Department of Developmental Biology

Research output

Research output per year 1967 2000 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

• 2183 Article
• 221 Review article
• 60 Comment/debate
• 58 Chapter
• 74 More
  • 22 Short survey
  • 21 Editorial
  • 14 Letter
  • 10 Conference contribution
  • 4 Conference article
  • 2 Paper
  • 1 Foreword/postscript

Research output per year

Research output per year

Search results

• 2023

  SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia

  Srivastava, S., Shaked, H. M., Gable, K., Gupta, S. D., Pan, X., Somashekarappa, N., Han, G., Mohassel, P., Gotkine, M., Doney, E., Goldenberg, P., Tan, Q. K. G., Gong, Y., Kleinstiver, B., Wishart, B., Cope, H., Pires, C. B., Stutzman, H., Spillmann, R. C., Alejandro, M. E., & 293 othersAzamian, M. S., Bacino, C. A., Balasubramanyam, A., Burrage, L. C., Chao, H. T., Clark, G. D., Craigen, W. J., Dai, H., Dhar, S. U., Emrick, L. T., Goldman, A. M., Hanchard, N. A., Jamal, F., Karaviti, L., Lalani, S. R., Lee, B. H., Lewis, R. A., Marom, R., Moretti, P. M., Murdock, D. R., Nicholas, S. K., Orengo, J. P., Posey, J. E., Potocki, L., Rosenfeld, J. A., Samson, S. L., Scott, D. A., Tran, A. A., Vogel, T. P., Wangler, M. F., Yamamoto, S., Eng, C. M., Liu, P., Ward, P. A., Behrens, E., Deardorff, M., Falk, M., Hassey, K., Sullivan, K., Vanderver, A., Goldstein, D. B., Cope, H., Mcconkie-Rosell, A., Schoch, K., Shashi, V., Smith, E. C., Spillmann, R. C., Sullivan, J. A., Tan, Q. K. G., Walley, N. M., Agrawal, P. B., Beggs, A. H., Berry, G. T., Briere, L. C., Cobban, L. A., Coggins, M., Cooper, C. M., Fieg, E. L., High, F., Holm, I. A., Korrick, S., Krier, J. B., Lincoln, S. A., Loscalzo, J., Maas, R. L., Macrae, C. A., Pallais, J. C., Rao, D. A., Rodan, L. H., Silverman, E. K., Stoler, J. M., Sweetser, D. A., Walker, M., Walsh, C. A., Esteves, C., Kelley, E. G., Kohane, I. S., Leblanc, K., Mccray, A. T., Nagy, A., Dasari, S., Lanpher, B. C., Lanza, I. R., Morava, E., Oglesbee, D., Bademci, G., Barbouth, D., Bivona, S., Carrasquillo, O., Chang, T. C. P., Forghani, I., Grajewski, A., Isasi, R., Lam, B., Levitt, R., Liu, X. Z., Mccauley, J., Sacco, R., Saporta, M., Schaechter, J., Tekin, M., Telischi, F., Thorson, W., Zuchner, S., Colley, H. A., Dayal, J. G., Eckstein, D. J., Findley, L. C., Krasnewich, D. M., Mamounas, L. A., Manolio, T. A., Mulvihill, J. J., Lamoure, G. L., Goldrich, M. P., Urv, T. K., Doss, A. L., Acosta, M. T., Bonnenmann, C., D'souza, P., Draper, D. D., Ferreira, C., Godfrey, R. A., Groden, C. A., Macnamara, E. F., Maduro, V. V., Markello, T. C., Nath, A., Novacic, D., Pusey, B. N., Toro, C., Wahl, C. E., Baker, E., Burke, E. A., Adams, D. R., Gahl, W. A., Malicdan, M. C. V., Tifft, C. J., Wolfe, L. A., Yang, J., Power, B., Gochuico, B., Huryn, L., Latham, L., Davis, J., Mosbrook-Davis, D., Rossignol, F., Solomon, B., Macdowall, J., Thurm, A., Zein, W., Yousef, M., Adam, M., Amendola, L., Bamshad, M., Beck, A., Bennett, J., Berg-Rood, B., Blue, E., Boyd, B., Byers, P., Chanprasert, S., Cunningham, M., Dipple, K., Doherty, D., Earl, D., Glass, I., Golden-Grant, K., Hahn, S., Hing, A., Hisama, F. M., Horike-Pyne, M., Jarvik, G. P., Jarvik, J., Jayadev, S., Lam, C., Maravilla, K., Mefford, H., Merritt, J. L., Mirzaa, G., Nickerson, D., Raskind, W., Rosenwasser, N., Scott, C. R., Sun, A., Sybert, V., Wallace, S., Wener, M., Wenger, T., Ashley, E. A., Bejerano, G., Bernstein, J. A., Bonner, D., Coakley, T. R., Fernandez, L., Fisher, P. G., Fresard, L., Hom, J., Huang, Y., Kohler, J. N., Kravets, E., Majcherska, M. M., Martin, B. A., Marwaha, S., Mccormack, C. E., Raja, A. N., Reuter, C. M., Ruzhnikov, M., Sampson, J. B., Smith, K. S., Sutton, S., Tabor, H. K., Tucker, B. M., Wheeler, M. T., Zastrow, D. B., Zhao, C., Byrd, W. E., Crouse, A. B., Might, M., Nakano-Okuno, M., Whitlock, J., Brown, G., Butte, M. J., Dell'angelica, E. C., Dorrani, N., Douine, E. D., Fogel, B. L., Gutierrez, I., Huang, A., Krakow, D., Lee, H., Loo, S. K., Mak, B. C., Martin, M. G., Martínez-Agosto, J. A., Mcgee, E., Nelson, S. F., Nieves-Rodriguez, S., Palmer, C. G. S., Papp, J. C., Parker, N. H., Renteria, G., Signer, R. H., Sinsheimer, J. S., Wan, J., Wang, L. K., Perry, K. W., Woods, J. D., Alvey, J., Andrews, A., Bale, J., Bohnsack, J., Botto, L., Carey, J., Pace, L., Longo, N., Marth, G., Moretti, P., Quinlan, A., Velinder, M., Viskochi, D., Bayrak-Toydemir, P., Mao, R., Westerfield, M., Bican, A., Brokamp, E., Duncan, L., Hamid, R., Kennedy, J., Kozuira, M., Newman, J. H., Phillipsiii, J. A., Rives, L., Robertson, A. K., Solem, E., Cogan, J. D., Cole, F. S., Hayes, N., Kiley, D., Sisco, K., Wambach, J., Wegner, D., Baldridge, D., Pak, S., Schedl, T., Shin, J., Solnica-Krezel, L., Sadjadi, R., Elpeleg, O., Lee, C. H., Bellen, H. J., Edvardson, S., Eichler, F. & Dunn, T. M., Apr 1 2023, In: Brain. 146, 4, p. 1420-1435 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hereditary Spastic Paraplegia 100%
  • Serine C-Palmitoyltransferase 94%
  • Sphingolipids 82%
  • Drosophila 20%
  • Exome 13%
  4 Scopus citations

