Center for Brain Immunology & Glia (BIG)

2017

Microbiota induces tonic CCL2 systemic levels that control pDC trafficking in steady state

Swiecki, M., Miller, H. L., Sesti-Costa, R., Cella, M., Gilfillan, S. & Colonna, M., Jul 1 2017, In: Mucosal Immunology. 10, 4, p. 936-945 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Neuropsychiatric Symptoms and Alzheimer's Disease Biomarkers Predict Driving Decline: Brief Report

Babulal, G. M., Stout, S. H., Head, D., Holtzman, D. M., Fagan, A. M., Morris, J. C. & Roe, C. M., 2017, In: Journal of Alzheimer's Disease. 58, 3, p. 675-680 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Neuropsychological measures that detect early impairment and decline in preclinical Alzheimer disease

Schindler, S. E., Jasielec, M. S., Weng, H., Hassenstab, J. J., Grober, E., McCue, L. M., Morris, J. C., Holtzman, D. M., Xiong, C. & Fagan, A. M., Aug 1 2017, In: Neurobiology of Aging. 56, p. 25-32 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia

Galindo, R., Banks Greenberg, M., Araki, T., Sasaki, Y., Mehta, N., Milbrandt, J. & Holtzman, D. M., Oct 2017, In: Annals of Clinical and Translational Neurology. 4, 10, p. 722-738 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Pattern Discovery in Brain Imaging Genetics via SCCA Modeling with a Generic Non-convex Penalty

