Center for Brain Immunology & Glia (BIG)

CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease

Strain, J. F., Barthelemy, N., Horie, K., Gordon, B. A., Kilgore, C., Aschenbrenner, A., Cruchaga, C., Xiong, C., Joseph-Mathurin, N., Hassenstab, J., Fagan, A. M., Li, Y., Karch, C. M., Perrin, R. J., Berman, S. B., Chhatwal, J. P., Graff-Radford, N. R., Mori, H., Levin, J., Noble, J. M., & 9 othersAllegri, R., Schofield, P. R., Marcus, D. S., Holtzman, D. M., Morris, J. C., Benzinger, T. L. S., McDade, E. M., Bateman, R. J. & Ances, B. M., Jun 15 2022, In: Neurobiology of Disease. 168, 105714.

Research output: Contribution to journal › Article › peer-review

Open Access

CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease

Tarawneh, R., Lee, J. M., Ladenson, J. H., Morris, J. C. & Holtzman, D. M., Mar 6 2012, In: Neurology. 78, 10, p. 709-719 11 p.

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

C-type lectin-like receptors in peptide-specific HLA class I-restricted cytotoxic T lymphocytes: Differential expression and modulation of effector functions in clones sharing identical TCR structure and epitope specificity

Noppen, C., Schaefer, C., Zajac, P., Schütz, A., Kocher, T., Kloth, J., Heberer, M., Colonna, M., De Libero, G. & Spagnoli, G. C., Apr 1998, In: European Journal of Immunology. 28, 4, p. 1134-1142 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Current thinking on the mechanistic basis of Alzheimer's and implications for drug development

Ising, C., Stanley, M. & Holtzman, D. M., Nov 1 2015, In: Clinical pharmacology and therapeutics. 98, 5, p. 469-471 3 p.

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Cutting edge: IFN-producing cells respond to CXCR3 ligands in the presence of CXCL12 and secrete inflammatory chemokines upon activation

Krug, A., Uppaluri, R., Facchetti, F., Dorner, B. G., Sheehan, K. C. F., Schreiber, R. D., Cella, M. & Colonna, M., Dec 1 2002, In: Journal of Immunology. 169, 11, p. 6079-6083 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

126 Scopus citations

Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties

Chang, C., Dietrich, J., Harpur, A. G., Lindquist, J. A., Haude, A., Loke, Y. W., King, A., Colonna, M., Trowsdale, J. & Wilson, M. J., Nov 6 1999, In: Journal of Immunology. 163, 9, p. 4651-4654 4 p.

Research output: Contribution to journal › Article › peer-review

113 Scopus citations

Cutting edge: TREM-2 attenuates macrophage activation

Turnbull, I. R., Gilfillan, S., Cella, M., Aoshi, T., Miller, M., Piccio, L., Hernandez, M. & Colonna, M., Sep 15 2006, In: Journal of Immunology. 177, 6, p. 3520-3524 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

476 Scopus citations

Cutting edge: Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I-molecules

Colonna, M., Samaridis, J., Cella, M., Angman, L., Allen, R. L., O'Callaghan, C. A., Dunbar, R., Ogg, G. S., Cerundolo, V. & Rolink, A., Apr 1 1998, In: Journal of Immunology. 160, 7, p. 3096-3100 5 p.

Research output: Contribution to journal › Article › peer-review

227 Scopus citations

Cutting edge: Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family

Bouchon, A., Cella, M., Grierson, H. L., Cohen, J. I. & Colonna, M., Nov 15 2001, In: Journal of Immunology. 167, 10, p. 5517-5521 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

139 Scopus citations

Cutting edge: Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor γ-chain

Nakajima, H., Samaridis, J., Angman, L. & Colonna, M., Jan 1 1999, In: Journal of Immunology. 162, 1, p. 5-8 4 p.

Research output: Contribution to journal › Article › peer-review

154 Scopus citations

Cutting edge: Human FcRL4 and FcRL5 are receptors for IgA and IgG

Wilson, T. J., Fuchs, A. & Colonna, M., May 15 2012, In: Journal of Immunology. 188, 10, p. 4741-4745 5 p.