• Targeted deletion of Fgf9 in tendon disrupts mineralization of the developing enthesis

  Ganji, E., Leek, C., Duncan, W., Patra, D., Ornitz, D. M. & Killian, M. L., Mar 2023, In: FASEB Journal. 37, 3, e22777.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fibroblast Growth Factor 9 100%
  • Tendons 53%
  • Mouse Fgf9 protein 31%
  • Collagen Type X 21%
  • Cre recombinase 19%
  1 Scopus citations

• The Mechanism of Enantioselective Neurosteroid Actions on GABA_A Receptors

  Tateiwa, H., Chintala, S. M., Chen, Z., Wang, L., Amtashar, F., Bracamontes, J., Germann, A. L., Pierce, S. R., Covey, D. F., Akk, G. & Evers, A. S., Feb 2023, In: Biomolecules. 13, 2, 341.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pregnanolone 100%
  • Neurosteroids 93%
  • GABA-A Receptors 74%
  • Binding Site 36%
  • Enantioselectivity 30%
  3 Scopus citations

• The serine/threonine kinase Back seat driver prevents cell fusion to maintain cell identity

  Yang, S. & Johnson, A. N., Mar 2023, In: Developmental Biology. 495, p. 35-41 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Cell Fusion 100%
  • Protein-Serine-Threonine Kinases 94%
  • Back 84%
  • Muscles 28%
  • Embryonic Structures 15%

