Center for Brain Immunology & Glia (BIG)

DAP12: A key accessory protein for relaying signals by Natural Killer cell receptors

Campbell, K. S. & Colonna, M., Jun 1999, In: International Journal of Biochemistry and Cell Biology. 31, 6, p. 631-636 6 p.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis

Turnbull, I. R., McDunn, J. E., Takai, T., Townsend, R. R., Cobb, J. P. & Colonna, M., Aug 1 2005, In: Journal of Experimental Medicine. 202, 3, p. 363-369 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

77 Scopus citations

DAP12 signaling: From immune cells to bone modeling and brain myelination

Colonna, M., Feb 2003, In: Journal of Clinical Investigation. 111, 3, p. 313-314 2 p.

Research output: Contribution to journal › Comment/debate

Open Access

30 Scopus citations

DC-SCRIPT deficiency delays mouse mammary gland development and branching morphogenesis

Tang, C., van den Bijgaart, R. J. E., Looman, M. W. G., Tel-Karthaus, N., de Graaf, A. M. A., Gilfillan, S., Colonna, M., Ansems, M. & Adema, G. J., Nov 1 2019, In: Developmental Biology. 455, 1, p. 42-50 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Dealing with Danger in the CNS: The Response of the Immune System to Injury

Gadani, S. P., Walsh, J. T., Lukens, J. R. & Kipnis, J., Jul 1 2015, In: Neuron. 87, 1, p. 47-62 16 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

152 Scopus citations

Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils

Daigle, I., Yousefi, S., Colonna, M., Green, D. R. & Simon, H. U., 2002, In: Nature medicine. 8, 1, p. 61-67 7 p.

Research output: Contribution to journal › Article › peer-review

157 Scopus citations

Debate: "Is increasing neuroinflammation beneficial for neural repair?"

Crutcher, K. A., Gendelman, H. E., Kipnis, J., Perez-Polo, J. R., Perry, V. H., Popovich, P. G. & Weaver, L. C., Sep 2006, In: Journal of Neuroimmune Pharmacology. 1, 3, p. 195-211 17 p.

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Deciphering alzheimer disease

Selkoe, D., Mandelkow, E. & Holtzman, D., Jan 2012, In: Cold Spring Harbor perspectives in medicine. 2, 1

Research output: Contribution to journal › Article › peer-review

Open Access

124 Scopus citations

Decreased cerebrospinal fluid Aβ ₄₂ correlates with brain atrophy in cognitively normal elderly

Fagan, A. M., Head, D., Shah, A. R., Marcus, D., Mintun, M., Morris, J. C. & Holtzman, D. M., Feb 2009, In: Annals of neurology. 65, 2, p. 176-183 8 p.

Research output: Contribution to journal › Article › peer-review

274 Scopus citations

Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration

Hagnerud, S., Manna, P. P., Cella, M., Stenberg, Å., Frazier, W. A., Colonna, M. & Oldenborg, P. A., May 15 2006, In: Journal of Immunology. 176, 10, p. 5772-5778 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

Deletion of Abca1 increases Aβ deposition in the PDAPP transgenic mouse model of Alzheimer disease

Wahrle, S. E., Jiang, H., Parsadanian, M., Hartman, R. E., Bales, K. R., Paul, S. M. & Holtzman, D. M., Dec 30 2005, In: Journal of Biological Chemistry. 280, 52, p. 43236-43242 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

255 Scopus citations

Dementia is not synonymous with Alzheimer’s disease

Jack, C., Holtzman, D. & Sperling, R., Dec 11 2019, In: Science translational medicine. 11, 522, eaav0511.

Research output: Contribution to journal › Editorial

7 Scopus citations

Dendritic cells at the host-pathogen interface

Colonna, M., Pulendran, B. & Iwasaki, A., Feb 1 2006, In: Nature immunology. 7, 2, p. 117-120 4 p.

