Center for Brain Immunology & Glia (BIG)

Cutting edge: TREM-2 attenuates macrophage activation

Turnbull, I. R., Gilfillan, S., Cella, M., Aoshi, T., Miller, M., Piccio, L., Hernandez, M. & Colonna, M., Sep 15 2006, In: Journal of Immunology. 177, 6, p. 3520-3524 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

445 Scopus citations

Cutting edge: Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor γ-chain

Nakajima, H., Samaridis, J., Angman, L. & Colonna, M., Jan 1 1999, In: Journal of Immunology. 162, 1, p. 5-8 4 p.

Research output: Contribution to journal › Article › peer-review

152 Scopus citations

Cutting edge: Polyinosinic:Polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells

Wang, Y., Cella, M., Gilfillan, S. & Colonna, M., Mar 15 2010, In: Journal of Immunology. 184, 6, p. 2751-2755 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

Cutting edge: Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I-molecules

Colonna, M., Samaridis, J., Cella, M., Angman, L., Allen, R. L., O'Callaghan, C. A., Dunbar, R., Ogg, G. S., Cerundolo, V. & Rolink, A., Apr 1 1998, In: Journal of Immunology. 160, 7, p. 3096-3100 5 p.

Research output: Contribution to journal › Article › peer-review

466 Scopus citations

Cutting edge: Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family

Bouchon, A., Cella, M., Grierson, H. L., Cohen, J. I. & Colonna, M., Nov 15 2001, In: Journal of Immunology. 167, 10, p. 5517-5521 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

144 Scopus citations

Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties

Chang, C., Dietrich, J., Harpur, A. G., Lindquist, J. A., Haude, A., Loke, Y. W., King, A., Colonna, M., Trowsdale, J. & Wilson, M. J., Nov 6 1999, In: Journal of Immunology. 163, 9, p. 4651-4654 4 p.

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Cutting edge: Signal-regulatory protein β1 is a DAP12-associated activating receptor expressed in myeloid cells

Dietrich, J., Cella, M., Seiffert, M., Bühring, H. J. & Colonna, M., Jan 1 2000, In: Journal of Immunology. 164, 1, p. 9-12 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

130 Scopus citations

Cutting edge: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

Bouchon, A., Dietrich, J. & Colonna, M., May 15 2000, In: Journal of Immunology. 164, 10, p. 4991-4995 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

882 Scopus citations

Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by Interacting with the Poliovirus Receptor (CD155)

Fuchs, A., Cella, M., Giurisato, E., Shaw, A. S. & Colonna, M., Apr 1 2004, In: Journal of Immunology. 172, 7, p. 3994-3998 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

266 Scopus citations

Cytokine-mediated inhibition of fibrillar amyloid-β peptide degradation by human mononuclear phagocytes

Yamamoto, M., Kiyota, T., Walsh, S. M., Liu, J., Kipnis, J. & Ikezu, T., Sep 15 2008, In: Journal of Immunology. 181, 6, p. 3877-3886 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

73 Scopus citations

Cytolytic responses: Cadherins put out the fire

Colonna, M., Feb 20 2006, In: Journal of Experimental Medicine. 203, 2, p. 261-264 4 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

21 Scopus citations

Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K⁺ efflux

Franchi, L., Eigenbrod, T., Muñoz-Planillo, R., Ozkurede, U., Kim, Y. G., Chakrabarti, A., Gale, M., Silverman, R. H., Colonna, M., Akira, S. & Núñez, G., Oct 15 2014, In: Journal of Immunology. 193, 8, p. 4214-4222 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

107 Scopus citations

DAMed in (Trem) 2 Steps

Da Mesquita, S. & Kipnis, J., Jun 15 2017, In: Cell. 169, 7, p. 1172-1174 3 p.

