Department of Biochemistry & Molecular Biophysics

Aebersold, R., Agar, J. N., Amster, I. J., Baker, M. S., Bertozzi, C. R., Boja, E. S., Costello, C. E., Cravatt, B. F., Fenselau, C., Garcia, B. A., Ge, Y., Gunawardena, J., Hendrickson, R. C., Hergenrother, P. J., Huber, C. G., Ivanov, A. R., Jensen, O. N., Jewett, M. C., Kelleher, N. L. & Kiessling, L. L. & 33 others, Krogan, N. J., Larsen, M. R., Loo, J. A., Ogorzalek Loo, R. R., Lundberg, E., Maccoss, M. J., Mallick, P., Mootha, V. K., Mrksich, M., Muir, T. W., Patrie, S. M., Pesavento, J. J., Pitteri, S. J., Rodriguez, H., Saghatelian, A., Sandoval, W., Schlüter, H., Sechi, S., Slavoff, S. A., Smith, L. M., Snyder, M. P., Thomas, P. M., Uhlén, M., Van Eyk, J. E., Vidal, M., Walt, D. R., White, F. M., Williams, E. R., Wohlschlager, T., Wysocki, V. H., Yates, N. A., Young, N. L. & Zhang, B., Feb 14 2018, In: Nature Chemical Biology. 14, 3, p. 206-214 9 p.

Research output: Contribution to journal › Review article › peer-review

540 Scopus citations

Human DNA Ligases I, III, and IV-Purification and New Specific Assays for These Enzymes

Chen, X., Pascal, J., Vijayakumar, S., Wilson, G. M., Ellenberger, T. & Tomkinson, A. E., 2006, In: Methods in enzymology. 409, p. 39-52 14 p.

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Identification and interrogation of combinatorial histone modifications

Karch, K. R., DeNizio, J. E., Black, B. E. & Garcia, B. A., 2013, In: Frontiers in Genetics. 4, DEC, 00264.

Research output: Contribution to journal › Review article › peer-review

Open Access

59 Scopus citations

Illustrated State-of-the-Art Capsules of the ISTH 2021 Congress

Krishnaswamy, S., Ageno, W., Arabi, Y., Barbui, T., Cannegieter, S., Carrier, M., Cleuren, A. C., Collins, P., Panicot-Dubois, L., Freedman, J. E., Freson, K., Hogg, P., James, A. H., Kretz, C. A., Lavin, M., Leebeek, F. W. G., Li, W., Maas, C., Machlus, K. & Makris, M. & 11 others, Martinelli, I., Medved, L., Neerman-Arbez, M., O’Donnell, J. S., O'Sullivan, J., Rajpurkar, M., Schroeder, V., Spiegel, P. C., Stanworth, S. J., Green, L. & Undas, A., Jul 2021, In: Research and Practice in Thrombosis and Haemostasis. 5, 5, e12532.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Scopus citations

Inhibitors of checkpoint kinases: From discovery to the clinic

Janetka, J. W., Ashwell, S., Zabludoff, S. & Lyne, P., Jul 2007, In: Current Opinion in Drug Discovery and Development. 10, 4, p. 473-486 14 p.

Research output: Contribution to journal › Review article › peer-review

60 Scopus citations

Innovator Organizations in New Drug Development: Assessing the Sustainability of the Biopharmaceutical Industry

Kinch, M. S. & Moore, R., 2016, In: Cell Chemical Biology. 23, 6, p. 644-653 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

9 Scopus citations

Integrating Proteomics and Targeted Metabolomics to Understand Global Changes in Histone Modifications

Simithy, J., Sidoli, S. & Garcia, B. A., Sep 2018, In: Proteomics. 18, 18, 1700309.

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Integration of signals to the Arp2/3 complex

Weaver, A. M., Young, M. E., Lee, W. L. & Cooper, J. A., Feb 2002, In: Current Opinion in Cell Biology. 15, 1, p. 23-30 8 p.

Research output: Contribution to journal › Review article › peer-review

162 Scopus citations

Interactions of CD4 with MHC class II molecules, T cell receptors and p56lck.

Vignali, D. A., Doyle, C., Kinch, M. S., Shin, J. & Strominger, J. L., Oct 29 1993, In: Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 342, 1299, p. 13-24 12 p.

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Intramembrane Thiol Oxidoreductases: Evolutionary Convergence and Structural Controversy

Li, S., Shen, G. & Li, W., Jan 23 2018, In: Biochemistry. 57, 3, p. 258-266 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

8 Scopus citations

Intrinsically disordered protein regions and phase separation: Sequence determinants of assembly or lack thereof

Martin, E. W. & Holehouse, A. S., Dec 2020, In: Emerging Topics in Life Sciences. 4, 3, p. 307-329 23 p.