Du, L., Liu, K., Yao, X., Yan, J., Risacher, S. L., Han, J., Guo, L., Saykin, A. J., Shen, L., Weiner, M. W., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Morris, J. & Shaw, L. M. & 293 others, Khachaturian, Z., Sorensen, G., Carrillo, M., Kuller, L., Raichle, M., Paul, S., Davies, P., Fillit, H., Hefti, F., Holtzman, D., Mesulam, M. M., Potter, W., Snyder, P., Schwartz, A., Montine, T., Thomas, R. G., Donohue, M., Walter, S., Gessert, D., Sather, T., Jiminez, G., Balasubramanian, A. B., Mason, J., Sim, I., Harvey, D., Bernstein, M., Fox, N., Thompson, P., Schuff, N., Decarli, C., Borowski, B., Gunter, J., Senjem, M., Vemuri, P., Jones, D., Kantarci, K., Ward, C., Koeppe, R. A., Foster, N., Reiman, E. M., Chen, K., Mathis, C., Landau, S., Cairns, N. J., Franklin, E., Taylor-Reinwald, L., Lee, V., Korecka, M., Figurski, M., Crawford, K., Neu, S., Foroud, T. M., Potkin, S., Faber, K., Kim, S., Nho, K., Thal, L., Buckholtz, N., Albert, M., Frank, R., Hsiao, J., Kaye, J., Quinn, J., Silbert, L., Lind, B., Carter, R., Dolen, S., Schneider, L. S., Pawluczyk, S., Beccera, M., Teodoro, L., Spann, B. M., Brewer, J., Vanderswag, H., Fleisher, A., Heidebrink, J. L., Lord, J. L., Mason, S. S., Albers, C. S., Knopman, D., Johnson, K., Doody, R. S., Villanueva-Meyer, J., Pavlik, V., Shibley, V., Chowdhury, M., Rountree, S., Dang, M., Stern, Y., Honig, L. S., Bell, K. L., Ances, B., Carroll, M., Creech, M. L., Franklin, E., Mintun, M. A., Schneider, S., Oliver, A., Marson, D., Geldmacher, D., Love, M. N., Griffith, R., Clark, D., Brockington, J., Roberson, E., Grossman, H., Mitsis, E., Shah, R. C., Detoledo-Morrell, L., Duara, R., Greig-Custo, M. T., Barker, W., Onyike, C., D'Agostino, D., Kielb, S., Sadowski, M., Sheikh, M. O., Ulysse, A., Gaikwad, M., Murali Doraiswamy, P., Petrella, J. R., Borges-Neto, S., Wong, T. Z., Coleman, E., Arnold, S. E., Karlawish, J. H., Wolk, D. A., Clark, C. M., Smith, C. D., Jicha, G., Hardy, P., Sinha, P., Oates, E., Conrad, G., Lopez, O. L., Oakley, M. A., Simpson, D. M., Porsteinsson, A. P., Goldstein, B. S., Martin, K., Makino, K. M., Ismail, M. S., Brand, C., Preda, A., Nguyen, D., Womack, K., Mathews, D., Quiceno, M., Levey, A. I., Lah, J. J., Cellar, J. S., Burns, J. M., Swerdlow, R. H., Brooks, W. M., Apostolova, L., Tingus, K., Woo, E., Silverman, D. H. S., Lu, P. H., Bartzokis, G., Graff-Radford, N. R., Parfitt, F., Poki-Walker, K., Farlow, M. R., Marie Hake, A., Matthews, B. R., Brosch, J. R., Herring, S., Van Dyck, C. H., Carson, R. E., MacAvoy, M. G., Varma, P., Chertkow, H., Bergman, H., Hosein, C., Black, S., Stefanovic, B., Caldwell, C., Robin Hsiung, G. Y., Mudge, B., Sossi, V., Feldman, H., Assaly, M., Finger, E., Pasternack, S., Rachisky, I., Rogers, J., Trost, D., Kertesz, A., Bernick, C., Munic, D., Rogalski, E., Lipowski, K., Weintraub, S., Bonakdarpour, B., Kerwin, D., Wu, C. K., Johnson, N., Sadowsky, C., Villena, T., Scott Turner, R., Johnson, K., Reynolds, B., Sperling, R. A., Johnson, K. A., Marshall, G., Yesavage, J., Taylor, J. L., Lane, B., Rosen, A., Tinklenberg, J., Sabbagh, M. N., Belden, C. M., Jacobson, S. A., Sirrel, S. A., Kowall, N., Killiany, R., Budson, A. E., Norbash, A., Lynn Johnson, P., Obisesan, T. O., Wolday, S., Allard, J., Lerner, A., Ogrocki, P., Tatsuoka, C., Fatica, P., Fletcher, E., Maillard, P., Olichney, J., Decarli, C., Carmichael, O., Kittur, S., Borrie, M., Lee, T. Y., Bartha, R., Johnson, S., Asthana, S., Carlsson, C. M., Tariot, P., Burke, A., Milliken, A. M., Trncic, N., Fleisher, A., Reeder, S., Bates, V., Capote, H., Rainka, M., Scharre, D. W., Kataki, M., Kelly, B., Zimmerman, E. A., Celmins, D., Brown, A. D., Pearlson, G. D., Blank, K., Anderson, K., Flashman, L. A., Seltzer, M., Hynes, M. L., Santulli, R. B., Sink, K. M., Gordineer, L., Williamson, J. D., Garg, P., Watkins, F., Ott, B. R., Tremont, G., Daiello, L. A., Salloway, S., Malloy, P., Correia, S., Rosen, H. J., Miller, B. L., Perry, D., Mintzer, J., Spicer, K., Bachman, D., Pomara, N., Hernando, R., Sarrael, A., Schultz, S. K., Ekstam Smith, K., Koleva, H., Nam, K. W., Shim, H., Relkin, N., Chaing, G., Lin, M., Ravdin, L., Smith, A., Ashok Raj, B. & Fargher, K., Dec 1 2017, In: Scientific reports. 7, 1, 14052.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Preclinical Alzheimer's disease and longitudinal driving decline

Roe, C. M., Babulal, G. M., Head, D. M., Stout, S. H., Vernon, E. K., Ghoshal, N., Garland, B., Barco, P. P., Williams, M. M., Johnson, A., Fierberg, R., Fague, M. S., Xiong, C., Mormino, E., Grant, E. A., Holtzman, D. M., Benzinger, T. L. S., Fagan, A. M., Ott, B. R. & Carr, D. B. & 1 others, Morris, J. C., Jan 1 2017, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 3, 1, p. 74-82 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies

West, T., Hu, Y., Verghese, P. B., Bateman, R. J., Braunstein, J. B., Fogelman, I., Budur, K., Florian, H., Mendonca, N. & Holtzman, D. M., 2017, In: The journal of prevention of Alzheimer's disease. 4, 4, p. 236-241 6 p.