• The structure of NAD⁺ consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations

  Klontz, E., Obi, J. O., Wang, Y., Glendening, G., Carr, J., Tsibouris, C., Buddula, S., Nallar, S., Soares, A. S., Beckett, D., Redzic, J. S., Eisenmesser, E., Palm, C., Schmidt, K., Scudder, A. H., Obiorah, T., Essuman, K., Milbrandt, J., Diantonio, A., Ray, K., & 3 othersSnyder, M. L. D., Deredge, D. & Snyder, G. A., Nov 2023, In: Journal of Biological Chemistry. 299, 11, 105290.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acinetobacter baumannii 100%
  • NAD 84%
  • Kinetics 59%
  • Hydrolases 48%
  • Protein 33%

• UNC-49 is a redox-sensitive GABA_A receptor that regulates the mitochondrial unfolded protein response cell nonautonomously

  Pohl, F., Germann, A. L., Mao, J., Hou, S., Bakare, B., Lin, P. K. T., Yates, K., Nonet, M. L., Akk, G., Kornfeld, K. & Held, J. M., Nov 2023, In: Science Advances. 9, 44, eadh2584.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Unfolded Protein Response 100%
  • Mitochondrial Proteins 91%
  • GABA-A Receptors 86%
  • Proteostasis 78%
  • Oxidation-Reduction 76%

• VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

  Lee, C., Chen, R., Sun, G., Liu, X., Lin, X., He, C., Xing, L., Liu, L., Jensen, L. D., Kumar, A., Langer, H. F., Ren, X., Zhang, J., Huang, L., Yin, X., Kim, J. K., Zhu, J., Huang, G., Li, J., Lu, W., & 28 othersChen, W., Liu, J., Hu, J., Sun, Q., Lu, W., Fang, L., Wang, S., Kuang, H., Zhang, Y., Tian, G., Mi, J., Kang, B. A., Narazaki, M., Prodeus, A., Schoonjans, L., Ornitz, D. M., Gariepy, J., Eelen, G., Dewerchin, M., Yang, Y., Ou, J. S., Mora, A., Yao, J., Zhao, C., Liu, Y., Carmeliet, P., Cao, Y. & Li, X., Dec 2023, In: Signal Transduction and Targeted Therapy. 8, 1, 305.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Vascular Endothelial Growth Factor B 100%
  • Fibroblast Growth Factor 2 66%
  • Vascular Endothelial Growth Factor A 11%
  • Angiogenesis Inhibitors 8%
  • Growth 3%
  1 Scopus citations
• 2022

  A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells

  Dong, C., Fu, S., Karvas, R. M., Chew, B., Fischer, L. A., Xing, X., Harrison, J. K., Popli, P., Kommagani, R., Wang, T., Zhang, B. & Theunissen, T. W., Dec 2022, In: Nature communications. 13, 1, 2548.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • stem cells 100%
  • genome 94%
  • genes 84%
  • Clustered Regularly Interspaced Short Palindromic Repeats 83%
  • Trophoblasts 79%
  12 Scopus citations

• Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment

  Whitson, J. A., Johnson, R., Wang, L., Bammler, T. K., Imai, S. I., Zhang, H., Fredrickson, J., Latorre-Esteves, E., Bitto, A., MacCoss, M. J. & Rabinovitch, P. S., Jun 2022, In: GeroScience. 44, 3, p. 1621-1639 19 p.

  Research output: Contribution to journal › Article › peer-review

  • Nicotinamide Mononucleotide 91%
  • nicotinamide 67%
  • acetylation 57%
  • Proteome 55%
  • proteome 51%
  4 Scopus citations

• Age-related Huntington’s disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy

  Oh, Y. M., Lee, S. W., Kim, W. K., Chen, S., Church, V. A., Cates, K., Li, T., Zhang, B., Dolle, R. E., Dahiya, S., Pak, S. C., Silverman, G. A., Perlmutter, D. H. & Yoo, A. S., Nov 2022, In: Nature neuroscience. 25, 11, p. 1420-1433 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Huntington Disease 100%
  • Corpus Striatum 87%
  • Autophagy 86%
  • Disease Progression 71%
  • Neurons 55%
  14 Scopus citations