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Dendritic cells process and present antigens across a range of maturation states

Veeraswamy, R. K., Cella, M., Colonna, M. & Unanue, E. R., Jun 1 2003, In: Journal of Immunology. 170, 11, p. 5367-5372 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Dendritic cells require a systemic type I interferon response to mature and induce CD4⁺ Th1 immunity with poly IC as adjuvant

Longhi, M. P., Trumpfheller, C., Idoyaga, J., Caskey, M., Matos, I., Kluger, C., Salazar, A. M., Colonna, M. & Steinman, R. M., Jul 6 2009, In: Journal of Experimental Medicine. 206, 7, p. 1589-1602 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

455 Scopus citations

Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways

Barchet, W., Krug, A., Cella, M., Newby, C., Fischer, J. A. A., Dzionek, A., Pekosz, A. & Colonna, M., Jan 2005, In: European Journal of Immunology. 35, 1, p. 236-242 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

105 Scopus citations

Depression and Alzheimer's Disease Biomarkers Predict Driving Decline

Babulal, G. M., Chen, S., Williams, M. M., Trani, J. F., Bakhshi, P., Chao, G. L., Stout, S. H., Fagan, A. M., Benzinger, T. L. S., Holtzman, D. M., Morris, J. C. & Roe, C. M., 2018, In: Journal of Alzheimer's Disease. 66, 3, p. 1213-1221 9 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Depressive symptoms and CSF Alzheimer's disease biomarkers in relation to clinical symptom onset of mild cognitive impairment

The BIOCARD Research Team, 2020, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 12, 1, e12106.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging

Sun, S. W., Song, S. K., Harms, M. P., Lin, S. J., Holtzman, D. M., Merchant, K. M. & Kotyk, J. J., Jan 2005, In: Experimental Neurology. 191, 1, p. 77-85 9 p.

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury

Mac Donald, C. L., Dikranian, K., Song, S. K., Bayly, P. V., Holtzman, D. M. & Brody, D. L., May 2007, In: Experimental Neurology. 205, 1, p. 116-131 16 p.

Research output: Contribution to journal › Article › peer-review

234 Scopus citations

Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications

Czajkowsky, D. M., Andersen, J. T., Fuchs, A., Wilson, T. J., Mekhaiel, D., Colonna, M., He, J., Shao, Z., Mitchell, D. A., Wu, G., Dell, A., Haslam, S., Lloyd, K. A., Moore, S. C., Sandlie, I., Blundell, P. A. & Pleass, R. J., Apr 27 2015, In: Scientific reports. 5, 9526.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Development, differentiation, and diversity of innate lymphoid cells

Diefenbach, A., Colonna, M. & Koyasu, S., Sep 18 2014, In: Immunity. 41, 3, p. 354-365 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

388 Scopus citations

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

Holtzman, D. M., Santucci, D., Kilbridge, J., Chua-Couzens, J., Fontana, D. J., Daniels, S. E., Johnson, R. M., Chen, K., Sun, Y., Carlson, E., Alleva, E., Epstein, C. J. & Mobley, W. C., Nov 12 1996, In: Proceedings of the National Academy of Sciences of the United States of America. 93, 23, p. 13333-13338 6 p.

Research output: Contribution to journal › Article › peer-review

373 Scopus citations

Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm's Canal Reporter Rat

Jung, E., Gardner, D., Choi, D., Park, E., Jin Seong, Y., Yang, S., Castorena-Gonzalez, J., Louveau, A., Zhou, Z., Lee, G. K., Perrault, D. P., Lee, S., Johnson, M., Daghlian, G., Lee, M., Jin Hong, Y., Kato, Y., Kipnis, J., Davis, M. J., Wong, A. K. & 1 others, Hong, Y. K., Dec 1 2017, In: Scientific reports. 7, 1, 5577.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Development and function of murine B220⁺CD11c ⁺NK1.1⁺ cells identify them as a subset of NK cells

Blasius, A. L., Barchet, W., Cella, M. & Colonna, M., Oct 29 2007, In: Journal of Experimental Medicine. 204, 11, p. 2561-2568 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

134 Scopus citations

Diagnostic and prognostic utility of the synaptic marker neurogranin in Alzheimer disease