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Pretreatment with human chorionic gonadotropin Protects the neonatal Brain against the effects of hypoxic-ischemic injury

Movsas, T. Z., Weiner, R. L., Greenberg, M. B., Holtzman, D. M. & Galindo, R., Nov 3 2017, In: Frontiers in Pediatrics. 5, 232.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels

Ju, Y. E. S., Ooms, S. J., Sutphen, C., Macauley, S. L., Zangrilli, M. A., Jerome, G., Fagan, A. M., Mignot, E., Zempel, J. M., Claassen, J. A. H. R. & Holtzman, D. M., Aug 1 2017, In: Brain. 140, 8, p. 2104-2111 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

461 Scopus citations

SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-β signaling

Cortez, V. S., Ulland, T. K., Cervantes-Barragan, L., Bando, J. K., Robinette, M. L., Wang, Q., White, A. J., Gilfillan, S., Cella, M. & Colonna, M., Aug 22 2017, In: Nature immunology. 18, 9, p. 995-1003 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

270 Scopus citations

The ILC World Revisited

Diefenbach, A., Colonna, M. & Romagnani, C., Mar 21 2017, In: Immunity. 46, 3, p. 327-332 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O'Loughlin, E., Xu, Y., Fanek, Z., Greco, D. J., Smith, S. T., Tweet, G., Humulock, Z., Zrzavy, T., Conde-Sanroman, P., Gacias, M., Weng, Z., Chen, H. & Tjon, E. & 18 others, Mazaheri, F., Hartmann, K., Madi, A., Ulrich, J. D., Glatzel, M., Worthmann, A., Heeren, J., Budnik, B., Lemere, C., Ikezu, T., Heppner, F. L., Litvak, V., Holtzman, D. M., Lassmann, H., Weiner, H. L., Ochando, J., Haass, C. & Butovsky, O., Sep 19 2017, In: Immunity. 47, 3, p. 566-581.e9

Research output: Contribution to journal › Article › peer-review

Open Access

1869 Scopus citations

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

Leyns, C. E. G., Ulrich, J. D., Finn, M. B., Stewart, F. R., Koscal, L. J., Serrano, J. R., Robinson, G. O., Anderson, E., Colonna, M. & Holtzman, D. M., Oct 24 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 43, p. 11524-11529 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

343 Scopus citations

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease

Ulland, T. K., Song, W. M., Huang, S. C. C., Ulrich, J. D., Sergushichev, A., Beatty, W. L., Loboda, A. A., Zhou, Y., Cairns, N. J., Kambal, A., Loginicheva, E., Gilfillan, S., Cella, M., Virgin, H. W., Unanue, E. R., Wang, Y., Artyomov, M. N., Holtzman, D. M. & Colonna, M., Aug 10 2017, In: Cell. 170, 4, p. 649-663.e13

Research output: Contribution to journal › Article › peer-review

Open Access

863 Scopus citations

Two distinct myeloid subsets at the term human fetal-maternal interface

Costa, M. L., Robinette, M. L., Bugatti, M., Longtine, M. S., Colvin, B. N., Lantelme, E., Vermi, W., Colonna, M., Nelson, D. M. & Cella, M., Oct 25 2017, In: Frontiers in immunology. 8, OCT, 1357.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2016

Aerobic glycolysis in the frontal cortex correlates with memory performance in wild-type mice but not the APP/PS1 mouse model of cerebral amyloidosis

Harris, R. A., Tindale, L., Lone, A., Singh, O., Macauley, S. L., Stanley, M., Holtzman, D. M., Bartha, R. & Cumming, R. C., Feb 10 2016, In: Journal of Neuroscience. 36, 6, p. 1871-1878 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease

O'Brien, V. P., Hannan, T. J., Yu, L., Livny, J., Roberson, E. D. O., Schwartz, D. J., Souza, S., Mendelsohn, C. L., Colonna, M., Lewis, A. L. & Hultgren, S. J., Oct 31 2016, In: Nature microbiology. 2, 16196.

Research output: Contribution to journal › Article › peer-review

Open Access

78 Scopus citations

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease

Minter, M. R., Zhang, C., Leone, V., Ringus, D. L., Zhang, X., Oyler-Castrillo, P., Musch, M. W., Liao, F., Ward, J. F., Holtzman, D. M., Chang, E. B., Tanzi, R. E. & Sisodia, S. S., Jul 21 2016, In: Scientific reports. 6, 30028.

