Assoc. Dean for Research

Research Output

Filter
Article
2020

Cryptococcus neoformans chitin synthase 3 plays a critical role in dampening host inflammatory responses

Hole, C. R., Lam, W. C., Upadhya, R. & Lodge, J. K., Jan 1 2020, In : mBio. 11, 1, e03373-19.

Research output: Contribution to journalArticle

Open Access

Melanin deposition in two Cryptococcus species depends on cell-wall composition and flexibility

Chrissian, C., Camacho, E., Fu, M. S., Prados-Rosales, R., Chatterjee, S., Cordero, R. J. B. X., Lodge, J. K. X., Casadevall, A. & Stark, R. E., Jan 1 2020, In : Journal of Biological Chemistry. 295, 7, p. 1815-1828 14 p.

Research output: Contribution to journalArticle

4 Scopus citations
2019

Chitosan biosynthesis and virulence in the human fungal pathogen Cryptococcus gattii

Lam, W. C., Upadhya, R., Specht, C. A., Ragsdale, A. E., Hole, C. R., Levitz, S. M. & Lodge, J. K., Jan 1 2019, In : mSphere. 4, 5, e00644-19.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Cryptococcus neoformans cda1 and its chitin deacetylase activity are required for fungal pathogenesis

Upadhya, R., Baker, L. G., Lam, W. C., Specht, C. A., Donlin, M. J. & Lodge, J. K., Nov 1 2018, In : mBio. 9, 6, e02087-18.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

The monothiol glutaredoxin Grx4 regulates iron homeostasis and virulence in cryptococcus neoformans

Attarian, R., Hu, G., Sánchez-León, E., Caza, M., Croll, D., Do, E., Bach, H., Missall, T., Lodge, J., Jung, W. H. & Kronstad, J. W., Nov 1 2018, In : mBio. 9, 6, e02377-18.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2017

A fluorogenic C. neoformans reporter strain with a robust expression of m-cherry expressed from a safe haven site in the genome

Upadhya, R., Lam, W. C., Maybruck, B. T., Donlin, M. J., Chang, A. L., Kayode, S., Ormerod, K. L., Fraser, J. A., Doering, T. L. & Lodge, J. K., Nov 2017, In : Fungal Genetics and Biology. 108, p. 13-25 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Vaccination with recombinant Cryptococcus proteins in glucan particles protects mice against cryptococcosis in a manner dependent upon mouse strain and cryptococcal species

Specht, C. A., Lee, C. K., Huang, H., Hester, M. M., Liu, J., Luckie, B. A., Torres Santana, M. A., Mirza, Z., Khoshkenar, P., Abraham, A., Shen, Z. T., Lodge, J. K., Akalin, A., Homan, J., Ostroff, G. R. & Levitz, S. M., Nov 1 2017, In : mBio. 8, 6, e01872-17.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations
2016

Induction of protective immunity to cryptococcal infection in mice by a heat-killed, chitosan-deficient strain of Cryptococcus neoformans

Upadhya, R., Lam, W. C., Maybruck, B., Specht, C. A., Levitz, S. M. & Lodge, J. K., Jan 1 2016, In : mBio. 7, 3, e00547-16.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Intracellular Action of a Secreted Peptide Required for Fungal Virulence

Homer, C. M., Summers, D. K., Goranov, A. I., Clarke, S. C., Wiesner, D. L., Diedrich, J. K., Moresco, J. J., Toffaletti, D., Upadhya, R., Caradonna, I., Petnic, S., Pessino, V., Cuomo, C. A., Lodge, J. K., Perfect, J., Yates, J. R., Nielsen, K., Craik, C. S. & Madhani, H. D., Jun 8 2016, In : Cell Host and Microbe. 19, 6, p. 849-864 16 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations
2015

Protection against experimental cryptococcosis following vaccination with glucan particles containing cryptococcus alkaline extracts

Specht, C. A., Lee, C. K., Huang, H., Tipper, D. J., Shen, Z. T., Lodge, J. K., Leszyk, J., Ostroff, G. R. & Levitz, S. M., Dec 22 2015, In : mBio. 6, 6, p. 1-11 11 p., 01905-15.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations
2014

Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation

Janbon, G., Ormerod, K. L., Paulet, D., Byrnes, E. J., Yadav, V., Chatterjee, G., Mullapudi, N., Hon, C. C., Billmyre, R. B., Brunel, F., Bahn, Y. S., Chen, W., Chen, Y., Chow, E. W. L., Coppée, J. Y., Floyd-Averette, A., Gaillardin, C., Gerik, K. J., Goldberg, J., Gonzalez-Hilarion, S. & 32 others, Gujja, S., Hamlin, J. L., Hsueh, Y. P., Ianiri, G., Jones, S., Kodira, C. D., Kozubowski, L., Lam, W., Marra, M., Mesner, L. D., Mieczkowski, P. A., Moyrand, F., Nielsen, K., Proux, C., Rossignol, T., Schein, J. E., Sun, S., Wollschlaeger, C., Wood, I. A., Zeng, Q., Neuvéglise, C., Newlon, C. S., Perfect, J. R., Lodge, J. K., Idnurm, A., Stajich, J. E., Kronstad, J. W., Sanyal, K., Heitman, J., Fraser, J. A., Cuomo, C. A. & Dietrich, F. S., Apr 2014, In : PLoS genetics. 10, 4, e1004261.

Research output: Contribution to journalArticle

Open Access
187 Scopus citations

Cross talk between the cell wall integrity and cyclic AMP/protein kinase a pathways in Cryptococcus neoformans

Donlin, M. J., Upadhya, R., Gerik, K. J., Lam, W., Vanarendonk, L. G., Specht, C. A., Sharma, N. K. & Lodge, J. K., Aug 12 2014, In : mBio. 5, 4, e01573-14.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Cryptococcus at work: Gene expression during human infection

Upadhya, R., Donlin, M. J. & Lodge, J. K., Apr 22 2014, In : mBio. 5, 2, e01097-14.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2013

Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes

Chabrier-Roselló, Y., Gerik, K. J., Koselny, K., DiDone, L., Lodge, J. K. & Krysan, D. J., Jan 1 2013, In : Eukaryotic Cell. 12, 1, p. 12-22 11 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Global Transcriptome Profile of Cryptococcus neoformans during Exposure to Hydrogen Peroxide Induced Oxidative Stress

Upadhya, R., Campbell, L. T., Donlin, M. J., Aurora, R. & Lodge, J. K., Jan 28 2013, In : PloS one. 8, 1, e55110.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations

Role of Cryptococcus neoformans Rho1 GTPases in the PKC1 signaling pathway in response to thermal stress

Lam, W. C., Gerik, K. J. & Lodge, J. K., Jan 1 2013, In : Eukaryotic Cell. 12, 1, p. 118-131 14 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Sulphiredoxin plays peroxiredoxin-dependent and -independent roles via the HOG signalling pathway in Cryptococcus neoformans and contributes to fungal virulence

Upadhya, R., Kim, H., Jung, K. W., Park, G., Lam, W., Lodge, J. K. & Bahn, Y. S., Nov 1 2013, In : Molecular Microbiology. 90, 3, p. 630-648 19 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations
2010

Going green in Cryptococcus neoformans: The recycling of a selectable drug marker

Patel, R. D., Lodge, J. K. & Baker, L. G., Mar 1 2010, In : Fungal Genetics and Biology. 47, 3, p. 191-198 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
Open Access
12 Scopus citations

KRE genes are required for β-1,6-glucan synthesis, maintenance of capsule architecture and cell wall protein anchoring in Cryptococcus neoformans

Gilbert, N. M., Donlin, M. J., Gerik, K. J., Specht, C. A., Djordjevic, J. T., Wilson, C. F., Sorrell, T. C. & Lodge, J. K., Apr 2010, In : Molecular Microbiology. 76, 2, p. 517-534 18 p.

Research output: Contribution to journalArticle

Open Access
49 Scopus citations
2009

Chitinases are essential for sexual development but not vegetative growth in cryptococcus neoformans

Baker, L. G., Specht, C. A. & Lodge, J. K., Nov 1 2009, In : Eukaryotic Cell. 8, 11, p. 1692-1705 14 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations
1998

Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl- CoA:Protein N-myristoyltransferase (Nmt) is Nmt-dependent

Lodge, J. K., Jackson-Machelski, E., Higgins, M., McWherter, C. A., Sikorski, J. A., Devadas, B. & Gordon, J. I., May 15 1998, In : Journal of Biological Chemistry. 273, 20, p. 12482-12491 10 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations

Novel biologically active nonpeptidic inhibitors of myristoylCoArprotein NMyristoyltransferase

Devadas, B., Freeman, S. K., McWherter, C. A., Kishore, N. S., Lodge, J., Jackson-Machelski, E., Gordon, J. & Sikorski, J. A., Mar 12 1998, In : Journal of Medicinal Chemistry. 41, 6, p. 996-1000 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

Transgenic plants expressing potato virus X ORF2 protein (p24) are resistant to tobacco mosaic virus and Ob tobamoviruses

Ares, X., Calamante, G., Cabral, S., Lodge, J., Hemenway, P., Beachy, R. N. & Mentaberry, A., Jan 1 1998, In : Journal of virology. 72, 1, p. 731-738 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
1997

Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitos of Candida albicans myristoylCoA:protein N- myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity

Devadas, B., Freeman, S. K., Zupec, M. E., Lu, H. F., Nagarajan, S. R., Kishore, N. S., Lodge, J., Kuneman, D. W., McWherter, C. A., Vinjamoori, D. V., Getman, D. P., Gordon, J. & Sikorski, J. A., Aug 1 1997, In : Journal of Medicinal Chemistry. 40, 16, p. 2609-2625 17 p.

Research output: Contribution to journalArticle

63 Scopus citations

N-Myristoylation of Arf proteins in Candida albicans: An in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: Protein N-myristoyltransferase

Lodge, J. K., Jackson-Machelski, E., Devadas, B., Zupec, M. E., Getman, D. P., Kishore, N., Freeman, S. K., McWherter, C. A., Sikorski, J. A. & Gordon, J. I., Feb 1997, In : Microbiology. 143, 2, p. 357-366 10 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations
1994
92 Scopus citations

Molecular approaches to identify novel targets for future development of antifungal agents

Maresca, B., Bennett, J., Fonzi, W., Hitchcock, C. A., Lodge, J. K. & Williamson, P. R., Jan 1 1994, In : Medical Mycology. 32, S1, p. 287-298 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
Open Access
161 Scopus citations
1993

Broad-spectrum virus resistance in transgenic plants expressing pokeweed antiviral protein

Lodge, J. K., Kaniewski, W. K. & Tumer, N. E., Aug 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 15, p. 7089-7093 5 p.

Research output: Contribution to journalArticle

Open Access
211 Scopus citations
1992

4-Oxatetradecanoic acid is fungicidal for Cryptococcus neoformans and inhibits replication of human immunodeficiency virus I

Langner, C. A., Lodge, J. K., Travis, S. J., Caldwell, J. E., Lu, T., Li, Q., Bryant, M. L., Devadas, B., Gokel, G. W., Kobayashi, G. S. & Gordon, J. I., Jan 1 1992, In : Journal of Biological Chemistry. 267, 24, p. 17159-17169 11 p.

Research output: Contribution to journalArticle

65 Scopus citations
1991

Tn 5 insertion specificity is not influenced by IS 50 end sequences in target DNA

Lodge, J. K., Weston-Hafer, K. & Berg, D. E., Aug 1 1991, In : MGG Molecular & General Genetics. 228, 1-2, p. 312-315 4 p.

Research output: Contribution to journalArticle

7 Scopus citations
1990

Mutations that affect Tn5 insertion into pBR322: Importance of local DNA supercoiling

Lodge, J. K. & Berg, D. E., Jan 1 1990, In : Journal of bacteriology. 172, 10, p. 5956-5960 5 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations
1989

Formation of supercoiling domains in plasmid pBR322

Lodge, J. K., Kazic, T. & Berg, D. E., Jan 1 1989, In : Journal of bacteriology. 171, 4, p. 2181-2187 7 p.

Research output: Contribution to journalArticle

Open Access
86 Scopus citations
1988

Transposon Tn5 target specificity: Preference for insertion at G/C pairs

Lodge, J. K., Weston-Hafer, K. & Berg, D. E., Jan 1 1988, In : Genetics. 120, 3, p. 645-650 6 p.

Research output: Contribution to journalArticle

32 Scopus citations
1984

Transposon Tn5: Specific sequence recognition and conservative transposition

Berg, D. E., Lodge, J. & Sasakawa, C., Jan 1 1984, In : Cold Spring Harbor symposia on quantitative biology. VOL. 49, p. 215-226 12 p.

Research output: Contribution to journalArticle

9 Scopus citations