• A laboratory and simulation platform to integrate individual life history traits and population dynamics

  Scharf, A., Mitteldorf, J., Armstead, B., Schneider, D., Jin, H., Kocsisova, Z., Tan, C. H., Sanchez, F., Brady, B., Ram, N., DiAntonio, G. B., Wilson, A. M. & Kornfeld, K., Feb 2022, In: Nature Computational Science. 2, 2, p. 90-101 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Population dynamics 100%
  • Simulation platform 76%
  • Aging of materials 54%
  • Animals 21%
  • Computer simulation 12%
  2 Scopus citations

• A novel DPH5-related diphthamide-deficiency syndrome causing embryonic lethality or profound neurodevelopmental disorder

  Undiagnosed Diseases Network, Jul 2022, In: Genetics in Medicine. 24, 7, p. 1567-1582 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • diphthamide 100%
  • Neurodevelopmental Disorders 61%
  • Adenosine 34%
  • Computer Simulation 33%
  • Yeasts 28%
  1 Scopus citations

• A pathogenic mechanism associated with myopathies and structural birth defects involves TPM2-directed myogenesis

  McAdow, J., Yang, S., Ou, T., Huang, G., Dobbs, M. B., Gurnett, C. A., Greenberg, M. J. & Johnson, A. N., Jun 22 2022, In: JCI Insight. 7, 12, e152466.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tropomyosin 100%
  • Muscle Development 89%
  • Muscular Diseases 82%
  • Arthrogryposis 55%
  • Nemaline Myopathies 40%
  3 Scopus citations

• A phytobacterial TIR domain effector manipulates NAD⁺ to promote virulence

  Eastman, S., Smith, T., Zaydman, M. A., Kim, P., Martinez, S., Damaraju, N., DiAntonio, A., Milbrandt, J., Clemente, T. E., Alfano, J. R. & Guo, M., Jan 2022, In: New Phytologist. 233, 2, p. 890-904 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-1 Receptors 100%
  • interleukin-1 99%
  • NAD (coenzyme) 89%
  • NAD 86%
  • Virulence 73%
  32 Scopus citations

• A SARM1-mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model

  Sato-Yamada, Y., Strickland, A., Sasaki, Y., Bloom, J., DiAntonio, A. & Milbrandt, J., Dec 1 2022, In: Journal of Clinical Investigation. 132, 23, e161566.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Type 2A Charcot-Marie-Tooth disease 100%
  • Interleukin-1 Receptors 59%
  • Mitochondria 23%
  • Pathology 13%
  • Mutation 12%
  8 Scopus citations

• Capybara: A computational tool to measure cell identity and fate transitions

  Kong, W., Fu, Y. C., Holloway, E. M., Garipler, G., Yang, X., Mazzoni, E. O. & Morris, S. A., Apr 7 2022, In: Cell Stem Cell. 29, 4, p. 635-649.e11

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Rodentia 100%
  • Cell Engineering 53%
  • Hybrid Cells 48%
  • Endoderm 25%
  • Motor Neurons 19%
  13 Scopus citations

• CARMIL3 is important for cell migration and morphogenesis during early development in zebrafish: CARMIL3 and early development

  Stark, B. C., Gao, Y., Sepich, D. S., Belk, L., Culver, M. A., Hu, B., Mekel, M., Ferris, W., Shin, J., Solnica-Krezel, L., Lin, F. & Cooper, J. A., Jan 2022, In: Developmental Biology. 481, p. 148-159 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Actin-Related Protein 2 100%
  • Myosin Type I 90%
  • Zebrafish 74%
  • Morphogenesis 73%
  • Cell Movement 59%
  2 Scopus citations

• Chronologically modified androgen receptor in recurrent castration-resistant prostate cancer and its therapeutic targeting

  Sawant, M., Mahajan, K., Renganathan, A., Weimholt, C., Luo, J., Kukshal, V., Jez, J. M., Jeon, M. S., Zhang, B., Li, T., Fang, B., Luo, Y., Lawrence, N. J., Lawrence, H. R., Feng, F. Y. & Mahajan, N. P., Jun 15 2022, In: Science translational medicine. 14, 649, eabg4132.