Research output: Contribution to journal › Review article › peer-review

125 Scopus citations

Intrinsically disordered regions are poised to act as sensors of cellular chemistry

Moses, D., Ginell, G. M., Holehouse, A. S. & Sukenik, S., Dec 2023, In: Trends in biochemical sciences. 48, 12, p. 1019-1034 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

20 Scopus citations

Ion channels that control fertility in mammalian spermatozoa

Navarro, B., Kirichok, Y., Chung, J. J. & Clapham, D. E., 2008, In: International Journal of Developmental Biology. 52, 5-6, p. 607-613 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

114 Scopus citations

Keeping checkpoint kinases in line: New selective inhibitors in clinical trials

Ashwell, S., Janetka, J. W. & Zabludoff, S., Sep 2008, In: Expert Opinion on Investigational Drugs. 17, 9, p. 1331-1340 10 p.

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Limiting assumptions in molecular modeling: Electrostatics

Marshall, G. R., Feb 2013, In: Journal of Computer-Aided Molecular Design. 27, 2, p. 107-114 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

21 Scopus citations

Limiting assumptions in structure-based design: Binding entropy

Marshall, G. R., Jan 2012, In: Journal of Computer-Aided Molecular Design. 26, 1, p. 3-8 6 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

15 Scopus citations

Lipid rafts: Heterogeneity on the high seas

Pike, L. J., Mar 1 2004, In: Biochemical Journal. 378, 2, p. 281-292 12 p.

Research output: Contribution to journal › Review article › peer-review

624 Scopus citations

Lipid rafts: Bringing order to chaos

Pike, L. J., Apr 2003, In: Journal of lipid research. 44, 4, p. 655-667 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

996 Scopus citations

Liquid Phase Partitioning in Virus Replication: Observations and Opportunities

Wu, C., Holehouse, A. S., Leung, D. W., Amarasinghe, G. K. & Dutch, R. E., 2022, In: Annual Review of Virology. 9, p. 285-306 22 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

25 Scopus citations

Macromolecular Crowding and Intrinsically Disordered Proteins: A Polymer Physics Perspective

Cubuk, J. & Soranno, A., Sep 2022, In: ChemSystemsChem. 4, 5, e202100051.

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Mannose-derived FimH antagonists: A promising anti-virulence therapeutic strategy for urinary tract infections and Crohns disease

Mydock-Mcgrane, L. K., Cusumano, Z. T. & Janetka, J. W., Feb 1 2016, In: Expert Opinion on Therapeutic Patents. 26, 2, p. 175-197 23 p.

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Mass spectrometric analysis of histone proteoforms

Yuan, Z. F., Arnaudo, A. M. & Garcia, B. A., Jun 2014, In: Annual Review of Analytical Chemistry. 7, p. 113-128 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

51 Scopus citations

Mass spectrometric analysis of histone variants and post-translational modifications

Garcia, B. A., Jun 1 2009, In: Frontiers in Bioscience - Scholar. 1 S, 1, p. 142-153 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

27 Scopus citations

Mechanics of cell spreading: Role of myosin II

Wakatsuki, T., Wysolmerski, R. B. & Elson, E. L., Apr 15 2003, In: Journal of cell science. 116, 8, p. 1617-1625 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

136 Scopus citations

Mechanisms of helicase-catalyzed DNA unwinding

Lohman, T. M. & Bjornson, K. P., 1996, In: Annual review of biochemistry. 65, p. 169-214 46 p.

Research output: Contribution to journal › Review article › peer-review

687 Scopus citations

Membrane dynamics studied by fluorescence correlation spectroscopy and photobleaching recovery.

Elson, E. L., 1986, In: Society of General Physiologists series. 40, p. 367-383 17 p.

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Metabolic and molecular action of Trigonella foenum-graecum (fenugreek) and trace metals in experimental diabetic tissues

Baquer, N. Z., Kumar, P., Taha, A., Kale, R., Cowsik, S. & McLean, P., Jun 2011, In: Journal of Biosciences. 36, 2, p. 383-396 14 p.

Research output: Contribution to journal › Review article › peer-review

104 Scopus citations

Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses

Green, E. M., Mas, G., Young, N. L., Garcia, B. A. & Gozani, O., Mar 2012, In: Nature Structural and Molecular Biology. 19, 3, p. 361-363 3 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

50 Scopus citations

Middle-down proteomics: a still unexploited resource for chromatin biology

Sidoli, S. & Garcia, B. A., Jul 3 2017, In: Expert Review of Proteomics. 14, 7, p. 617-626 10 p.