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Cutting edge: Salivary gland nk cells develop independently of Nfil3 in steady-state

Cortez, V. S., Fuchs, A., Cella, M., Gilfillan, S. & Colonna, M., May 15 2014, In: Journal of Immunology. 192, 10, p. 4487-4491 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

117 Scopus citations

Cutting edge: Polyinosinic:Polycytidylic acid boosts the generation of memory CD8 T cells through melanoma differentiation-associated protein 5 expressed in stromal cells

Wang, Y., Cella, M., Gilfillan, S. & Colonna, M., Mar 15 2010, In: Journal of Immunology. 184, 6, p. 2751-2755 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

Cutting edge: Paradoxical roles of BST2/tetherin in promoting type I IFN response and viral infection

Swiecki, M., Wang, Y., Gilfillan, S., Lenschow, D. J. & Colonna, M., Mar 15 2012, In: Journal of Immunology. 188, 6, p. 2488-2492 5 p.

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Cutting edge: Signal-regulatory protein β1 is a DAP12-associated activating receptor expressed in myeloid cells

Dietrich, J., Cella, M., Seiffert, M., Bühring, H. J. & Colonna, M., Jan 1 2000, In: Journal of Immunology. 164, 1, p. 9-12 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Cutting edge: Expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia

Knapp, S., Gibot, S., De Vos, A., Versteeg, H. H., Colonna, M. & Van Der Poll, T., Dec 15 2004, In: Journal of Immunology. 173, 12, p. 7131-7134 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

131 Scopus citations

Cutting edge: Inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

Bouchon, A., Dietrich, J. & Colonna, M., May 15 2000, In: Journal of Immunology. 164, 10, p. 4991-4995 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

915 Scopus citations

Cutting Edge: CD96 (Tactile) Promotes NK Cell-Target Cell Adhesion by Interacting with the Poliovirus Receptor (CD155)

Fuchs, A., Cella, M., Giurisato, E., Shaw, A. S. & Colonna, M., Apr 1 2004, In: Journal of Immunology. 172, 7, p. 3994-3998 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

279 Scopus citations

Cytokine-mediated inhibition of fibrillar amyloid-β peptide degradation by human mononuclear phagocytes

Yamamoto, M., Kiyota, T., Walsh, S. M., Liu, J., Kipnis, J. & Ikezu, T., Sep 15 2008, In: Journal of Immunology. 181, 6, p. 3877-3886 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Cytolytic responses: Cadherins put out the fire

Colonna, M., Feb 20 2006, In: Journal of Experimental Medicine. 203, 2, p. 261-264 4 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

17 Scopus citations

Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K⁺ efflux

Franchi, L., Eigenbrod, T., Muñoz-Planillo, R., Ozkurede, U., Kim, Y. G., Chakrabarti, A., Gale, M., Silverman, R. H., Colonna, M., Akira, S. & Núñez, G., Oct 15 2014, In: Journal of Immunology. 193, 8, p. 4214-4222 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

114 Scopus citations

DAMed in (Trem) 2 Steps

Da Mesquita, S. & Kipnis, J., Jun 15 2017, In: Cell. 169, 7, p. 1172-1174 3 p.

Research output: Contribution to journal › Short survey › peer-review

Open Access

3 Scopus citations

DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo

Tassi, I., Le Friec, G., Gilfillan, S., Takai, T., Yokohama, W. M. & Colonna, M., 2009, In: European Journal of Immunology. 39, 4, p. 1129-1135 7 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

DAP10 contributes to CD8⁺ T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection

Heßmann, M., Rausch, A., Rückerl, D., Adams, P. S., Simon, M., Gilfillan, S., Colonna, M., Ehlers, S. & Hölscher, C., May 2011, In: Immunobiology. 216, 5, p. 639-647 9 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

DAP12: A key accessory protein for relaying signals by Natural Killer cell receptors

Campbell, K. S. & Colonna, M., Jun 1999, In: International Journal of Biochemistry and Cell Biology. 31, 6, p. 631-636 6 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis

Turnbull, I. R., McDunn, J. E., Takai, T., Townsend, R. R., Cobb, J. P. & Colonna, M., Aug 1 2005, In: Journal of Experimental Medicine. 202, 3, p. 363-369 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

DAP12 signaling: From immune cells to bone modeling and brain myelination

Colonna, M., Feb 2003, In: Journal of Clinical Investigation. 111, 3, p. 313-314 2 p.