  Research output: Contribution to journal › Article › peer-review

  • Castration 100%
  • Androgen Receptors 97%
  • Prostatic Neoplasms 71%
  • MDV 3100 61%
  • Acetylation 21%
  10 Scopus citations

• Clinical application of a scale to assess genomic healthcare empowerment (GEmS): Process and illustrative case examples

  Undiagnosed Disease Network, Feb 2022, In: Journal of Genetic Counseling. 31, 1, p. 59-70 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Empowerment 100%
  • Genome 55%
  • Delivery of Health Care 49%
  • Emotions 21%
  • Parents 20%
  2 Scopus citations

• Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients

  Bloom, A. J., Mao, X., Strickland, A., Sasaki, Y., Milbrandt, J. & DiAntonio, A., Dec 2022, In: Molecular neurodegeneration. 17, 1, 1.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amyotrophic Lateral Sclerosis 100%
  • Alleles 45%
  • Neurons 38%
  • Axons 27%
  • NAD+ Nucleosidase 26%
  32 Scopus citations

• Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling

  Manik, M. K., Shi, Y., Li, S., Zaydman, M. A., Damaraju, N., Eastman, S., Smith, T. G., Gu, W., Masic, V., Mosaiab, T., Weagley, J. S., Hancock, S. J., Vasquez, E., Hartley-Tassell, L., Kargios, N., Maruta, N., Lim, B. Y. J., Burdett, H., Landsberg, M. J., Schembri, M. A., & 9 othersProkes, I., Song, L., Grant, M., DiAntonio, A., Nanson, J. D., Guo, M., Milbrandt, J., Ve, T. & Kobe, B., Sep 30 2022, In: Science. 377, 6614, eadc8969.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cyclic ADP-Ribose 100%
  • Interleukin-1 Receptors 45%
  • NAD 26%
  • Plant Immunity 22%
  • Cyclization 19%
  36 Scopus citations

• Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes

  Zaydman, M. A., Little, A. S., Haro, F., Aksianiuk, V., Buchser, W. J., Diantonio, A., Gordon, J. I., Milbrandt, J. & Raman, A. S., 2022, In: eLife. 11, e74104.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Interaction Maps 100%
  • Proteome 83%
  • Bacteria 54%
  • Phenotype 48%
  • Pseudomonas aeruginosa 37%
  1 Scopus citations

• Distinct developmental and degenerative functions of SARM1 require NAD⁺ hydrolase activity

  Brace, E. J., Essuman, K., Mao, X., Palucki, J., Sasaki, Y., Milbrandt, J. & DiAntonio, A., Jun 23 2022, In: PLoS genetics. 18, 6, e1010246.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hydrolases 100%
  • NAD+ Nucleosidase 94%
  • NAD 86%
  • hydrolases 83%
  • hydrolysis 61%
  6 Scopus citations

• Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine

  Yang, N. D., Kanyo, R., Zhao, L., Li, J., Kang, P. W., Dou, A. K., White, K. M. F., Shi, J., Nerbonne, J. M., Kurata, H. T. & Cui, J., Jul 2022, In: Science Advances. 8, 29, eabo3625.

  Research output: Contribution to journal › Article › peer-review

  • ezogabine 100%
  • Epilepsy 50%
  • Anticonvulsants 38%
  • Mutation 33%
  • Pharmacology 13%
  3 Scopus citations

• Endocannabinoid dysfunction in neurological disease: Neuro-ocular DAGLA-related syndrome

  Undiagnosed Disease Network, Oct 1 2022, In: Brain. 145, 10, p. 3383-3390 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Endocannabinoids 100%
  • Ataxia 86%
  • Exons 68%
  • Haploinsufficiency 52%
  • Eye 50%
  2 Scopus citations

• FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells

  Jones, M. R., Lingampally, A., Ahmadvand, N., Chong, L., Wu, J., Wilhem, J., Vazquez-Armendariz, A. I., Ansari, M., Herold, S., Ornitz, D. M., Schiller, H. B., Chao, C. M., Zhang, J. S., Carraro, G. & Bellusci, S., Dec 2022, In: Cellular and Molecular Life Sciences. 79, 12, 609.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Receptor, Fibroblast Growth Factor, Type 2 100%
  • Alveolar Epithelial Cells 74%
  • Lung 35%
  • Wounds and Injuries 16%
  • Embryonic Development 15%
  1 Scopus citations