Tarawneh, R., D'Angelo, G., Crimmins, D., Herries, E., Griest, T., Fagan, A. M., Zipfel, G. J., Ladenson, J. H., Morris, J. C. & Holtzman, D. M., May 2016, In: JAMA Neurology. 73, 5, p. 561-571 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

110 Scopus citations

Dietary salt promotes cognitive impairment through tau phosphorylation

Faraco, G., Hochrainer, K., Segarra, S. G., Schaeffer, S., Santisteban, M. M., Menon, A., Jiang, H., Holtzman, D. M., Anrather, J. & Iadecola, C., Oct 31 2019, In: Nature. 574, 7780, p. 686-690 5 p.

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Differences in the Aβ40/Aβ42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype

Fagan, A. M., Younkin, L. H., Morris, J. C., Fryer, J. D., Cole, T. G., Younkin, S. G. & Holtzman, D. M., 2000, In: Annals of neurology. 48, 2, p. 201-210 10 p.

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Differential effects of cAMP in neurons and astrocytes. Role of B-raf

Dugan, L. L., Kim, J. S., Zhang, Y., Bart, R. D., Sun, Y., Holtzman, D. M. & Gutmann, D. H., Sep 3 1999, In: Journal of Biological Chemistry. 274, 36, p. 25842-25848 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

191 Scopus citations

Differential metabolism of ApoE isoforms in plasma and CSF

Wahrle, S. E. & Holtzman, D. M., Sep 1 2003, In: Experimental Neurology. 183, 1, p. 4-6 3 p.

Research output: Contribution to journal › Comment/debate

16 Scopus citations

Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity

Cella, M., Fujikawa, K., Tassi, I., Kim, S., Latinis, K., Nishi, S., Yokoyama, W., Colonna, M. & Swat, W., Sep 20 2004, In: Journal of Experimental Medicine. 200, 6, p. 817-823 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

87 Scopus citations

Differential usage of transcriptional repressor Zeb2 enhancers distinguishes adult and embryonic hematopoiesis

Huang, X., Ferris, S. T., Kim, S., Choudhary, M. N. K., Belk, J. A., Fan, C., Qi, Y., Sudan, R., Xia, Y., Desai, P., Chen, J., Ly, N., Shi, Q., Bagadia, P., Liu, T., Guilliams, M., Egawa, T., Colonna, M., Diamond, M. S., Murphy, T. L. & 3 others, Satpathy, A. T., Wang, T. & Murphy, K. M., Jul 13 2021, In: Immunity. 54, 7, p. 1417-1432.e7

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Diffusion characteristics associated with neuronal injury and glial activation following hypoxia-ischemia in the immature brain

Lodygensky, G. A., West, T., Moravec, M. D., Back, S. A., Dikranian, K., Holtzman, D. M. & Neil, J. J., Sep 2011, In: Magnetic resonance in medicine. 66, 3, p. 839-845 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid deposition

Song, S. K., Kim, J. H., Lin, S. J., Brendza, R. P. & Holtzman, D. M., Apr 2004, In: Neurobiology of Disease. 15, 3, p. 640-647 8 p.

Research output: Contribution to journal › Article › peer-review

153 Scopus citations

Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury

Mac Donald, C. L., Dikranian, K., Bayly, P., Holtzman, D. & Brody, D., Oct 31 2007, In: Journal of Neuroscience. 27, 44, p. 11869-11876 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

327 Scopus citations

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

Deczkowska, A., Keren-Shaul, H., Weiner, A., Colonna, M., Schwartz, M. & Amit, I., May 17 2018, In: Cell. 173, 5, p. 1073-1081 9 p.

Research output: Contribution to journal › Review article › peer-review

322 Scopus citations

Disparate antiviral responses in Molluscum contagiosum virus-induced skin lesions

Swiecki, M. & Colonna, M., Feb 2011, In: Journal of Investigative Dermatology. 131, 2, p. 288-290 3 p.