Research output: Contribution to journal › Article › peer-review

Open Access

543 Scopus citations

ApoE4 upregulates the activity of mitochondria-associated ER membranes

Tambini, M. D., Pera, M., Kanter, E., Yang, H., Guardia-Laguarta, C., Holtzman, D., Sulzer, D., Area-Gomez, E. & Schon, E. A., Jan 1 2016, In: EMBO Reports. 17, 1, p. 27-36 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

126 Scopus citations

A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin

Deming, Y., Xia, J., Cai, Y., Lord, J., Holmans, P., Bertelsen, S., Holtzman, D., Morris, J. C., Bales, K., Pickering, E. H., Kauwe, J., Goate, A. & Cruchaga, C., Jan 1 2016, In: Neurobiology of Aging. 37, p. 208.e1-208.e9

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects

Ghosal, K., Haag, M., Verghese, P. B., West, T., Veenstra, T., Braunstein, J. B., Bateman, R. J., Holtzman, D. M. & Landreth, G. E., Jun 1 2016, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2, 2, p. 110-120 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans

Hölttä, M., Dean, R. A., Siemers, E., Mawuenyega, K. G., Sigurdson, W., May, P. C., Holtzman, D. M., Portelius, E., Zetterberg, H., Bateman, R. J., Blennow, K. & Gobom, J., Mar 7 2016, In: Alzheimer's Research and Therapy. 8, 1, 11.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease

Moore, K. M., Girens, R. E., Larson, S. K., Jones, M. R., Restivo, J. L., Holtzman, D. M., Cirrito, J. R., Yuede, C. M., Zimmerman, S. D. & Timson, B. F., Jan 1 2016, In: Neurobiology of Disease. 85, p. 218-224 7 p.

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults

Alzheimer's Disease Neuroimaging Initiative, Jun 2016, In: JAMA Neurology. 73, 6, p. 721-732 12 p.

Research output: Contribution to journal › Article › peer-review

274 Scopus citations

BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease

Lim, Y. Y., Hassenstab, J., Cruchaga, C., Goate, A., Fagan, A. M., Benzinger, T. L. S., Maruff, P., Snyder, P. J., Masters, C. L., Allegri, R., Chhatwal, J., Farlow, M. R., Graff-Radford, N. R., Laske, C., Levin, J., McDade, E., Ringman, J. M., Rossor, M., Salloway, S. & Schofield, P. R. & 3 others, Holtzman, D. M., Morris, J. C. & Bateman, R. J., Oct 1 2016, In: Brain. 139, 10, p. 2766-2777 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability

Ivanov, S., Scallan, J. P., Kim, K. W., Werth, K., Johnson, M. W., Saunders, B. T., Wang, P. L., Kuan, E. L., Straub, A. C., Ouhachi, M., Weinstein, E. G., Williams, J. W., Briseño, C., Colonna, M., Isakson, B. E., Gautier, E. L., Förster, R., Davis, M. J., Zinselmeyer, B. H. & Randolph, G. J., Apr 1 2016, In: Journal of Clinical Investigation. 126, 4, p. 1581-1591 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

73 Scopus citations

Cerebrospinal Fluid Biomarkers and Reserve Variables as Predictors of Future "non-Cognitive" Outcomes of Alzheimer's Disease

Ingber, A. P., Hassenstab, J., Fagan, A. M., Benzinger, T. L. S., Grant, E. A., Holtzman, D. M., Morris, J. C. & Roe, C. M., 2016, In: Journal of Alzheimer's Disease. 52, 3, p. 1055-1064 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

Piccio, L., Deming, Y., Del-Águila, J. L., Ghezzi, L., Holtzman, D. M., Fagan, A. M., Fenoglio, C., Galimberti, D., Borroni, B. & Cruchaga, C., Jun 1 2016, In: Acta Neuropathologica. 131, 6, p. 925-933 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

279 Scopus citations

Changes in insulin and insulin signaling in Alzheimer's disease: Cause or consequence?

