Center for Brain Immunology & Glia (BIG)

2013

RNA helicase signaling is critical for type I interferon production and protection against rift valley fever virus during mucosal challenge

Ermler, M. E., Yerukhim, E., Schriewer, J., Schattgen, S., Traylor, Z., Wespiser, A. R., Caffrey, D. R., Chen, Z. J., King, C. H., Gale Michael, J., Colonna, M., Fitzgerald, K. A., Buller, R. M. L. & Hise, A. G., May 2013, In: Journal of virology. 87, 9, p. 4846-4860 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Role of TREM1-DAP12 in renal inflammation during obstructive nephropathy

Tammaro, A., Stroo, I., Rampanelli, E., Blank, F., Butter, L. M., Claessen, N., Takai, T., Colonna, M., Leemans, J. C., Florquin, S. & Dessing, M. C., Dec 16 2013, In: PloS one. 8, 12, e82498.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Sca-1 expression defines developmental stages of mouse pDCs that show functional heterogeneity in the endosomal but not lysosomal TLR9 response

Niederquell, M., Kurig, S., Fischer, J. A. A., Tomiuk, S., Swiecki, M., Colonna, M., Johnston, I. C. D. & Dzionek, A., Nov 1 2013, In: European Journal of Immunology. 43, 11, p. 2993-3005 13 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Sleep quality and preclinical Alzheimer disease

Ju, Y. E. S., McLeland, J. S., Toedebusch, C. D., Xiong, C., Fagan, A. M., Duntley, S. P., Morris, J. C. & Holtzman, D. M., May 2013, In: JAMA Neurology. 70, 5, p. 587-593 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

405 Scopus citations

SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy

Winer, L., Srinivasan, D., Chun, S., Lacomis, D., Jaffa, M., Fagan, A., Holtzman, D. M., Wancewicz, E., Bennett, C. F., Bowser, R., Cudkowicz, M. & Miller, T. M., Feb 2013, In: JAMA Neurology. 70, 2, p. 201-207 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

74 Scopus citations

The choroid plexus and cerebrospinal fluid: Emerging roles in development, disease, and therapy

Lehtinen, M. K., Bjornsson, C. S., Dymecki, S. M., Gilbertson, R. J., Holtzman, D. M. & Monuki, E. S., 2013, In: Journal of Neuroscience. 33, 45, p. 17553-17559 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

109 Scopus citations

The PSEN1, p.E318G Variant Increases the Risk of Alzheimer's Disease in APOE-ε4 Carriers

Benitez, B. A., Karch, C. M., Cai, Y., Jin, S. C., Cooper, B., Carrell, D., Bertelsen, S., Chibnik, L., Schneider, J. A., Bennett, D. A., Fagan, A. M., Holtzman, D., Morris, J. C., Goate, A. M. & Cruchaga, C., Aug 2013, In: PLoS genetics. 9, 8, e1003685.

Research output: Contribution to journal › Article › peer-review

Open Access

47 Scopus citations

Transepithelial migration of neutrophils into the lung requires TREM-1

Klesney-Tait, J., Keck, K., Li, X., Gilfillan, S., Otero, K., Baruah, S., Meyerholz, D. K., Varga, S. M., Knudson, C. J., Moninger, T. O., Moreland, J., Zabner, J. & Colonna, M., Jan 2 2013, In: Journal of Clinical Investigation. 123, 1, p. 138-149 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

107 Scopus citations

Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation

Dalal, J., Roh, J. H., Maloney, S. E., Akuffo, A., Shah, S., Yuan, H., Wamsley, B., Jones, W. B., Strong, C. D. G., Gray, P. A., Holtzman, D. M., Heintz, N. & Dougherty, J. D., Mar 1 2013, In: Genes and Development. 27, 5, p. 565-578 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

2012

¹¹C-PiB imaging of human immunodeficiency virus-associated neurocognitive disorder

Ances, B. M., Benzinger, T. L., Christensen, J. J., Thomas, J., Venkat, R., Teshome, M., Aldea, P., Fagan, A. M., Holtzman, D. M., Morris, J. C. & Clifford, D. B., Jan 2012, In: Archives of neurology. 69, 1, p. 72-77 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

Lee, J. S., Cella, M., McDonald, K. G., Garlanda, C., Kennedy, G. D., Nukaya, M., Mantovani, A., Kopan, R., Bradfield, C. A., Newberry, R. D. & Colonna, M., Feb 2012, In: Nature immunology. 13, 2, p. 144-152 9 p.

Research output: Contribution to journal › Article › peer-review

530 Scopus citations

Alzheimer disease in 2020

Holtzman, D. M., Mandelkow, E. & Selkoe, D. J., Nov 2012, In: Cold Spring Harbor perspectives in medicine. 2, 11, a011585.

