., Griffith, M., Chu, A., Robertson, G., Cheung, D., Li, I., Heravi-Moussavi, A., Moksa, M., Mingay, M., Hussainkhel, A., Davis, B., & 21 othersNagarajan, R. P., Hong, C., Echipare, L., O'Geen, H., Hangauer, M. J., Cheng, J. B., Neel, D., Hu, D., McManus, M. T., Moore, R., Mungall, A., Ma, Y., Plettner, P., Ziv, E., Wang, T., Farnham, P. J., Jones, S. J. M., Marra, M. A., Tlsty, T. D., Costello, J. F. & Hirst, M., Feb 18 2015, In: Nature communications. 6, 6351.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    52 Scopus citations
  • Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area

    Koo, J. W., Mazei-Robison, M. S., Laplant, Q., Egervari, G., Braunscheidel, K. M., Adank, D. N., Ferguson, D., Feng, J., Sun, H., Scobie, K. N., Damez-Werno, D. M., Ribeiro, E., Peña, C. J., Walker, D., Bagot, R. C., Cahill, M. E., Anderson, S. A. R., Labonté, B., Hodes, G. E., Browne, H., & 12 othersChadwick, B., Robison, A. J., Vialou, V. F., Dias, C., Lorsch, Z., Mouzon, E., Lobo, M. K., Dietz, D. M., Russo, S. J., Neve, R. L., Hurd, Y. L. & Nestler, E. J., Mar 27 2015, In: Nature neuroscience. 18, 3, p. 415-425 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    92 Scopus citations
  • Epigenomic annotation of genetic variants using the Roadmap Epigenome Browser

    Zhou, X., Li, D., Zhang, B., Lowdon, R. F., Rockweiler, N. B., Sears, R. L., Madden, P. A. F., Smirnov, I., Costello, J. F. & Wang, T., Apr 1 2015, In: Nature Biotechnology. 33, 4, p. 345-346 2 p.

    Research output: Contribution to journalEditorial

    Open Access
    67 Scopus citations
  • Erratum: Novel genetic locus implicated for HIV-1 acquisition with putative regulatory links to HIV replication and infectivity: A genome-wide association study (PLoS ONE (2015) 10:3( e0118149) 10.1371/journal.pone.0118149)

    Johnson, E. O., Hancock, D. B., Gaddis, N. C., Levy, J. L., Page, G., Novak, S. P., Glasheen, C., Saccone, N. L., Rice, J. P., Moreau, M. P., Doheny, K. F., Romm, J. M., Brooks, A. I. & Kral, A. H., May 29 2015, In: PloS one. 10, 5, e0129671.

    Research output: Contribution to journalComment/debate

    Open Access
  • Examination of endogenous rotund expression and function in developing Drosophila olfactory system using CRISPR-Cas9-mediated protein tagging

    Li, Q., Barish, S., Okuwa, S. & Volkan, P. C., 2015, In: G3: Genes, Genomes, Genetics. 5, 12, p. 2809-2816 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    11 Scopus citations
  • Excess of rare, inherited truncating mutations in autism

    Krumm, N., Turner, T. N., Baker, C., Vives, L., Mohajeri, K., Witherspoon, K., Raja, A., Coe, B. P., Stessman, H. A., He, Z. X., Leal, S. M., Bernier, R. & Eichler, E. E., May 27 2015, In: Nature Genetics. 47, 6, p. 582-588 7 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    414 Scopus citations
  • Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders

    Fairfield, H., Srivastava, A., Ananda, G., Liu, R., Kircher, M., Lakshminarayana, A., Harris, B. S., Karst, S. Y., Dionne, L. A., Kane, C. C., Curtain, M., Berry, M. L., Ward-Bailey, P. F., Greenstein, I., Byers, C., Czechanski, A., Sharp, J., Palmer, K., Gudis, P., Martin, W., & 19 othersTadenev, A., Bogdanik, L., Pratt, C. H., Chang, B., Schroeder, D. G., Cox, G. A., Cliften, P., Milbrandt, J., Murray, S., Burgess, R., Bergstrom, D. E., Donahue, L. R., Hamamy, H., Masri, A., Santoni, F. A., Makrythanasis, P., Antonarakis, S. E., Shendure, J. & Reinholdt, L. G., Jul 1 2015, In: Genome research. 25, 7, p. 948-957 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    43 Scopus citations
  • Open Access
    108 Scopus citations
  • Fmrp targets or not: Long, highly brain-expressed genes tend to be implicated in autism and brain disorders

    Ouwenga, R. L. & Dougherty, J., Mar 11 2015, In: Molecular Autism. 6, 1, 16.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    27 Scopus citations
  • FoxP1 orchestration of ASD-relevant signaling pathways in the striatum

    Araujo, D. J., Anderson, A. G., Berto, S., Runnels, W., Harper, M., Ammanuel, S., Rieger, M. A., Huang, H. C., Rajkovich, K., Loerwald, K. W., Dekker, J. D., Tucker, H. O., Dougherty, J. D., Gibson, J. R. & Konopka, G., Oct 15 2015, In: Genes and Development. 29, 20, p. 2081-2096 16 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    75 Scopus citations
  • Gene × dietary pattern interactions in obesity: Analysis of up to 68 317 adults of European ancestry

    Nettleton, J. A., Follis, J. L., Ngwa, J. S., Smith, C. E., Ahmad, S., Tanaka, T., Wojczynski, M. K., Voortman, T., Lemaitre, R. N., Kristiansson, K., Nuotio, M. L., Houston, D. K., Perälä, M. M., Qi, Q., Sonestedt, E., Manichaikul, A., Kanoni, S., Ganna, A., Mikkilä, V., North, K. E., & 51 othersSiscovick, D. S., Harald, K., Mckeown, N. M., Johansson, I., Rissanen, H., Liu, Y., Lahti, J., Hu, F. B., Bandinelli, S., Rukh, G., Rich, S., Booij, L., Dmitriou, M., Ax, E., Raitakari, O., Mukamal, K., Männistö, S., Hallmans, G., Jula, A., Ericson, U., Jacobs, D. R., Frank, F. J., Deloukas, P., Sjögren, P., Kähönen, M., Djousse, L., Perola, M., Barroso, I., Hofman, A., Stirrups, K., Viikari, J., Uitterlinden, A. G., Kalafati, I. P., Franco, O. H., Mozaffarian, D., Salomaa, V., Borecki, I. B., Knekt, P., Kritchevsky, S. B., Eriksson, J. G., Dedoussis, G. V., Qi, L., Ferrucci, L., Orho-Melander, M., Carola Zillikens, M., Ingelsson, E., Lehtimäki, T., Renström, F., Adrienne Cupples, L., Loos, R. J. F. & Franks, P. W., Apr 28 2015, In: Human molecular genetics. 24, 16, p. 4728-4738 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    80 Scopus citations
  • Gene-environment interactions of circadian-related genes for cardiometabolic traits

    Dashti, H. S., Follis, J. L., Smith, C. E., Tanaka, T., Garaulet, M., Gottlieb, D. J., Hruby, A., Jacques, P. F., Kiefte-De Jong, J. C., Lamon-Fava, S., Scheer, F. A. J. L., Bartz, T. M., Kovanen, L., Wojczynski, M. K., Frazier-Wood, A. C., Ahluwalia, T. S., Perälä, M. M., Jonsson, A., Muka, T., Kalafati, I. P., & 2 othersMikkilä, V. & Ordovás, J. M., Aug 2015, In: Diabetes care. 38, 8, p. 1456-1466 11 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    53 Scopus citations
  • Genetic and genomic approaches to identify genes involved in flagellar assembly in Chlamydomonas reinhardtii

    Lin, H. & Dutcher, S. K., 2015, In: Methods in cell biology. 127, p. 349-386 38 p.