Stanley, M., Macauley, S. L. & Holtzman, D. M., Jul 25 2016, In: Journal of Experimental Medicine. 213, 8, p. 1375-1385 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

168 Scopus citations

Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40

Deming, Y., Black, K., Carrell, D., Cai, Y., Del-Aguila, J. L., Fernandez, M. V., Budde, J., Ma, S. M., Saef, B., Howells, B., Bertelsen, S., Huang, K. L., Sutphen, C. L., Tarawneh, R., Fagan, A. M., Holtzman, D. M., Morris, J. C., Goate, A. M., Dougherty, J. D. & Cruchaga, C., Nov 10 2016, In: BMC Neurology. 16, 1, 217.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Comparison of a single-channel EEG sleep study to polysomnography

Lucey, B. P., Mcleland, J. S., Toedebusch, C. D., Boyd, J., Morris, J. C., Landsness, E. C., Yamada, K. & Holtzman, D. M., Dec 1 2016, In: Journal of Sleep Research. 25, 6, p. 625-635 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

129 Scopus citations

CSF sTREM2: Marking the tipping point between preclinical AD and dementia?

Schindler, S. E. & Holtzman, D. M., May 1 2016, In: EMBO Molecular Medicine. 8, 5, p. 437-438 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Diagnostic and prognostic utility of the synaptic marker neurogranin in Alzheimer disease

Tarawneh, R., D'Angelo, G., Crimmins, D., Herries, E., Griest, T., Fagan, A. M., Zipfel, G. J., Ladenson, J. H., Morris, J. C. & Holtzman, D. M., May 2016, In: JAMA Neurology. 73, 5, p. 561-571 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

173 Scopus citations

Distinct Gene Regulatory Pathways for Human Innate versus Adaptive Lymphoid Cells

Koues, O. I., Collins, P. L., Cella, M., Robinette, M. L., Porter, S. I., Pyfrom, S. C., Payton, J. E., Colonna, M. & Oltz, E. M., May 19 2016, In: Cell. 165, 5, p. 1134-1146 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

141 Scopus citations

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

the Alzheimer's Disease Neuroimaging Initiative, Jun 21 2016, In: Nature communications. 7, 11934.

Research output: Contribution to journal › Article › peer-review

Open Access

868 Scopus citations

Expression profiling of constitutive mast cells reveals a unique identity within the immune system

Dwyer, D. F., Barrett, N. A., Austen, K. F., Kim, E. Y., Brenner, M. B., Shaw, L., Yu, B., Goldrath, A., Mostafavi, S., Regev, A., Rhoades, A., Moodley, D., Yoshida, H., Mathis, D., Benoist, C., Nabekura, T., Lam, V., Lanier, L. L., Brown, B. & Merad, M. & 16 others, Cremasco, V., Turley, S., Monach, P., Dustin, M. L., Li, Y., Shinton, S. A., Hardy, R. R., Shay, T., Qi, Y., Sylvia, K., Kang, J., Fairfax, K., Randolph, G. J., Robinette, M. L., Fuchs, A. & Colonna, M., Jun 21 2016, In: Nature immunology. 17, 7, p. 878-887 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

294 Scopus citations

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

Deming, Y., Xia, J., Cai, Y., Lord, J., Del-Aguila, J. L., Fernandez, M. V., Carrell, D., Black, K., Budde, J., Ma, S., Saef, B., Howells, B., Bertelsen, S., Bailey, M., Ridge, P. G., Holtzman, D., Morris, J. C., Bales, K., Pickering, E. H. & Lee, J. M. & 5 others, Heitsch, L., Kauwe, J., Goate, A., Piccio, L. & Cruchaga, C., Jan 4 2016, In: Scientific reports. 6, 18092.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

Achariyar, T. M., Li, B., Peng, W., Verghese, P. B., Shi, Y., McConnell, E., Benraiss, A., Kasper, T., Song, W., Takana, T., Holtzman, D. M., Nedergaard, M. & Deane, R., Dec 8 2016, In: Molecular neurodegeneration. 11, 1, 74.

Research output: Contribution to journal › Article › peer-review

Open Access

192 Scopus citations

Human Central Nervous System (CNS) apoE isoforms are increased by age, differentially altered by amyloidosis, and relative amounts reversed in the CNS compared with plasma

Baker-Nigh, A. T., Mawuenyega, K. G., Bollinger, J. G., Ovod, V., Kasten, T., Franklin, E. E., Liao, F., Jiang, H., Holtzman, D., Cairns, N. J., Morris, J. C. & Bateman, R. J., Dec 30 2016, In: Journal of Biological Chemistry. 291, 53, p. 27204-27218 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Imaging and cerebrospinal fluid biomarkers in early preclinical alzheimer disease

Vlassenko, A. G., McCue, L., Jasielec, M. S., Su, Y., Gordon, B. A., Xiong, C., Holtzman, D. M., Benzinger, T. L. S., Morris, J. C. & Fagan, A. M., Sep 1 2016, In: Annals of neurology. 80, 3, p. 379-387 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

87 Scopus citations

Impaired Autophagy in APOE4 Astrocytes

Simonovitch, S., Schmukler, E., Bespalko, A., Iram, T., Frenkel, D., Holtzman, D. M., Masliah, E., Michaelson, D. M. & Pinkas-Kramarski, R., Mar 30 2016, In: Journal of Alzheimer's Disease. 51, 3, p. 915-927 13 p.