Research output: Contribution to journal › Article › peer-review

Open Access

88 Scopus citations

Amyloid-β_1-15/16 as a marker for γ-secretase inhibition in Alzheimer's disease

Portelius, E., Zetterberg, H., Dean, R. A., Marcil, A., Bourgeois, P., Nutu, M., Andreasson, U., Siemers, E., Mawuenyega, K. G., Sigurdson, W. C., May, P. C., Paul, S. M., Holtzman, D. M., Blennow, K. & Bateman, R. J., 2012, In: Journal of Alzheimer's Disease. 31, 2, p. 335-341 7 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis

Kim, J., Eltorai, A. E. M., Jiang, H., Liao, F., Verghese, P. B., Kim, J., Stewart, F. R., Basak, J. M. & Holtzman, D. M., Nov 2012, In: Journal of Experimental Medicine. 209, 12, p. 2149-2156 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

91 Scopus citations

Apolipoprotein e, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide

Hashimoto, T., Serrano-Pozo, A., Hori, Y., Adams, K. W., Takeda, S., Banerji, A. O., Mitani, A., Joyner, D., Thyssen, D. H., Bacskai, B. J., Frosch, M. P., Spires-Jones, T. L., Finn, M. B., Holtzman, D. M. & Hyman, B. T., Oct 24 2012, In: Journal of Neuroscience. 32, 43, p. 15181-15192 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

182 Scopus citations

Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β

Koffie, R. M., Hashimoto, T., Tai, H. C., Kay, K. R., Serrano-Pozo, A., Joyner, D., Hou, S., Kopeikina, K. J., Frosch, M. P., Lee, V. M., Holtzman, D. M., Hyman, B. T. & Spires-Jones, T. L., Jul 2012, In: Brain. 135, 7, p. 2155-2168 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

182 Scopus citations

Apolipoprotein E and apolipoprotein E receptors: Normal biology and roles in Alzheimer disease

Holtzman, D. M., Herz, J. & Bu, G., Mar 2012, In: Cold Spring Harbor perspectives in medicine. 2, 3

Research output: Contribution to journal › Article › peer-review

Open Access

494 Scopus citations

Apolipoprotein e controls cerebrovascular integrity via cyclophilin A

Bell, R. D., Winkler, E. A., Singh, I., Sagare, A. P., Deane, R., Wu, Z., Holtzman, D. M., Betsholtz, C., Armulik, A., Sallstrom, J., Berk, B. C. & Zlokovic, B. V., May 24 2012, In: Nature. 485, 7399, p. 512-516 5 p.

Research output: Contribution to journal › Article › peer-review

793 Scopus citations

Bcl-x Pre-mRNA splicing regulates brain injury after neonatal hypoxia-ischemia

Xiao, Q., Ford, A. L., Xu, J., Yan, P., Lee, K. Y., Gonzales, E., West, T., Holtzman, D. M. & Lee, J. M., Sep 26 2012, In: Journal of Neuroscience. 32, 39, p. 13587-13596 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Bidirectional relationship between functional connectivity and amyloid-β deposition in mouse brain

Bero, A. W., Bauer, A. Q., Stewart, F. R., White, B. R., Cirrito, J. R., Raichle, M. E., Culver, J. P. & Holtzman, D. M., Mar 28 2012, In: Journal of Neuroscience. 32, 13, p. 4334-4340 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

126 Scopus citations

CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection

Welch, M. J., Teijaro, J. R., Lewicki, H. A., Colonna, M. & Oldstone, M. B. A., Aug 1 2012, In: Virology. 429, 2, p. 163-170 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Cerebrospinal fluid APOE levels: An endophenotype for genetic studies for Alzheimer's disease

Cruchaga, C., Kauwe, J. S. K., Nowotny, P., Bales, K., Pickering, E. H., Mayo, K., Bertelsen, S., Hinrichs, A., Fagan, A. M., Holtzman, D. M., Morris, J. C. & Goate, A. M., Oct 2012, In: Human molecular genetics. 21, 20, p. 4558-4571 14 p., dds296.