Research output: Contribution to journal › Comment/debate

Open Access

3 Scopus citations

Disruption of the sleep-wake cycle and diurnal fluctuation of amyloid-β in mice with Alzheimer's disease pathology

Roh, J. H., Huang, Y., Bero, A. W., Kasten, T., Stewart, F. R., Bateman, R. J. & Holtzman, D. M., Sep 5 2012, In: Science translational medicine. 4, 150, 150ra122.

Research output: Contribution to journal › Article › peer-review

349 Scopus citations

Dissecting natural killer cell activation pathways through analysis of genetic mutations in human and mouse

Tassi, I., Klesney-Tait, J. & Colonna, M., Dec 1 2006, In: Immunological Reviews. 214, 1, p. 92-105 14 p.

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells

McCartney, S., Vermi, W., Gilfillan, S., Cella, M., Murphy, T. L., Schreiber, R. D., Murphy, K. M. & Colonna, M., Dec 21 2009, In: Journal of Experimental Medicine. 206, 13, p. 2967-2976 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

160 Scopus citations

Distinct Gene Regulatory Pathways for Human Innate versus Adaptive Lymphoid Cells

Koues, O. I., Collins, P. L., Cella, M., Robinette, M. L., Porter, S. I., Pyfrom, S. C., Payton, J. E., Colonna, M. & Oltz, E. M., May 19 2016, In: Cell. 165, 5, p. 1134-1146 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

105 Scopus citations

Distinct therapeutic mechanisms of Tau antibodies: Promoting microglial clearance versus blocking neuronal uptake

Funk, K. E., Mirbaha, H., Jiang, H., Holtzman, D. M. & Diamond, M. I., Aug 28 2015, In: Journal of Biological Chemistry. 290, 35, p. 21652-21662 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

73 Scopus citations

Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia

Sessa, G., Podini, P., Mariani, M., Meroni, A., Spreafico, R., Sinigaglia, F., Colonna, M., Panina, P. & Meldolesi, J., Nov 2004, In: European Journal of Neuroscience. 20, 10, p. 2617-2628 12 p.

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Diurnal oscillation of CSF Aβ and other AD biomarkers

Lucey, B. P., Fagan, A. M., Holtzman, D. M., Morris, J. C. & Bateman, R. J., May 8 2017, In: Molecular neurodegeneration. 12, 1, 36.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Diversity and function of group 1 innate lymphoid cells

Cortez, V. S. & Colonna, M., Nov 1 2016, In: Immunology Letters. 179, p. 19-24 6 p.

Research output: Contribution to journal › Review article › peer-review

65 Scopus citations

DNA damage response impacts macrophage functions

Colonna, M., Nov 26 2015, In: Blood. 126, 22, p. 2440-2442 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases

Chan, C. J., Andrews, D. M., McLaughlin, N. M., Yagita, H., Gilfillan, S., Colonna, M. & Smyth, M. J., Jan 15 2010, In: Journal of Immunology. 184, 2, p. 902-911 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

129 Scopus citations

DNAM-1 controls NK cell activation via an ITT-like motif

Zhang, Z., Wu, N., Lu, Y., Davidson, D., Colonna, M. & Veillette, A., Nov 16 2015, In: Journal of Experimental Medicine. 212, 12, p. 2165-2182 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

71 Scopus citations

DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors

Gilfillan, S., Chan, C. J., Cella, M., Haynes, N. M., Rapaport, A. S., Boles, K. S., Andrews, D. M., Smyth, M. J. & Colonna, M., Dec 22 2008, In: Journal of Experimental Medicine. 205, 13, p. 2965-2973 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

224 Scopus citations

Does inflammation in an autoimmune disease differ from inflammation in neurodegenerative diseases? Possible implications for therapy

Schwartz, M., Butovsky, O. & Kipnis, J., Mar 2006, In: Journal of Neuroimmune Pharmacology. 1, 1, p. 4-10 7 p.

Research output: Contribution to journal › Short survey › peer-review

17 Scopus citations

Center for Brain Immunology & Glia (BIG)

Research output

Search results