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells

Yun, T. J., Lee, J. S., Machmach, K., Shim, D., Choi, J., Wi, Y. J., Jang, H. S., Jung, I. H., Kim, K., Yoon, W. K., Miah, M. A., Li, B., Chang, J., Bego, M. G., Pham, T. N. Q., Loschko, J., Fritz, J. H., Krug, A. B., Lee, S. P. & Keler, T. & 9 others, Guimond, J. V., Haddad, E., Cohen, E. A., Sirois, M. G., El-Hamamsy, I., Colonna, M., Oh, G. T., Choi, J. H. & Cheong, C., May 10 2016, In: Cell metabolism. 23, 5, p. 852-866 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

78 Scopus citations

Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection

Rovis, T. L., Brlic, P. K., Kaynan, N., Lisnic, V. J., Brizic, I., Jordan, S., Tomic, A., Kvestak, D., Babic, M., Tsukerman, P., Colonna, M., Koszinowski, U., Messerle, M., Mandelboim, O., Krmpotic, A. & Jonjic, S., Aug 22 2016, In: Journal of Experimental Medicine. 213, 9, p. 1835-1850 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models

Zhao, L., Gottesdiener, A. J., Parmar, M., Li, M., Kaminsky, S. M., Chiuchiolo, M. J., Sondhi, D., Sullivan, P. M., Holtzman, D. M., Crystal, R. G. & Paul, S. M., Aug 1 2016, In: Neurobiology of Aging. 44, p. 159-172 14 p.

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Longitudinal β-amyloid deposition and hippocampal volume in preclinical Alzheimer disease and suspected non-Alzheimer disease pathophysiology

Gordon, B. A., Blazey, T., Su, Y., Fagan, A. M., Holtzman, D. M., Morris, J. C. & Benzinger, T. L. S., Oct 1 2016, In: JAMA Neurology. 73, 10, p. 1192-1200 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

87 Scopus citations

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

Huang, S. C. C., Smith, A. M., Everts, B., Colonna, M., Pearce, E. L., Schilling, J. D. & Pearce, E. J., Oct 18 2016, In: Immunity. 45, 4, p. 817-830 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

503 Scopus citations

MHC II⁺ resident peritoneal and pleural macrophages rely on IRF4 for development from circulating monocytes

Kim, K. W., Williams, J. W., Wang, Y. T., Ivanov, S., Gilfillan, S., Colonna, M., Virgin, H. W., Gautier, E. L. & Randolph, G. J., Sep 19 2016, In: Journal of Experimental Medicine. 213, 10, p. 1951-1959 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

114 Scopus citations

Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2

Hirayasu, K., Saito, F., Suenaga, T., Shida, K., Arase, N., Oikawa, K., Yamaoka, T., Murota, H., Chibana, H., Nakagawa, I., Kubori, T., Nagai, H., Nakamaru, Y., Katayama, I., Colonna, M. & Arase, H., Apr 25 2016, In: Nature microbiology. 1, 6, 16054.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Mood Changes in Cognitively Normal Older Adults are Linked to Alzheimer Disease Biomarker Levels

Babulal, G. M., Ghoshal, N., Head, D., Vernon, E. K., Holtzman, D. M., Benzinger, T. L. S., Fagan, A. M., Morris, J. C. & Roe, C. M., Nov 1 2016, In: American Journal of Geriatric Psychiatry. 24, 11, p. 1095-1104 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

108 Scopus citations

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

Kober, D. L., Alexander-Brett, J. M., Karch, C. M., Cruchaga, C., Colonna, M., Holtzman, M. J. & Brett, T. J., Dec 20 2016, In: eLife. 5, DECEMBER2016, e20391.

Research output: Contribution to journal › Article › peer-review

Open Access

157 Scopus citations

Center for Brain Immunology & Glia (BIG)

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