Research output: Contribution to journal › Article › peer-review

Open Access

148 Scopus citations

Cerebrospinal fluid proteins predict longitudinal hippocampal degeneration in early-stage dementia of the Alzheimer type

Wang, L., Fagan, A. M., Shah, A. R., Beg, M. F., Csernansky, J. G., Morris, J. C. & Holtzman, D. M., Oct 2012, In: Alzheimer disease and associated disorders. 26, 4, p. 314-321 8 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Clinical and biomarker changes in dominantly inherited Alzheimer's disease

Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., Holtzman, D. M., Santacruz, A., Buckles, V., Oliver, A., Moulder, K., Aisen, P. S., Ghetti, B., Klunk, W. E., McDade, E., Martins, R. N. & 8 others, Masters, C. L., Mayeux, R., Ringman, J. M., Rossor, M. N., Schofield, P. R., Sperling, R. A., Salloway, S. & Morris, J. C., Aug 30 2012, In: New England Journal of Medicine. 367, 9, p. 795-804 10 p.

Research output: Contribution to journal › Article › peer-review

2212 Scopus citations

CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease

Tarawneh, R., Lee, J. M., Ladenson, J. H., Morris, J. C. & Holtzman, D. M., Mar 6 2012, In: Neurology. 78, 10, p. 709-719 11 p.

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Cutting edge: Paradoxical roles of BST2/tetherin in promoting type I IFN response and viral infection

Swiecki, M., Wang, Y., Gilfillan, S., Lenschow, D. J. & Colonna, M., Mar 15 2012, In: Journal of Immunology. 188, 6, p. 2488-2492 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

Cutting edge: Human FcRL4 and FcRL5 are receptors for IgA and IgG

Wilson, T. J., Fuchs, A. & Colonna, M., May 15 2012, In: Journal of Immunology. 188, 10, p. 4741-4745 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

83 Scopus citations

Deciphering alzheimer disease

Selkoe, D., Mandelkow, E. & Holtzman, D., Jan 2012, In: Cold Spring Harbor perspectives in medicine. 2, 1

Research output: Contribution to journal › Article › peer-review

Open Access

124 Scopus citations

Disruption of the sleep-wake cycle and diurnal fluctuation of amyloid-β in mice with Alzheimer's disease pathology

Roh, J. H., Huang, Y., Bero, A. W., Kasten, T., Stewart, F. R., Bateman, R. J. & Holtzman, D. M., Sep 5 2012, In: Science translational medicine. 4, 150, 150ra122.

Research output: Contribution to journal › Article › peer-review

353 Scopus citations

Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice

Hunter, J. M., Cirrito, J. R., Restivo, J. L., Kinley, R. D., Sullivan, P. M., Holtzman, D. M., Koger, D., Delong, C., Lin, S., Zhao, L., Liu, F., Bales, K. & Paul, S. M., Jul 27 2012, In: Brain Research. 1467, p. 120-132 13 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation

Oh, J., Riek, A. E., Weng, S., Petty, M., Kim, D., Colonna, M., Cella, M. & Bernal-Mizrachi, C., Apr 6 2012, In: Journal of Biological Chemistry. 287, 15, p. 11629-11641 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

205 Scopus citations

Exercise engagement as a moderator of the effects of APOE genotype on amyloid deposition

Head, D., Bugg, J. M., Goate, A. M., Fagan, A. M., Mintun, M. A., Benzinger, T., Holtzman, D. M. & Morris, J. C., May 2012, In: Archives of neurology. 69, 5, p. 636-643 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

186 Scopus citations

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

Wang, Y., Szretter, K. J., Vermi, W., Gilfillan, S., Rossini, C., Cella, M., Barrow, A. D., Diamond, M. S. & Colonna, M., Aug 2012, In: Nature immunology. 13, 8, p. 753-760 8 p.

Research output: Contribution to journal › Article › peer-review

581 Scopus citations

Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells

Drobits, B., Holcmann, M., Amberg, N., Swiecki, M., Grundtner, R., Hammer, M., Colonna, M. & Sibilia, M., Feb 2012, In: Journal of Clinical Investigation. 122, 2, p. 575-585 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

199 Scopus citations

Immunoglobulin-like transcript receptors on human dermal CD14⁺ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming

Banchereau, J., Zurawsk, S., Thompson-Snipes, L. A., Blanck, J. P., Clayton, S., Munk, A., Cao, Y., Wang, Z., Khandelwal, S., Hu, J., McCoy IV, W. H., Palucka, K. A., Reiter, Y., Fremont, D. H., Zurawski, G., Colonna, M., Shaw, A. S. & Klechevsky, E., Nov 13 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 46, p. 18885-18890 6 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

In vivo human apolipoprotein E isoform fractional turnover rates in the CNS

Wildsmith, K. R., Basak, J. M., Patterson, B. W., Pyatkivskyy, Y., Kim, J., Yarasheski, K. E., Wang, J. X., Mawuenyega, K. G., Jiang, H., Parsadanian, M., Yoon, H., Kasten, T., Sigurdson, W. C., Xiong, C., Goate, A., Holtzman, D. M. & Bateman, R. J., Jun 4 2012, In: PloS one. 7, 6, e38013.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