Research output: Contribution to journal › Comment/debate

Open Access

7 Scopus citations

DC-SCRIPT deficiency delays mouse mammary gland development and branching morphogenesis

Tang, C., van den Bijgaart, R. J. E., Looman, M. W. G., Tel-Karthaus, N., de Graaf, A. M. A., Gilfillan, S., Colonna, M., Ansems, M. & Adema, G. J., Nov 1 2019, In: Developmental Biology. 455, 1, p. 42-50 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Dealing with Danger in the CNS: The Response of the Immune System to Injury

Gadani, S. P., Walsh, J. T., Lukens, J. R. & Kipnis, J., Jul 1 2015, In: Neuron. 87, 1, p. 47-62 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

188 Scopus citations

Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils

Daigle, I., Yousefi, S., Colonna, M., Green, D. R. & Simon, H. U., 2002, In: Nature medicine. 8, 1, p. 61-67 7 p.

Research output: Contribution to journal › Article › peer-review

160 Scopus citations

Debate: "Is increasing neuroinflammation beneficial for neural repair?"

Crutcher, K. A., Gendelman, H. E., Kipnis, J., Perez-Polo, J. R., Perry, V. H., Popovich, P. G. & Weaver, L. C., Sep 2006, In: Journal of Neuroimmune Pharmacology. 1, 3, p. 195-211 17 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Deciphering alzheimer disease

Selkoe, D., Mandelkow, E. & Holtzman, D., Jan 2012, In: Cold Spring Harbor perspectives in medicine. 2, 1

Research output: Contribution to journal › Article › peer-review

Open Access

110 Scopus citations

Decreased cerebrospinal fluid Aβ ₄₂ correlates with brain atrophy in cognitively normal elderly

Fagan, A. M., Head, D., Shah, A. R., Marcus, D., Mintun, M., Morris, J. C. & Holtzman, D. M., Feb 2009, In: Annals of neurology. 65, 2, p. 176-183 8 p.

Research output: Contribution to journal › Article › peer-review

285 Scopus citations

Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration

Hagnerud, S., Manna, P. P., Cella, M., Stenberg, Å., Frazier, W. A., Colonna, M. & Oldenborg, P. A., May 15 2006, In: Journal of Immunology. 176, 10, p. 5772-5778 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Deletion of Abca1 increases Aβ deposition in the PDAPP transgenic mouse model of Alzheimer disease

Wahrle, S. E., Jiang, H., Parsadanian, M., Hartman, R. E., Bales, K. R., Paul, S. M. & Holtzman, D. M., Dec 30 2005, In: Journal of Biological Chemistry. 280, 52, p. 43236-43242 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

259 Scopus citations

Dementia is not synonymous with Alzheimer’s disease

Jack, C., Holtzman, D. & Sperling, R., Dec 11 2019, In: Science translational medicine. 11, 522, eaav0511.

Research output: Contribution to journal › Editorial

10 Scopus citations

Dendritic cells at the host-pathogen interface

Colonna, M., Pulendran, B. & Iwasaki, A., Feb 2006, In: Nature immunology. 7, 2, p. 117-120 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

Dendritic cells process and present antigens across a range of maturation states

Veeraswamy, R. K., Cella, M., Colonna, M. & Unanue, E. R., Jun 1 2003, In: Journal of Immunology. 170, 11, p. 5367-5372 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Dendritic cells require a systemic type I interferon response to mature and induce CD4⁺ Th1 immunity with poly IC as adjuvant

Longhi, M. P., Trumpfheller, C., Idoyaga, J., Caskey, M., Matos, I., Kluger, C., Salazar, A. M., Colonna, M. & Steinman, R. M., Jul 6 2009, In: Journal of Experimental Medicine. 206, 7, p. 1589-1602 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

