Department of Developmental Biology

1989

Inhibition of cytotoxic T lymphocyte-mediated lysis and cellular proliferation by isoquinoline sulfonamide protein kinase inhibitors. Evidence for the involvement of protein kinase C in lymphocyte function

Juszczak, R. J. & Russell, J. H., 1989, In: Journal of Biological Chemistry. 264, 2, p. 810-815 6 p.

Research output: Contribution to journal › Article › peer-review

Mutagenesis and chimeric genes define determinants in the β subunits of human chorionic gonadotropin and lutropin for secretion and assembly

Matzuk, M. M., Spangler, M. M., Camel, M., Suganuma, N. & Boime, I., 1989, In: Journal of Cell Biology. 109, 4 I, p. 1429-1438 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

56 Scopus citations

Preparation of 14,15-secoestra-1,3,5(10)-trien-15-ynes, inhibitors of estradiol dehydrogenase

Auchus, R. J., Palmer, J. O., Carrell, H. L. & Covey, D. F., 1989, In: Steroids. 53, 1-2, p. 77-96 20 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Protein kinase C regulation of terminal deoxynucleotidyl transferase

Tillinghast, J. P., Russell, J. H., Fields, L. E. & Loh, D. Y., Jan 1 1989, In: Journal of Immunology. 143, 7, p. 2378-2383 6 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Regulation of the human chorionic gonadotrophin beta subunit genes.

Boime, I., Otani, T., Otani, F. & Chaplin, D., 1989, In: Journal of reproduction and fertility. Supplement. 37, p. 1-10 10 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Site specificity of the chorionic gonadotropin N-linked oligosaccharides in signal transduction

Matzuk, M. M., Keene, J. L. & Boime, I., 1989, In: Journal of Biological Chemistry. 264, 5, p. 2409-2414 6 p.

Research output: Contribution to journal › Article › peer-review

224 Scopus citations

Site-specific processing of the N-linked oligosaccharides of the human chorionic gonadotropin α subunit

Bielinska, M., Matzuk, M. M. & Boime, I., 1989, In: Journal of Biological Chemistry. 264, 29, p. 17113-17118 6 p.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila.

Kornfeld, K., Saint, R. B., Beachy, P. A., Harte, P. J., Peattie, D. A. & Hogness, D. S., Feb 1989, In: Genes & development. 3, 2, p. 243-258 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

131 Scopus citations

Studies on the control mechanism of hCGβ gene expression - Focusing on identification of promoter and other transcriptional regulatory elements

Otani, T., Boime, I. & Mochizuki, M., Jan 1 1989, In: Acta Obstetrica et Gynaecologica Japonica. 41, 7, p. 837-844 8 p.

Research output: Contribution to journal › Article › peer-review

Studies on the transcriptional regulatory elements of the hCGβ. Gene cluster using a choriocarcinoma cell Line which expresses hCGβ eutopically

Otani, T., Boime, I. & Mochizuki, M., Dec 1 1989, In: Acta Obstetrica et Gynaecologica Japonica. 41, 12, p. 1885-1890 6 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages

Wilhelm, S. M., Collier, I. E., Marmer, B. L., Eisen, A. Z., Grant, G. A. & Goldberg, G. I., 1989, In: Journal of Biological Chemistry. 264, 29, p. 17213-17221 9 p.

Research output: Contribution to journal › Article › peer-review

1103 Scopus citations

The function of PS integrins in Drosophila wing morphogenesis

Wilcox, M., DiAntonio, A. & Leptin, M., 1989, In: Development. 107, 4, p. 891-897 7 p.

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

The localization of the divergent beta 2-tubulin isotype in the microtubular arrays of Physarum polycephalum.

Diggins-Gilicinski, M., Solnica-Krezel, L., Burland, T. G., Paul, E. C. & Dove, W. F., Oct 1989, In: Journal of cell science. 94 ( Pt 2), p. 217-226 10 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase

He, C., Wilhelm, S. M., Pentland, A. P., Marmer, B. L., Grant, G. A., Eisen, A. Z. & Goldberg, G. I., 1989, In: Proceedings of the National Academy of Sciences of the United States of America. 86, 8, p. 2632-2636 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

569 Scopus citations

Transcriptional activation and repression by Ultrabithorax proteins in cultured Drosophila cells

Krasnow, M. A., Saffman, E. E., Kornfeld, K. & Hogness, D. S., Jun 16 1989, In: Cell. 57, 6, p. 1031-1043 13 p.