• Fibroblast growth factor-9 expression in airway epithelial cells amplifies the type I interferon response and alters influenza A virus pathogenesis

  Hiller, B. E., Yin, Y., Perng, Y. C., de Araujo Castro, Í., Fox, L. E., Locke, M. C., Monte, K. J., López, C. B., Ornitz, D. M. & Lenschow, D. J., Jun 2022, In: PLoS pathogens. 18, 6, e1010228.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fibroblast Growth Factor 9 100%
  • Mouse Fgf9 protein 83%
  • fibroblast growth factors 74%
  • Interferon Type I 67%
  • interferons 64%
  2 Scopus citations

• Fibroblast growth factor receptor signaling in cardiomyocytes is protective in the acute phase following ischemia-reperfusion injury

  Matsiukevich, D., House, S. L., Weinheimer, C., Kovacs, A. & Ornitz, D. M., Sep 23 2022, In: Frontiers in Cardiovascular Medicine. 9, 1011167.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fibroblast Growth Factor Receptors 100%
  • Reperfusion Injury 75%
  • Cardiac Myocytes 72%
  • Reperfusion 22%
  • Vascular Endothelial Growth Factor Receptor 20%
  1 Scopus citations

• FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury

  Lee, B., Oh, Y., Cho, E., DiAntonio, A., Cavalli, V., Shin, J. E., Choi, H. W. & Cho, Y., Mar 1 2022, In: Journal of Biological Chemistry. 298, 3, 101647.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tacrolimus Binding Proteins 100%
  • Leucine Zippers 90%
  • Leucine 71%
  • Axons 59%
  • Phosphotransferases 52%
  4 Scopus citations

• Further Evidence that Inhibition of Neuronal Voltage-Gated Calcium Channels Contributes to the Hypnotic Effect of Neurosteroid Analogue, 3β-OH

  Timic Stamenic, T., Manzella, F. M., Maksimovic, S., Krishnan, K., Covey, D. F., Jevtovic-Todorovic, V. & Todorovic, S. M., May 23 2022, In: Frontiers in Pharmacology. 13, 850658.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neurosteroids 100%
  • Calcium Channels 80%
  • Hypnotics and Sedatives 75%
  • Psychological Inhibition 60%
  • Hypnosis 52%

• Genetic counselor roles in the undiagnosed diseases network research study: Clinical care, collaboration, and curation

  Undiagnosed Diseases Network, Apr 2022, In: Journal of Genetic Counseling. 31, 2, p. 326-337 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Undiagnosed Diseases 100%
  • Counselors 75%
  • Clinical Studies 44%
  • Cluster Analysis 12%
  • Genetic Phenomena 9%
  1 Scopus citations

• Genome sequencing reveals novel noncoding variants in PLA2G6 and LMNB1 causing progressive neurologic disease

  Undiagnosed Disease Network, Apr 1 2022, In: Molecular Genetics and Genomic Medicine. 10, 4, e1892.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nervous System Diseases 100%
  • Genome 72%
  • Exome 64%
  • RNA Sequence Analysis 59%
  • Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant 54%
  2 Scopus citations

• Helping others enhances graduate student wellness and mental health

  Hermanstyne, T. O., Johnson, L., Wylie, K. M. & Skeath, J. B., Apr 1 2022, In: Nature Biotechnology. 40, 4, p. 618-619 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Scopus citations

• High temporal resolution measurements of movement reveal novel early-life physiological decline in C. elegans

  Sinha, D. B. & Pincus, Z. S., Feb 2022, In: PloS one. 17, 2 February, e0257591.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Observation 100%
  3 Scopus citations

• Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells

  Luff, S. A., Creamer, J. P., Valsoni, S., Dege, C., Scarfò, R., Dacunto, A., Cascione, S., Randolph, L. N., Cavalca, E., Merelli, I., Morris, S. A., Ditadi, A. & Sturgeon, C. M., May 2022, In: Nature Cell Biology. 24, 5, p. 616-624 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Pluripotent Stem Cells 100%
  • Tretinoin 87%
  • Endothelium 75%
  • Mesoderm 46%
  • Hematopoietic Stem Cells 42%
  9 Scopus citations

• Identification of kidney injury–released circulating osteopontin as causal agent of respiratory failure

  Khamissi, F. Z., Ning, L., Kefaloyianni, E., Dun, H., Arthanarisami, A., Keller, A., Atkinson, J. J., Li, W., Wong, B., Dietmann, S., Lavine, K., Kreisel, D. & Herrlich, A., Feb 2022, In: Science Advances. 8, 8, eabm5900.