Leukocyte-associated Ig-like receptor-1 - Deficient mice have an altered immune cell phenotype

Tang, X., Tian, L., Esteso, G., Choi, S. C., Barrow, A. D., Colonna, M., Borrego, F. & Coligan, J. E., Jan 15 2012, In: Journal of Immunology. 188, 2, p. 548-558 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Loss of intranetwork and internetwork resting state functional connections with Alzheimer's disease progression

Brier, M. R., Thomas, J. B., Snyder, A. Z., Benzinger, T. L., Zhang, D., Raichle, M. E., Holtzman, D. M., Morris, J. C. & Ances Dr., B. M., Jun 27 2012, In: Journal of Neuroscience. 32, 26, p. 8890-8899 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

379 Scopus citations

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis

Castellano, J. M., Deane, R., Gottesdiener, A. J., Verghese, P. B., Stewart, F. R., West, T., Paoletti, A. C., Kasper, T. R., DeMattos, R. B., Zlokovic, B. V. & Holtzman, D. M., Sep 18 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 38, p. 15502-15507 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

121 Scopus citations

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes

Basak, J. M., Verghese, P. B., Yoon, H., Kim, J. & Holtzman, D. M., Apr 20 2012, In: Journal of Biological Chemistry. 287, 17, p. 13959-13971 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

127 Scopus citations

Measurement of apolipoprotein e and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling

Basak, J. M., Kim, J., Pyatkivskyy, Y., Wildsmith, K. R., Jiang, H., Parsadanian, M., Patterson, B. W., Bateman, R. J. & Holtzman, D. M., 2012, In: Molecular neurodegeneration. 7, 1, 14.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Melanoma differentiation-associated gene 5 is critical for protection against theiler's virus-induced demyelinating disease

Jin, Y. H., Kim, S. J., So, E. Y., Meng, L., Colonna, M. & Kim, B. S., Feb 2012, In: Journal of virology. 86, 3, p. 1531-1543 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimers disease subjects

Hata, S., Taniguchi, M., Piao, Y., Ikeuchi, T., Fagan, A. M., Holtzman, D. M., Bateman, R., Sohrabi, H. R., Martins, R. N., Gandy, S., Urakami, K. & Suzuki, T., 2012, In: Molecular neurodegeneration. 7, 1, 16.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

Jiang, M., Wang, J., Fu, J., Du, L., Jeong, H., West, T., Xiang, L., Peng, Q., Hou, Z., Cai, H., Seredenina, T., Arbez, N., Zhu, S., Sommers, K., Qian, J., Zhang, J., Mori, S., Yang, X. W., Tamashiro, K. L. K., Aja, S. & 10 others, Moran, T. H., Luthi-Carter, R., Martin, B., Maudsley, S., Mattson, M. P., Cichewicz, R. H., Ross, C. A., Holtzman, D. M., Krainc, D. & Duan, W., Jan 2012, In: Nature medicine. 18, 1, p. 153-158 6 p.

Research output: Contribution to journal › Article › peer-review

259 Scopus citations

Plasma multianalyte profiling in mild cognitive impairment and Alzheimer Disease

Hu, W. T., Holtzman, D. M., Fagan, A. M., Shaw, L. M., Perrin, R., Arnold, S. E., Grossman, M., Xiong, C., Craig-Schapiro, R., Clark, C. M., Pickering, E., Kuhn, M., Chen, Y., Van Deerlin, V. M., McCluskey, L., Elman, L., Karlawish, J., Chen-Plotkin, A., Hurtig, H. I., Siderowf, A. & 5 others, Swenson, F., Lee, V. M. Y., Morris, J. C., Trojanowski, J. Q. & Soares, H., Aug 28 2012, In: Neurology. 79, 9, p. 897-905 9 p.

Research output: Contribution to journal › Article › peer-review

179 Scopus citations

Spontaneous mutation of the Dock2 gene in Irf5 ^-/- mice complicates interpretation of type I interferon production and antibody responses

Purtha, W. E., Swiecki, M., Colonna, M., Diamond, M. S. & Bhattacharya, D., Apr 10 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 15, p. E898-E904

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Tau elevations in the brain extracellular space correlate with reduced amyloid-β levels and predict adverse clinical outcomes after severe traumatic brain injury

Magnoni, S., Esparza, T. J., Conte, V., Carbonara, M., Carrabba, G., Holtzman, D. M., Zipfel, G. J., Stocchetti, N. & Brody, D. L., Apr 2012, In: Brain. 135, 4, p. 1268-1280 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access