Research output: Contribution to journal › Article › peer-review

251 Scopus citations

1988

[19-¹⁴C]androstenedione: A new substrate for assaying aromatase and studying its reaction mechanism

Covey, D. F., McMullan, P. C., Wixler, L. L. & Cabell, M., Nov 30 1988, In: Biochemical and Biophysical Research Communications. 157, 1, p. 81-86 6 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Activation of a β-tubulin gene during early development of the plasmodium in Physarum polycephalum

Solnica-Krezel, L., Dove, W. F. & Burland, T. G., 1988, In: Journal of General Microbiology. 134, 5, p. 1323-1331 9 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Amino acid sequence of porcine heart fumarase

Sacchettini, J. C., Frazier, M. W., Chiara, D. C., Banaszak, L. J. & Grant, G. A., May 31 1988, In: Biochemical and Biophysical Research Communications. 153, 1, p. 435-440 6 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Amino Acid Sequence of κ-Flavitoxin: Establishment of a New Family of Snake Venom Neurotoxins

Grant, G. A., Frazier, M. W. & Chiappinelli, V. A., May 1 1988, In: Biochemistry. 27, 10, p. 3794-3798 5 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Antigen as a positive and negative regulator of proliferation in cytotoxic lymphocytes. A model for the differential regulation of proliferation and lytic activity

Russell, J. H., Manning, D. E., McCulley, D. E. & Meleedy-Rey, P., 1988, In: Journal of Immunology. 140, 6, p. 1796-1801 6 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Characterization of pregnant mare's serum gonadotropin-stimulated rat ovarian aromatase and its inhibition by 10-propargylestr-4-ene-3,17-dione

Brandt, M. E., Puett, D., Covey, D. F. & Zimniski, S. J., Sep 1988, In: Journal of Steroid Biochemistry. 31, 3, p. 317-324 8 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen

Collier, I. E., Wilhelm, S. M., Eisen, A. Z., Marmer, B. L., Grant, G. A., Seltzer, J. L., Kronberger, A., He, C., Bauer, E. A. & Goldberg, G. I., 1988, In: Journal of Biological Chemistry. 263, 14, p. 6579-6587 9 p.

Research output: Contribution to journal › Article › peer-review

1039 Scopus citations

Identification of a promoter region in the CGβ gene cluster

Otani, T., Otani, F., Krych, M., Chaplin, D. D. & Boime, I., 1988, In: Journal of Biological Chemistry. 263, 15, p. 7322-7329 8 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Loss of adhesion. A novel and distinct effect of the cytotoxic T lymphocyte-target interaction

Russell, J. H., Musil, L. & McCulley, D. E., 1988, In: Journal of Immunology. 140, 2, p. 427-432 6 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Phosphorylation of a 15- to 17-kDa protein correlated with lytic function in cytotoxic T lymphocytes

Filiaggi, M. C., McCulley, D. E. & Russell, J. H., 1988, In: Journal of Immunology. 140, 8, p. 2702-2707 6 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Site-specific mutagenesis defines the intracellular role of the asparagine-linked oligosaccharides of chorionic gonadotropin β subunit

Matzuk, M. M. & Boime, I., 1988, In: Journal of Biological Chemistry. 263, 32, p. 17106-17111 6 p.

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Solid-state NMR observatioon of cysteine and lysine Michael adducts of inactivated estradiol dehydrogenase

Asuchus, R. J., Covey, D. F., Bork, V. & Schaefer, J., 1988, In: Journal of Biological Chemistry. 263, 24, p. 11640-11645 6 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

The glycoprotein α-subunit is critical for secretion and stability of the human thyrotropin β-subunit

Matzuk, M. M., Kornmeier, C. M., Whitfield, G. K., Kourides, I. A. & Boime, I., 1988, In: Molecular Endocrinology. 2, 2, p. 95-100 6 p.

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

The role of the asparagine-linked oligosaccharides of the α subunit in the secretion and assembly of human chorionic gonadotropin

Matzuk, M. M. & Boime, I., 1988, In: Journal of Cell Biology. 106, 4, p. 1049-1059 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

202 Scopus citations

α₁-Adrenergic agonists selectively suppress voltage-dependent K⁺ currents in rat ventricular myocytes

Apkon, M. & Nerbonne, J. M., 1988, In: Proceedings of the National Academy of Sciences of the United States of America. 85, 22, p. 8756-8760 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

191 Scopus citations

α-Substituted thiobutyrolactones potentiate GABA currents in voltage-clamped chick spinal cord neurons

Baker, K., Yang, J., Covey, D. F., Clifford, D. B. & Zorumski, C. F., Apr 22 1988, In: Neuroscience Letters. 87, 1-2, p. 133-138 6 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

1987

An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice.

Pinkert, C. A., Ornitz, D. M., Brinster, R. L. & Palmiter, R. D., May 1987, In: Genes & development. 1, 3, p. 268-276 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

343 Scopus citations

A rare example of extremely strong carbon—carbon coupling: Analysis of ¹³C and ¹H NMR spectra of a ¹³C₂‐acetylenic ketone

Auchus, R. J., d'Avignon, A. & Covey, D. F., May 1987, In: Magnetic Resonance in Chemistry. 25, 5, p. 462-465 4 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Blockade of Ca²⁺ and K⁺ currents in bag cell neurons of Aplysia californica by dihydropyridine Ca²⁺ antagonists

Nerbonne, J. M. & Gurney, A. M., 1987, In: Journal of Neuroscience. 7, 3, p. 882-893 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

cDNA sequence of a novel sex-limited protein (Slp) from mice constitutive for Slp expression. Sequence comparisons suggest that Slp has no functional role.