  Research output: Contribution to journal › Article › peer-review

  • Osteopontin 100%
  • Acute Kidney Injury 80%
  • Respiratory Insufficiency 79%
  • Acute Lung Injury 72%
  • Kidney 45%
  23 Scopus citations

• In preprints: The fast-paced field of single-cell lineage tracing

  Rodriguez-Fraticelli, A. & Morris, S. A., Jun 2022, In: Development (Cambridge). 149, 11, dev200877.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Scopus citations

• Integrated multi-omic characterization of congenital heart disease

  Hill, M. C., Kadow, Z. A., Long, H., Morikawa, Y., Martin, T. J., Birks, E. J., Campbell, K. S., Nerbonne, J., Lavine, K., Wadhwa, L., Wang, J., Turaga, D., Adachi, I. & Martin, J. F., Aug 4 2022, In: Nature. 608, 7921, p. 181-191 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Heart Diseases 100%
  • Hypoplastic Left Heart Syndrome 34%
  • Heart 24%
  • Fibroblasts 18%
  • Tetralogy of Fallot 15%
  21 Scopus citations

• Intrinsic Mechanisms in the Gating of Resurgent Na⁺ Currents

  Ransdell, J., Moreno, J., Bhagavan, D., Silva, J. R. & Nerbonne, J. M., Jan 2022, In: eLife. 11, e70173.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Purkinje Cells 100%
  • Kinetics 95%
  • Simulation 82%
  • Sodium Atom 82%
  • Membranes 78%
  4 Scopus citations

• Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice

  Strong, R., Miller, R. A., Cheng, C. J., Nelson, J. F., Gelfond, J., Allani, S. K., Diaz, V., Dorigatti, A. O., Dorigatti, J., Fernandez, E., Galecki, A., Ginsburg, B., Hamilton, K. L., Javors, M. A., Kornfeld, K., Kaeberlein, M., Kumar, S., Lombard, D. B., Lopez-Cruzan, M., Miller, B. F., & 11 othersRabinovitch, P., Reifsnyder, P., Rosenthal, N. A., Bogue, M. A., Salmon, A. B., Suh, Y., Verdin, E., Weissbach, H., Newman, J., Maccchiarini, F. & Harrison, D. E., Dec 2022, In: Aging Cell. 21, 12, e13724.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acarbose 100%
  • Captopril 82%
  • Sirolimus 74%
  • Longevity 62%
  • syringaresinol 25%
  9 Scopus citations

• Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling

  Undiagnosed Diseases Network, Jan 2022, In: Science Advances. 8, 3, eabl5613.

  Research output: Contribution to journal › Article › peer-review

  • Interferon Regulatory Factor-2 100%
  • Carrier Proteins 47%
  • Maintenance 39%
  • Diptera 24%
  • Zebrafish 22%
  9 Scopus citations

• Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy

  Krus, K. L., Strickland, A., Yamada, Y., Devault, L., Schmidt, R. E., Bloom, A. J., Milbrandt, J. & DiAntonio, A., Jun 28 2022, In: Cell Reports. 39, 13, 111001.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Stathmin 100%
  • Neuromuscular 90%
  • Amyotrophic Lateral Sclerosis 69%
  • Cord 26%
  • Neuromuscular Junction 25%
  17 Scopus citations

• Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1

  Shin, H. R., Citron, Y. R., Wang, L., Tribouillard, L., Goul, C. S., Stipp, R., Sugasawa, Y., Jain, A., Samson, N., Lim, C. Y., Davis, O. B., Castaneda-Carpio, D., Qian, M., Nomura, D. K., Perera, R. M., Park, E., Covey, D. F., Laplante, M., Evers, A. S. & Zoncu, R., Sep 16 2022, In: Science. 377, 6612, p. 1290-1298 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Mechanistic Target of Rapamycin Complex 1 100%
  • Cholesterol 58%
  • Proteins 29%
  • Lysosomes 20%
  • GTPase-Activating Proteins 13%
  20 Scopus citations