Research output: Contribution to journal › Short survey › peer-review

Open Access

3 Scopus citations

DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo

Tassi, I., Le Friec, G., Gilfillan, S., Takai, T., Yokohama, W. M. & Colonna, M., 2009, In: European Journal of Immunology. 39, 4, p. 1129-1135 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

DAP10 contributes to CD8⁺ T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection

Heßmann, M., Rausch, A., Rückerl, D., Adams, P. S., Simon, M., Gilfillan, S., Colonna, M., Ehlers, S. & Hölscher, C., May 2011, In: Immunobiology. 216, 5, p. 639-647 9 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

DAP12: A key accessory protein for relaying signals by Natural Killer cell receptors

Campbell, K. S. & Colonna, M., Jun 1999, In: International Journal of Biochemistry and Cell Biology. 31, 6, p. 631-636 6 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis

Turnbull, I. R., McDunn, J. E., Takai, T., Townsend, R. R., Cobb, J. P. & Colonna, M., Aug 1 2005, In: Journal of Experimental Medicine. 202, 3, p. 363-369 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

DAP12 signaling: From immune cells to bone modeling and brain myelination

Colonna, M., Feb 2003, In: Journal of Clinical Investigation. 111, 3, p. 313-314 2 p.

Research output: Contribution to journal › Comment/debate

Open Access

31 Scopus citations

DC-SCRIPT deficiency delays mouse mammary gland development and branching morphogenesis

Tang, C., van den Bijgaart, R. J. E., Looman, M. W. G., Tel-Karthaus, N., de Graaf, A. M. A., Gilfillan, S., Colonna, M., Ansems, M. & Adema, G. J., Nov 1 2019, In: Developmental Biology. 455, 1, p. 42-50 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Dealing with Danger in the CNS: The Response of the Immune System to Injury

Gadani, S. P., Walsh, J. T., Lukens, J. R. & Kipnis, J., Jul 1 2015, In: Neuron. 87, 1, p. 47-62 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

172 Scopus citations

Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils

Daigle, I., Yousefi, S., Colonna, M., Green, D. R. & Simon, H. U., 2002, In: Nature medicine. 8, 1, p. 61-67 7 p.

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Debate: "Is increasing neuroinflammation beneficial for neural repair?"

Crutcher, K. A., Gendelman, H. E., Kipnis, J., Perez-Polo, J. R., Perry, V. H., Popovich, P. G. & Weaver, L. C., Sep 2006, In: Journal of Neuroimmune Pharmacology. 1, 3, p. 195-211 17 p.

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Deciphering alzheimer disease

Selkoe, D., Mandelkow, E. & Holtzman, D., Jan 2012, In: Cold Spring Harbor perspectives in medicine. 2, 1

Research output: Contribution to journal › Article › peer-review

Open Access

128 Scopus citations

Decreased cerebrospinal fluid Aβ ₄₂ correlates with brain atrophy in cognitively normal elderly

Fagan, A. M., Head, D., Shah, A. R., Marcus, D., Mintun, M., Morris, J. C. & Holtzman, D. M., Feb 2009, In: Annals of neurology. 65, 2, p. 176-183 8 p.

Research output: Contribution to journal › Article › peer-review

279 Scopus citations

Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration

Hagnerud, S., Manna, P. P., Cella, M., Stenberg, Å., Frazier, W. A., Colonna, M. & Oldenborg, P. A., May 15 2006, In: Journal of Immunology. 176, 10, p. 5772-5778 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

56 Scopus citations

Deletion of Abca1 increases Aβ deposition in the PDAPP transgenic mouse model of Alzheimer disease

Wahrle, S. E., Jiang, H., Parsadanian, M., Hartman, R. E., Bales, K. R., Paul, S. M. & Holtzman, D. M., Dec 30 2005, In: Journal of Biological Chemistry. 280, 52, p. 43236-43242 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

260 Scopus citations

Dementia is not synonymous with Alzheimer’s disease

Jack, C., Holtzman, D. & Sperling, R., Dec 11 2019, In: Science translational medicine. 11, 522, eaav0511.