    Research output: Contribution to journalArticlepeer-review

    15 Scopus citations
  • Genetic studies of body mass index yield new insights for obesity biology

    Lifelines Cohort Study & ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium, Feb 12 2015, In: Nature. 518, 7538, p. 197-206 10 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    3120 Scopus citations
  • Genetic variation (CHRNA5), medication (combination nicotine replacement therapy vs. varenicline), and smoking cessation

    Chen, L. S., Baker, T. B., Jorenby, D., Piper, M., Saccone, N., Johnson, E., Breslau, N., Hatsukami, D., Carney, R. M. & Bierut, L. J., Sep 1 2015, In: Drug and Alcohol Dependence. 154, p. 278-282 5 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    34 Scopus citations
  • Genome-wide association study and linkage analysis of the healthy aging index

    Minster, R. L., Sanders, J. L., Singh, J., Kammerer, C. M., Barmada, M. M., Matteini, A. M., Zhang, Q., Wojczynski, M. K., Daw, E. W., Brody, J. A., Arnold, A. M., Lunetta, K. L., Murabito, J. M., Christensen, K., Perls, T. T., Province, M. A. & Newman, A. B., Aug 2015, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 70, 8, p. 1003-1008 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    15 Scopus citations
  • Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI Genetics of Lipid Lowering Drugs and Diet Network (GOLDN)

    Wojczynski, M. K., Parnell, L. D., Pollin, T. I., Lai, C. Q., Feitosa, M. F., O'Connell, J. R., Frazier-Wood, A. C., Gibson, Q., Aslibekyan, S., Ryan, K. A., Province, M. A., Tiwari, H. K., Ordovas, J. M., Shuldiner, A. R., Arnett, D. K. & Borecki, I. B., Oct 1 2015, In: Metabolism: clinical and experimental. 64, 10, p. 1359-1371 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    30 Scopus citations
  • Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