Sepich, D. S., Rosa, P. A. & Ogata, R. T., Apr 15 1987, In: Journal of Biological Chemistry. 262, 11, p. 4935-4938 4 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Comparison of the Precursor and Mature Forms of Rat Heart Mitochondrial Malate Dehydrogenase

Grant, P. M., Roderick, S. L., Grant, G. A., Banaszak, L. J. & Strauss, A. W., 1987, In: Biochemistry. 26, 1, p. 128-134 7 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Cosmid mapping of the human chorionic gonadotropin β subunit genes by field-inversion gel elect rophoresis

Graham, M. Y., Otani, T., Boime, I., Olson, M. V., Carle, G. F. & Chaplin, D. D., Jun 11 1987, In: Nucleic acids research. 15, 11, p. 4437-4448 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Cytotoxic Activity of a Polyamine Analogue, Monoaziridinylputrescine, against the PC-3 Human Prostatic Carcinoma Cell Line

Heston, W. D. W., Yang, C. R., Pliner, L., Russo, P. & Covey, D. F., Jul 1987, In: Cancer research. 47, 14, p. 3627-3631 5 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Cytotoxic and non-cytotoxic N-alkyl derivatives of putrescine: effect on polyamine uptake and growth of prostatic cancer cells in vitro

Heston, W. D. W., Watanabe, K. A., Pankiewicz, K. W. & Covey, D. F., Jun 1 1987, In: Biochemical Pharmacology. 36, 11, p. 1849-1852 4 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Dehydrogenase Inactivation by an Enzyme-Generated Acetylenic Ketone: Identification of a Lysyl Enaminone by¹³C NMR

Auchus, R. J. & Covey, D. F., Jan 1 1987, In: Journal of the American Chemical Society. 109, 1, p. 280-282 3 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Effects of anticonvulsant and convulsant gamma-butyrolactones and thiobutyrolactones on gaba-mediated chloride uptake

Naritoku, D. K., Levine, J. A., Covey, D. F. & Ferrendelli, J. A., Mar 15 1987, In: Biochemical Pharmacology. 36, 6, p. 797-800 4 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Effects of preventing O-glycosylation on the secretion of human chorionic gonadotropin in Chinese hamster ovary cells

Matzuk, M. M., Krieger, M., Corless, C. L. & Boime, I., 1987, In: Proceedings of the National Academy of Sciences of the United States of America. 84, 18, p. 6354-6358 5 p.

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Gonadotropin beta subunits determine the rate of assembly and the oligosaccharide processing of hormone dimmer in transfected cells

Corless, C. L., Matzuk, M. M., Ramabhadran, T. V., Krichevsky, A. & Boime, I., 1987, In: Journal of Cell Biology. 104, 5, p. 1173-1181 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

95 Scopus citations

Gonadotropin α subunit. Differential processing of free and combined forms in human trophoblast and transfected mouse cells

Corless, C. L., Bielinska, M., Ramabhadran, T. V., Daniels-McQueen, S., Otani, T., Reitz, B. A., Tiemeier, D. C. & Boime, I., 1987, In: Journal of Biological Chemistry. 262, 29, p. 14197-14203 7 p.

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Human skin fibroblast stromelysin: Structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells

Wilhelm, S. M., Collier, I. E., Kronberger, A., Eisen, A. Z., Marmer, B. L., Grant, G. A., Bauer, E. A. & Goldberg, G. I., 1987, In: Proceedings of the National Academy of Sciences of the United States of America. 84, 19, p. 6725-6729 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

314 Scopus citations

Inhibition of aromatase activity and of endocrine-responsive tumor growth by 10-propargylestr-4-ene-3, 17-dione and its 17-propionate derivative

Zimniski, S. J., Brandt, M. E., Covey, D. F. & Puett, D., 1987, In: Steroids. 50, 1-3, p. 135-146 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

In vivo depletion of mannose receptor bearing cells from rat liver by ricin A chain: Effects on clearance of β-glucuronidase

Simmons, B. M., Stahl, P. D. & Russell, J. H., Jul 31 1987, In: Biochemical and Biophysical Research Communications. 146, 2, p. 849-854 6 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Metabolism of 19-methyl substituted steroids and a proposal for the third aromatase monooxygenation

Covey, D. F., Carrell, H. L. & Beusen, D. D., 1987, In: Steroids. 50, 4-6, p. 363-374 12 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Metabolism of 19-Methyl-Substituted Steroids by Human Placental Aromatase

Beusen, D. D., Covey, D. F. & Carrell, H. L., 1987, In: Biochemistry. 26, 24, p. 7833-7841 9 p.

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

MHC-specific cytotoxic T lymphocyte killing of dissociated sympathetic neuronal cultures

Manning, P. T., Johnson, E. M., Wilcox, C. L., Palmatier, M. A. & Russell, J. H., 1987, In: American Journal of Pathology. 128, 3, p. 395-409 15 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Department of Developmental Biology

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