Research output: Contribution to journal › Review article › peer-review

64 Scopus citations

Mitochondrial H Leak and Thermogenesis

Bertholet, A. M. & Kirichok, Y., 2022, In: Annual review of physiology. 84, p. 381-407 27 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

40 Scopus citations

Mitochondrial phosphorylation in apoptosis: Flipping the death switch

Niemi, N. M. & Mackeigan, J. P., Aug 20 2013, In: Antioxidants and Redox Signaling. 19, 6, p. 572-582 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

27 Scopus citations

Mobility, localization, and heterogeneity of beta-adrenergic receptors.

Hekman, M., Schiltz, E., Henis, Y. I., Elson, E. L. & Helmreich, E. J., Jan 1 1984, In: Advances in cyclic nucleotide and protein phosphorylation research. 17, p. 47-60 14 p.

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Mobility of proteins and lipids in membranes.

Helmreich, E. J. & Elson, E. L., Jan 1 1984, In: Advances in cyclic nucleotide and protein phosphorylation research. 18, p. 1-62 62 p.

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Modern approaches for investigating signaling pathways

Evertts, A. G., Zee, B. M. & Garcia, B. A., Sep 2010, In: Journal of Applied Physiology. 109, 3, p. 927-933 7 p.

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG

Lau, A. Y., Waytt, M. D., Glassner, B. J., Samson, L. D., Ellenberger, T., Guliaev, A. B. & Singer, B., Jan 1 2001, In: Chemtracts. 14, 3, p. 142-147 6 p.

Research output: Contribution to journal › Review article › peer-review

Molecular insights into the prototypical single-stranded DNA-binding protein from E. coli

Bonde, N. J., Kozlov, A. G., Cox, M. M., Lohman, T. M. & Keck, J. L., 2024, In: Critical Reviews in Biochemistry and Molecular Biology. 59, 1-2, p. 99-127 29 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

1 Scopus citations

Monitoring proteolytic processing events by quantitative mass spectrometry

Coradin, M., Karch, K. R. & Garcia, B. A., May 4 2017, In: Expert Review of Proteomics. 14, 5, p. 409-418 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

11 Scopus citations

Monte Carlo applications to thermal and chemical denaturation experiments of nucleic acids and proteins

Williams, D. J. & Hall, K. B., 2000, In: Methods in enzymology. 321, p. 330-352 23 p.

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Mu opioid receptor antagonists: Recent developments

Goodman, A. J., Le Bourdonnec, B. & Dolle, R. E., Nov 12 2007, In: ChemMedChem. 2, 11, p. 1552-1570 19 p.

Research output: Contribution to journal › Review article › peer-review

71 Scopus citations

Mutations in TUBB8 and Human Oocyte Meiotic Arrest

Feng, R., Sang, Q., Kuang, Y., Sun, X., Yan, Z., Zhang, S., Shi, J., Tian, G., Luchniak, A., Fukuda, Y., Li, B., Yu, M., Chen, J., Xu, Y., Guo, L., Qu, R., Wang, X., Sun, Z., Liu, M. & Shi, H. & 13 others, Wang, H., Feng, Y., Shao, R., Chai, R., Li, Q., Xing, Q., Zhang, R., Nogales, E., Jin, L., He, L., Gupta, M. L., Cowan, N. J. & Wang, L., Jan 21 2016, In: New England Journal of Medicine. 374, 3, p. 223-232 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

214 Scopus citations

Negative co-operativity in the EGF receptor

Pike, L. J., Feb 2012, In: Biochemical Society transactions. 40, 1, p. 15-19 5 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

15 Scopus citations

Network models for molecular kinetics and their initial applications to human health

Bowman, G. R., Huang, X. & Pande, V. S., Jun 2010, In: Cell Research. 20, 6, p. 622-630 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

46 Scopus citations

NMR and protein folding: Equilibrium and stopped‐flow studies

Frieden, C., Hoeltzli, S. D. & Ropson, I. J., Dec 1993, In: Protein Science. 2, 12, p. 2007-2014 8 p.

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Non-hexameric DNA helicases and translocases: Mechanisms and regulation

Lohman, T. M., Tomko, E. J. & Wu, C. G., May 2008, In: Nature Reviews Molecular Cell Biology. 9, 5, p. 391-401 11 p.

Research output: Contribution to journal › Review article › peer-review

286 Scopus citations

Novel approaches to glycomimetic design: development of small molecular weight lectin antagonists

Damalanka, V. C., Maddirala, A. R. & Janetka, J. W., 2021, In: Expert Opinion on Drug Discovery. 16, 5, p. 513-536 24 p.

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Department of Biochemistry & Molecular Biophysics

Research output

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