    Cornelis, M. C., Byrne, E. M., Esko, T., Nalls, M. A., Ganna, A., Paynter, N., Monda, K. L., Amin, N., Fischer, K., Renstrom, F., Ngwa, J. S., Huikari, V., Cavadino, A., Nolte, I. M., Teumer, A., Yu, K., Marques-Vidal, P., Rawal, R., Manichaikul, A., Wojczynski, M. K., & 286 othersVink, J. M., Zhao, J. H., Burlutsky, G., Lahti, J., Mikkilä, V., Lemaitre, R. N., Eriksson, J., Musani, S. K., Tanaka, T., Geller, F., Luan, J., Hui, J., Mägi, R., Dimitriou, M., Garcia, M. E., Ho, W. K., Wright, M. J., Rose, L. M., Magnusson, P. K. E., Pedersen, N. L., Couper, D., Oostra, B. A., Hofman, A., Ikram, M. A., Tiemeier, H. W., Uitterlinden, A. G., van Rooij, F. J. A., Barroso, I., Johansson, I., Xue, L., Kaakinen, M., Milani, L., Power, C., Snieder, H., Stolk, R. P., Baumeister, S. E., Biffar, R., Gu, F., Bastardot, F., Kutalik, Z., Jacobs, D. R., Forouhi, N. G., Mihailov, E., Lind, L., Lindgren, C., Michaëlsson, K., Morris, A., Jensen, M., Khaw, K. T., Luben, R. N., Wang, J. J., Männistö, S., Perälä, M. M., Kähönen, M., Lehtimäki, T., Viikari, J., Mozaffarian, D., Mukamal, K., Psaty, B. M., Döring, A., Heath, A. C., Montgomery, G. W., Dahmen, N., Carithers, T., Tucker, K. L., Ferrucci, L., Boyd, H. A., Melbye, M., Treur, J. L., Mellström, D., Hottenga, J. J., Prokopenko, I., Tönjes, A., Deloukas, P., Kanoni, S., Lorentzon, M., Houston, D. K., Liu, Y., Danesh, J., Rasheed, A., Mason, M. A., Zonderman, A. B., Franke, L., Kristal, B. S., Karjalainen, J., Reed, D. R., Westra, H. J., Evans, M. K., Saleheen, D., Harris, T. B., Dedoussis, G., Curhan, G., Stumvoll, M., Beilby, J., Pasquale, L. R., Feenstra, B., Bandinelli, S., Ordovas, J. M., Chan, A. T., Peters, U., Ohlsson, C., Gieger, C., Martin, N. G., Waldenberger, M., Siscovick, D. S., Raitakari, O., Eriksson, J. G., Mitchell, P., Hunter, D. J., Kraft, P., Rimm, E. B., Boomsma, D. I., Borecki, I. B., Loos, R. J. F., Wareham, N. J., Vollenweider, P., Caporaso, N., Grabe, H. J., Neuhouser, M. L., Wolffenbuttel, B. H. R., Hu, F. B., Hyppönen, E., Järvelin, M. R., Cupples, L. A., Franks, P. W., Ridker, P. M., van Duijn, C. M., Heiss, G., Metspalu, A., North, K. E., Ingelsson, E., Nettleton, J. A., van Dam, R. M., Chasman, D. I., Nalls, M. A., Plagnol, V., Hernandez, D. G., Sharma, M., Sheerin, U. M., Saad, M., Simón-Sánchez, J., Schulte, C., Lesage, S., Sveinbjörnsdóttir, S., Arepalli, S., Barker, R., Ben-Shlomo, Y., Berendse, H. W., Berg, D., Bhatia, K., de Bie, R. M. A., Biffi, A., Bloem, B., Bochdanovits, Z., Bonin, M., Bras, J. M., Brockmann, K., Brooks, J., Burn, D. J., Charlesworth, G., Chen, H., Chinnery, P. F., Chong, S., Clarke, C. E., Cookson, M. R., Cooper, J. M., Corvol, J. C., Counsell, C., Damier, P., Dartigues, J. F., Deloukas, P., Deuschl, G., Dexter, D. T., Dijk, K. D. V., Dillman, A., Durif, F., Dürr, A., Edkins, S., Evans, J. R., Foltynie, T., Dong, J., Gardner, M., Gibbs, J. R., Goate, A., Gray, E., Guerreiro, R., Harris, C., Hilten, J. J. V., Hofman, A., Hollenbeck, A., Holton, J., Hu, M., Huang, X., Wurster, I., Mätzler, W., Hudson, G., Hunt, S. E., Huttenlocher, J., Illig, T., Jónsson, P. V., Lambert, J. C., Langford, C., Lees, A., Lichtner, P., Limousin, P., Lopez, G., Lorenz, D., McNeill, A., Moorby, C., Moore, M., Morris, H. R., Morrison, K. E., Mudanohwo, E., O’sullivan, S. S., Pearson, J., Perlmutter, J. S., Pétursson, H., Pollak, P., Post, B., Potter, S., Ravina, B., Revesz, T., Riess, O., Rivadeneira, F., Rizzu, P., Ryten, M., Sawcer, S., Schapira, A., Scheffer, H., Shaw, K., Shoulson, I., Sidransky, E., Smith, C., Spencer, C. C. A., Stefánsson, H., Bettella, F., Stockton, J. D., Strange, A., Talbot, K., Tanner, C. M., Tashakkori-Ghanbaria, A., Tison, F., Trabzuni, D., Traynor, B. J., Uitterlinden, A. G., Velseboer, D., Vidailhet, M., Walker, R., Warrenburg, B. V. D., Wickremaratchi, M., Williams, N., Williams-Gray, C. H., Winder-Rhodes, S., Stefánsson, K., Martinez, M., Wood, N. W., Hardy, J., Heutink, P., Brice, A., Gasser, T., Singleton, A. B., Singleton, A., Cookson, M., Gibbs, J. R., Lila, R., Hernandez, D., Lila, R., Dillman, A., Nalls, M., Zonderman, A., Arepalli, S., Johnson, R., Longo, D., O'brien, R., Traynor, B., Troncoso, J., Brug, M. V. D., Zielke, R., Hardy, J., Weale, M., Ryten, M., Ramasamy, A., Lila, R., Trabzuni, D., Smith, C. & Walker, R., May 30 2015, In: Molecular Psychiatry. 20, 5, p. 647-656 10 p.

