Department of Cell Biology & Physiology

2022

Singlet Oxygen Leads to Structural Changes to Chloroplasts during their Degradation in the Arabidopsis thaliana plastid ferrochelatase two Mutant

Fisher, K. E., Krishnamoorthy, P., Joens, M. S., Chory, J., Fitzpatrick, J. A. J. & Woodson, J. D., Feb 1 2022, In: Plant and Cell Physiology. 63, 2, p. 248-264 17 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Snapshot image mapping spectrometer with 3D printed multifaceted mapping mirror for biomedical applications

Lu, J., Ng, X. W., Piston, D. & Tkaczyk, T. S., 2022, Novel Optical Systems, Methods, and Applications XXV. Hahlweg, C. F. & Mulley, J. R. (eds.). SPIE, 122160B. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 12216).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

4 Scopus citations

Sorting Out the Receptor Isoforms Underlying Dopamine Inhibition of Insulin Secretion

Kebede, M. A. & Piston, D. W., Sep 2022, In: Diabetes. 71, 9, p. 1831-1833 3 p.

Research output: Contribution to journal › Comment/debate

Open Access

1 Scopus citations

Stress response regulates cancer fibroblasts

Faget, D. V. & Stewart, S. A., Jun 2022, In: Nature Cell Biology. 24, 6, p. 812-814 3 p.

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel

Mount, J., Maksaev, G., Summers, B. T., Fitzpatrick, J. & Yuan, P., Dec 2022, In: Nature communications. 13, 1, 6904.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Structure and functionality of a multimeric human COQ7:COQ9 complex

Manicki, M., Aydin, H., Abriata, L. A., Overmyer, K. A., Guerra, R. M., Coon, J. J., Dal Peraro, M., Frost, A. & Pagliarini, D. J., Nov 17 2022, In: Molecular cell. 82, 22, p. 4307-4323.e10

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Structure of the Wilson disease copper transporter ATP7B

Bitter, R. M., Oh, S. C., Deng, Z., Rahman, S., Hite, R. K. & Yuan, P., Mar 2022, In: Science Advances. 8, 9, eabl5508.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

Sulfonylurea-Insensitive Permanent Neonatal Diabetes Caused by a Severe Gain-of-Function Tyr330His Substitution in Kir6.2

McClenaghan, C., Rapini, N., De Rose, D. U., Gao, J., Roeglin, J., Bizzarri, C., Schiaffini, R., Tiberi, E., Mucciolo, M., Deodati, A., Perri, A., Vento, G., Barbetti, F., Nichols, C. G. & Cianfarani, S., Aug 1 2022, In: Hormone Research in Paediatrics. 95, 3, p. 215-223 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Synaptosomes and Synaptic Vesicles

Stunault, M. I. & Ashrafi, G., Jan 1 2022, Encyclopedia of Cell Biology: Volume 1-6, Second Edition. Elsevier, Vol. 2. p. 363-377 15 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Targeted mRNA Degradation in Eukaryotes

Jungers, C. F. & Djuranovic, S., Jan 1 2022, Encyclopedia of Cell Biology: Volume 1-6, Second Edition. Elsevier, Vol. 5. p. 116-126 11 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

The challenges of interrogating adipose tissue extracellular vesicle functions in physiology

Crewe, C., Dec 2022, In: Communications Biology. 5, 1, 581.