495 Scopus citations

Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways

Barchet, W., Krug, A., Cella, M., Newby, C., Fischer, J. A. A., Dzionek, A., Pekosz, A. & Colonna, M., Jan 2005, In: European Journal of Immunology. 35, 1, p. 236-242 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

108 Scopus citations

Depression and Alzheimer's Disease Biomarkers Predict Driving Decline

Babulal, G. M., Chen, S., Williams, M. M., Trani, J. F., Bakhshi, P., Chao, G. L., Stout, S. H., Fagan, A. M., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C. & Roe, C. M., 2018, In: Journal of Alzheimer's Disease. 66, 3, p. 1213-1221 9 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Depressive symptoms and CSF Alzheimer's disease biomarkers in relation to clinical symptom onset of mild cognitive impairment

The BIOCARD Research Team, 2020, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 12, 1, e12106.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging

Sun, S. W., Song, S. K., Harms, M. P., Lin, S. J., Holtzman, D. M., Merchant, K. M. & Kotyk, J. J., Jan 2005, In: Experimental Neurology. 191, 1, p. 77-85 9 p.

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury

Mac Donald, C. L., Dikranian, K., Song, S. K., Bayly, P. V., Holtzman, D. M. & Brody, D. L., May 2007, In: Experimental Neurology. 205, 1, p. 116-131 16 p.

Research output: Contribution to journal › Article › peer-review

247 Scopus citations

Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications

Czajkowsky, D. M., Andersen, J. T., Fuchs, A., Wilson, T. J., Mekhaiel, D., Colonna, M., He, J., Shao, Z., Mitchell, D. A., Wu, G., Dell, A., Haslam, S., Lloyd, K. A., Moore, S. C., Sandlie, I., Blundell, P. A. & Pleass, R. J., Apr 27 2015, In: Scientific reports. 5, 9526.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Development, differentiation, and diversity of innate lymphoid cells

Diefenbach, A., Colonna, M. & Koyasu, S., Sep 18 2014, In: Immunity. 41, 3, p. 354-365 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

432 Scopus citations

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

Holtzman, D. M., Santucci, D., Kilbridge, J., Chua-Couzens, J., Fontana, D. J., Daniels, S. E., Johnson, R. M., Chen, K., Sun, Y., Carlson, E., Alleva, E., Epstein, C. J. & Mobley, W. C., Nov 12 1996, In: Proceedings of the National Academy of Sciences of the United States of America. 93, 23, p. 13333-13338 6 p.

Research output: Contribution to journal › Article › peer-review

392 Scopus citations

Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm's Canal Reporter Rat

Jung, E., Gardner, D., Choi, D., Park, E., Jin Seong, Y., Yang, S., Castorena-Gonzalez, J., Louveau, A., Zhou, Z., Lee, G. K., Perrault, D. P., Lee, S., Johnson, M., Daghlian, G., Lee, M., Jin Hong, Y., Kato, Y., Kipnis, J., Davis, M. J., Wong, A. K., & 1 othersHong, Y. K., Dec 1 2017, In: Scientific reports. 7, 1, 5577.

Research output: Contribution to journal › Article › peer-review

Open Access

37 Scopus citations

Development and function of murine B220⁺CD11c ⁺NK1.1⁺ cells identify them as a subset of NK cells

Blasius, A. L., Barchet, W., Cella, M. & Colonna, M., Oct 29 2007, In: Journal of Experimental Medicine. 204, 11, p. 2561-2568 8 p.

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Diagnostic and prognostic utility of the synaptic marker neurogranin in Alzheimer disease

Tarawneh, R., D'Angelo, G., Crimmins, D., Herries, E., Griest, T., Fagan, A. M., Zipfel, G. J., Ladenson, J. H., Morris, J. C. & Holtzman, D. M., May 2016, In: JAMA Neurology. 73, 5, p. 561-571 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

131 Scopus citations

Center for Brain Immunology & Glia (BIG)

Research output

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