    Research output: Contribution to journalComment/debate

    Open Access
    199 Scopus citations
  • Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence

    Hancock, D. B., Reginsson, G. W., Gaddis, N. C., Chen, X., Saccone, N. L., Lutz, S. M., Qaiser, B., Sherva, R., Steinberg, S., Zink, F., Stacey, S. N., Glasheen, C., Chen, J., Gu, F., Frederiksen, B. N., Loukola, A., Gudbjartsson, D. F., Brüske, I., Landi, M. T., Bickeböller, H., & 14 othersMadden, P., Farrer, L., Kaprio, J., Kranzler, H. R., Gelernter, J., Baker, T. B., Kraft, P., Amos, C. I., Caporaso, N. E., Hokanson, J. E., Bierut, L. J., Thorgeirsson, T. E., Johnson, E. O. & Stefansson, K., Oct 6 2015, In: Translational psychiatry. 5, e651.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    70 Scopus citations
  • Gut DNA viromes of Malawian twins discordant for severe acute malnutrition

    Reyes, A., Blanton, L. V., Cao, S., Zhao, G., Manary, M., Trehan, I., Smith, M. I., Wang, D., Virgin, S., Rohwer, F. & Gordon, J. I., Sep 22 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 38, p. 11941-11946 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    212 Scopus citations
  • Heritability of telomere length in a study of long-lived families

    Honig, L. S., Kang, M. S., Cheng, R., Eckfeldt, J. H., Thyagarajan, B., Leiendecker-Foster, C., Province, M. A., Sanders, J. L., Perls, T., Christensen, K., Lee, J. H., Mayeux, R. & Schupf, N., Oct 1 2015, In: Neurobiology of Aging. 36, 10, p. 2785-2790 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    61 Scopus citations
  • Identification of medically actionable secondary findings in the 1000 genomes

    Olfson, E., Cottrell, C. E., Davidson, N. O., Gurnett, C. A., Heusel, J. W., Stitziel, N. O., Chen, L. S., Hartz, S., Nagarajan, R., Saccone, N. L. & Bierut, L. J., Sep 2 2015, In: PloS one. 10, 9, e0135193.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    73 Scopus citations
  • Induction of hematopoietic and endothelial cell program orchestrated by ETS transcription factor ER71/ETV2

    Liu, F., Li, D., Yu, Y. Y. L., Kang, I., Cha, M. J., Kim, J. Y., Park, C., Watson, D. K., Wang, T. & Choi, K., May 1 2015, In: EMBO Reports. 16, 5, p. 654-669 16 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    83 Scopus citations
  • Integrative analysis of 111 reference human epigenomes