Research output: Contribution to journal › Comment/debate

Open Access

6 Scopus citations

The Interplay Between Eukaryotic mRNA Degradation and Translation

Hu, W. & Djuranovic, S., Jan 1 2022, Encyclopedia of Cell Biology: Volume 1-6, Second Edition. Elsevier, Vol. 1. p. 445-453 9 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

The microenvironment—a general hypothesis on the homeostatic function of extracellular vesicles

Stratman, A. N., Crewe, C. & Stahl, P. D., May 2022, In: FASEB BioAdvances. 4, 5, p. 284-297 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

The Polyamine Spermine Potentiates the Propagation of Negatively Charged Molecules through the Astrocytic Syncytium

Benedikt, J., Malpica-Nieves, C. J., Rivera, Y., Méndez-González, M., Nichols, C. G., Veh, R. W., Eaton, M. J. & Skatchkov, S. N., Dec 2022, In: Biomolecules. 12, 12, 1812.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

The role of circular RNAs in pulmonary hypertension

Ali, M. K., Schimmel, K., Zhao, L., Chen, C. K., Dua, K., Nicolls, M. R. & Spiekerkoetter, E., Dec 1 2022, In: European Respiratory Journal. 60, 6, 2200012.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

The T1-tetramerisation domain of Kv1.2 rescues expression and preserves function of a truncated NaChBac sodium channel

D’Avanzo, N., Miles, A. J., Powl, A. M., Nichols, C. G., Wallace, B. A. & O’Reilly, A. O., Mar 2022, In: FEBS Letters. 596, 6, p. 772-783 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

TP53, CDKN2A/P16, and NFE2L2/NRF2 regulate the incidence of pure- and combined-small cell lung cancer in mice

Hamad, S. H., Montgomery, S. A., Simon, J. M., Bowman, B. M., Spainhower, K. B., Murphy, R. M., Knudsen, E. S., Fenton, S. E., Randell, S. H., Holt, J. R., Hayes, D. N., Witkiewicz, A. K., Oliver, T. G., Major, M. B. & Weissman, B. E., Jun 17 2022, In: Oncogene. 41, 25, p. 3423-3432 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Uncovering translation roadblocks during the development of a synthetic tRNA

Prabhakar, A., Krahn, N., Zhang, J., Vargas-Rodriguez, O., Krupkin, M., Fu, Z., Acosta-Reyes, F. J., Ge, X., Choi, J., Crnković, A., Ehrenberg, M., Puglisi, E. V., Söll, D. & Puglisi, J., Oct 14 2022, In: Nucleic acids research. 50, 18, p. 10201-10211 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2021

Accelerating Biological Insight for Understudied Genes

Reynolds, K. A., Rosa-Molinar, E., Ward, R. E., Zhang, H., Urbanowicz, B. R. & Mark Settles, A., Dec 1 2021, In: Integrative and Comparative Biology. 61, 6, p. 2233-2243 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Activating a collaborative innate-adaptive immune response to control metastasis

Sun, L., Kees, T., Almeida, A. S., Liu, B., He, X. Y., Ng, D., Han, X., Spector, D. L., McNeish, I. A., Gimotty, P., Adams, S. & Egeblad, M., Oct 11 2021, In: Cancer Cell. 39, 10, p. 1361-1374.e9

Research output: Contribution to journal › Article › peer-review

Open Access

171 Scopus citations

Acute effects of cheddar cheese consumption on circulating amino acids and human skeletal muscle

de Hart, N. M. M. P., Mahmassani, Z. S., Reidy, P. T., Kelley, J. J., McKenzie, A. I., Petrocelli, J. J., Bridge, M. J., Baird, L. M., Bastian, E. D., Ward, L. S., Howard, M. T. & Drummond, M. J., Feb 2021, In: Nutrients. 13, 2, p. 1-17 17 p., 614.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity

Zhang, Z., Funcke, J. B., Zi, Z., Zhao, S., Straub, L. G., Zhu, Y., Zhu, Q., Crewe, C., An, Y. A., Chen, S., Li, N., Wang, M. Y., Ghaben, A. L., Lee, C., Gautron, L., Engelking, L. J., Raj, P., Deng, Y., Gordillo, R. & Kusminski, C. M. & 1 others, Scherer, P. E., Aug 3 2021, In: Cell metabolism. 33, 8, p. 1624-1639.e9