• Macrophage depletion blocks congenital SARM1-dependent neuropathy

  Dingwall, C. B., Strickland, A., Yum, S. W., Yim, A. K. Y., Zhu, J., Wang, P. L., Yamada, Y., Schmidt, R. E., Sasaki, Y., Joseph Bloom, A., DiAntonio, A. & Milbrandt, J., Dec 1 2022, In: Journal of Clinical Investigation. 132, 23, e159800.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Axons 100%
  • Macrophages 79%
  • NAD+ synthase 44%
  • Neuroimmunomodulation 33%
  • Phenotype 27%
  4 Scopus citations

• Mitochondrial RNA modifications shape metabolic plasticity in metastasis

  Delaunay, S., Pascual, G., Feng, B., Klann, K., Behm, M., Hotz-Wagenblatt, A., Richter, K., Zaoui, K., Herpel, E., Münch, C., Dietmann, S., Hess, J., Benitah, S. A. & Frye, M., Jul 21 2022, In: Nature. 607, 7919, p. 593-603 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mitochondrial RNA 100%
  • mitochondrial messenger RNA 43%
  • Neoplasm Metastasis 41%
  • 5-formylcytosine 24%
  • RNA, Transfer, Met 20%
  68 Scopus citations

• Myostatin is a negative regulator of adult neurogenesis after spinal cord injury in zebrafish

  Saraswathy, V. M., Zhou, L., McAdow, A. R., Burris, B., Dogra, D., Reischauer, S. & Mokalled, M. H., Nov 22 2022, In: Cell Reports. 41, 8, 111705.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myostatin 100%
  • Cord 86%
  • Neurogenesis 74%
  • Zebrafish 71%
  • Spinal Cord Injuries 67%
  5 Scopus citations

• Nanomolar, Noncovalent Antagonism of Hedgehog Cholesterolysis: Exception to the "irreversibility Rule" for Protein Autoprocessing Inhibition

  Wagner, A. G., Stagnitta, R. T., Xu, Z., Pezzullo, J. L., Kandel, N., Giner, J. L., Covey, D. F., Wang, C. & Callahan, B. P., Jun 7 2022, In: Biochemistry. 61, 11, p. 1022-1028 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Allosteric Site 100%
  • Fluorescence Resonance Energy Transfer 46%
  • Photoaffinity Labelling 44%
  • Resonance Energy 44%
  • Hedgehog Proteins 44%
  4 Scopus citations

• Neurosteroid Modulation of GABA_A Receptor Function by Independent Action at Multiple Specific Binding Sites

  Wang, L., Covey, D. F., Akk, G. & Evers, A., May 2022, In: Current Neuropharmacology. 20, 5, p. 886-890 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Neurosteroids 100%
  • GABA-A Receptors 80%
  • Pregnanolone 71%
  • Binding Sites 57%
  • Hydroxyl Radical 27%
  2 Scopus citations

• NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

  Stanford TDA, University of Connecticut TMC, University of Michigan TDA, University of Minnesota TMC, University of Pittsburgh TMC, University of Washington TDA, Washington University TMC, Yale TMC, SenNet Consortium, Writing Group, Brown University TDA, Buck Institute for Research on Aging TMC/TDA, Consortium Organization and Data Coordinating Center (CODCC), Columbia TMC, Duke University TMC, Massachusetts General Hospital TDA, Mayo Clinic TDA & National Institute of Health (NIH), Dec 2022, In: Nature Aging. 2, 12, p. 1090-1100 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Longevity 100%
  • Cellular Senescence 81%
  • Health 54%
  • Atlases 19%
  • National Institutes of Health (U.S.) 19%
  12 Scopus citations

• Orsay Virus Infection of Caenorhabditis elegans Is Modulated by Zinc and Dependent on Lipids

  Casorla-Perez, L. A., Guennoun, R., Cubillas, C., Peng, B., Kornfeld, K. & Wang, D., Nov 2022, In: Journal of virology. 96, 22

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Caenorhabditis elegans 100%
  • Zinc 87%
  • zinc 72%
  • Virus Diseases 66%
  • Lipids 59%
  1 Scopus citations