    Roadmap Epigenomics Consortium, E. C., Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., Ziller, M. J., Amin, V., Whitaker, J. W., Schultz, M. D., Ward, L. D., Sarkar, A., Quon, G., Sandstrom, R. S., Eaton, M. L., Wu, Y. C., & 76 othersPfenning, A. R., Wang, X., Claussnitzer, M., Liu, Y., Coarfa, C., Harris, R. A., Shoresh, N., Epstein, C. B., Gjoneska, E., Leung, D., Xie, W., Hawkins, R. D., Lister, R., Hong, C., Gascard, P., Mungall, A. J., Moore, R., Chuah, E., Tam, A., Canfield, T. K., Hansen, R. S., Kaul, R., Sabo, P. J., Bansal, M. S., Carles, A., Dixon, J. R., Farh, K. H., Feizi, S., Karlic, R., Kim, A. R., Kulkarni, A., Li, D., Lowdon, R., Elliott, G., Mercer, T. R., Neph, S. J., Onuchic, V., Polak, P., Rajagopal, N., Ray, P., Sallari, R. C., Siebenthall, K. T., Sinnott-Armstrong, N. A., Stevens, M., Thurman, R. E., Wu, J., Zhang, B., Zhou, X., Beaudet, A. E., Boyer, L. A., De Jager, P. L., Farnham, P. J., Fisher, S. J., Haussler, D., Jones, S. J. M., Li, W., Marra, M. A., McManus, M. T., Sunyaev, S., Thomson, J. A., Tlsty, T. D., Tsai, L. H., Wang, W., Waterland, R. A., Zhang, M. Q., Chadwick, L. H., Bernstein, B. E., Costello, J. F., Ecker, J. R., Hirst, M., Meissner, A., Milosavljevic, A., Ren, B., Stamatoyannopoulos, J. A., Wang, T. & Kellis, M., Feb 19 2015, In: Nature. 518, 7539, p. 317-329 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    4165 Scopus citations
  • Intermediate DNA methylation is a conserved signature of genome regulation

    Elliott, G., Hong, C., Xing, X., Zhou, X., Li, D., Coarfa, C., Bell, R. J. A., Maire, C. L., Ligon, K. L., Sigaroudinia, M., Gascard, P., Tlsty, T. D., Harris, R. A., Schalkwyk, L. C., Bilenky, M., Mill, J., Farnham, P. J., Kellis, M., Marra, M. A., Milosavljevic, A., & 4 othersHirst, M., Stormo, G. D., Wang, T. & Costello, J. F., Feb 18 2015, In: Nature communications. 6, 6363.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    75 Scopus citations
  • Interrogating the function of metazoan histones using engineered gene clusters

    McKay, D. J., Klusza, S., Penke, T. J. R., Meers, M. P., Curry, K. P., McDaniel, S. L., Malek, P. Y., Cooper, S. W., Tatomer, D. C., Lieb, J. D., Strahl, B. D., Duronio, R. J. & Matera, A. G., Feb 9 2015, In: Developmental cell. 32, 3, p. 373-386 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    105 Scopus citations
  • Leukocyte Telomere Length and Coronary Artery Calcium

    Hunt, S. C., Kimura, M., Hopkins, P. N., Carr, J. J., Heiss, G., Province, M. A. & Aviv, A., Jul 15 2015, In: American Journal of Cardiology. 116, 2, p. 214-218 5 p., 21114.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    36 Scopus citations
  • Loss of δ-catenin function in severe autism

    Turner, T. N., Sharma, K., Oh, E. C., Liu, Y. P., Collins, R. L., Sosa, M. X., Auer, D. R., Brand, H., Sanders, S. J., Moreno-De-Luca, D., Pihur, V., Plona, T., Pike, K., Soppet, D. R., Smith, M. W., Cheung, S. W., Martin, C. L., State, M. W., Talkowski, M. E., Cook, E., & 3 othersHuganir, R., Katsanis, N. & Chakravarti, A., Apr 2 2015, In: Nature. 520, 7545, p. 51-56 6 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    117 Scopus citations
  • Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