Research output: Contribution to journal › Article › peer-review

Open Access

73 Scopus citations

Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis

Zhu, Y., Li, N., Huang, M., Bartels, M., Dogné, S., Zhao, S., Chen, X., Crewe, C., Straub, L., Vishvanath, L., Zhang, Z., Shao, M., Yang, Y., Gliniak, C. M., Gordillo, R., Smith, G. I., Holland, W. L., Gupta, R. K., Dong, B. & Caron, N. & 4 others, Xu, Y., Akgul, Y., Klein, S. & Scherer, P. E., Dec 1 2021, In: Nature communications. 12, 1, 4829.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

Alpha/Beta Hydrolase Domain-Containing Protein 2 Regulates the Rhythm of Follicular Maturation and Estrous Stages of the Female Reproductive Cycle

Björkgren, I., Chung, D. H., Mendoza, S., Gabelev-Khasin, L., Petersen, N. T., Modzelewski, A., He, L. & Lishko, P. V., Sep 8 2021, In: Frontiers in Cell and Developmental Biology. 9, 710864.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

A Novel Body Plan Alters Diversification of Body Shape and Genitalia in Live-Bearing Fish

Langerhans, R. B. & Rosa-Molinar, E., Feb 3 2021, In: Frontiers in Ecology and Evolution. 9, 619232.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Anti-parallel β-hairpin structure in soluble aβ oligomers of aβ40-dutch and Aβ40-iowa

Fu, Z., Van Nostrand, W. E. & Smith, S. O., Feb 1 2021, In: International journal of molecular sciences. 22, 3, p. 1-12 12 p., 1225.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Assessment of Vascular Patterning in the Zebrafish

Stratman, A. N. & Weinstein, B. M., 2021, Methods in Molecular Biology. Humana Press Inc., p. 205-222 18 p. (Methods in Molecular Biology; vol. 2206).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

ATF3 induces RAB7 to govern autodegradation in paligenosis, a conserved cell plasticity program

Radyk, M. D., Spatz, L. B., Peña, B. L., Brown, J. W., Burclaff, J., Cho, C. J., Kefalov, Y., Shih, C. C., Fitzpatrick, J. A. J. & Mills, J. C., Sep 6 2021, In: EMBO Reports. 22, 9, e51806.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Biological Preparation and Mechanical Technique for Determining Viscoelastic Properties of Zonular Fibers

Rodriguez, J., Reilly, M., Mecham, R. P. & Bassnett, S., Dec 2021, In: Journal of Visualized Experiments. 2021, 178, e63171.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Bone hormones survival of the glycosylated

Blair, H. C. & Schlesinger, P. H., Jan 2021, In: eLife. 10, p. 1-3 3 p., e65719.

Research output: Contribution to journal › Comment/debate

Open Access

1 Scopus citations

Breast cancer-derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment

Su, X., Xu, Y., Fox, G. C., Xiang, J., Kwakwa, K. A., Davis, J. L., Belle, J. I., Lee, W. C., Wong, W. H., Fontana, F., Hernandez-Aya, L. F., Kobayashi, T., Tomasson, H. M., Su, J., Bakewell, S. J., Stewart, S. A., Egbulefu, C., Karmakar, P., Meyer, M. A. & Veis, D. J. & 4 others, DeNardo, D. G., Lanza, G. M., Achilefu, S. & Weilbaecher, K. N., 2021, In: Journal of Clinical Investigation. 131, 20, e145296.

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Channelopathies in fragile X syndrome

Deng, P. Y. & Klyachko, V. A., May 2021, In: Nature Reviews Neuroscience. 22, 5, p. 275-289 15 p.