Research output: Contribution to journal › Editorial

7 Scopus citations

Dendritic cells at the host-pathogen interface

Colonna, M., Pulendran, B. & Iwasaki, A., Feb 2006, In: Nature immunology. 7, 2, p. 117-120 4 p.

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Dendritic cells process and present antigens across a range of maturation states

Veeraswamy, R. K., Cella, M., Colonna, M. & Unanue, E. R., Jun 1 2003, In: Journal of Immunology. 170, 11, p. 5367-5372 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

Dendritic cells require a systemic type I interferon response to mature and induce CD4⁺ Th1 immunity with poly IC as adjuvant

Longhi, M. P., Trumpfheller, C., Idoyaga, J., Caskey, M., Matos, I., Kluger, C., Salazar, A. M., Colonna, M. & Steinman, R. M., Jul 6 2009, In: Journal of Experimental Medicine. 206, 7, p. 1589-1602 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

478 Scopus citations

Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways

Barchet, W., Krug, A., Cella, M., Newby, C., Fischer, J. A. A., Dzionek, A., Pekosz, A. & Colonna, M., Jan 2005, In: European Journal of Immunology. 35, 1, p. 236-242 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

106 Scopus citations

Depression and Alzheimer's Disease Biomarkers Predict Driving Decline

Babulal, G. M., Chen, S., Williams, M. M., Trani, J. F., Bakhshi, P., Chao, G. L., Stout, S. H., Fagan, A. M., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C. & Roe, C. M., 2018, In: Journal of Alzheimer's Disease. 66, 3, p. 1213-1221 9 p.

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Depressive symptoms and CSF Alzheimer's disease biomarkers in relation to clinical symptom onset of mild cognitive impairment

The BIOCARD Research Team, 2020, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 12, 1, e12106.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging

Sun, S. W., Song, S. K., Harms, M. P., Lin, S. J., Holtzman, D. M., Merchant, K. M. & Kotyk, J. J., Jan 2005, In: Experimental Neurology. 191, 1, p. 77-85 9 p.

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury

Mac Donald, C. L., Dikranian, K., Song, S. K., Bayly, P. V., Holtzman, D. M. & Brody, D. L., May 2007, In: Experimental Neurology. 205, 1, p. 116-131 16 p.

Research output: Contribution to journal › Article › peer-review

241 Scopus citations

Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications

Czajkowsky, D. M., Andersen, J. T., Fuchs, A., Wilson, T. J., Mekhaiel, D., Colonna, M., He, J., Shao, Z., Mitchell, D. A., Wu, G., Dell, A., Haslam, S., Lloyd, K. A., Moore, S. C., Sandlie, I., Blundell, P. A. & Pleass, R. J., Apr 27 2015, In: Scientific reports. 5, 9526.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Development, differentiation, and diversity of innate lymphoid cells

Diefenbach, A., Colonna, M. & Koyasu, S., Sep 18 2014, In: Immunity. 41, 3, p. 354-365 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

413 Scopus citations

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

Holtzman, D. M., Santucci, D., Kilbridge, J., Chua-Couzens, J., Fontana, D. J., Daniels, S. E., Johnson, R. M., Chen, K., Sun, Y., Carlson, E., Alleva, E., Epstein, C. J. & Mobley, W. C., Nov 12 1996, In: Proceedings of the National Academy of Sciences of the United States of America. 93, 23, p. 13333-13338 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

383 Scopus citations

Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm's Canal Reporter Rat

Jung, E., Gardner, D., Choi, D., Park, E., Jin Seong, Y., Yang, S., Castorena-Gonzalez, J., Louveau, A., Zhou, Z., Lee, G. K., Perrault, D. P., Lee, S., Johnson, M., Daghlian, G., Lee, M., Jin Hong, Y., Kato, Y., Kipnis, J., Davis, M. J., Wong, A. K., & 1 othersHong, Y. K., Dec 1 2017, In: Scientific reports. 7, 1, 5577.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Development and function of murine B220⁺CD11c ⁺NK1.1⁺ cells identify them as a subset of NK cells

Blasius, A. L., Barchet, W., Cella, M. & Colonna, M., Oct 29 2007, In: Journal of Experimental Medicine. 204, 11, p. 2561-2568 8 p.