    Wessel, J., Chu, A. Y., Willems, S. M., Wang, S., Yaghootkar, H., Brody, J. A., Dauriz, M., Hivert, M. F., Raghavan, S., Lipovich, L., Hidalgo, B., Fox, K., Huffman, J. E., An, P., Lu, Y., Rasmussen-Torvik, L. J., Grarup, N., Ehm, M. G., Li, L., Baldridge, A. S., & 184 othersStančáková, A., Abrol, R., Besse, C., Boland, A., Bork-Jensen, J., Fornage, M., Freitag, D. F., Garcia, M. E., Guo, X., Hara, K., Isaacs, A., Jakobsdottir, J., Lange, L. A., Layton, J. C., Li, M., Hua Zhao, J., Meidtner, K., Morrison, A. C., Nalls, M. A., Peters, M. J., Sabater-Lleal, M., Schurmann, C., Silveira, A., Smith, A. V., Southam, L., Stoiber, M. H., Strawbridge, R. J., Taylor, K. D., Varga, T. V., Allin, K. H., Amin, N., Aponte, J. L., Aung, T., Barbieri, C., Bihlmeyer, N. A., Boehnke, M., Bombieri, C., Bowden, D. W., Burns, S. M., Chen, Y., Chen, Y. D., Cheng, C. Y., Correa, A., Czajkowski, J., Dehghan, A., Ehret, G. B., Eiriksdottir, G., Escher, S. A., Farmaki, A. E., Frånberg, M., Gambaro, G., Giulianini, F., Goddard, W. A., Goel, A., Gottesman, O., Grove, M. L., Gustafsson, S., Hai, Y., Hallmans, G., Heo, J., Hoffmann, P., Ikram, M. K., Jensen, R. A., Jørgensen, M. E., Jørgensen, T., Karaleftheri, M., Khor, C. C., Kirkpatrick, A., Kraja, A. T., Kuusisto, J., Lange, E. M., Lee, I. T., Lee, W. J., Leong, A., Liao, J., Liu, C., Liu, Y., Lindgren, C. M., Linneberg, A., Malerba, G., Mamakou, V., Marouli, E., Maruthur, N. M., Matchan, A., McKean-Cowdin, R., McLeod, O., Metcalf, G. A., Mohlke, K. L., Muzny, D. M., Ntalla, I., Palmer, N. D., Pasko, D., Peter, A., Rayner, N. W., Renström, F., Rice, K., Sala, C. F., Sennblad, B., Serafetinidis, I., Smith, J. A., Soranzo, N., Speliotes, E. K., Stahl, E. A., Stirrups, K., Tentolouris, N., Thanopoulou, A., Torres, M., Traglia, M., Tsafantakis, E., Javad, S., Yanek, L. R., Zengini, E., Becker, D. M., Bis, J. C., Brown, J. B., Adrienne Cupples, L., Hansen, T., Ingelsson, E., Karter, A. J., Lorenzo, C., Mathias, R. A., Norris, J. M., Peloso, G. M., Sheu, W. H. H., Toniolo, D., Vaidya, D., Varma, R., Wagenknecht, L. E., Boeing, H., Bottinger, E. P., Dedoussis, G., Deloukas, P., Ferrannini, E., Franco, O. H., Franks, P. W., Gibbs, R. A., Gudnason, V., Hamsten, A., Harris, T. B., Hattersley, A. T., Hayward, C., Hofman, A., Jansson, J. H., Langenberg, C., Launer, L. J., Levy, D., Oostra, B. A., O'Donnell, C. J., O'Rahilly, S., Padmanabhan, S., Pankow, J. S., Polasek, O., Province, M. A., Rich, S. S., Ridker, P. M., Rudan, I., Schulze, M. B., Smith, B. H., Uitterlinden, A. G., Walker, M., Watkins, H., Wong, T. Y., Zeggini, E., Laakso, M., Borecki, I. B., Chasman, D. I., Pedersen, O., Psaty, B. M., Shyong Tai, E., Van Duijn, C. M., Wareham, N. J., Waterworth, D. M., Boerwinkle, E., Linda Kao, W. H., Florez, J. C., Loos, R. J. F., Wilson, J. G., Frayling, T. M., Siscovick, D. S., Dupuis, J., Rotter, J. I., Meigs, J. B., Scott, R. A. & Goodarzi, M. O., Feb 2015, In: Nature communications. 6, 5897.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    155 Scopus citations