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus

Yang, R., Lee, E. E., Kim, J., Choi, J. H., Kolitz, E., Chen, Y., Crewe, C., Salisbury, N. J. H., Schereri, P. E., Cockerell, C., Smith, T. R., Rosen, L., Verlinden, L., Galloway, D. A., Buck, C. B., Feltkamp, M. C., Sullivan, C. S. & Wang, R. C., May 2021, In: PLoS pathogens. 17, 5, e1009582.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum

Reddy, N. C., Majidi, S. P., Kong, L., Nemera, M., Ferguson, C. J., Moore, M., Goncalves, T. M., Liu, H. K., Fitzpatrick, J. A. J., Zhao, G., Yamada, T., Bonni, A. & Gabel, H. W., Dec 1 2021, In: Nature communications. 12, 1, 5702.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Choroid plexus epithelial cells as a model to study nongenomic steroid signaling and its effect on ion channel function

Haoui, M., Petersen, N. T., Björkgren, I., Chung, D. H. & Lishko, P. V., Jan 2021, Ion Channels: Channel Chemical Biology, Engineering, and Physiological Function. Minor, D. L. & Colecraft, H. M. (eds.). Academic Press Inc., p. 297-314 18 p. (Methods in Enzymology; vol. 654).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

7 Scopus citations

Classification of T-cell activation via autofluorescence lifetime imaging

Walsh, A. J., Mueller, K. P., Tweed, K., Jones, I., Walsh, C. M., Piscopo, N. J., Niemi, N. M., Pagliarini, D. J., Saha, K. & Skala, M. C., Jan 2021, In: Nature Biomedical Engineering. 5, 1, p. 77-88 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

118 Scopus citations

Compartmentalization of phosphatidylinositol 4,5-bisphosphate metabolism into plasma membrane liquid-ordered/raft domains

Myeong, J., Park, C. G., Suh, B. C. & Hille, B., Mar 2 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 9, e2025343118.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice

Zhang, H., Hanson, A., de Almeida, T. S., Emfinger, C., McClenaghan, C., Harter, T., Yan, Z., Cooper, P. E., Schuyler Brown, G., Arakel, E. C., Mecham, R. P., Kovacs, A., Halabi, C. M., Schwappach, B., Remedi, M. S. & Nichols, C. G., Mar 8 2021, In: JCI Insight. 6, 5, e145934.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK⁺ CD8⁺ T Cells as Conserved Hallmark of Inflammaging

Mogilenko, D. A., Shpynov, O., Andhey, P. S., Arthur, L., Swain, A., Esaulova, E., Brioschi, S., Shchukina, I., Kerndl, M., Bambouskova, M., Yao, Z., Laha, A., Zaitsev, K., Burdess, S., Gillfilan, S., Stewart, S. A., Colonna, M. & Artyomov, M. N., Jan 12 2021, In: Immunity. 54, 1, p. 99-115.e12

Research output: Contribution to journal › Article › peer-review

Open Access

359 Scopus citations

Consequences of sur2[a478v] mutation in skeletal muscle of murine model of cantu syndrome

Scala, R., Maqoud, F., Zizzo, N., Passantino, G., Mele, A., Camerino, G. M., McClenaghan, C., Harter, T. M., Nichols, C. G. & Tricarico, D., Jul 2021, In: Cells. 10, 7, 1791.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Correlation of alterations in the KEAP1/CUL3/NFE2L2 pathway with radiation failure in larynx squamous cell carcinoma

Sheth, S., Farquhar, D. R., Schrank, T. P., Stepp, W., Mazul, A., Hayward, M., Lenze, N., Little, P., Jo, H., Major, M. B., Chera, B. S., Zevallos, J. P. & Hayes, D. N., Aug 2021, In: Laryngoscope investigative otolaryngology. 6, 4, p. 699-707 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Cryo-EM structure of a proton-activated chloride channel TMEM206

Deng, Z., Zhao, Y., Feng, J., Zhang, J., Zhao, H., Rau, M. J., Fitzpatrick, J. A. J., Hu, H. & Yuan, P., Feb 24 2021, In: Science Advances. 7, 9, eabe5983.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome

Pandey, K. K., Bera, S., Shi, K., Rau, M. J., Oleru, A. V., Fitzpatrick, J. A. J., Engelman, A. N., Aihara, H. & Grandgenett, D. P., Dec 2021, In: Communications Biology. 4, 1, 330.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Cryo-EM structures of human coagulation factors V and Va

Ruben, E. A., Rau, M. J., Fitzpatrick, J. A. J. & Di Cera, E., Jun 3 2021, In: Blood. 137, 22, p. 3137-3144 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Defining intermediates and redundancies in coenzyme Q precursor biosynthesis

Robinson, K. P., Jochem, A., Johnson, S. E., Reddy, T. R., Russell, J. D., Coon, J. J. & Pagliarini, D. J., Apr 14 2021, In: Journal of Biological Chemistry. 296, 100643.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Deletion of type VIII collagen reduces blood pressure, increases carotid artery functional distensibility and promotes elastin deposition

Mohabeer, A. L., Kroetsch, J. T., McFadden, M., Khosraviani, N., Broekelmann, T. J., Hou, G., Zhang, H., Zhou, Y. Q., Wang, M., Gramolini, A. O., Mecham, R. P., Heximer, S. P., Bolz, S. S. & Bendeck, M. P., Dec 2021, In: Matrix Biology Plus. 12, 100085.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

DIAPH1 Variants in Non-East Asian Patients with Sporadic Moyamoya Disease

Kundishora, A. J., Peters, S. T., Pinard, A., Duran, D., Panchagnula, S., Barak, T., Miyagishima, D. F., Dong, W., Smith, H., Ocken, J., Dunbar, A., Nelson-Williams, C., Haider, S., Walker, R. L., Li, B., Zhao, H., Thumkeo, D., Marlier, A., Duy, P. Q. & Diab, N. S. & 28 others, Reeves, B. C., Robert, S. M., Sujijantarat, N., Stratman, A. N., Chen, Y. H., Zhao, S., Roszko, I., Lu, Q., Zhang, B., Mane, S., Castaldi, C., López-Giráldez, F., Knight, J. R., Bamshad, M. J., Nickerson, D. A., Geschwind, D. H., Chen, S. S. L., Storm, P. B., Diluna, M. L., Matouk, C. C., Orbach, D. B., Alper, S. L., Smith, E. R., Lifton, R. P., Gunel, M., Milewicz, D. M., Jin, S. C. & Kahle, K. T., Aug 2021, In: JAMA Neurology. 78, 8, p. 993-1003 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N-Methyl-d-aspartate Receptors

Strong, K. L., Epplin, M. P., Ogden, K. K., Burger, P. B., Kaiser, T. M., Wilding, T. J., Kusumoto, H., Camp, C. R., Shaulsky, G., Bhattacharya, S., Perszyk, R. E., Menaldino, D. S., McDaniel, M. J., Zhang, J., Le, P., Banke, T. G., Hansen, K. B., Huettner, J. E., Liotta, D. C. & Traynelis, S. F., Jan 6 2021, In: ACS Chemical Neuroscience. 12, 1, p. 79-98 20 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Early aberrant angiogenesis due to elastic fiber fragmentation in aortic valve disease

Hinton, R. B., Juraszek, A. L., Opoka, A. M., Landis, B. J., Smith, J. M., Mecham, R. P. & Bove, K. E., Jul 2021, In: Journal of Cardiovascular Development and Disease. 8, 7, 75.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans

Hershberger, K. A., Rooney, J. P., Turner, E. A., Donoghue, L. J., Bodhicharla, R., Maurer, L. L., Ryde, I. T., Kim, J. J., Joglekar, R., Hibshman, J. D., Smith, L. L., Bhatt, D. P., Ilkayeva, O. R., Hirschey, M. D. & Meyer, J. N., Jul 2021, In: Redox Biology. 43, 102000.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Department of Cell Biology & Physiology

Research output

Search results