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Diagnostic and prognostic utility of the synaptic marker neurogranin in Alzheimer disease

Tarawneh, R., D'Angelo, G., Crimmins, D., Herries, E., Griest, T., Fagan, A. M., Zipfel, G. J., Ladenson, J. H., Morris, J. C. & Holtzman, D. M., May 2016, In: JAMA Neurology. 73, 5, p. 561-571 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

119 Scopus citations

Dietary salt promotes cognitive impairment through tau phosphorylation

Faraco, G., Hochrainer, K., Segarra, S. G., Schaeffer, S., Santisteban, M. M., Menon, A., Jiang, H., Holtzman, D. M., Anrather, J. & Iadecola, C., Oct 31 2019, In: Nature. 574, 7780, p. 686-690 5 p.

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Differences in the Aβ40/Aβ42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype

Fagan, A. M., Younkin, L. H., Morris, J. C., Fryer, J. D., Cole, T. G., Younkin, S. G. & Holtzman, D. M., 2000, In: Annals of neurology. 48, 2, p. 201-210 10 p.

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Differential effects of cAMP in neurons and astrocytes. Role of B-raf

Dugan, L. L., Kim, J. S., Zhang, Y., Bart, R. D., Sun, Y., Holtzman, D. M. & Gutmann, D. H., Sep 3 1999, In: Journal of Biological Chemistry. 274, 36, p. 25842-25848 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

196 Scopus citations

Differential metabolism of ApoE isoforms in plasma and CSF

Wahrle, S. E. & Holtzman, D. M., Sep 1 2003, In: Experimental Neurology. 183, 1, p. 4-6 3 p.

Research output: Contribution to journal › Comment/debate

16 Scopus citations

Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity

Cella, M., Fujikawa, K., Tassi, I., Kim, S., Latinis, K., Nishi, S., Yokoyama, W., Colonna, M. & Swat, W., Sep 20 2004, In: Journal of Experimental Medicine. 200, 6, p. 817-823 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

88 Scopus citations

Differential usage of transcriptional repressor Zeb2 enhancers distinguishes adult and embryonic hematopoiesis

Huang, X., Ferris, S. T., Kim, S., Choudhary, M. N. K., Belk, J. A., Fan, C., Qi, Y., Sudan, R., Xia, Y., Desai, P., Chen, J., Ly, N., Shi, Q., Bagadia, P., Liu, T., Guilliams, M., Egawa, T., Colonna, M., Diamond, M. S., Murphy, T. L., & 3 othersSatpathy, A. T., Wang, T. & Murphy, K. M., Jul 13 2021, In: Immunity. 54, 7, p. 1417-1432.e7

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Diffusion characteristics associated with neuronal injury and glial activation following hypoxia-ischemia in the immature brain

Lodygensky, G. A., West, T., Moravec, M. D., Back, S. A., Dikranian, K., Holtzman, D. M. & Neil, J. J., Sep 2011, In: Magnetic resonance in medicine. 66, 3, p. 839-845 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition

Song, S. K., Kim, J. H., Lin, S. J., Brendza, R. P. & Holtzman, D. M., Apr 2004, In: Neurobiology of Disease. 15, 3, p. 640-647 8 p.

Research output: Contribution to journal › Article › peer-review

156 Scopus citations

Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury

Mac Donald, C. L., Dikranian, K., Bayly, P., Holtzman, D. & Brody, D., Oct 31 2007, In: Journal of Neuroscience. 27, 44, p. 11869-11876 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

339 Scopus citations

Center for Brain Immunology & Glia (BIG)

Research output

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